{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:32:59Z","timestamp":1789475579987,"version":"build-2803163510"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 AI170587"],"award-info":[{"award-number":["R01 AI170587"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.molimm.2024.09.006","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T09:04:46Z","timestamp":1726909486000},"page":"74-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Exploring the genome-wide transcriptomic responses of Bulinus truncatus to Schistosoma haematobium infection: An important host-parasite system involved in the transmission of human urogenital schistosomiasis"],"prefix":"10.1016","volume":"175","author":[{"given":"Mohamed R.","family":"Habib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijan","family":"Posavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelmalek","family":"Lekired","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2024.09.006_bib1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molimm.2009.10.019","article-title":"Differential transcriptomic responses of Biomphalaria glabrata (Gastropoda, Mollusca) to bacteria and metazoan parasites, Schistosoma mansoni and Echinostoma paraensei (Digenea, Platyhelminthes)","volume":"47","author":"Adema","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib2","article-title":"Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail","volume":"8","author":"Adema","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2024.09.006_bib3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bjid.2014.11.004","article-title":"Impact of human schistosomiasis in sub-Saharan Africa","volume":"19","author":"Adenowo","year":"2015","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib4","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1128\/JB.01336-07","article-title":"Crystal structure of the NADH oxidoreductase WrbA from Escherichia coli","volume":"189","author":"Andrade","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.molimm.2024.09.006_bib5","unstructured":"Andrews, S., 2010. Babraham Bioinformatics - FastQC: A Quality Control tool for High Throughput Sequence Data. Available from: \u3008https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/\u3009."},{"key":"10.1016\/j.molimm.2024.09.006_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00424-004-1311-4","article-title":"The bile salt export pump: molecular properties, function and regulation","volume":"449","author":"Arrese","year":"2004","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.molimm.2024.09.006_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Gene Ontol. Consort. Nat. Genet"},{"key":"10.1016\/j.molimm.2024.09.006_bib8","article-title":"Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications","volume":"33","author":"Begolli","year":"2023","journal-title":"Biochem. Med. (Zagreb)"},{"key":"10.1016\/j.molimm.2024.09.006_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"10.1016\/j.molimm.2024.09.006_bib10","doi-asserted-by":"crossref","unstructured":"Blighe, K., Rana, S., Lewis, M., 2024. EnhancedVolcano: publication-ready volcano plots with enhanced coloring and labeling, R package version 1.22.0. Available: \u3008https:\/\/github.com\/kevinblighe\/EnhancedVolcano\u3009.","DOI":"10.32614\/CRAN.package.ggvolcano"},{"key":"10.1016\/j.molimm.2024.09.006_bib11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(15)00084-5","article-title":"Schistosomiasis reaches Europe","volume":"15","author":"Boissier","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib12","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2024.09.006_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.02.050","article-title":"Roles for RNA-binding proteins in development and disease","volume":"1647","author":"Brinegar","year":"2016","journal-title":"Brain Res"},{"key":"10.1016\/j.molimm.2024.09.006_bib14","series-title":"Freshwater snails of Africa and their medical importance","author":"Brown","year":"2014"},{"key":"10.1016\/j.molimm.2024.09.006_bib15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/s42003-022-03844-5","article-title":"Compatibility between snails and schistosomes: insights from new genetic resources, comparative genomics, and genetic mapping","volume":"5","author":"Bu","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011208","article-title":"A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni","volume":"17","author":"Bu","year":"2023","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105150","article-title":"Transcriptional profiling of Bulinus globosus provides insights into immune gene families in snails supporting the transmission of urogenital schistosomiasis","volume":"154","author":"Bu","year":"2024","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005984","article-title":"Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species","volume":"11","author":"Buddenborg","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006927","article-title":"Transcriptional responses of Biomphalaria pfeifferi and Schistosoma mansoni following exposure to niclosamide, with evidence for a synergistic effect on snails following exposure to both