{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:23:22Z","timestamp":1782624202682,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470609"],"award-info":[{"award-number":["81470609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500695"],"award-info":[{"award-number":["81500695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870632"],"award-info":[{"award-number":["81870632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101095"],"award-info":[{"award-number":["82101095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019BH004"],"award-info":[{"award-number":["ZR2019BH004"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.molimm.2022.04.007","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T10:58:20Z","timestamp":1651316300000},"page":"50-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis"],"prefix":"10.1016","volume":"147","author":[{"given":"Junjie","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2022.04.007_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00795-016-0133-8","article-title":"Chondroitin sulfate prevents peritoneal fibrosis in mice by suppressing NF-\u03baB activation","volume":"49","author":"Abe","year":"2016","journal-title":"Med. Mol. Morphol."},{"key":"10.1016\/j.molimm.2022.04.007_bib2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.joca.2011.08.006","article-title":"Chondroitin sulfate effect on induced arthritis in rats","volume":"19","author":"Bauerova","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.molimm.2022.04.007_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2020.08.013","article-title":"Steroid-eluting contact lenses for corneal and intraocular inflammation","volume":"116","author":"Bengani","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.molimm.2022.04.007_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-21735-8_2","article-title":"Understanding the role of pro-resolving lipid mediators in infectious keratitis","volume":"1161","author":"Berger","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molimm.2022.04.007_bib5","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molimm.2022.04.007_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0306-4530(88)90054-6","article-title":"Systemic hormonal and physiological abnormalities in anxiety disorders","volume":"13","author":"Cameron","year":"1988","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.molimm.2022.04.007_bib7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.neuroscience.2010.02.069","article-title":"Chondroitin sulfate inhibits lipopolysaccharide-induced inflammation in rat astrocytes by preventing nuclear factor kappa B activation","volume":"167","author":"Ca\u00f1as","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.molimm.2022.04.007_bib8","first-page":"80","article-title":"Signal transduction pathways mediated by Toll-like receptors and their relations with fungal keratitis","volume":"48","author":"Chen","year":"2012","journal-title":"Chin. J. Ophthalmol."},{"key":"10.1016\/j.molimm.2022.04.007_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5213\/inj.1938176.088","article-title":"Comparison of intravesical hyaluronic acid, chondroitin sulfate, and combination of hyaluronic acid-chondroitin sulfate therapies in animal model of interstitial cystitis","volume":"25","author":"Danacioglu","year":"2021","journal-title":"Int. Neurourol. J."},{"key":"10.1016\/j.molimm.2022.04.007_bib10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.mib.2011.07.001","article-title":"The role of Dectin-1 in the host defence against fungal infections","volume":"14","author":"Drummond","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.molimm.2022.04.007_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1167\/iovs.61.6.51","article-title":"Perillaldehyde ameliorates aspergillus fumigatus keratitis by activating the Nrf2\/HO-1 signaling pathway and inhibiting dectin-1-mediated inflammation","volume":"61","author":"Fan","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1099\/mic.0.000651","article-title":"Microbe profile: Aspergillus fumigatus: a saprotrophic and opportunistic fungal pathogen","volume":"164","author":"Fang","year":"2018","journal-title":"Microbiology"},{"key":"10.1016\/j.molimm.2022.04.007_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ni.2222","article-title":"Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1\u03b2 via a noncanonical caspase-8 inflammasome","volume":"13","author":"Gringhuis","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2022.04.007_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/imcb.12316","article-title":"Dimethyl itaconate protects against fungal keratitis by activating the Nrf2\/HO-1 signaling pathway","volume":"98","author":"Gu","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.molimm.2022.04.007_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00281-014-0465-1","article-title":"Interference of Aspergillus fumigatus with the immune response","volume":"37","author":"Heinekamp","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.molimm.2022.04.007_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1185\/03007995.2012.753430","article-title":"Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what\u2019s the evidence?","volume":"29","author":"Hochberg","year":"2013","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.molimm.2022.04.007_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.61.8.28","article-title":"Indoleamine 2,3-dioxygenase regulates macrophage recruitment, polarization and phagocytosis in aspergillus fumigatus keratitis","volume":"61","author":"Jiang","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1742-7843.2007.00158.x","article-title":"Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes","volume":"102","author":"Jomphe","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.molimm.2022.04.007_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/1574887113666181102111247","article-title":"Effect of chondroitin sulfate on blood serum cytokine profile during carrageenan-induced edema and monoiodoacetate-induced osteoarthritis in rats","volume":"14","author":"Korotkyi","year":"2019","journal-title":"Rev. Recent Clin. Trials"},{"key":"10.1016\/j.molimm.2022.04.007_bib20","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.3390\/ijms20153631","article-title":"An