{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:50:42Z","timestamp":1791935442428,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360027"],"award-info":[{"award-number":["82360027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960163"],"award-info":[{"award-number":["31960163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Jiangxi Provincial Department of Education","doi-asserted-by":"publisher","award":["GJJ2401314"],"award-info":[{"award-number":["GJJ2401314"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Jiangxi Provincial Department of Education","doi-asserted-by":"publisher","award":["GJJ211543"],"award-info":[{"award-number":["GJJ211543"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020784","name":"Gannan Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.molimm.2025.03.004","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T01:53:42Z","timestamp":1742262822000},"page":"75-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dock2 deficiency reveals abnormal activation and differentiation of T cells under the physiological condition"],"prefix":"10.1016","volume":"181","author":[{"given":"Li","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Sheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10875-017-0468-5","article-title":"DOCK2 deficiency in a patient with hyper IgM phenotype","volume":"38","author":"Alizadeh","year":"2018","journal-title":"J. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jaci.2019.02.020","article-title":"T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients","volume":"144","author":"Alosaimi","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.immuni.2009.10.011","article-title":"CD44 regulates survival and memory development in Th1 cells","volume":"32","author":"Baaten","year":"2010","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051173","article-title":"Aberrant DOCK2, GRASP, HIF3A and PKFP hypermethylation has potential as a prognostic biomarker for prostate cancer","volume":"20","author":"Bjerre","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"6513","key":"10.1016\/j.molimm.2025.03.004_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/373441a0","article-title":"Cell-autonomous Fas (CD95)\/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas","volume":"373","author":"Brunner","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2025.03.004_bib6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yjmcc.2019.01.030","article-title":"Dedicator of cytokinesis 2 silencing therapy inhibits neointima formation and improves blood flow in rat vein grafts","volume":"128","author":"Cao","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/s13287-021-02459-7","article-title":"Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by modulating T cell function through CCR2-CCL2 axis","volume":"12","author":"Cao","year":"2021","journal-title":"Stem Cell Res Ther."},{"issue":"10","key":"10.1016\/j.molimm.2025.03.004_bib8","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.4049\/jimmunol.1400036","article-title":"Impaired B cell inhibition by lupus bone marrow mesenchymal stem cells is caused by reduced CCL2 expression","volume":"193","author":"Che","year":"2014","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2025.03.004_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/JLB.1MR0520-221RR","article-title":"The regulation of DOCK family proteins on T and B cells","volume":"109","author":"Chen","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.molimm.2025.03.004_bib10","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s10875-021-01040-4","article-title":"DOCK2 Deficiency Diagnosed 18 Years After Hematopoietic Stem Cell Transplantation","volume":"41","author":"D'Astous-Gauthier","year":"2021","journal-title":"J. Clin. Immunol."},{"issue":"6513","key":"10.1016\/j.molimm.2025.03.004_bib11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/373438a0","article-title":"Autocrine T-cell suicide mediated by APO-1\/(Fas\/CD95)","volume":"373","author":"Dhein","year":"1995","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.molimm.2025.03.004_bib12","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1056\/NEJMoa1413462","article-title":"Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections","volume":"372","author":"Dobbs","year":"2015","journal-title":"N. Engl. J. Med"},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib13","first-page":"2264","article-title":"Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival","volume":"11","author":"Du","year":"2021","journal-title":"Am. J. Cancer Res"},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0092-8674(92)90123-T","article-title":"Induction of apoptosis in fibroblasts by c-myc protein","volume":"69","author":"Evan","year":"1992","journal-title":"Cell"},{"issue":"6849","key":"10.1016\/j.molimm.2025.03.004_bib15","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/35090591","article-title":"Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration","volume":"412","author":"Fukui","year":"2001","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.molimm.2025.03.004_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/intimm\/dxh339","article-title":"Involvement of IL-32 in activation-induced cell death in T cells","volume":"18","author":"Goda","year":"2006","journal-title":"Int Immunol."},{"issue":"4","key":"10.1016\/j.molimm.2025.03.004_bib17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1084\/jem.20091776","article-title":"Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation","volume":"207","author":"Gotoh","year":"2010","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.molimm.2025.03.004_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1034\/j.1600-065X.2003.00051.x","article-title":"Activation-induced cell death in T cells","volume":"193","author":"Green","year":"2003","journal-title":"Immunol. Rev."