stressors","volume":"13","author":"Buddenborg","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib20","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1101\/gad.1411206","article-title":"The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway","volume":"20","author":"Chen","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.molimm.2024.09.006_bib21","doi-asserted-by":"crossref","first-page":"D67","DOI":"10.1093\/nar\/gkv1276","article-title":"GenBank","volume":"44","author":"Clark","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2024.09.006_bib22","doi-asserted-by":"crossref","first-page":"30880","DOI":"10.1074\/jbc.R114.609248","article-title":"Multidrug resistance protein 1 (MRP1, ABCC1), a \"multitasking\" ATP-binding cassette (ABC) transporter","volume":"289","author":"Cole","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.molimm.2024.09.006_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/10409230590918612","article-title":"RNA-binding proteins in early development","volume":"40","author":"Colegrove-Otero","year":"2005","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/JLB.3RU0618-246R","article-title":"Heparan sulfate as a regulator of inflammation and immunity","volume":"105","author":"Collins","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.fsi.2015.01.036","article-title":"Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: a review of research progress over the last decade","volume":"46","author":"Coustau","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"Gigascience"},{"key":"10.1016\/j.molimm.2024.09.006_bib27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/nar\/gkg186","article-title":"Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression","volume":"31","author":"Decker","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2024.09.006_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.dci.2014.10.009","article-title":"A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata","volume":"48","author":"Dheilly","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib29","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2022.0274","article-title":"Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective","volume":"378","author":"D\u00edaz","year":"2023","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.molimm.2024.09.006_bib30","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.ygeno.2006.06.011","article-title":"Analysis of ESTs from Lutzomyia longipalpis sand flies and their contribution toward understanding the insect-parasite relationship","volume":"88","author":"Dillon","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.molimm.2024.09.006_bib31","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.3389\/fimmu.2018.02773","article-title":"Proteomic analysis of Biomphalaria glabrata hemocytes during in vitro encapsulation of Schistosoma mansoni sporocysts","volume":"9","author":"Dinguirard","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib32","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1021\/acs.chemrev.0c00983","article-title":"Structures and general transport mechanisms by the major facilitator superfamily (MFS)","volume":"121","author":"Drew","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.molimm.2024.09.006_bib33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/genes11010069","article-title":"A new assessment of thioester-containing proteins diversity of the freshwater snail Biomphalaria glabrata","volume":"11","author":"Duval","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.molimm.2024.09.006_bib34","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2024.09.006_bib35","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkr367","article-title":"HMMER web server: interactive sequence similarity searching","volume":"39","author":"Finn","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.molimm.2024.09.006_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003216","article-title":"Biomphalysin, a new \u03b2 pore-forming toxin involved in Biomphalaria glabrata immune defense against Schistosoma mansoni","volume":"9","author":"Galinier","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2024.09.006_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005398","article-title":"A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni","volume":"11","author":"Galinier","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.706907","article-title":"ggVennDiagram: an intuitive, easy-to-use, and highly customizable R package to generate Venn diagrams","volume":"12","author":"Gao","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.molimm.2024.09.006_bib39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/tx700079z","article-title":"Cytochrome p450 and chemical toxicology","volume":"21","author":"Guengerich","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.molimm.2024.09.006_bib40","article-title":"Invasion and dispersal of Biomphalaria species: increased vigilance needed to prevent the introduction and spread of schistosomiasis","volume":"8","author":"Habib","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.molimm.2024.09.006_bib41","doi-asserted-by":"crossref","first-page":"21087","DOI":"10.1073\/pnas.1011242107","article-title":"Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection","volume":"107","author":"Hanington","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.molimm.2024.09.006_bib42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.dci.2009.12.001","article-title":"Identification of protein components of egg masses indicates parental investment in immunoprotection of offspring by Biomphalaria glabrata (gastropoda, mollusca)","volume":"34","author":"Hathaway","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/prot.24186","article-title":"Solution structures of polcalcin Phl p 7 in three ligation states: Apo-, hemi-Mg2+-bound, and fully Ca2+-bound","volume":"81","author":"Henzl","year":"2013","journal-title":"Proteins"},{"key":"10.1016\/j.molimm.2024.09.006_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000412","article-title":"Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden","volume":"3","author":"Hotez","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib45","first-page":"108","article-title":"CateGOrizer: a web-based program to batch analyze gene ontology classification categories","volume":"9","author":"Hu","year":"2008","journal-title":"Online J. Bioinforma."