{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:33:15Z","timestamp":1787164395681,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.molimm.2025.01.013","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T17:30:46Z","timestamp":1738690246000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Stigmasterol mitigates rheumatoid arthritis progression by decreasing Nrf2\/NLRP3-mediated pyroptosis in chondrocyte"],"prefix":"10.1016","volume":"179","author":[{"given":"Li","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaile","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiechao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianbo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2025.01.013_bib1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fpls.2019.00354","article-title":"Why do plants convert sitosterol to stigmasterol?","volume":"10","author":"Aboobucker","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.molimm.2025.01.013_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106642","article-title":"Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines","volume":"85","author":"Ahmad Khan","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.molimm.2025.01.013_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/pharmaceutics12060488","article-title":"Stigmasterol causes ovarian cancer cell apoptosis by inducing endoplasmic reticulum and mitochondrial dysfunction","volume":"12","author":"Bae","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.molimm.2025.01.013_bib4","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3390\/antiox11101912","article-title":"Health benefits and pharmacological properties of stigmasterol","volume":"11","author":"Bakrim","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.molimm.2025.01.013_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186993","article-title":"Resveratrol downregulates inflammatory pathway activated by lymphotoxin alpha (TNF-beta) in articular chondrocytes: comparison with TNF-alpha","volume":"12","author":"Buhrmann","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2025.01.013_bib6","article-title":"Molecular mechanisms of chondrocyte proliferation and differentiation","volume":"9","author":"Chen","year":"2021","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.molimm.2025.01.013_bib7","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.3390\/nu15214584","article-title":"New potentiality of bioactive substances: regulating the nlrp3 inflammasome in autoimmune diseases","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.molimm.2025.01.013_bib8","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221146398","article-title":"Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress","volume":"18","author":"Cheng","year":"2022","journal-title":"Mol. Pain."},{"key":"10.1016\/j.molimm.2025.01.013_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111469","article-title":"Gamma-oryzanol alleviates osteoarthritis development by targeting Keap1-Nrf2 binding to interfere with chondrocyte ferroptosis","volume":"128","author":"Dai","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.molimm.2025.01.013_bib10","first-page":"595","article-title":"Commonly used disease-modifying antirheumatic drugs in the treatment of inflammatory arthritis: an update on mechanisms of action","volume":"16","author":"Danning","year":"1998","journal-title":"Clin. Exp. Rheuma"},{"key":"10.1016\/j.molimm.2025.01.013_bib11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1053\/joca.2002.0806","article-title":"Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering","volume":"10","author":"van der Kraan","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.molimm.2025.01.013_bib12","doi-asserted-by":"crossref","first-page":"10956","DOI":"10.3390\/molecules190810956","article-title":"Triterpenoids from Gymnema sylvestre and their pharmacological activities","volume":"19","author":"Fabio","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.molimm.2025.01.013_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3830212","article-title":"Molecular and cellular pathways contributing to joint damage in rheumatoid arthritis","volume":"2020","author":"Fang","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.molimm.2025.01.013_bib14","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molimm.2025.01.013_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153766","article-title":"Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: a systematic review","volume":"93","author":"Gandhi","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.molimm.2025.01.013_bib16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s11427-020-1939-1","article-title":"Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-kappaB signaling pathway","volume":"65","author":"Ge","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.molimm.2025.01.013_bib17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41419-022-05047-6","article-title":"A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol beta deficiency","volume":"13","author":"Gu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molimm.2025.01.013_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112261","article-title":"Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-kappaB activity and pyroptosis in chondrocytes","volume":"247","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.01.013_bib19","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.molimm.2025.01.013_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116006","article-title":"Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2\/HO-1-mediated pathway","volume":"170","author":"Hung","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.molimm.2025.01.013_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.797855","article-title":"Mechanical stimulation protects against chondrocyte pyroptosis through irisin-induced suppression of PI3K\/Akt\/NF-kappaB signal pathway in osteoarthritis","volume":"10","author":"Jia","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.molimm.2025.01.013_bib22","article-title":"Stigmasterol attenuates inflammatory response of microglia via NF-kappaB and NLRP3 signaling by AMPK activation","volume":"153","author":"Jie","year":"2022","journal-title":"Biomed. Pharmacother. =\u2009Biomedecine Pharmacother."},{"key":"10.1016\/j.molimm.2025.01.013_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10295-015-1723-5","article-title":"Natural product discovery: past, present, and future","volume":"43","author":"Katz","year":"2016","journal-title":"J. Ind. Microbiol Biotechnol."},{"key":"10.1016\/j.molimm.2025.01.013_bib24","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.3390\/ijms21113956","article-title":"Natural product-based nanomedicine in treatment of inflammatory bowel disease","volume":"21","author":"Khare","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2025.01.013_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2796.1995.tb00923.x","article-title":"Immunopathogenesis and immunotherapy in rheumatoid arthritis: an area in transition","volume":"238","author":"Klareskog","year":"1995","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.molimm.2025.01.013_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154479","article-title":"Triptolide improves chondrocyte proliferation and secretion via down-regulation of miR-221 in synovial cell exosomes","volume":"107","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.molimm.2025.01.013_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110542","article-title":"Role of the NLRP3 inflammasome in autoimmune diseases","volume":"130","author":"Li","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.molimm.2025.01.013_bib28","article-title":"A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4\/NFkappaB\/NLRP3 activation-induced pyroptosis","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.01.013_bib29","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192133","article-title":"Stigmasterol alleviates cerebral ischemia\/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats","volume":"40","author":"Liang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.molimm.2025.01.013_bib30","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s13346-023-01501-w","article-title":"Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: a pilot study","volume":"14","author":"Lim","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.molimm.2025.01.013_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172854","article-title":"Leocarpinolide B attenuates LPS-induced inflammation on RAW264.7 macrophages by mediating NF-kappaB and Nrf2 pathways","volume":"868","author":"Linghu","year":"2020","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.molimm.2025.01.013_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.molimm.2025.01.013_bib33","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/1756-185X.14818","article-title":"TTC4 inhibits NLRP3 inflammation in rheumatoid arthritis by HSP70","volume":"26","author":"Lu","year":"2023","journal-title":"Int J. Rheum. Dis."