{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:18:24Z","timestamp":1786994304294,"version":"build-2736575974"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.803395\/2023-00"],"award-info":[{"award-number":["88887.803395\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE031058"],"award-info":[{"award-number":["DE031058"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023838"],"award-info":[{"award-number":["DE023838"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR079693"],"award-info":[{"award-number":["AR079693"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DE030646"],"award-info":[{"award-number":["DE030646"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DE028033"],"award-info":[{"award-number":["DE028033"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DE032707"],"award-info":[{"award-number":["DE032707"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI181002"],"award-info":[{"award-number":["AI181002"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.molimm.2024.08.003","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T18:38:22Z","timestamp":1724783902000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Altered characteristics of regulatory T cells in target tissues of Sj\u00f6gren\u2019s syndrome in murine models"],"prefix":"10.1016","volume":"174","author":[{"given":"Jing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Arag\u00e3o","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daesong","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2024.08.003_bib1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.immuni.2016.05.001","article-title":"Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation","volume":"44","author":"Anderson","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2024.08.003_bib2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/cei\/uxac123","article-title":"Treg specialization and functions beyond immune suppression","volume":"211","author":"Astarita","year":"2023","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib3","doi-asserted-by":"crossref","first-page":"C1191","DOI":"10.1152\/ajpcell.00144.2008","article-title":"Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line","volume":"295","author":"Baker","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.molimm.2024.08.003_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12172","article-title":"Treg functional stability and its responsiveness to the microenvironment","volume":"259","author":"Barbi","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2024.08.003_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/imm.12948","article-title":"Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of Sjogren syndrome","volume":"155","author":"Barr","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.molimm.2024.08.003_bib6","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1136\/annrheumdis-2011-200744","article-title":"Increased interleukin (IL)-7Ralpha expression in salivary glands of patients with primary Sjogren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity","volume":"71","author":"Bikker","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2024.08.003_bib7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/rheumatology\/ker448","article-title":"IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Ralpha","volume":"51","author":"Bikker","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.molimm.2024.08.003_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-3083.2001.00958.x","article-title":"IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjogren's syndrome","volume":"54","author":"Brayer","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2019.09.010","article-title":"Roles of regulatory T cells in tissue pathophysiology and metabolism","volume":"31","author":"Campbell","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.molimm.2024.08.003_bib10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.0300-9475.2004.01508.x","article-title":"A dual role for interferon-gamma in the pathogenesis of Sjogren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse","volume":"60","author":"Cha","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib11","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/art.10258","article-title":"Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjogren's syndrome) on a healthy murine background","volume":"46","author":"Cha","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2024.08.003_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jaut.2009.09.009","article-title":"Sjogren syndrome: advances in the pathogenesis from animal models","volume":"33","author":"Chiorini","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2024.08.003_bib13","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2353\/ajpath.2008.080246","article-title":"Foxp3+ T-regulatory cells in Sjogren's syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors","volume":"173","author":"Christodoulou","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molimm.2024.08.003_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/BOR.0b013e32832efe55","article-title":"B cell depletion in lupus and Sjogren's syndrome: an update","volume":"21","author":"Coca","year":"2009","journal-title":"Curr. Opin. Rheuma"},{"key":"10.1016\/j.molimm.2024.08.003_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jaut.2012.05.014","article-title":"B cells in Sjogren's syndrome: from pathophysiology to diagnosis and treatment","volume":"39","author":"Cornec","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2024.08.003_bib16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/imr.12520","article-title":"Tim-3 and its role in regulating anti-tumor immunity","volume":"276","author":"Das","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2024.08.003_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/1759720X17746319","article-title":"Management of primary Sjogren's syndrome: recent developments and new classification criteria","volume":"10","author":"Del Papa","year":"2018","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"10.1016\/j.molimm.2024.08.003_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat. Med"},{"key":"10.1016\/j.molimm.2024.08.003_bib19","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1053\/j.gastro.2011.03.009","article-title":"Interleukin-12 converts Foxp3+ regulatory T cells to interferon-gamma-producing Foxp3+ T cells that inhibit colitis","volume":"140","author":"Feng","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2024.08.003_bib20","first-page":"179","article-title":"One year in review 2017: primary Sjogren's syndrome","volume":"35","author":"Ferro","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.molimm.2024.08.003_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1196\/annals.1384.003","article-title":"Autoimmune diseases and Sjogren's syndrome: an autoimmune exocrinopathy","volume":"1098","author":"Fox","year":"2007","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.molimm.2024.08.003_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD-1 pathway in tolerance and