},{"key":"10.1016\/j.molimm.2024.09.006_bib46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.exppara.2009.07.015","article-title":"Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails","volume":"123","author":"Ittiprasert","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.molimm.2024.09.006_bib47","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/ppl.13280","article-title":"Introgression of a novel cold and drought regulatory-protein encoding CORA-like gene, SbCDR, induced osmotic tolerance in transgenic tobacco","volume":"172","author":"Jha","year":"2021","journal-title":"Physiol. Plant."},{"key":"10.1016\/j.molimm.2024.09.006_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009380","article-title":"Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of The Gambia","volume":"15","author":"Joof","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib49","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkr988","article-title":"KEGG for integration and interpretation of large-scale molecular data sets","volume":"40","author":"Kanehisa","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.molimm.2024.09.006_bib50","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1186\/s12879-016-1944-x","article-title":"Deep, multi-stage transcriptome of the schistosomiasis vector Biomphalaria glabrata provides platform for understanding molluscan disease-related pathways","volume":"16","author":"Kenny","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2024.09.006_bib52","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.3390\/cancers12092613","article-title":"DNA polymerase alpha subunit B is a binding protein for erlotinib resistance in non-small cell lung cancer","volume":"12","author":"Kim","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.molimm.2024.09.006_bib53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/pr.118.015578","article-title":"Organic cation transporters in health and disease","volume":"72","author":"Koepsell","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.molimm.2024.09.006_bib54","unstructured":"Kolde, R., 2019. pheatmap: pretty heatmaps, R package version 1.0.12. Available: \u3008https:\/\/CRAN.R-project.org\/package=pheatmap\u3009."},{"key":"10.1016\/j.molimm.2024.09.006_bib55","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib56","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1093\/cid\/ciae074","article-title":"How does treatment coverage and proportion never treated influence the success of Schistosoma mansoni elimination as a public health problem by 2030?","volume":"78","author":"Kura","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib57","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41420-021-00555-4","article-title":"Methyltransferase-like protein 7A (METTL7A) promotes cell survival and osteogenic differentiation under metabolic stress","volume":"7","author":"Lee","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.molimm.2024.09.006_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000267","article-title":"The NIH-NIAID schistosomiasis resource center","volume":"2","author":"Lewis","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00251-021-01236-3","article-title":"Single-cell RNA-seq profiling of individual Biomphalaria glabrata immune cells with a focus on immunologically relevant transcripts","volume":"74","author":"Li","year":"2022","journal-title":"Immunogenetics"},{"key":"10.1016\/j.molimm.2024.09.006_bib60","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1017\/S0007114521004566","article-title":"Important roles of amino acids in immune responses","volume":"127","author":"Li","year":"2022","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.molimm.2024.09.006_bib61","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1016\/j.ygeno.2020.06.046","article-title":"The transcriptome analysis of the whole-body of the gastropod mollusk Limax flavus and screening of putative antimicrobial peptide and protein genes","volume":"112","author":"Li","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.molimm.2024.09.006_bib62","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2024.09.006_bib63","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1186\/1471-2164-9-634","article-title":"Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.","volume":"9","author":"Lockyer","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.molimm.2024.09.006_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051102","article-title":"Early differential gene expression in haemocytes from resistant and susceptible Biomphalaria glabrata strains in response to Schistosoma