{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:07:33Z","timestamp":1779332853362,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.molimm.2022.10.007","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T06:40:34Z","timestamp":1666248034000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dysfunctional O-glycosylation exacerbates LPS-induced ARDS in mice through impairment of podoplanin expression on alveolar macrophages"],"prefix":"10.1016","volume":"152","author":[{"given":"Xichen","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-0163","authenticated-orcid":false,"given":"Tao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2022.10.007_bib1","first-page":"22","article-title":"Early stage nonclinical pulmonary disorder in COVID-19 may present asymptomatic and fuel the contagion","volume":"8","author":"Adedokun","year":"2021","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.molimm.2022.10.007_bib2","doi-asserted-by":"crossref","unstructured":"Amore, A., Knott, B.C., Supekar, N.T., Shajahan, A., Azadi, P., Zhao, P., Wells, L., Linger, J.G., Hobdey, S.E., Vander Wall, T.A., Shollenberger, T., Yarbrough, J.M., Tan, Z., Crowley, M.F., Himmel, M.E., Decker, S.R., Beckham, G.T., Taylor, L.E., 2017. Distinct roles of N- and O-glycans in cellulase activity and stability. Proc. Natl. Acad. Sci. U. S. A. 114, 13667\u201313672.","DOI":"10.1073\/pnas.1714249114"},{"key":"10.1016\/j.molimm.2022.10.007_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/molecules23123063","article-title":"Functional roles of O-glycosylation","volume":"23","author":"Breloy","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.molimm.2022.10.007_bib4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3390\/cells8060544","article-title":"Glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis","volume":"8","author":"Brown Chandler, K., E. Costello, C., Rahimi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.molimm.2022.10.007_bib5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/0897190019830504","article-title":"Moderate to severe acute respiratory distress syndrome management strategies: a narrative review","volume":"32","author":"Buckley","year":"2019","journal-title":"J. Pharm. Pr."},{"key":"10.1016\/j.molimm.2022.10.007_bib6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/BST20170483","article-title":"O-linked mucin-type glycosylation in breast cancer","volume":"46","author":"Burchell","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.molimm.2022.10.007_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/eji.202048617","article-title":"CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock","volume":"51","author":"Cao","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2022.10.007_bib8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","article-title":"Acute respiratory distress syndrome: advances in diagnosis and treatment","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.molimm.2022.10.007_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-018-0756-5","article-title":"Regulation of alveolar macrophage death in acute lung inflammation","volume":"19","author":"Fan","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.molimm.2022.10.007_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/tan.12900","article-title":"Tumor-associated antigens: Tn antigen, sTn antigen, and T antigen","volume":"88","author":"Fu","year":"2016","journal-title":"Hla"},{"key":"10.1016\/j.molimm.2022.10.007_bib11","first-page":"11","article-title":"The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status","volume":"7","author":"Guo","year":"2020","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.molimm.2022.10.007_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.02089","article-title":"Deficient O-GlcNAc glycosylation impairs regulatory T cell differentiation and notch signaling in autoimmune hepatitis","volume":"9","author":"Hao","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2022.10.007_bib13","article-title":"Deficiency of O-linked-glycosylation regulates activation of T cells and aggravates Concanavalin A-induced liver injury","volume":"433\u2013434","author":"Hao","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.molimm.2022.10.007_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1056\/NEJMe2018629","article-title":"Covid-19, Angiogenesis, and ARDS Endotypes","volume":"383","author":"Hariri","year":"2020","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.molimm.2022.10.007_bib15","first-page":"2018","article-title":"The role of macrophages in the pathogenesis of ali\/ards","author":"Huang","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.molimm.2022.10.007_bib16","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1158\/0008-5472.CAN-07-2345","article-title":"Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc","volume":"68","author":"Ju","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.molimm.2022.10.007_bib17","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/prca.201300024","article-title":"Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers","volume":"7","author":"Ju","year":"2013","journal-title":"Proteom. - Clin. Appl."