},{"key":"10.1016\/j.molimm.2025.01.013_bib34","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1080\/21655979.2021.2000742","article-title":"Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis","volume":"12","author":"Mo","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.molimm.2025.01.013_bib35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jbspin.2018.01.012","article-title":"The chondrocyte channelome: a narrative review","volume":"86","author":"Mobasheri","year":"2019","journal-title":"Bone Spine"},{"key":"10.1016\/j.molimm.2025.01.013_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.autrev.2017.11.016","article-title":"Curcumin: a natural modulator of immune cells in systemic lupus erythematosus","volume":"17","author":"Momtazi-Borojeni","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2025.01.013_bib37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/ard.59.9.750a","article-title":"Enlarged spleen detected by abdominal ultrasonography in patients with RA","volume":"59","author":"Nishiya","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2025.01.013_bib38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/ar2292","article-title":"Cells of the synovium in rheumatoid arthritis. Chondrocytes","volume":"9","author":"Otero","year":"2007","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2025.01.013_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110835","article-title":"Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2\/SLC7A11\/GPX4 signaling pathway","volume":"388","author":"Ruan","year":"2024","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.molimm.2025.01.013_bib40","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1136\/annrheumdis-2019-215920","article-title":"Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017","volume":"78","author":"Safiri","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2025.01.013_bib41","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/rheumatology\/37.5.546","article-title":"The clinical management of rheumatoid arthritis and osteoarthritis: strategies for improving clinical effectiveness","volume":"37","author":"Scott","year":"1998","journal-title":"Br. J. Rheuma"},{"key":"10.1016\/j.molimm.2025.01.013_bib42","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41577-021-00602-2","article-title":"Gasdermins: making pores for pyroptosis","volume":"21","author":"Shao","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2025.01.013_bib43","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1189\/jlb.0410205","article-title":"Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism","volume":"88","author":"Silva","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2025.01.013_bib44","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s10787-023-01238-5","article-title":"Fractionated whole body gamma-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative potential of ebselen","volume":"31","author":"Thabet","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.molimm.2025.01.013_bib45","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/ijms21031071","article-title":"Dual role of chondrocytes in rheumatoid arthritis: the chicken and the egg","volume":"21","author":"Tseng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molimm.2025.01.013_bib46","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00210-017-1416-x","article-title":"Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain","volume":"390","author":"Walker","year":"2017","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.molimm.2025.01.013_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.755844","article-title":"Toward Overcoming Treatment Failure in Rheumatoid Arthritis","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.01.013_bib48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fphar.2020.00515","article-title":"Anti-rheumatic properties of gentiopicroside are associated with suppression of ROS-NF-kappaB-NLRP3 axis in fibroblast-like synoviocytes and NF-kappaB pathway in adjuvant-induced arthritis","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.molimm.2025.01.013_bib49","article-title":"Can pyroptosis be a new target in rheumatoid arthritis treatment?","volume":"14","author":"Wu","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.01.013_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.102982","article-title":"Differentiated embryonic chondrocyte expressed gene-1 is a central signaling component in the development of collagen-induced rheumatoid arthritis","volume":"299","author":"Wu","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molimm.2025.01.013_bib51","doi-asserted-by":"crossref","first-page":"12899","DOI":"10.1080\/21655979.2022.2078942","article-title":"Curcumin alleviates rheumatoid arthritis progression through the phosphatidylinositol 3-kinase\/protein kinase B pathway: an in vitro and in vivo study","volume":"13","author":"Xu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.molimm.2025.01.013_bib52","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/s41374-022-00774-y","article-title":"Nesfatin-1 exerts protective effects on acidosis-stimulated chondrocytes and rats with adjuvant-induced arthritis by inhibiting ASIC1a expression","volume":"102","author":"Xu","year":"2022","journal-title":"Lab Invest"},{"key":"10.1016\/j.molimm.2025.01.013_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113447","article-title":"Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-kappaB signaling","volume":"266","author":"Yu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.01.013_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1101289","article-title":"Advances in Stigmasterol on its anti-tumor effect and mechanism of action","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.molimm.2025.01.013_bib55","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13018-019-1307-6","article-title":"Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis","volume":"14","author":"Zu","year":"2019","journal-title":"J. Orthop. Surg. Res."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025000215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025000215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T16:25:32Z","timestamp":1740673532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589025000215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":55,"alternative-id":["S0161589025000215"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2025.01.013","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stigmasterol mitigates rheumatoid arthritis progression by decreasing Nrf2\/NLRP3-mediated pyroptosis in chondrocyte","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2025.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}