autoimmunity","volume":"236","author":"Francisco","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.molimm.2024.08.003_bib23","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1002\/eji.201344392","article-title":"Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells","volume":"44","author":"Gautron","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2020.04.006","article-title":"Differences in T regulatory cells between mouse strains frequently used in immunological research: treg cell quantities and subpopulations in NOD, B6 and BALB\/c mice","volume":"223","author":"Godoy","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.molimm.2024.08.003_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaut.2005.01.015","article-title":"CD4 CD25high regulatory T cells are not impaired in patients with primary Sjogren's syndrome","volume":"24","author":"Gottenberg","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2024.08.003_bib26","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.4049\/jimmunol.1201286","article-title":"IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells","volume":"189","author":"Heninger","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.immuni.2018.03.015","article-title":"KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, differentiate into all memory t cell lineages, and convey enhanced protective immunity","volume":"48","author":"Herndler-Brandstetter","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2024.08.003_bib28","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.immuni.2018.03.033","article-title":"Bach2: an instrument of heterogeneity for long-term protection","volume":"48","author":"Huang","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2024.08.003_bib29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.immuni.2008.02.019","article-title":"Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis","volume":"28","author":"Izcue","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2024.08.003_bib30","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/art.38007","article-title":"Interleukin-7 enhances the Th1 response to promote the development of Sjogren's syndrome-like autoimmune exocrinopathy in mice","volume":"65","author":"Jin","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2024.08.003_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077605","article-title":"Innate immune signaling induces interleukin-7 production from salivary gland cells and accelerates the development of primary Sjogren's syndrome in a mouse model","volume":"8","author":"Jin","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.molimm.2024.08.003_bib32","article-title":"T cell-associated cytokines in the pathogenesis of sjogren's syndrome","author":"Jin","year":"2013","journal-title":"J. Clin. Cell. Immunol. S"},{"key":"10.1016\/j.molimm.2024.08.003_bib33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.immuni.2014.02.012","article-title":"Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses","volume":"40","author":"Joller","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2024.08.003_bib34","doi-asserted-by":"crossref","first-page":"17675","DOI":"10.1038\/s41598-019-53240-z","article-title":"IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases","volume":"9","author":"Kannan","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2024.08.003_bib35","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12016-007-8011-8","article-title":"T lymphocytes in Sjogren's syndrome: contributors to and regulators of pathophysiology","volume":"32","author":"Katsifis","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13075-022-02769-y","article-title":"Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjogren's syndrome","volume":"24","author":"Keindl","year":"2022","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2024.08.003_bib37","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.4049\/jimmunol.1102328","article-title":"An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis","volume":"188","author":"Kim","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib38","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/ecco-jcc\/jjac101","article-title":"Intestinal epithelial responses to IL-17 in adult stem cell-derived human intestinal organoids","volume":"16","author":"Lee","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.molimm.2024.08.003_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00005-009-0002-4","article-title":"Sjogren's syndrome: an old tale with a new twist","volume":"57","author":"Lee","year":"2009","journal-title":"Arch. Immunol. Ther. Exp. (Warsz."},{"key":"10.1016\/j.molimm.2024.08.003_bib40","first-page":"2438","article-title":"T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjogren's syndrome","volume":"34","author":"Li","year":"2007","journal-title":"J. Rheuma"},{"key":"10.1016\/j.molimm.2024.08.003_bib41","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.3389\/fimmu.2020.02104","article-title":"ICOS(+) Tregs: a functional subset of tregs in immune diseases","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib42","article-title":"Altered subgroups of regulatory T cells in patients with primary Sjogren's syndrome","volume":"9","author":"Lin","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.molimm.2024.08.003_bib43","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/annrheumdis-2013-204584","article-title":"Th17 cells play a critical role in the development of experimental Sjogren's syndrome","volume":"74","author":"Lin","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2024.08.003_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0961203307085248","article-title":"Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren's syndrome","volume":"17","author":"Liu","year":"2008","journal-title":"Lupus"},{"key":"10.1016\/j.molimm.2024.08.003_bib45","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.4049\/jimmunol.1003224","article-title":"CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game","volume":"187","author":"Long","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124427","article-title":"TIGIT signaling restores suppressor function of Th1 Tregs","volume":"4","author":"Lucca","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.molimm.2024.08.003_bib47","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s12016-007-8008-3","article-title":"Conventional therapy of Sjogren's syndrome","volume":"32","author":"Mavragani","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fimmu.2017.00192","article-title":"Murine Cytomegalovirus Infection Induces Susceptibility to EAE in Resistant BALB\/c Mice","volume":"8","author":"Milovanovic","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib49","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jcmgh.2021.07.005","article-title":"The production and function of endogenous interleukin-10 in intestinal epithelial cells and gut homeostasis","volume":"12","author":"Nguyen","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.molimm.2024.08.003_bib50","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2741\/2187","article-title":"Sjogren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies","volume":"12","author":"Nguyen","year":"2007","journal-title":"Front Biosci."