},{"issue":"9","key":"10.1016\/j.molimm.2025.03.004_bib19","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1194\/jlr.M073049","article-title":"DOCK2 deficiency mitigates HFD-induced obesity by reducing adipose tissue inflammation and increasing energy expenditure","volume":"58","author":"Guo","year":"2017","journal-title":"J. Lipid Res"},{"issue":"8","key":"10.1016\/j.molimm.2025.03.004_bib20","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/jcp.25512","article-title":"Dedicator of cytokinesis 2 in cell signaling regulation and disease development","volume":"232","author":"Guo","year":"2017","journal-title":"J. Cell Physiol."},{"issue":"2","key":"10.1016\/j.molimm.2025.03.004_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1182\/blood-2017-12-819383","article-title":"Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1\/2 in chronic lymphocytic leukemia","volume":"132","author":"Hasan","year":"2018","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.molimm.2025.03.004_bib22","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/s41375-020-01055-7","article-title":"Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1\/2 phosphorylation via a ROR1\/DOCK2-dependent mechanism","volume":"35","author":"Hasan","year":"2021","journal-title":"Leukemia"},{"issue":"24","key":"10.1016\/j.molimm.2025.03.004_bib23","doi-asserted-by":"crossref","first-page":"6088","DOI":"10.7150\/jca.33244","article-title":"High expression of DOCK2 indicates good prognosis in acute myeloid leukemia","volume":"10","author":"Hu","year":"2019","journal-title":"J. Cancer"},{"issue":"9","key":"10.1016\/j.molimm.2025.03.004_bib24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2025.03.004_bib25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/cei.13590","article-title":"The role of Dock2 on macrophage migration and functions during Citrobacter rodentium infection","volume":"204","author":"Ji","year":"2021","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib26","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.jaci.2019.05.041","article-title":"Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation","volume":"144","author":"Jing","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6513","key":"10.1016\/j.molimm.2025.03.004_bib27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/373444a0","article-title":"Fas(CD95)\/FasL interactions required for programmed cell death after T-cell activation","volume":"373","author":"Ju","year":"1995","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.molimm.2025.03.004_bib28","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/eji.202049055","article-title":"T cells at work: How post-transcriptional mechanisms control T cell homeostasis and activation","volume":"51","author":"Jurgens","year":"2021","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/intimm\/dxz067","article-title":"DOCK family proteins: key players in immune surveillance mechanisms","volume":"32","author":"Kunimura","year":"2020","journal-title":"Int Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200602142","article-title":"DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis","volume":"174","author":"Kunisaki","year":"2006","journal-title":"J. Cell Biol."},{"issue":"6804","key":"10.1016\/j.molimm.2025.03.004_bib31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/35036608","article-title":"A common E2F-1 and p73 pathway mediates cell death induced by TCR activation","volume":"407","author":"Lissy","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2025.03.004_bib32","doi-asserted-by":"crossref","first-page":"27814","DOI":"10.1038\/srep27814","article-title":"DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib33","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41423-021-00835-0","article-title":"DOCK2 regulates antifungal immunity by regulating RAC GTPase activity","volume":"19","author":"Ma","year":"2022","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.molimm.2025.03.004_bib34","doi-asserted-by":"crossref","first-page":"1180886","DOI":"10.3389\/fimmu.2023.1180886","article-title":"Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis","volume":"14","author":"Machin","year":"2023","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4049\/jimmunol.1900440","article-title":"DOCK2 sets the threshold for entry into the virtual memory CD8(+) T cell compartment by negatively regulating Tonic TCR triggering","volume":"204","author":"Mahajan","year":"2020","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib36","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1492::AID-IMMU1492>3.0.CO;2-X","article-title":"Surface expression of TRAIL\/Apo-2 ligand in activated mouse T and B cells","volume":"28","author":"Mariani","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"23","key":"10.1016\/j.molimm.2025.03.004_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103730118","article-title":"Critical role of the CD44(low)CD62L(low) CD8(+) T cell subset in restoring antitumor immunity in aged mice","volume":"118","author":"Nakajima","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13062-025-00612-3","article-title":"Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation","volume":"20","author":"Qiu","year":"2025","journal-title":"Biol. Direct"},{"issue":"6","key":"10.1016\/j.molimm.2025.03.004_bib39","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1183\/13993003.01558-2014","article-title":"CC-chemokine