{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:39:19Z","timestamp":1793691559577,"version":"4.5.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.molimm.2022.01.002","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T05:40:27Z","timestamp":1642225227000},"page":"68-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages"],"prefix":"10.1016","volume":"143","author":[{"given":"Ying","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daomin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wukai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2022.01.002_bib0005","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/art.1780200502","article-title":"Bone marrow transplantation in patients with gold-induced marrow aplasia","volume":"20","author":"Baldwin","year":"1977","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2022.01.002_bib0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1755-8166-5-27","article-title":"Exosome-delivered microRNAs of \u201cchromosome 19 microRNA cluster\u201d as immunomodulators in pregnancy and tumorigenesis","volume":"5","author":"Bullerdiek","year":"2012","journal-title":"Mol. Cytogenet."},{"key":"10.1016\/j.molimm.2022.01.002_bib0015","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ki.2010.278","article-title":"Exosomes\/microvesicles as a mechanism of cell-to-cell communication","volume":"78","author":"Camussi","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.molimm.2022.01.002_bib0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00296-013-2720-5","article-title":"MicroRNA-223: a double-edged sword in rheumatoid arthritis","volume":"34","author":"Chen","year":"2014","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.molimm.2022.01.002_bib0025","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1177\/0363546520905853","article-title":"Application of bone marrow-derived mesenchymal stem cells for muscle healing after contusion injury in mice","volume":"48","author":"Chiu","year":"2020","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.molimm.2022.01.002_bib0030","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.7150\/thno.21072","article-title":"Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis","volume":"8","author":"Cosenza","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.molimm.2022.01.002_bib0035","first-page":"347","article-title":"One year in review 2019: pathogenesis of rheumatoid arthritis","volume":"37","author":"Croia","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0040","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.berh.2015.09.004","article-title":"Arthroplasty in patients with established rheumatoid arthritis (RA): mitigating risks and optimizing outcomes","volume":"29","author":"Goodman","year":"2015","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0045","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2011.01046.x","article-title":"The inflammasome: an integrated view","volume":"243","author":"Gross","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2022.01.002_bib0050","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.intimp.2014.12.009","article-title":"Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation","volume":"24","author":"Guo","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0055","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1128\/MMBR.00015-18","article-title":"Cytosolic recognition of microbes and pathogens: inflammasomes in action","volume":"82","author":"Hayward","year":"2018","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.molimm.2022.01.002_bib0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/cells9010111","article-title":"The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?","volume":"9","author":"Keewan","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.molimm.2022.01.002_bib0065","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0301-472X(03)00110-3","article-title":"HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells","volume":"31","author":"Le Blanc","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0070","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00018-017-2473-5","article-title":"Interactions between mesenchymal stem cells and the immune system","volume":"74","author":"Li","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.molimm.2022.01.002_bib0075","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1517\/14712598.2015.1051528","article-title":"Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy","volume":"15","author":"Li","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.molimm.2022.01.002_bib0080","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1189\/jlb.1RU0814-369R","article-title":"microRNAs function in CD8+T cell biology","volume":"97","author":"Liang","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0085","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s13287-019-1410-y","article-title":"Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT\/mTOR pathway","volume":"10","author":"Liang","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.molimm.2022.01.002_bib0090","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"Suppl 2","key":"10.1016\/j.molimm.2022.01.002_bib0095","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/rheumatology\/keh616","article-title":"B cells: a fundamental role in the pathogenesis of rheumatoid arthritis?","volume":"44","author":"Panayi","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.molimm.2022.01.002_bib0100","doi-asserted-by":"crossref","first-page":"28309","DOI":"10.1074\/jbc.C100250200","article-title":"Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1","volume":"276","author":"Poyet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2022.01.002_bib0105","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2022.01.002_bib0110","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3109\/s10165-012-0710-1","article-title":"Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation","volume":"23","author":"Shibuya","year":"2013","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0115","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bcp.2019.03.029","article-title":"The many facets of macrophages in rheumatoid arthritis","volume":"165","author":"Siouti","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0120","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2022.01.002_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225472","article-title":"Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis","volume":"14","author":"Takeuchi","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2022.01.002_bib0130","first-page":"22","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"3","author":"Thery","year":"2006","journal-title":"Curr. Protoc. Cell Biol Chapter 3, Unit"},{"key":"10.1016\/j.molimm.2022.01.002_bib0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature13322","article-title":"Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis","volume":"512","author":"Vande Walle","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2022.01.002_bib0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2174\/1574888X12666161114122059","article-title":"Mesenchymal stem cells as a source of dopaminergic neurons: a potential cell based therapy for parkinson\u2019s disease","volume":"12","author":"Venkatesh","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.molimm.2022.01.002_bib0145","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.imlet.2016.09.001","article-title":"The bispecific antibody aimed at the vicious circle of IL-1beta and IL-17A, is beneficial for the collagen-induced rheumatoid arthritis of mice through NF-kappaB signaling pathway","volume":"179","author":"Wu","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.molimm.2022.01.002_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116165","article-title":"Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy","volume":"9","author":"Xing","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2022.01.002_bib0155","doi-asserted-by":"crossref","first-page":"8777","DOI":"10.18632\/aging.102264","article-title":"LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c\/SATB2 axis","volume":"11","author":"Yang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.molimm.2022.01.002_bib0160","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3389\/fimmu.2019.02538","article-title":"Pharmacological inhibitors of the NLRP3 inflammasome","volume":"10","author":"Zahid","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2022.01.002_bib0165","doi-asserted-by":"crossref","first-page":"e7023","DOI":"10.7717\/peerj.7023","article-title":"Comparison of therapeutic effects of different mesenchymal stem cells on rheumatoid arthritis in mice","volume":"7","author":"Zhang","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.molimm.2022.01.002_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105985","article-title":"Bone marrow-derived mesenchymal stem cells-secreted exosomal microRNA-192-5p delays inflammatory response in rheumatoid arthritis","volume":"78","author":"Zheng","year":"2020","journal-title":"Int. Immunopharmacol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022000025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022000025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:40:30Z","timestamp":1758980430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589022000025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":34,"alternative-id":["S0161589022000025"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2022.01.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2022.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}