{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:22:13Z","timestamp":1783196533988,"version":"3.54.6"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016077","name":"Dongguan Science and Technology Bureau","doi-asserted-by":"publisher","award":["20211800904592"],"award-info":[{"award-number":["20211800904592"]}],"id":[{"id":"10.13039\/501100016077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016077","name":"Dongguan Science and Technology Bureau","doi-asserted-by":"publisher","award":["20221800905232"],"award-info":[{"award-number":["20221800905232"]}],"id":[{"id":"10.13039\/501100016077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515110369"],"award-info":[{"award-number":["2019A1515110369"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204718"],"award-info":[{"award-number":["82204718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.molimm.2025.04.017","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T12:13:12Z","timestamp":1747051992000},"page":"115-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Phillyrin for sepsis-related acute lung injury: A potential strategy suppressing GSK-3\u03b2"],"prefix":"10.1016","volume":"183","author":[{"given":"Guangli","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-3920","authenticated-orcid":false,"given":"Weifu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaocong","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wujuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maorun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-9508","authenticated-orcid":false,"given":"Liling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2025.04.017_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2019.10.411","article-title":"iNOS as a metabolic enzyme under stress conditions","volume":"146","author":"Anavi","year":"2020","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.690118","article-title":"Identification of Tumor Necrosis Factor-Alpha (TNF-\u03b1) Inhibitor in Rheumatoid Arthritis Using Network Pharmacology and Molecular Docking","volume":"12","author":"Bai","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.molimm.2025.04.017_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pro.4213","article-title":"RCSB Protein Data Bank: Celebrating 50\u2009years of the PDB with new tools for understanding and visualizing biological macromolecules in 3D","volume":"31","author":"Burley","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2015.12.032","article-title":"Identifying Chinese herbal medicine network for treating acne: Implications from a nationwide database","volume":"179","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2025.04.017_bib6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/35096075","article-title":"The renaissance of GSK3","volume":"2","author":"Cohen","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molimm.2025.04.017_bib7","doi-asserted-by":"crossref","first-page":"L1267","DOI":"10.1152\/ajplung.00097.2006","article-title":"Functional and genomic changes induced by alveolar transmigration in human neutrophils","volume":"291","author":"Coldren","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib8","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1038\/s41467-021-26970-w","article-title":"Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics","volume":"12","author":"Darrous","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2025.04.017_bib9","first-page":"P3","volume":"4","author":"Dennis","year":"2003"},{"key":"10.1016\/j.molimm.2025.04.017_bib10","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1164\/rccm.201201-0003OC","article-title":"Inflammasome-regulated cytokines are critical mediators of acute lung injury","volume":"185","author":"Dolinay","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13054-021-03463-2","article-title":"Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs","volume":"25","author":"Friedrichson","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.molimm.2025.04.017_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.706907","article-title":"ggVennDiagram: An Intuitive, Easy-to-Use, and Highly Customizable R Package to Generate Venn Diagram","volume":"12","author":"Gao","year":"2021","journal-title":"Front Genet"},{"key":"10.1016\/j.molimm.2025.04.017_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yjmcc.2015.04.025","article-title":"Curcumin induces M2 macrophage polarization by secretion IL-4 and\/or IL-13","volume":"85","author":"Gao","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2025.04.017_bib15","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/sim.6522","article-title":"Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome","volume":"34","author":"Greco M","year":"2015","journal-title":"Stat. Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.254","article-title":"Wnt3a mitigates acute lung injury by reducing P2X7 receptor-mediated alveolar epithelial type I cell death","volume":"5","author":"Guo","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molimm.2025.04.017_bib18","article-title":"Detrimental ELAVL-1\/HuR-dependent GSK3\u03b2 mRNA stabilization impairs resolution in acute respiratory distress syndrome","volume":"12","author":"Hoffman","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.molimm.2025.04.017_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1152\/physiolgenomics.90275.2008","article-title":"Discovery of the gene signature for acute lung injury in patients with sepsis","volume":"37","author":"Howrylak","year":"2009","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.molimm.2025.04.017_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153242","article-title":"Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial","volume":"85","author":"Hu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.molimm.2025.04.017_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134824","article-title":"Molecular dynamics simulation of the interaction of food proteins with small molecules","volume":"405","author":"Hu","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.molimm.2025.04.017_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2025.04.017_bib23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1196\/annals.1310.015","article-title":"Application of the random forest classification algorithm to a SELDI-TOF proteomics study in the setting of a cancer prevention trial","volume":"1020","author":"Izmirlian","year":"2004","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib24","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.ymthe.2019.07.003","article-title":"Peripheral circulating exosome-mediated delivery of miR-155 as a novel mechanism for acute lung inflammation","volume":"27","author":"Jiang","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.molimm.2025.04.017_bib25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.molimm.2025.04.017_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.molimm.2025.04.017_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tibs.2016.10.009","article-title":"Stressed and