{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:03:21Z","timestamp":1784880201035,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.molimm.2022.11.016","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T13:55:57Z","timestamp":1669816557000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Serum proteomics analysis of biomarkers for evaluating clinical response to MTX\/IGU therapy in early rheumatoid arthritis"],"prefix":"10.1016","volume":"153","author":[{"given":"Tianqi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.molimm.2022.11.016_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.molimm.2022.11.016_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13075-015-0553-1","article-title":"Haptoglobin-\u03b11, -\u03b12, vitamin D-binding protein and apolipoprotein C-III as predictors of etanercept drug response in rheumatoid arthritis","volume":"17","author":"Blaschke","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molimm.2022.11.016_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109026","article-title":"Proteomic analysis of biomarkers predicting the response to triple therapy in patients with rheumatoid arthritis","volume":"116","author":"Chen","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"7","key":"10.1016\/j.molimm.2022.11.016_bib4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1357-2725(01)00046-2","article-title":"S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles","volume":"33","author":"Donato","year":"2001","journal-title":"Int J. Biochem. Cell Biol."},{"issue":"22","key":"10.1016\/j.molimm.2022.11.016_bib5","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1158\/1078-0432.CCR-17-2578","article-title":"LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis","volume":"24","author":"Dorneburg","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.molimm.2022.11.016_bib6","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10067-015-2999-6","article-title":"Efficacy and safety evaluation of a combination of iguratimod and methotrexate therapy for active rheumatoid arthritis patients: a randomized controlled trial","volume":"34","author":"Duan","year":"2015","journal-title":"Clin. Rheuma."},{"issue":"2","key":"10.1016\/j.molimm.2022.11.016_bib7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nbt.1524","article-title":"Prediction of high-responding peptides for targeted protein assays by mass spectrometry","volume":"27","author":"Fusaro","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molimm.2022.11.016_bib8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3389\/fphys.2018.00939","article-title":"Andrographolide sulfonate attenuates acute lung injury by reducing expression of myeloperoxidase and neutrophil-derived proteases in mice","volume":"9","author":"Gao","year":"2018","journal-title":"Front Physiol."},{"issue":"10","key":"10.1016\/j.molimm.2022.11.016_bib9","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/1529-0131(199810)41:10<1845::AID-ART17>3.0.CO;2-K","article-title":"Validation of rheumatoid arthritis improvement criteria that include simplified joint counts","volume":"41","author":"van Gestel","year":"1998","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.molimm.2022.11.016_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/s10165-006-0542-y","article-title":"Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study","volume":"17","author":"Hara","year":"2007","journal-title":"Mod. Rheuma."},{"issue":"3","key":"10.1016\/j.molimm.2022.11.016_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/14397595.2013.843756","article-title":"Safety and efficacy of combination therapy of iguratimod with methotrexate for patients with active rheumatoid arthritis with an inadequate response to methotrexate: an open-label extension of a randomized, double-blind, placebo-controlled trial","volume":"24","author":"Hara","year":"2014","journal-title":"Mod. Rheuma."},{"issue":"3","key":"10.1016\/j.molimm.2022.11.016_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3109\/s10165-012-0724-8","article-title":"Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double-blind, placebo-controlled trial","volume":"23","author":"Ishiguro","year":"2013","journal-title":"Mod. Rheuma."},{"key":"10.1016\/j.molimm.2022.11.016_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bone.2017.01.022","article-title":"Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1","volume":"97","author":"Jin","year":"2017","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.molimm.2022.11.016_bib14","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3390\/biom10060964","article-title":"Reelin functions, mechanisms of action and signaling pathways during brain development and maturation","volume":"10","author":"Jossin","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.molimm.2022.11.016_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41413-019-0067-6","article-title":"Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology","volume":"7","author":"Li","year":"2019","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.molimm.2022.11.016_bib16","first-page":"516","article-title":"Proteomic analysis to define predictors of treatment response to adalimumab or methotrexate in rheumatoid arthritis patients","volume":"20","author":"Ling","year":"2020","journal-title":"Pharm. J."