omics approach to diagnosing or investigating fungal keratitis","volume":"20","author":"Kuo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.molimm.2022.04.007_bib21","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.01.017","article-title":"Chondroitin sulfate improves synovitis in rabbits with chronic antigen-induced arthritis","volume":"18","author":"Largo","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.molimm.2022.04.007_bib22","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1038\/s41598-019-46361-y","article-title":"Histone deacetylase inhibitor attenuates experimental fungal keratitis in mice","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2022.04.007_bib23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3390\/microorganisms7100457","article-title":"CRISPR\/Cas9-mediated gene replacement in the fungal keratitis pathogen Fusarium solani var. petroliphilum","volume":"7","author":"Lightfoot","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.molimm.2022.04.007_bib24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1055\/s-0038-1657753","article-title":"Chondroitin sulphate attenuates atherosclerosis in ApoE knockout mice involving cellular regulation of the inflammatory response","volume":"118","author":"Melgar-Lesmes","year":"2018","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.molimm.2022.04.007_bib25","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/ard.2006.068882","article-title":"Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues","volume":"67","author":"Monfort","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2022.04.007_bib26","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.3390\/cells9071713","article-title":"Experimental models for fungal keratitis: an overview of principles and protocols","volume":"9","author":"Montgomery","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.molimm.2022.04.007_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tox.2014.02.012","article-title":"A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability","volume":"319","author":"Nagai","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.molimm.2022.04.007_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1167\/iovs.17-21887","article-title":"Aspergillus fumigatus increased PAR-2 expression and elevated proinflammatory cytokines expression through the pathway of PAR-2\/ERK1\/2 in cornea","volume":"59","author":"Niu","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107706","article-title":"Galectin-3 plays an important pro-inflammatory role in A. fumigatus keratitis by recruiting neutrophils and activating p38 in neutrophils","volume":"97","author":"Niu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.62.4.16","article-title":"IL-36\u03b1 exerts proinflammatory effects in Aspergillus fumigatus keratitis of mice through the pathway of IL-36\u03b1\/IL-36R\/NF-\u03baB","volume":"62","author":"Niu","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib31","doi-asserted-by":"crossref","first-page":"e02669","DOI":"10.1128\/AAC.02669-18","article-title":"In vitro activity of chlorhexidine compared with seven antifungal agents against 98 fusarium isolates recovered from fungal keratitis patients","volume":"63","author":"Oliveira Dos Santos","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.molimm.2022.04.007_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12886-018-0847-6","article-title":"Phospholipase C\u03b32 is critical for Ca(2+) flux and cytokine production in anti-fungal innate immunity of human corneal epithelial cells","volume":"18","author":"Peng","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.molimm.2022.04.007_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.intimp.2018.08.003","article-title":"Interaction of mannose binding lectin and other pattern recognition receptors in human corneal epithelial cells during Aspergillus fumigatus infection","volume":"63","author":"Peng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/08830185.2013.777065","article-title":"C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways","volume":"32","author":"Plato","year":"2013","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.molimm.2022.04.007_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/microorganisms7090309","article-title":"Alterations in the ocular surface fungal microbiome in fungal keratitis patients","volume":"7","author":"Prashanthi","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.molimm.2022.04.007_bib36","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/febs.14748","article-title":"The dual role of the glycosaminoglycan chondroitin-6-sulfate in the development. progression and metastasis of cancer","volume":"286","author":"Pude\u0142ko","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.molimm.2022.04.007_bib37","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3390\/antiox9121241","author":"Rondanelli","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.molimm.2022.04.007_bib38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.survophthal.2019.02.007","article-title":"Pharmacologic therapy of mycotic keratitis","volume":"64","author":"Sahay","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.molimm.2022.04.007_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijpharm.2016.05.045","article-title":"Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions","volume":"509","author":"Sandri","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.molimm.2022.04.007_bib40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joca.2016.08.012","article-title":"Chondroitin sulphate inhibits NF-\u03baB activity induced by interaction of pathogenic and damage associated molecules","volume":"25","author":"Stabler","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.molimm.2022.04.007_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.intimp.2019.02.017","article-title":"Celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1","volume":"70","author":"Sun","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijbiomac.2018.05.124","article-title":"Chondroitin sulfate from sturgeon bone ameliorates pain of osteoarthritis induced by monosodium iodoacetate in