mansoni","volume":"7","author":"Lockyer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2024.09.006_bib65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008780","article-title":"Genomic and transcriptional analysis of genes containing fibrinogen and IgSF domains in the schistosome vector Biomphalaria glabrata, with emphasis on the differential responses of snails susceptible or resistant to Schistosoma mansoni","volume":"14","author":"Lu","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.805882","article-title":"An overview of transcriptional responses of schistosome-susceptible (M line) or -resistant (BS-90) Biomphalaria glabrata exposed or not to Schistosoma mansoni infection","volume":"12","author":"Lu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib68","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1186\/s12864-024-10454-4","article-title":"Different metazoan parasites, different transcriptomic responses, with new insights on parasitic castration by digenetic trematodes in the schistosome vector snail Biomphalaria glabrata","volume":"25","author":"Lu","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.molimm.2024.09.006_bib69","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2024.09.006_bib70","doi-asserted-by":"crossref","first-page":"257","DOI":"10.32800\/abc.2019.42.0257","article-title":"Risk map of transmission of urogenital schistosomiasis by Bulinus truncatus (Audouin, 1827) (Mollusca Gastropoda, Bulinidae) in Spain and Portugal","volume":"42","author":"Mart\u00ednez-Ort\u00ed","year":"2019","journal-title":"Anim. Biodivers. Conserv."},{"key":"10.1016\/j.molimm.2024.09.006_bib71","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.dci.2004.10.002","article-title":"Gene discovery and expression analysis of immune-relevant genes from Biomphalaria glabrata hemocytes","volume":"29","author":"Mitta","year":"2005","journal-title":"Dev. Comp. Immunol."},{"issue":"9","key":"10.1016\/j.molimm.2024.09.006_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000813","article-title":"A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host\/parasite model","volume":"4","author":"Mon\u00e9","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib73","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1017\/S0031182001007703","article-title":"Schistosoma mansoni and Biomphalaria: past history and future trends","volume":"123","author":"Morgan","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.molimm.2024.09.006_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.664788","article-title":"Functions of oxysterol-binding proteins at membrane contact sites and their control by phosphoinositide metabolism","volume":"9","author":"Nakatsu","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.molimm.2024.09.006_bib75","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.it.2006.12.002","article-title":"The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN\/GIMAP family proteins","volume":"28","author":"Nitta","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib76","first-page":"giac012","article-title":"Genome of the ramshorn snail Biomphalaria straminea\u2014an obligate intermediate host of schistosomiasis","volume":"11","author":"Nong","year":"2022","journal-title":"Gigascience"},{"key":"10.1016\/j.molimm.2024.09.006_bib77","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13071-020-04136-9","article-title":"Interactions between Schistosoma haematobium group species and their Bulinus spp. intermediate hosts along the Niger River Valley","volume":"13","author":"Pennance","year":"2020","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.molimm.2024.09.006_bib78","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12864-024-10103-w","article-title":"The genome and transcriptome of the snail Biomphalaria sudanica s.l.: immune gene diversification and highly polymorphic genomic regions in an important African vector of Schistosoma mansoni","volume":"25","author":"Pennance","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.molimm.2024.09.006_bib79","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.23297.1","article-title":"GFF Utilities: GffRead and GffCompare","volume":"9","author":"Pertea","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.molimm.2024.09.006_bib80","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.molimm.2024.09.006_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005513","article-title":"A novel Toll-Like Receptor (TLR) influences compatibility between the gastropod Biomphalaria glabrata, and the digenean trematode Schistosoma mansoni","volume":"12","author":"Pila","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2024.09.006_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005361","article-title":"A shift from cellular to humoral responses contributes to innate immune memory in the vector snail Biomphalaria glabrata","volume":"12","author":"Pinaud","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molimm.2024.09.006_bib83","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.dci.2018.12.001","article-title":"Molecular characterisation of immunological memory following homologous or heterologous challenges in the schistosomiasis vector snail, Biomphalaria glabrata","volume":"92","author":"Pinaud","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.635131","article-title":"New insights into Biomphalysin gene family diversification in the vector snail Biomphalaria