{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:20:24Z","timestamp":1769700024727,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.molimm.2024.07.002","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T21:37:09Z","timestamp":1721857029000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Evaluation of the prophylactic effect of egg yolk antibody (IgY) produced against the recombinant protein containing IpaD, IpaB, StxB, and VirG proteins from Shigella"],"prefix":"10.1016","volume":"173","author":[{"given":"Alireza","family":"Felegary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Nazarian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Zafarmand-Samarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davoud","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Fathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Samiei-Abianeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molimm.2024.07.002_bib1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/21645515.2018.1514224","article-title":"IgY antibodies for the immunoprophylaxis and therapy of respiratory infections","volume":"15","author":"Abbas","year":"2019","journal-title":"Hum. Vaccin Immunother."},{"issue":"9163","key":"10.1016\/j.molimm.2024.07.002_bib2","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(99)00961-7","article-title":"Isolation of Shigella sonnei lysogenic for a bacteriophage encoding gene for production of Shiga toxin","volume":"353","author":"Beutin","year":"1999","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.molimm.2024.07.002_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1083\/jcb.147.3.683","article-title":"The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes","volume":"147","author":"Blocker","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molimm.2024.07.002_bib4","first-page":"308","article-title":"Production and characterization of IgY specific to Escherichia coli O157: H7 from egg yolk","volume":"13","author":"Chae","year":"2000","journal-title":"ASIAN AUSTRALASIAN J. Anim. Sci."},{"issue":"1-2","key":"10.1016\/j.molimm.2024.07.002_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jmb.2012.03.025","article-title":"Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneri","volume":"420","author":"Epler","year":"2012","journal-title":"J. Mol. Biol."},{"issue":"8","key":"10.1016\/j.molimm.2024.07.002_bib6","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1128\/IAI.00440-06","article-title":"IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri","volume":"74","author":"Espina","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2024.07.002_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104199","article-title":"Production of egg yolk antibody (IgY) against shiga-like toxin (stx) and evaluation of its prophylaxis potency in mice","volume":"145","author":"Fathi","year":"2020","journal-title":"Micro Pathog."},{"key":"10.1016\/j.molimm.2024.07.002_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108132","article-title":"An approach to chimeric subunit immunogen provides efficient protection against toxicity, type III and type v secretion systems of Shigella","volume":"100","author":"Felegary","year":"2021","journal-title":"Int Immunopharmacol."},{"issue":"10","key":"10.1016\/j.molimm.2024.07.002_bib9","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3201\/eid2010.140292","article-title":"Clinical isolates of Shiga toxin 1a-producing Shigella flexneri with an epidemiological link to recent travel to Hispa\u00f1iola","volume":"20","author":"Gray","year":"2014","journal-title":"Emerg. Infect. Dis."},{"issue":"6","key":"10.1016\/j.molimm.2024.07.002_bib10","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.4269\/ajtmh.2007.76.1163","article-title":"Emergence of Shiga toxin 1 genes within Shigella dysenteriae type 4 isolates from travelers returning from the Island of Hispa\u00f1ola","volume":"76","author":"Gupta","year":"2007","journal-title":"Am. J. Trop. Med Hyg."},{"issue":"4","key":"10.1016\/j.molimm.2024.07.002_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.0033-0124.1964.006_q.x","article-title":"Determination of population thresholds for settlement functions by the Reed-Muench method","volume":"16","author":"Haggett","year":"1964","journal-title":"Prof. Geogr."},{"issue":"2","key":"10.1016\/j.molimm.2024.07.002_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1586\/eri.09.119","article-title":"Epidemiology and control of human gastrointestinal parasites in children","volume":"8","author":"Harhay","year":"2010","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.molimm.2024.07.002_bib13","first-page":"41","article-title":"Ricin and Shiga toxins: effects on host cell signal transduction","volume":"357","author":"Jandhyala","year":"2012","journal-title":"Curr. Top. Microbiol Immunol."},{"issue":"52","key":"10.1016\/j.molimm.2024.07.002_bib14","doi-asserted-by":"crossref","first-page":"42929","DOI":"10.1074\/jbc.M508377200","article-title":"The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus","volume":"280","author":"Kenjale","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.molimm.2024.07.002_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1504\/IJCBDD.2018.096127","article-title":"An in silico approach for construction of a chimeric protein, targeting virulence factors of Shigella spp","volume":"11","author":"Kordbacheh","year":"2018","journal-title":"Int. J. Comput. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.molimm.2024.07.002_bib16","article-title":"Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses","volume":"8","author":"Lee","year":"2016","journal-title":"Role Pathog. Ther. Appl., Toxins (Basel)"},{"issue":"1-2","key":"10.1016\/j.molimm.2024.07.002_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.vetpar.2009.04.020","article-title":"Protective effect of hyperimmune egg yolk IgY antibodies against Eimeria tenella and Eimeria maxima infections","volume":"163","author":"Lee","year":"2009","journal-title":"Vet. Parasitol."},{"issue":"9","key":"10.1016\/j.molimm.2024.07.002_bib18","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1128\/IAI.05139-11","article-title":"Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2","volume":"79","author":"Lentz","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2024.07.002_bib19","unstructured":"M. Mafi, S.L.M. Gargari, S. Nazarian, Production of Egg Yolk Immunoglobulin (IgY) Against Recombinant LTB of Enterotoxigenic Escherichia coli (ETEC) and Evaluation of Its Protective Effect in Animal Model, (2018)."},{"issue":"2","key":"10.1016\/j.molimm.2024.07.002_bib20","first-page":"110","article-title":"Immunogenicity of a new recombinant IpaC from Shigella dysenteriae type I in guinea pig as a vaccine candidate","volume":"10","author":"Malaei","year":"2013","journal-title":"Iran. J. Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2024.07.002_bib21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4161\/gmic.19325","article-title":"Shigella: a model of virulence regulation in vivo","volume":"3","author":"Marteyn","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.molimm.2024.07.002_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fcimb.2012.00081","article-title":"Shiga toxin in enterohemorrhagic E.coli: regulation and novel anti-virulence strategies","volume":"2","author":"Pacheco","year":"2012","journal-title":"Front Cell Infect. Microbiol"},{"issue":"51","key":"10.1016\/j.molimm.2024.07.002_bib23","doi-asserted-by":"crossref","DOI":"10.3791\/3084-v","article-title":"IgY technology: extraction of chicken antibodies from egg yolk by polyethylene glycol (PEG) precipitation","author":"Pauly","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.molimm.2024.07.002_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.intimp.2019.05.015","article-title":"Egg yolk antibodies (IgY) and their applications in human and veterinary health: A review","volume":"73","author":"Pereira","year":"2019","journal-title":"Int Immunopharmacol."},{"issue":"4","key":"10.1016\/j.molimm.2024.07.002_bib25","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/j.1365-2621.2002.tb10310.x","article-title":"Growth inhibitory effect of chicken egg yolk antibody (IgY) on Escherichia coli O157: H7","volume":"67","author":"Sunwoo","year":"2002","journal-title":"J. Food Sci."},{"issue":"Pt B","key":"10.1016\/j.molimm.2024.07.002_bib26","article-title":"Protective effects of egg yolk immunoglobulins (IgYs) developed against recombinant immunogens CtxB, OmpW and TcpA on infant mice infected with Vibrio cholerae","volume":"89","author":"Taheri","year":"2020","journal-title":"Int Immunopharmacol."},{"issue":"Pt 8","key":"10.1016\/j.molimm.2024.07.002_bib27","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1099\/mic.0.2007\/006858-0","article-title":"Membrane cytosolic translocation of verotoxin A1 subunit in target cells","volume":"153","author":"Tam","year":"2007","journal-title":"Microbiol. (Read. )"},{"key":"10.1016\/j.molimm.2024.07.002_bib28","series-title":"Overproduction of Recombinant VirG from Shigella flexneri","author":"Tashiro","year":"2015"},{"issue":"8","key":"10.1016\/j.molimm.2024.07.002_bib29","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.vaccine.2014.11.048","article-title":"Recommendations regarding the development of combined enterotoxigenic Eschericha coli and Shigella vaccines for infants","volume":"33","author":"Walker","year":"2015","journal-title":"Vaccine"},{"issue":"sup1","key":"10.1016\/j.molimm.2024.07.002_bib30","doi-asserted-by":"crossref","first-page":"s50","DOI":"10.1080\/20469047.2017.1409454","article-title":"Guidelines for the treatment of dysentery (shigellosis): a systematic review of the evidence","volume":"38","author":"Williams","year":"2018","journal-title":"Paediatr. Int Child Health"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024001226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024001226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T08:16:32Z","timestamp":1724141792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589024001226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":30,"alternative-id":["S0161589024001226"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2024.07.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the prophylactic effect of egg yolk antibody (IgY) produced against the recombinant protein containing IpaD, IpaB, StxB, and VirG proteins from Shigella","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2024.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}