},{"key":"10.1016\/j.molimm.2022.10.007_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1538-7836.2011.04614.x","article-title":"Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2","volume":"10","author":"Kerrigan","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.molimm.2022.10.007_bib19","first-page":"53","article-title":"Simple sugars to complex disease-mucin-type O-glycans in cancer","author":"Kudelka","year":"2015","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.molimm.2022.10.007_bib20","doi-asserted-by":"crossref","first-page":"L1016","DOI":"10.1152\/ajplung.00023.2017","article-title":"Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse","volume":"313","author":"Lax","year":"2017","journal-title":"Am. J. Physiol. - Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molimm.2022.10.007_bib21","first-page":"5","article-title":"Acute respiratory distress syndrome","author":"Matthay","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.molimm.2022.10.007_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/TA.0b013e3182aaa499","article-title":"Role of alveolar macrophages in the regulation of local and systemic inflammation after lung contusion","volume":"76","author":"Niesler","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.molimm.2022.10.007_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.92321","article-title":"Podoplanin is a negative regulator of Th17 inflammation","volume":"2","author":"Nylander","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.molimm.2022.10.007_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.semcancer.2017.03.002","article-title":"Role of protein glycosylation in cancer metastasis","volume":"44","author":"Oliveira-Ferrer","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.molimm.2022.10.007_bib25","first-page":"18","article-title":"Plant lectins targeting O-glycans at the cell surface as tools for cancer diagnosis, prognosis and therapy","author":"Poiroux","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2022.10.007_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030707","article-title":"Podoplanin in inflammation and cancer. Int","volume":"20","author":"Quintanilla","year":"2019","journal-title":"J. Mol. Sci."},{"key":"10.1016\/j.molimm.2022.10.007_bib27","first-page":"8","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","author":"Rayes","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2022.10.007_bib28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease","volume":"15","author":"Reily","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.molimm.2022.10.007_bib29","doi-asserted-by":"crossref","first-page":"F518","DOI":"10.1152\/ajprenal.00399.2019","article-title":"Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function","volume":"312","author":"Stotter","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.molimm.2022.10.007_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.131195","article-title":"TLR3 absence confers increased survival with improved macrophage activity against pneumonia","volume":"4","author":"Suresh","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.molimm.2022.10.007_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/10409239891204198","article-title":"Concepts and principles of O-linked glycosylation","volume":"33","author":"Van Den Steen","year":"1998","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.molimm.2022.10.007_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.sbi.2018.12.006","article-title":"O-glycosylation disorders pave the road for understanding the complex human O-glycosylation machinery","volume":"56","author":"van Tol","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.molimm.2022.10.007_bib33","doi-asserted-by":"crossref","first-page":"27519","DOI":"10.1074\/jbc.M113.471045","article-title":"Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL)","volume":"288","author":"Van Vliet","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2022.10.007_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/SHK.0000000000001144","article-title":"GTS-21 reduces inflammation in acute lung injury by regulating M1 polarization and function of alveolar macrophages","volume":"51","author":"Wang","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.molimm.2022.10.007_bib35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1083\/jcb.200311112","article-title":"Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans","volume":"164","author":"Xia","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molimm.2022.10.007_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.134749","article-title":"Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function","volume":"5","author":"Xie","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.molimm.2022.10.007_bib37","doi-asserted-by":"crossref","DOI":"10.1080\/08923973.2021.1979035","article-title":"Inhibition of O-glycosylation aggravates GalN\/LPS-induced liver injury through activation of ER stress","author":"Xu","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol. 43, 741\u2013748. 5"},{"key":"10.1016\/j.molimm.2022.10.007_bib38","doi-asserted-by":"crossref","DOI":"10.1097\/ALN.0000000000000429","article-title":"Extracellular histones play an inflammatory role in acid aspiration-induced acute respiratory distress syndrome","volume":"122","author":"Zhang","year":"2015","journal-title":"Anesthesiology"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022004515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022004515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:43:51Z","timestamp":1758980631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589022004515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":38,"alternative-id":["S0161589022004515"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2022.10.007","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysfunctional O-glycosylation exacerbates LPS-induced ARDS in mice through impairment of podoplanin expression on alveolar macrophages","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2022.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}