},{"issue":"2","key":"10.1016\/j.molimm.2022.11.016_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/annrheumdis-2013-204021","article-title":"Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNF\u03b1 inhibitors and rituximab","volume":"74","author":"Listing","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.molimm.2022.11.016_bib18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/art.24643","article-title":"Multicenter, randomized, double-blind, controlled trial of treatment of active rheumatoid arthritis with T-614 compared with methotrexate","volume":"61","author":"Lu","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.molimm.2022.11.016_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13075-017-1389-7","article-title":"IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis","volume":"19","author":"Lundstr\u00f6m","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.molimm.2022.11.016_bib20","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.21873\/anticanres.11435","article-title":"Stable shRNA silencing of lactate dehydrogenase A (LDHA) in Human MDA-MB-231 breast cancer cells fails to alter lactic acid production, glycolytic activity, ATP or survival","volume":"37","author":"Mack","year":"2017","journal-title":"Anticancer Res."},{"issue":"4","key":"10.1016\/j.molimm.2022.11.016_bib21","first-page":"546","article-title":"Reelin levels are increased in synovial fluid of patients with rheumatoid arthritis","volume":"28","author":"Magnani","year":"2010","journal-title":"Clin. Exp. Rheuma."},{"issue":"6","key":"10.1016\/j.molimm.2022.11.016_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/exd.12967","article-title":"Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis","volume":"25","author":"Martel","year":"2016","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.molimm.2022.11.016_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s41927-019-0090-7","article-title":"A systematic review of guidelines for managing rheumatoid arthritis","volume":"3","author":"Mian","year":"2019","journal-title":"BMC Rheuma."},{"issue":"5","key":"10.1016\/j.molimm.2022.11.016_bib24","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.3390\/ijms22052426","article-title":"The role of collagen triple helix repeat-containing 1 Protein (CTHRC1) in Rheumatoid Arthritis","volume":"22","author":"Myngbay","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.molimm.2022.11.016_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13075-016-1201-0","article-title":"Calprotectin (S100A8\/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis","volume":"19","author":"Nordal","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"10.1016\/j.molimm.2022.11.016_bib26","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.7150\/thno.12403","article-title":"Identification of 7 proteins in sera of RA patients with potential to predict ETA\/MTX treatment response","volume":"5","author":"Obry","year":"2015","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.molimm.2022.11.016_bib27","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of Rheumatoid Arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.molimm.2022.11.016_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/art.27740","article-title":"Interleukin-6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: the role of acute-phase reactants","volume":"63","author":"Smolen","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"10055","key":"10.1016\/j.molimm.2022.11.016_bib29","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.molimm.2022.11.016_bib30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/annrheumdis-2019-216655","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update","volume":"79","author":"Smolen","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.molimm.2022.11.016_bib31","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/1756-185X.12380","article-title":"High serum level of haptoglobin is associated with the response of 12 weeks methotrexate therapy in recent-onset rheumatoid arthritis patients","volume":"19","author":"Tan","year":"2016","journal-title":"Int J. Rheum. Dis."},{"key":"10.1016\/j.molimm.2022.11.016_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2012-201821","article-title":"Performance of the 2011 ACR\/EULAR preliminary remission criteria compared with DAS28 remission in unselected patients with rheumatoid arthritis","volume":"72","author":"Thiele","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.molimm.2022.11.016_bib33","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms20092085","article-title":"Unappreciated role of LDHA and LDHB to control apoptosis and autophagy in tumor cells","volume":"20","author":"Urba\u0144ska","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2022.11.016_bib34","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in Inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2022.11.016_bib35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2022.11.016_bib36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fphar.2020.00073","article-title":"Iguratimod as a new drug for Rheumatoid Arthritis: current landscape","volume":"11","author":"Xie","year":"2020","journal-title":"Front Pharm."},{"issue":"9","key":"10.1016\/j.molimm.2022.11.016_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23969","article-title":"Influences of the lncRNA TUG1-miRNA-34a-5p network on fibroblast-like synoviocytes (FLSs) dysfunction in rheumatoid arthritis through targeting the lactate dehydrogenase A (LDHA)","volume":"35","author":"Zhang","year":"2021","journal-title":"J. Clin. Lab Anal."},{"key":"10.1016\/j.molimm.2022.11.016_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-1-4939-6990-6_19","article-title":"Mass spectrometry\u2010based biomarker discovery","volume":"1606","author":"Zhou","year":"2017","journal-title":"Methods Mol. Biol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022004837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589022004837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:44:13Z","timestamp":1758980653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589022004837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":38,"alternative-id":["S0161589022004837"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2022.11.016","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum proteomics analysis of biomarkers for evaluating clinical response to MTX\/IGU therapy in early rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2022.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}