glabrata","volume":"12","author":"Pinaud","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib85","doi-asserted-by":"crossref","first-page":"D284","DOI":"10.1093\/nar\/gkr1060","article-title":"eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges","volume":"40","author":"Powell","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2024.09.006_bib86","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3389\/fgene.2020.00858","article-title":"The globin gene family in arthropods: evolution and functional diversity","volume":"11","author":"Prothmann","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.molimm.2024.09.006_bib87","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/s13071-015-1022-z","article-title":"Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni","volume":"8","author":"Ranasinghe","year":"2015","journal-title":"Parasit. Vectors"},{"issue":"2","key":"10.1016\/j.molimm.2024.09.006_bib88","first-page":"241","article-title":"Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes","volume":"8","author":"Reuber","year":"1996","journal-title":"Plant Cell"},{"key":"10.1016\/j.molimm.2024.09.006_bib89","series-title":"Biomphalaria Snails and Larval Trematodes","article-title":"Biomphalaria: Natural history, ecology and schistosome transmission","author":"Rollinson","year":"2011"},{"key":"10.1016\/j.molimm.2024.09.006_bib90","doi-asserted-by":"crossref","first-page":"S245","DOI":"10.1017\/S0031182001008046","article-title":"Interactions between intermediate snail hosts of the genus Bulinus and schistosomes of the Schistosoma haematobium group","volume":"123","author":"Rollinson","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.molimm.2024.09.006_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002691","article-title":"An investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix","volume":"8","author":"Rose","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2024.107212","article-title":"Combining a transcriptomic approach and a targeted metabolomics approach for deciphering the molecular bases of compatibility phenotype in the snail Biomphalaria glabrata toward Schistosoma mansoni","volume":"255","author":"Simphor","year":"2024","journal-title":"Acta Trop."},{"key":"10.1016\/j.molimm.2024.09.006_bib93","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1996","article-title":"The role of P450 enzymes in malaria and other vector-borne infectious diseases","volume":"50","author":"Skorokhod","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.molimm.2024.09.006_bib94","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1096\/fj.03-0590fje","article-title":"Granularin, a novel molluscan opsonin comprising a single vWF type C domain is up-regulated during parasitation","volume":"18","author":"Smit","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.molimm.2024.09.006_bib95","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1534\/g3.116.029314","article-title":"Transcriptomic analysis of differentially expressed genes during larval development of Rapana venosa by digital gene expression profiling","volume":"6","author":"Song","year":"2016","journal-title":"G3 (Bethesda"},{"key":"10.1016\/j.molimm.2024.09.006_bib96","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13742-015-0089-y","article-title":"Rcorrector: efficient and accurate error correction for Illumina RNA-seq reads","volume":"4","author":"Song","year":"2015","journal-title":"Gigascience"},{"key":"10.1016\/j.molimm.2024.09.006_bib97","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1017\/S0031182009991272","article-title":"Control of schistosomiasis in sub-Saharan Africa: progress made, new opportunities and remaining challenges","volume":"136","author":"Stothard","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.molimm.2024.09.006_bib98","series-title":"Animal Lectins: A Functional View","first-page":"475","article-title":"The biology of FREPs: diversified lectins with fibrinogen-related domains from the freshwater snail B. glabrata","author":"Stout","year":"2009"},{"key":"10.1016\/j.molimm.2024.09.006_bib99","article-title":"Bulinus truncatus transcriptome - a resource to enable molecular studies of snail and schistosome biology","volume":"1","author":"Stroehlein","year":"2021","journal-title":"Curr. Res. Parasitol. Vector Borne Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13071-019-3381-3","article-title":"Molecular characterization and distribution of Schistosoma cercariae collected from naturally infected bulinid snails in northern and central C\u00f4te d\u2032Ivoire","volume":"12","author":"Tian-Bi","year":"2019","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.molimm.2024.09.006_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1901s103","article-title":"Schistosomiasis","volume":"103","author":"Tucker","year":"2013","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib102","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"UniProt Consortium","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2024.09.006_bib103","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0031182009991600","article-title":"Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution","volume":"136","author":"Utzinger","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.molimm.2024.09.006_bib104","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0001-706X(03)00029-9","article-title":"Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa","volume":"86","author":"van der