{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:43:56Z","timestamp":1787496236127,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.molimm.2022.01.014","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T23:47:34Z","timestamp":1643932054000},"page":"122-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Genome-wide identification and characterization of NLR genes in lamprey (Lethenteron reissneri) and their responses to lipopolysaccharide\/poly(I:C) challenge"],"prefix":"10.1016","volume":"143","author":[{"given":"Fan","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2022.01.014_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cyto.2008.07.013","article-title":"The microbial and danger signals that activate Nod-like receptors","volume":"43","author":"Benko","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2022.01.014_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.dci.2015.10.008","article-title":"Inflammatory immune response by lipopolysaccharide-responsive nucleotide binding oligomerization domain (NOD)-like receptors in the Japanese pufferfish (Takifugu rubripes)","volume":"55","author":"Biswas","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.arplant.57.032905.105346","article-title":"A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors","volume":"60","author":"Boller","year":"2009","journal-title":"Annu Rev. Plant Biol."},{"key":"10.1016\/j.molimm.2022.01.014_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fimmu.2014.00459","article-title":"Evolution of innate immunity: clues from invertebrates via fish to mammals","volume":"5","author":"Buchmann","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3390\/ani10081328","article-title":"Molecular evolution and characterization of fish Stathmin genes","volume":"10","author":"Cao","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.molimm.2022.01.014_bib6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.fsi.2010.09.014","article-title":"Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains","volume":"30","author":"Chang","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103859","article-title":"The expanding and function of NLRC3 or NLRC3-like in teleost fish: Recent advances and novel insights","volume":"114","author":"Chang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.pathol.4.110807.092239","article-title":"NOD-like receptors: role in innate immunity and inflammatory disease","volume":"4","author":"Chen","year":"2009","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.molimm.2022.01.014_bib9","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2022.01.014_bib10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/icb\/icz111","article-title":"Responding to threats both foreign and domestic: NOD-Like receptors in corals","volume":"59","author":"Dimos","year":"2019","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.molimm.2022.01.014_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034375","article-title":"The tandem CARDs of NOD2: intramolecular interactions and recognition of RIP2","volume":"7","author":"Fridh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2022.01.014_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.fsi.2017.12.012","article-title":"Molecular characterization, expression and functional analysis of NOD1, NOD2 and NLRC3 in Nile tilapia (Oreochromis niloticus)","volume":"73","author":"Gao","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib13","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1016\/j.ygeno.2021.06.022","article-title":"Evolutionary history and functional characterization of Lj-TICAM-a and Lj-TICAM-b formed via lineage-specific tandem duplication in lamprey (Lampetra japonica)","volume":"113","author":"Geng","year":"2021","journal-title":"Genomics"},{"key":"10.1016\/j.molimm.2022.01.014_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12862-018-1323-x","article-title":"Cluster expansion of apolipoprotein D (ApoD) genes in teleost fishes","volume":"19","author":"Gu","year":"2019","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.molimm.2022.01.014_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12863-018-0667-y","article-title":"The NOD1 and NOD2 in mandarinfish (Siniperca chuatsi): molecular characterization, tissue distribution, and expression analysis","volume":"19","author":"Gu","year":"2018","journal-title":"BMC Genet."},{"key":"10.1016\/j.molimm.2022.01.014_bib16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbrc.2018.01.024","article-title":"Functional and evolution characterization of SWEET sugar transporters in Ananas comosus","volume":"496","author":"Guo","year":"2018","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.molimm.2022.01.014_bib17","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature08068","article-title":"Dual nature of the adaptive immune system in lampreys","volume":"459","author":"Guo","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2022.01.014_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/molbev\/mss213","article-title":"The complex NOD-like receptor repertoire of the coral Acropora digitifera includes novel domain combinations","volume":"30","author":"Hamada","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molimm.2022.01.014_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ydbio.2006.08.065","article-title":"The immune gene repertoire encoded in the purple sea urchin genome","volume":"300","author":"Hibino","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.molimm.2022.01.014_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12974-019-1498-0","article-title":"NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes","volume":"16","author":"Hong","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.molimm.2022.01.014_bib21","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1101\/gr.069674.107","article-title":"Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity","volume":"18","author":"Huang","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.molimm.2022.01.014_bib22","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1002\/cbin.11414","article-title":"NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6\/JAK2\/STAT3 pathway activation","volume":"44","author":"Kang","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.molimm.2022.01.014_bib23","first-page":"656","article-title":"BLAT--the BLAST-like alignment tool","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/j.molimm.2022.01.014_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/bies.201300145","article-title":"Evolution of adaptive immunity: implications of a third lymphocyte lineage in lampreys","volume":"36","author":"Kishishita","year":"2014","journal-title":"BioEssays"},{"key":"10.1016\/j.molimm.2022.01.014_bib25","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/jnr.24004","article-title":"The function of NOD-like receptors in central nervous system diseases","volume":"95","author":"Kong","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.molimm.2022.01.014_bib26","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molimm.2022.01.014_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2148-8-42","article-title":"A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish","volume":"8","author":"Laing","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.molimm.2022.01.014_bib28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.dci.2016.03.011","article-title":"A genome-wide