rats","volume":"117","author":"Sun","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.molimm.2022.04.007_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1167\/iovs.62.3.38","article-title":"Isorhamnetin ameliorates Aspergillus fumigatus keratitis by reducing fungal load, inhibiting pattern-recognition receptors and inflammatory cytokines","volume":"62","author":"Tian","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/md16100389","article-title":"Structure and anti-inflammatory activity of a new unusual fucosylated chondroitin sulfate from Cucumaria djakonovi","volume":"16","author":"Ustyuzhanina","year":"2018","journal-title":"Mar. Drugs"},{"issue":"Suppl 1","key":"10.1016\/j.molimm.2022.04.007_bib45","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.joca.2010.02.017","article-title":"Modulation of inflammation by chondroitin sulfate","volume":"18","author":"Valli\u00e8res","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.molimm.2022.04.007_bib46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro.2017.90","article-title":"Aspergillus fumigatus morphology and dynamic host interactions","volume":"15","author":"van de Veerdonk","year":"2017","journal-title":"Nat. Rev., Microbiol."},{"key":"10.1016\/j.molimm.2022.04.007_bib47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0039-6257(01)00211-9","article-title":"The Draize eye test","volume":"45","author":"Wilhelmus","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.molimm.2022.04.007_bib48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2014.11.003","article-title":"An overview of current techniques for ocular toxicity testing","volume":"327","author":"Wilson","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.molimm.2022.04.007_bib49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11626-020-00443-8","article-title":"Inhibitory effects of skate cartilage chondroitin sulfate-rich extract on the production of inflammatory mediators and ROS in lipopolysaccharide-treated murine macrophages: a comparison with shark cartilage chondroitin sulfate","volume":"56","author":"Woo","year":"2020","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.molimm.2022.04.007_bib50","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3390\/nu12041130","article-title":"Sturgeon (acipenser)-derived chondroitin sulfate suppresses human colon cancer HCT-116 both in vitro and in vivo by inhibiting proliferation and inducing apoptosis","volume":"12","author":"Wu","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.molimm.2022.04.007_bib51","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.intimp.2015.10.018","article-title":"The production mechanism and immunosuppression effect of pulmonary surfactant protein D via toll like receptor 4 signaling pathway in human corneal epithelial cells during Aspergillus fumigatus infection","volume":"29","author":"Wu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106118","article-title":"Nerolidol inhibits the LOX-1 \/ IL-1\u03b2 signaling to protect against the Aspergillus fumigatus keratitis inflammation damage to the cornea","volume":"80","author":"Yang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107435","article-title":"Quercetin amelioratesAspergillus fumigatuskeratitis by inhibiting fungal growth, toll-like receptors and inflammatory cytokines","volume":"93","author":"Yin","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1167\/iovs.61.4.48","article-title":"Honokiol reduces fungal load, toll-like receptor-2, and inflammatory cytokines in Aspergillus fumigatus keratitis","volume":"61","author":"Zhan","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib55","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/glycob\/cwaa096","article-title":"Study on the relationships between molecular weights of chondroitin sulfate oligosaccharides and A\u03b2-induced oxidative stress and the related mechanisms","volume":"31","author":"Zhao","year":"2021","journal-title":"Glycobiology"},{"key":"10.1016\/j.molimm.2022.04.007_bib56","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.3390\/ijms21155303","article-title":"Chondroitin sulfate prevents STZ induced diabetic osteoporosis through decreasing blood glucose, antioxidative stress, anti-inflammation and OPG\/RANKL expression regulation","volume":"21","author":"Zheng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib57","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.intimp.2019.03.047","article-title":"The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection","volume":"71","author":"Zhou","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106473","article-title":"FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway","volume":"83","author":"Zhu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107785","article-title":"Lipoxin A4 activates ALX\/FPR2 to attenuate inflammation in Aspergillus fumigatus keratitis","volume":"96","author":"Zhu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2022.04.007_bib60","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.62.6.26","article-title":"Baicalein protects against Aspergillus fumigatus keratitis by reducing fungal load and inhibiting TSLP-induced inflammatory response","volume":"62","author":"Zhu","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molimm.2022.04.007_bib61","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1177\/154405910408301111","article-title":"Chondroitin sulfate in palatal wound healing","volume":"83","author":"Zou","year":"2004","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molimm.2022.04.007_bib62","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ijbiomac.2019.10.192","article-title":"Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities","volume":"152","author":"Zou","year":"2020","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022001936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022001936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:42:58Z","timestamp":1758980578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589022001936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":62,"alternative-id":["S0161589022001936"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2022.04.007","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2022.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}