{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:29:39Z","timestamp":1779888579540,"version":"3.53.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.molimm.2023.10.002","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T23:47:10Z","timestamp":1696636030000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Comparison and subsets analysis of peripheral CD4+T cells in patients with psoriasis and psoriatic arthritis"],"prefix":"10.1016","volume":"163","author":[{"given":"Weiqin","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxuan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-6784","authenticated-orcid":false,"given":"Guangjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2023.10.002_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","article-title":"Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies","volume":"80","author":"Alinaghi","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.molimm.2023.10.002_bib2","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of Psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.molimm.2023.10.002_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.615673","article-title":"Recent advances in Lupus B cell biology: PI3K, IFN\u03b3, and chromatin","volume":"11","author":"Bacalao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12016-018-8702-3","article-title":"The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis","volume":"55","author":"Blauvelt","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib5","article-title":"Th17 cells and the IL-23\/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases","volume":"20","author":"Bunte","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2023.10.002_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00353","article-title":"Effector functions of CD4+ T cells at the site of local autoimmune inflammation-lessons from rheumatoid arthritis","volume":"10","author":"Chemin","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12016-012-8302-6","article-title":"Psoriatic arthritis: a critical review","volume":"44","author":"Dhir","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.autrev.2014.11.012","article-title":"T cell responses in psoriasis and psoriatic arthritis","volume":"14","author":"Diani","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2023.10.002_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.641013","article-title":"Frontiers of autoantibodies in autoimmune disorders: crosstalk between Tfh\/Tfr and regulatory B cells","volume":"12","author":"Ding","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib10","article-title":"Psoriatic arthritis","volume":"7","author":"FitzGerald","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.molimm.2023.10.002_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/annrheumdis-2021-220458","article-title":"Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis","volume":"81","author":"Floudas","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2023.10.002_bib12","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.molimm.2023.10.002_bib13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/bjd.18227","article-title":"Modifiable risk factors and the development of psoriatic arthritis in people with psoriasis","volume":"182","author":"Green","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.molimm.2023.10.002_bib14","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2023.10.002_bib15","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.1800013","article-title":"Discovery of the IL-23\/IL-17 signaling pathway and the treatment of psoriasis","volume":"201","author":"Hawkes","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imr.13071","article-title":"Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases","volume":"307","author":"Krovi","year":"2022","journal-title":"Immunol. Rev."},{"issue":"Suppl 2","key":"10.1016\/j.molimm.2023.10.002_bib17","article-title":"Psoriasis: epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2023.10.002_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.758418","article-title":"High dimensional analyses of circulating immune cells in psoriatic arthritis detects elevated phosphorylated STAT3","volume":"12","author":"Macaubas","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/brain\/awz017","article-title":"Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosis","volume":"142","author":"Mexhitaj","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.molimm.2023.10.002_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.molimm.2023.10.002_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/imr.12860","article-title":"T follicular helper cells in germinal center B cell selection and lymphomagenesis","volume":"296","author":"Mintz","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2023.10.002_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/ar4545","article-title":"CD4+CD25+\/highCD127low\/\u2212 regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints--analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood","volume":"16","author":"Moradi","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molimm.2023.10.002_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092111","article-title":"Infiltration profile of regulatory T cells in osteoarthritis-related pain and disability","volume":"10","author":"Nees","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.molimm.2023.10.002_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-018-1690-0","article-title":"Enhanced IL-6\/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper\/T follicular regulatory cells in patients with rheumatoid arthritis","volume":"20","author":"Niu","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molimm.2023.10.002_bib25","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.it.2021.04.006","article-title":"Cytokine-skewed Tfh cells: functional consequences for B cell help","volume":"42","author":"Olatunde","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib26","article-title":"National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.molimm.2023.10.002_bib27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/ced.13795","article-title":"Effect of methotrexate monotherapy on T-cell subsets in the peripheral circulation in psoriasis","volume":"44","author":"Priyadarssini","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.molimm.2023.10.002_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109602","article-title":"ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis","volume":"36","author":"Qian","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.molimm.2023.10.002_bib29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.autrev.2019.05.012","article-title":"Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states","volume":"18","author":"Rahimi","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2023.10.002_bib30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.autrev.2016.09.015","article-title":"Are psoriasis and psoriatic arthritis the same disease? The IL-23\/IL-17 axis data","volume":"16","author":"Sakkas","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2023.10.002_bib31","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41423-019-0220-6","article-title":"Helper T cell differentiation","volume":"16","author":"Saravia","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","article-title":"Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition","volume":"15","author":"Scher","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.molimm.2023.10.002_bib33","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.cell.2022.05.020","article-title":"Bone marrow hematopoiesis drives multiple sclerosis progression","volume":"185","author":"Shi","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2023.10.002_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312793","article-title":"The cytokine mediated molecular pathophysiology of psoriasis and its clinical implications","volume":"22","author":"Singh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2023.10.002_bib35","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/art.42154","article-title":"Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modeling","volume":"74","author":"Soomro","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.molimm.2023.10.002_bib36","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: development of new criteria from a large international study","volume":"54","author":"Taylor","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2023.10.002_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21207488","article-title":"New treatment addressing the pathogenesis of psoriasis","volume":"21","author":"Tokuyama","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2023.10.002_bib38","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"vol. 391","author":"Veale","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2023.10.002_bib39","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/annrheumdis-2018-214138","article-title":"Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis","volume":"78","author":"Wade","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2023.10.002_bib40","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/annrheumdis-2018-214138","article-title":"Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis","volume":"78","author":"Wade","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2023.10.002_bib41","article-title":"T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2023.10.002_bib42","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/art.41271","article-title":"Interleukin-17A is produced by CD4+ but Not CD8+ T cells in synovial fluid following T cell receptor activation and regulates different inflammatory mediators compared to tumor necrosis factor in a model of psoriatic arthritis synovitis","volume":"72","author":"Xu","year":"2020","journal-title":"Arthritis Rheuma"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589023002006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589023002006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:48:12Z","timestamp":1758980892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589023002006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":42,"alternative-id":["S0161589023002006"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2023.10.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison and subsets analysis of peripheral CD4+T cells in patients with psoriasis and psoriatic arthritis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2023.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}