},{"key":"10.1016\/j.molimm.2024.08.003_bib51","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-3083.2006.01828.x","article-title":"Sjogren's syndrome-like disease of C57BL\/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus","volume":"64","author":"Nguyen","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib52","doi-asserted-by":"crossref","first-page":"R220","DOI":"10.1186\/ar3207","article-title":"Pathogenic effect of interleukin-17A in induction of Sjogren's syndrome-like disease using adenovirus-mediated gene transfer","volume":"12","author":"Nguyen","year":"2010","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2024.08.003_bib53","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/labinvest.2010.164","article-title":"IL17: potential therapeutic target in Sjogren's syndrome using adenovirus-mediated gene transfer","volume":"91","author":"Nguyen","year":"2011","journal-title":"Lab Invest"},{"key":"10.1016\/j.molimm.2024.08.003_bib54","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/BOR.0b013e32832eba21","article-title":"Pathogenesis of Sjogren's syndrome","volume":"21","author":"Nikolov","year":"2009","journal-title":"Curr. Opin. Rheuma"},{"key":"10.1016\/j.molimm.2024.08.003_bib55","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1038\/s41467-023-41683-y","article-title":"IFNgamma-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration","volume":"14","author":"Omrani","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2024.08.003_bib56","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2017.05.005","article-title":"Interferon-gamma drives treg fragility to promote anti-tumor immunity","volume":"169","author":"Overacre-Delgoffe","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2024.08.003_bib57","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.immuni.2010.08.013","article-title":"gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism","volume":"33","author":"Petermann","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2024.08.003_bib58","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149656","article-title":"The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function","volume":"6","author":"Prakhar","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.molimm.2024.08.003_bib59","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/jama.2010.1014","article-title":"Treatment of primary Sjogren syndrome: a systematic review","volume":"304","author":"Ramos-Casals","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.molimm.2024.08.003_bib60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/art.41558","article-title":"Interleukin-7\/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjogren's Syndrome","volume":"73","author":"Riviere","year":"2021","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.molimm.2024.08.003_bib61","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/rheumatology\/keu417","article-title":"Biologic treatment in Sjogren's syndrome","volume":"54","author":"Sada","year":"2015","journal-title":"Rheumatology"},{"key":"10.1016\/j.molimm.2024.08.003_bib62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/imcb.1003","article-title":"Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells","volume":"96","author":"Sasidharan Nair","year":"2018","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.molimm.2024.08.003_bib63","doi-asserted-by":"crossref","first-page":"13330","DOI":"10.1073\/pnas.1510045112","article-title":"IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice","volume":"112","author":"Schmaler","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molimm.2024.08.003_bib64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1477-7525-7-46","article-title":"Primary Sjogren's Syndrome: health experiences and predictors of health quality among patients in the United States","volume":"7","author":"Segal","year":"2009","journal-title":"Health Qual. Life Outcomes"},{"key":"10.1016\/j.molimm.2024.08.003_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036596","article-title":"Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis","volume":"7","author":"Simonetta","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.molimm.2024.08.003_bib66","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1182\/blood-2011-11-388918","article-title":"Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells","volume":"119","author":"Tai","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2024.08.003_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aay8556","article-title":"T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage","volume":"4","author":"Takashima","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib68","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molimm.2017.01.008","article-title":"IL-12 and IL-23 modulate plasticity of FoxP3(+) regulatory T cells in human Leprosy","volume":"83","author":"Tarique","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2024.08.003_bib69","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaut.2017.11.003","article-title":"Th17 cells in primary Sjogren's syndrome: pathogenicity and plasticity","volume":"87","author":"Verstappen","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2024.08.003_bib70","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrrheum.2010.118","article-title":"Pathogenetic mechanisms in the initiation and perpetuation of Sjogren's syndrome","volume":"6","author":"Voulgarelis","year":"2010","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.molimm.2024.08.003_bib71","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1038\/s41598-017-06410-w","article-title":"Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2024.08.003_bib72","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/ar3348","article-title":"Disturbance of cytokine networks in Sjogren's syndrome","volume":"13","author":"Youinou","year":"2011","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2024.08.003_bib73","doi-asserted-by":"crossref","first-page":"39105","DOI":"10.1038\/srep39105","article-title":"Endogenous programmed death ligand-1 restrains the development and onset of Sjgren's syndrome in non-obese diabetic mice","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2024.08.003_bib74","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.bbadis.2018.04.010","article-title":"Anti-IL-7 receptor-alpha treatment ameliorates newly established Sjogren's-like exocrinopathy in non-obese diabetic mice","volume":"1864","author":"Zhou","year":"2018","journal-title":"Biochim. Et. Biophys. Acta"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024001597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024001597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:52:03Z","timestamp":1725843123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589024001597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":74,"alternative-id":["S0161589024001597"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2024.08.003","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered characteristics of regulatory T cells in target tissues of Sj\u00f6gren\u2019s syndrome in murine models","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2024.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}