{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:48:17Z","timestamp":1776185297515,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.molimm.2024.02.008","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T18:09:30Z","timestamp":1708452570000},"page":"25-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Predicting the risk of interstitial lung disease in patients with primary Sj\u00f6gren's syndrome: Novel nomogram and elevated Th2 cells"],"prefix":"10.1016","volume":"168","author":[{"given":"Yanlin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaojun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangcong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2024.02.008_bib1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10753-013-9675-2","article-title":"As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-lymphocyte ratio","volume":"36","author":"Ahsen","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.molimm.2024.02.008_bib2","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.41726","article-title":"Inclusion of synovial tissue-derived characteristics in a nomogram for the prediction of treatment response in treatment-naive rheumatoid arthritis patients","volume":"73","author":"Alivernini","year":"2021","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.molimm.2024.02.008_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102374","article-title":"Inflammatory markers in systemic lupus erythematosus","volume":"110","author":"Aringer","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2024.02.008_bib4","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.2147\/IJGM.S310917","article-title":"Correlation between serum tumor marker levels and connective tissue disease-related interstitial lung disease","volume":"14","author":"Bao","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.molimm.2024.02.008_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12890-019-0960-1","article-title":"Acute exacerbations of fibrosing interstitial lung disease associated with connective tissue diseases: a population-based study","volume":"19","author":"Cao","year":"2019","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.molimm.2024.02.008_bib6","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.12659\/MSM.916583","article-title":"Platelet\/lymphocyte, lymphocyte\/monocyte, and neutrophil\/lymphocyte ratios as biomarkers in patients with rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease","volume":"25","author":"Chen","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.molimm.2024.02.008_bib7","doi-asserted-by":"crossref","unstructured":"Chen, W.-H., Ye, H.-F., Wu, Y.-X., Dai, W.-T., Ling, X.-W., Zhao, S., Lin, C., 2023. Association of creatinine-albumin ratio with 28-day mortality in major burned patients: A retrospective cohort study. Burns S0305-4179(23)00076\u20131 10.1016\/j.burns.2023.04.002..","DOI":"10.1016\/j.burns.2023.04.002"},{"key":"10.1016\/j.molimm.2024.02.008_bib8","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s12013-014-0345-2","article-title":"Serum CA242, CA199, CA125, CEA, and TSGF are biomarkers for the efficacy and prognosis of cryoablation in pancreatic cancer patients","volume":"71","author":"Chen","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.molimm.2024.02.008_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren\u2019s syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2024.02.008_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3343\/alm.2019.39.4.345","article-title":"The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases","volume":"39","author":"Gasparyan","year":"2019","journal-title":"Ann. Lab Med."},{"key":"10.1016\/j.molimm.2024.02.008_bib11","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/1756-185X.13881","article-title":"Prevalence and risk factors of interstitial lung disease in patients with primary Sj\u00f6gren\u2019s syndrome: a systematic review and meta-analysis","volume":"23","author":"He","year":"2020","journal-title":"Int J. Rheum. Dis."},{"key":"10.1016\/j.molimm.2024.02.008_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.clinbiochem.2014.08.022","article-title":"Red blood cell distribution width and neutrophil\/lymphocyte ratio are positively correlated with disease activity in primary Sj\u00f6gren\u2019s syndrome","volume":"47","author":"Hu","year":"2014","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.molimm.2024.02.008_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jjco\/hyu159","article-title":"Prognostic value of neutrophil-lymphocyte ratio and level of C-reactive protein in a large cohort of pancreatic cancer patients: a retrospective study in a single institute in Japan","volume":"45","author":"Inoue","year":"2015","journal-title":"Jpn J. Clin. Oncol."},{"key":"10.1016\/j.molimm.2024.02.008_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13075-017-1475-x","article-title":"Comparison of 2002 AECG and 2016 ACR\/EULAR classification criteria and added value of salivary gland ultrasonography in a patient cohort with suspected primary Sj\u00f6gren\u2019s syndrome","volume":"19","author":"Le Goff","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molimm.2024.02.008_bib15","article-title":"Inflammatory indexes for assessing the severity and disease progression of ulcerative colitis: a single-center retrospective study","volume":"10","author":"Lin","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.molimm.2024.02.008_bib16","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0021-2020","article-title":"Lung complications of Sjogren syndrome","volume":"29","author":"Luppi","year":"2020","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.molimm.2024.02.008_bib17","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1136\/annrheumdis-2011-200460","article-title":"Responsiveness of disease activity indices ESSPRI and ESSDAI in patients with primary Sj\u00f6gren\u2019s syndrome treated with