ligand 2 inhibition in idiopathic pulmonary fibrosis: a phase 2 trial of carlumab","volume":"46","author":"Raghu","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.molimm.2025.03.004_bib40","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood-2012-12-475897","article-title":"The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation","volume":"122","author":"Sakai","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1074-7613(03)00169-9","article-title":"DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells","volume":"19","author":"Sanui","year":"2003","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.molimm.2025.03.004_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132479","article-title":"Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-gamma Producing Helper T Cells","volume":"10","author":"Schumann","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib43","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13223-021-00631-5","article-title":"First patient in the Iranian Registry with novel DOCK2 gene mutation, presenting with skeletal tuberculosis, and review of literature","volume":"17","author":"Sharifinejad","year":"2021","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.molimm.2025.03.004_bib44","doi-asserted-by":"crossref","first-page":"1240301","DOI":"10.1155\/2016\/1240301","article-title":"CCR2 positive exosome released by mesenchymal stem cells suppresses macrophage functions and alleviates ischemia\/reperfusion-induced renal injury","volume":"2016","author":"Shen","year":"2016","journal-title":"Stem Cells Int"},{"issue":"5067","key":"10.1016\/j.molimm.2025.03.004_bib45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.1378649","article-title":"Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas","volume":"257","author":"Shi","year":"1992","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.molimm.2025.03.004_bib46","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.1700562","article-title":"Mesenchymal stem cells recruit CCR2(+) monocytes to suppress allergic airway inflammation","volume":"200","author":"Takeda","year":"2018","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.molimm.2025.03.004_bib47","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/ni1506","article-title":"T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2","volume":"8","author":"Tanaka","year":"2007","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.molimm.2025.03.004_bib48","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fimmu.2018.00243","article-title":"The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production","author":"Ushijima","year":"2018","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib49","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1365-2567.2003.01710.x","article-title":"The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes","volume":"110","author":"Wan","year":"2003","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.molimm.2025.03.004_bib50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1074-7613(03)00053-0","article-title":"The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression","volume":"18","author":"Wan","year":"2003","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.molimm.2025.03.004_bib51","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/j.celrep.2017.10.117","article-title":"Growth of B cell receptor microclusters is regulated by PIP(2) and PIP(3) equilibrium and Dock2 recruitment and activation","volume":"21","author":"Wang","year":"2017","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.molimm.2025.03.004_bib52","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.4049\/jimmunol.1400885","article-title":"DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation","volume":"193","author":"Watanabe","year":"2014","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.03.004_bib53","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13099-021-00449-x","article-title":"Dock2 affects the host susceptibility to Citrobacter rodentium infection through regulating gut microbiota","volume":"13","author":"Xie","year":"2021","journal-title":"Gut Pathog."},{"key":"10.1016\/j.molimm.2025.03.004_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114399","article-title":"DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages","volume":"184","author":"Xu","year":"2021","journal-title":"Biochem Pharm."},{"issue":"5","key":"10.1016\/j.molimm.2025.03.004_bib55","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.181.5.1673","article-title":"Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids","volume":"181","author":"Yang","year":"1995","journal-title":"J. Exp. Med"},{"issue":"6547","key":"10.1016\/j.molimm.2025.03.004_bib56","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/377348a0","article-title":"Induction of apoptosis in mature T cells by tumour necrosis factor","volume":"377","author":"Zheng","year":"1995","journal-title":"Nature"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025000744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025000744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:22:13Z","timestamp":1776446533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589025000744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":56,"alternative-id":["S0161589025000744"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2025.03.004","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dock2 deficiency reveals abnormal activation and differentiation of T cells under the physiological condition","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2025.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}