{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:03:30Z","timestamp":1767827010826,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.molimm.2021.12.021","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T16:51:53Z","timestamp":1641228713000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-496X","authenticated-orcid":false,"given":"Yingyun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2021.12.021_bib0005","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1073\/pnas.0611551104","article-title":"Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125","volume":"104","author":"Arimoto","year":"2007","journal-title":"PNAS"},{"key":"10.1016\/j.molimm.2021.12.021_bib0010","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.4049\/jimmunol.1501557","article-title":"Cutting edge: critical role of glycolysis in human plasmacytoid dendritic cell antiviral responses","volume":"196","author":"Bajwa","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0015","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ijc.28035","article-title":"Novel signatures of cancer-associated fibroblasts","volume":"133","author":"Bozoky","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.molimm.2021.12.021_bib0020","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.aaa1578","article-title":"Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency","volume":"348","author":"Ciancanelli","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molimm.2021.12.021_bib0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ni.2239","article-title":"NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4","volume":"13","author":"Cui","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-981-13-9367-9_8","article-title":"Structures of RIG-I-like receptors and insights into viral RNA sensing","volume":"1172","author":"Fan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0035","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature13590","article-title":"Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5\u2019-diphosphates","volume":"514","author":"Goubau","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2021.12.021_bib0040","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.molimm.2020.03.011","article-title":"E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1\/IKKi homeostasis","volume":"121","author":"Guo","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0045","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9440(10)63688-7","article-title":"Dorfin localizes to the ubiquitylated inclusions in Parkinson\u2019s disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis","volume":"163","author":"Hishikawa","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0050","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.1132505","article-title":"5\u2019-Triphosphate RNA is the ligand for RIG-I","volume":"314","author":"Hornung","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.molimm.2021.12.021_bib0055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2006.09.017","article-title":"Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity","volume":"25","author":"Ishigaki","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.molimm.2021.12.021_bib0060","doi-asserted-by":"crossref","first-page":"29106","DOI":"10.1074\/jbc.M302763200","article-title":"Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1","volume":"278","author":"Ito","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2021.12.021_bib0065","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1183\/09031936.00032412","article-title":"Expression of the nuclear factor-\u03baB inhibitor A20 is altered in the cystic fibrosis epithelium","volume":"41","author":"Kelly","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.molimm.2021.12.021_bib0070","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1007\/s11033-012-1874-7","article-title":"Porcine dorfin: molecular cloning of the RNF19 gene, sequence comparison, mapping and expression analysis","volume":"39","author":"Larsen","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.molimm.2021.12.021_bib0075","doi-asserted-by":"crossref","first-page":"e01438","DOI":"10.1128\/JVI.01438-19","article-title":"The E3 ubiquitin ligase TBK1 mediates the degradation of multiple picornavirus VP3 proteins by phosphorylation and ubiquitination","volume":"93","author":"Li","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0080","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1038\/ncomms9840","article-title":"Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer","volume":"6","author":"Maxfield","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2021.12.021_bib0085","first-page":"856","article-title":"Neurodegenerative diseases and dorfin","volume":"55","author":"Niwa","year":"2003","journal-title":"No To Shinkei"},{"key":"10.1016\/j.molimm.2021.12.021_bib0090","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.2001.4414","article-title":"A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity","volume":"281","author":"Niwa","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molimm.2021.12.021_bib0095","first-page":"21","article-title":"The role of tissue-specific ubiquitin ligases, RNF183, RNF186, RNF182 and RNF152, in disease and biological function","author":"Okamoto","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2021.12.021_bib0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2121-11-41","article-title":"RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand","volume":"11","author":"Peng","year":"2010","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0105","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/dvdy.22004","article-title":"Rnf19a, a ubiquitin protein ligase, and Psmc3, a component of the 26S proteasome, tether to the acrosome membranes and the head-tail coupling apparatus during rat spermatid development","volume":"238","author":"Rivkin","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.molimm.2021.12.021_bib0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jnr.22175","article-title":"Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"88","author":"Sone","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.molimm.2021.12.021_bib0115","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/ni.3588","article-title":"E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1","volume":"17","author":"Song","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0120","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1046\/j.1471-4159.2003.02289.x","article-title":"Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis","volume":"89","author":"Takeuchi","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.molimm.2021.12.021_bib0125","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/ni.1742","article-title":"The E3 ubiquitin ligase Nrdp1\u2019 preferentially\u2019 promotes TLR-mediated production of type I interferon","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0130","doi-asserted-by":"crossref","first-page":"9581","DOI":"10.1073\/pnas.1604277113","article-title":"RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.molimm.2021.12.021_bib0135","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1002\/jcb.28038","article-title":"Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia-reperfusion injury","volume":"120","author":"Wang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.molimm.2021.12.021_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008387","article-title":"RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation","volume":"16","author":"Yang","year":"2020","journal-title":"PLoS Path."},{"key":"10.1016\/j.molimm.2021.12.021_bib0145","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ecco-jcc\/jjw023","article-title":"E3 ubiquitin ligase RNF183 is a novel regulator in inflammatory bowel disease","volume":"10","author":"Yu","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.molimm.2021.12.021_bib0150","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.20120024","article-title":"TRAF-interacting protein (TRIP) negatively regulates IFN-\u03b2 production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1","volume":"209","author":"Zhang","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molimm.2021.12.021_bib0155","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/JLB.2A0819-055R","article-title":"RNF144B inhibits LPS-induced inflammatory responses via binding TBK1","volume":"106","author":"Zhang","year":"2019","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.molimm.2021.12.021_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104748","article-title":"Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy","volume":"155","author":"Zhang","year":"2020","journal-title":"Pharmacol. Res."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021003667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589021003667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:39:35Z","timestamp":1758980375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589021003667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":32,"alternative-id":["S0161589021003667"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2021.12.021","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2021.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}