rituximab","volume":"71","author":"Meiners","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2024.02.008_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/bjc.1992.44","article-title":"Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9","volume":"65","author":"Nilsson","year":"1992","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.molimm.2024.02.008_bib19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/14397595.2015.1091136","article-title":"Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients","volume":"26","author":"Qin","year":"2016","journal-title":"Mod. Rheuma"},{"key":"10.1016\/j.molimm.2024.02.008_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.molimm.2021.01.014","article-title":"Double-negative T cells are absolutely elevated in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis","volume":"132","author":"Qin","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2024.02.008_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.autrev.2016.09.017","article-title":"Interstitial lung disease in primary Sj\u00f6gren\u2019s syndrome","volume":"16","author":"Roca","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2024.02.008_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102447","article-title":"Clinical, morphological features and prognostic factors associated with interstitial lung disease in primary Sj\u04e7gren\u2019s syndrome: a systematic review from the Italian Society of Rheumatology","volume":"19","author":"Sambataro","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2024.02.008_bib23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/MPA.0b013e3182056b1c","article-title":"Selective use of staging laparoscopy based on carbohydrate antigen 19-9 level and tumor size in patients with radiographically defined potentially or borderline resectable pancreatic cancer","volume":"40","author":"Satoi","year":"2011","journal-title":"Pancreas"},{"key":"10.1016\/j.molimm.2024.02.008_bib24","article-title":"Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children","volume":"9","author":"Shaikh","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.molimm.2024.02.008_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/2040622320944802","article-title":"Increases in tumor markers are associated with primary Sj\u00f6gren\u2019s syndrome-associated interstitial lung disease","volume":"11","author":"Shi","year":"2020","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.molimm.2024.02.008_bib26","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/eurheartj\/ehu207","article-title":"Towards better clinical prediction models: seven steps for development and an ABCD for validation","volume":"35","author":"Steyerberg","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.molimm.2024.02.008_bib27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.molimm.2024.02.008_bib28","doi-asserted-by":"crossref","first-page":"R166","DOI":"10.1186\/ar3486","article-title":"Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease","volume":"13","author":"Truchetet","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.molimm.2024.02.008_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12890-023-02426-3","article-title":"In-hospital antibiotic use for severe chronic obstructive pulmonary disease exacerbations: a retrospective observational study","volume":"23","author":"Vanoverschelde","year":"2023","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.molimm.2024.02.008_bib30","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s10067-022-06089-z","article-title":"Tumor markers are associated with rapidly progressive interstitial lung disease in adult-dermatomyositis","volume":"41","author":"Wang","year":"2022","journal-title":"Clin. Rheuma"},{"key":"10.1016\/j.molimm.2024.02.008_bib31","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.21037\/jtd.2018.03.120","article-title":"Risk factors for primary Sj\u00f6gren syndrome-associated interstitial lung disease","volume":"10","author":"Wang","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.molimm.2024.02.008_bib32","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1007\/s10753-022-01661-w","article-title":"Serum Uric Acid as a diagnostic biomarker for rheumatoid arthritis-associated interstitial lung disease","volume":"45","author":"Wang","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.molimm.2024.02.008_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.clinbiochem.2020.05.018","article-title":"Increased levels of BPI-ANCA in patients with primary Sj\u00f6gren\u2019s syndrome are associated with lung involvement","volume":"83","author":"Wu","year":"2020","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.molimm.2024.02.008_bib34","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.21037\/apm-21-1043","article-title":"The ratio of neutrophil to lymphocyte predicts interstitial lung disease and its prognosis in patients with primary Sj\u00f6gren\u2019s syndrome: a retrospective analysis.","volume":"10","author":"Zhang","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.molimm.2024.02.008_bib35","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cyto.2014.06.008","article-title":"Increased levels of serum galectin-3 in patients with primary Sj\u00f6gren\u2019s syndrome: associated with interstitial lung disease","volume":"69","author":"Zhang","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.molimm.2024.02.008_bib36","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00296-012-2561-7","article-title":"Effect of cyclophosphamide on cytokines in patients with primary Sj\u00f6gren\u2019s syndrome-associated interstitial lung disease in South China","volume":"33","author":"Zhang","year":"2013","journal-title":"Rheuma Int."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:47:04Z","timestamp":1758980824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589024000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":36,"alternative-id":["S0161589024000348"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2024.02.008","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting the risk of interstitial lung disease in patients with primary Sj\u00f6gren's syndrome: Novel nomogram and elevated Th2 cells","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2024.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}