Werf","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.molimm.2024.09.006_bib105","article-title":"Comparative transcriptome analysis of Bombyx mori (Lepidoptera) larval midgut response to BmNPV in susceptible and near-isogenic resistant strains","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2024.09.006_bib106","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/1471-2164-14-400","article-title":"The acute transcriptional response of the coral Acropora millepora to immune challenge: expression of GiMAP\/IAN genes links the innate immune responses of corals with those of mammals and plants","volume":"14","author":"Weiss","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.molimm.2024.09.006_bib107","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2009"},{"key":"10.1016\/j.molimm.2024.09.006_bib108","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13059-019-1891-0","article-title":"Improved metagenomic analysis with Kraken 2","volume":"20","author":"Wood","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib109","unstructured":"WHO), 2021. Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021\u20132030. World Health Organization, Geneva."},{"key":"10.1016\/j.molimm.2024.09.006_bib110","unstructured":"WHO), 2023. Schistosomiasis Fact Sheet, World Health Organization, Geneva. \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis\u3009."},{"issue":"13","key":"10.1016\/j.molimm.2024.09.006_bib111","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3748\/wjg.v10.i13.1849","article-title":"Biological functions of melanoma-associated antigens","volume":"10","author":"Xiao","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.molimm.2024.09.006_bib112","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cbpb.2009.05.012","article-title":"Identification of the molecules involved in zebra mussel (Dreissena polymorpha) hemocytes host defense","volume":"154","author":"Xu","year":"2009","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.molimm.2024.09.006_bib113","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1124\/dmd.121.000702","article-title":"Emerging roles of the human solute carrier 22 family","volume":"50","author":"Yee","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.molimm.2024.09.006_bib114","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/s41467-022-28634-9","article-title":"Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium","volume":"13","author":"Young","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2024.09.006_bib115","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12192-010-0176-z","article-title":"Larval excretory-secretory products from the parasite Schistosoma mansoni modulate HSP70 protein expression in defence cells of its snail host, Biomphalaria glabrata","volume":"15","author":"Zahoor","year":"2010","journal-title":"Cell Stress Chaperon-.-."},{"key":"10.1016\/j.molimm.2024.09.006_bib116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093215","article-title":"Differences in the gene expression profiles of haemocytes from schistosome-susceptible and -resistant Biomphalaria glabrata exposed to Schistosoma mansoni excretory-secretory products","volume":"9","author":"Zahoor","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2024.09.006_bib117","article-title":"Roles of acyl-coenzyme A synthetase family members in airway epithelia cells","volume":"3","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Discov."},{"key":"10.1016\/j.molimm.2024.09.006_bib118","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004131","article-title":"Altered gene expression in the schistosome-transmitting snail Biomphalaria glabrata following exposure to niclosamide, the active ingredient in the widely used molluscicide Bayluscide","volume":"9","author":"Zhang","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib119","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.dci.2015.11.008","article-title":"Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata","volume":"56","author":"Zhang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.molimm.2024.09.006_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011983","article-title":"A haplotype-like, chromosome-level assembled and annotated genome of Biomphalaria glabrata, an important intermediate host of schistosomiasis and the best studied model of schistosomiasis vector snails","volume":"18","author":"Zhong","year":"2024","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molimm.2024.09.006_bib121","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/abbs\/gmt066","article-title":"The crystal structure of human GDP-L-fucose synthase","volume":"45","author":"Zhou","year":"2013","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024001767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589024001767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:58:05Z","timestamp":1778669885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589024001767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":121,"alternative-id":["S0161589024001767"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2024.09.006","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the genome-wide transcriptomic responses of Bulinus truncatus to Schistosoma haematobium infection: An important host-parasite system involved in the transmission of human urogenital schistosomiasis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2024.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}