survey of expansive NLR-C subfamily in miiuy croaker and characterization of the NLR-B30.2 genes","volume":"61","author":"Li","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib29","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1073\/pnas.1314540110","article-title":"Definition of a third VLR gene in hagfish","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molimm.2022.01.014_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molimm.2021.01.017","article-title":"Analysis of the lamprey genotype provides insights into caspase evolution and functional divergence","volume":"132","author":"Liu","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/imr.12901","article-title":"The microbiome and cytosolic innate immune receptors","volume":"297","author":"Liwinski","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2022.01.014_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112575","article-title":"Identification of benzofused five-membered sultams, potent dual NOD1\/NOD2 antagonists in vitro and in vivo","volume":"204","author":"Ma","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.molimm.2022.01.014_bib33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish (overview)","volume":"20","author":"Magnadottir","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2018.04.061","article-title":"Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) in Asian seabass, Lates calcarifer: Cloning, ontogeny and expression analysis following bacterial infection or ligand stimulation","volume":"79","author":"Paria","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002119","article-title":"The Nod-like receptor (NLR) family: a tale of similarities and differences","volume":"3","author":"Proell","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2022.01.014_bib36","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature06967","article-title":"The amphioxus genome and the evolution of the chordate karyotype","volume":"453","author":"Putnam","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2022.01.014_bib37","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.fsi.2019.09.067","article-title":"Duplication of toll-like receptor 22 in teleost fishes","volume":"94","author":"Qi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dci.2011.12.005","article-title":"Pathogen recognition receptors in channel catfish: I. Identification, phylogeny and expression of NOD-like receptors","volume":"37","author":"Rajendran","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib39","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s00018-008-7502-y","article-title":"NOD-like receptors: ancient sentinels of the innate immune system","volume":"65","author":"Rosenstiel","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.molimm.2022.01.014_bib40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/ni.2378","article-title":"The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB","volume":"13","author":"Schneider","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib41","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.fsi.2012.02.018","volume":"32","author":"Swain","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clim.2005.02.007","article-title":"The CATERPILLER family: an ancient family of immune\/apoptotic proteins","volume":"115","author":"Ting","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2008.02.005","article-title":"The NLR gene family: a standard nomenclature","volume":"28","author":"Ting","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2022.01.014_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/imr.12902","article-title":"NOD1 and NOD2 in inflammatory and infectious diseases","volume":"297","author":"Trindade","year":"2020","journal-title":"Immunol. Rev."},{"issue":"Pt 3","key":"10.1016\/j.molimm.2022.01.014_bib45","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.margen.2015.09.003","article-title":"Molecular characterization, origin, and evolution of teleost p68 gene family: Insights from Japanese flounder, Paralichthys olivaceus","volume":"24","author":"Wang","year":"2015","journal-title":"Mar. Genom."},{"key":"10.1016\/j.molimm.2022.01.014_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103734","article-title":"Pattern recognition receptors in grass carp Ctenopharyngodon idella: II. Organization and expression analysis of NOD-like receptors","volume":"110","author":"Xu","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00438-013-0786-0","article-title":"Evolution, functional divergence and conserved exon-intron structure of bHLH\/PAS gene family","volume":"289","author":"Yan","year":"2014","journal-title":"Mol. Genet. Genom."},{"key":"10.1016\/j.molimm.2022.01.014_bib48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coi.2008.01.003","article-title":"NLR, the nucleotide-binding domain leucine-rich repeat containing gene family","volume":"20","author":"Ye","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/molbev\/mst174","article-title":"The characterization of sponge NLRs provides insight into the origin and evolution of this innate immune gene family in animals","volume":"31","author":"Yuen","year":"2014","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molimm.2022.01.014_bib50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.molimm.2021.02.003","article-title":"Genome-wide identification of NOD-like receptors and their expression profiling in mucosal tissues of turbot (Scophthalmus maximus L.) upon bacteria challenge","volume":"134","author":"Zhang","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib51","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/jfd.12841","article-title":"Nucleotide-binding and oligomerization domain (NOD)-like receptors in teleost fish: current knowledge and future perspectives","volume":"41","author":"Zhang","year":"2018","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.molimm.2022.01.014_bib52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.molimm.2021.06.004","article-title":"Identification, molecular evolution, and expression analysis of the transcription factor Smad gene family in lamprey","volume":"136","author":"Zhong","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2022.01.014_bib53","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/1755-0998.13279","article-title":"Chromosome-level genome assembly of Lethenteron reissneri provides insights into lamprey evolution","volume":"21","author":"Zhu","year":"2021","journal-title":"Mol. Ecol. Resour."},{"key":"10.1016\/j.molimm.2022.01.014_bib54","first-page":"847","article-title":"Lamprey: an important animal model of evolution and disease research","volume":"42","author":"Zhu","year":"2020","journal-title":"Yi Chuan"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022000207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022000207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:41:11Z","timestamp":1758980471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589022000207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":54,"alternative-id":["S0161589022000207"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2022.01.014","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide identification and characterization of NLR genes in lamprey (Lethenteron reissneri) and their responses to lipopolysaccharide\/poly(I:C) challenge","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2022.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}