inflamed, can GSK3 be blamed","volume":"42","author":"Jope","year":"2017","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnmol.2011.00040","article-title":"GSK-3: functional insights from cell biology and animal models","volume":"4","author":"Kaidanovich-Beilin","year":"2011","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.molimm.2025.04.017_bib29","doi-asserted-by":"crossref","first-page":"L1102","DOI":"10.1152\/ajplung.00380.2014","article-title":"Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS","volume":"308","author":"Kangelaris","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jep.2005.06.029","article-title":"Dual regulatory effect of plant extracts of Forsythia suspense on RANTES and MCP-1 secretion in influenza A virus-infected human bronchial epithelial cells","volume":"102","author":"Ko","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib31","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3389\/fimmu.2020.01722","article-title":"Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury","volume":"11","author":"Kumar","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.04.017_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.754241","article-title":"Phillyrin for COVID-19 and influenza co-infection: a potential therapeutic strategy targeting host based on bioinformatics analysis","volume":"12","author":"Lai","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.molimm.2025.04.017_bib33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.molimm.2025.04.017_bib34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jep.2017.07.015","article-title":"Antiviral effect of forsythoside A from Forsythia suspensa (Thunb.) Vahl fruit against influenza A virus through reduction of viral M1 protein","volume":"209","author":"Law","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2018.08.027","article-title":"Anti-inflammatory activity of the decoction of Forsythia suspensa (Thunb.) Vahl is related to Nrf2 and A20","volume":"227","author":"Lee","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib36","doi-asserted-by":"crossref","first-page":"2274512","DOI":"10.1080\/07853890.2023.2274512","article-title":"Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study","volume":"55","author":"Li","year":"2023","journal-title":"Ann. Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib37","first-page":"21","article-title":"Bioinformatics approaches for anti-cancer drug discovery","author":"Li","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.molimm.2025.04.017_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2024.108080","article-title":"Evaluation of genotoxicity and teratogenicity of phillyrin","volume":"249","author":"Li","year":"2024","journal-title":"Toxicon"},{"key":"10.1016\/j.molimm.2025.04.017_bib39","first-page":"4","article-title":"Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.molimm.2025.04.017_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118798","article-title":"GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm","volume":"1867","author":"Liu","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Cell Res"},{"key":"10.1016\/j.molimm.2025.04.017_bib41","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1007\/s00125-010-1882-x","article-title":"Conditional ablation of Gsk-3\u03b2 in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice","volume":"53","author":"Liu","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.molimm.2025.04.017_bib42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41401-019-0228-6","article-title":"CB-Dock: a web server for cavity detection-guided protein-ligand blind docking","volume":"41","author":"Liu","year":"2020","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.molimm.2025.04.017_bib43","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bcp.2018.10.034","article-title":"3-Dehydroandrographolide protects against lipopolysaccharide-induced inflammation through the cholinergic anti-inflammatory pathway","volume":"158","author":"Lu","year":"2018","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.molimm.2025.04.017_bib44","doi-asserted-by":"crossref","first-page":"1352946","DOI":"10.3389\/fimmu.2024.1352946","article-title":"Macrophage polarization: an important role in inflammatory diseases","volume":"15","author":"Luo","year":"2024","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.04.017_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112960","article-title":"Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-\u03baB and Nrf2 signaling pathways","volume":"141","author":"Ma","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib46","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1189\/jlb.0512231","article-title":"The mannose receptor","volume":"92","author":"Martinez-Pomares","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molimm.2025.04.017_bib47","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S2213-2600(17)30188-1","article-title":"Clinical trials in acute respiratory distress syndrome: challenges and opportunities","volume":"5","author":"Matthay","year":"2017","journal-title":"Lancet Respir. Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib48","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1021\/ct300418h","article-title":"MMPBSA.py: an efficient program for end-state free energy calculations","volume":"8","author":"Miller","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.molimm.2025.04.017_bib49","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1615\/CritRevImmunol.v32.i6.10","article-title":"M1 and M2 macrophages: oracles of health and disease","volume":"32","author":"Mills","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.molimm.2025.04.017_bib50","first-page":"22","article-title":"Phosphodiesterase inhibitors in acute lung injury: what are the perspectives","author":"Mokra","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib51","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41586-023-05710-8","article-title":"Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis","volume":"614","author":"Nassour","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2025.04.017_bib52","first-page":"13","article-title":"Furofuranoid-type lignans and related phenolics from anisacanthus virgularis (Salisb.) Nees with promising anticholinesterase and anti-ageing properties: a study supported by molecular modelling","author":"Orabi","year":"2024","journal-title":"Plants (Basel)"},{"key":"10.1016\/j.molimm.2025.04.017_bib53","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41556-020-0569-x","article-title":"STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury","volume":"22","author":"Paris","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molimm.2025.04.017_bib54","doi-asserted-by":"crossref","first-page":"L735","DOI":"10.1152\/ajplung.00165.2014","article-title":"GSK3\u03b2-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury","volume":"307","author":"Park","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.676752","article-title":"Characterizing the Role of glycogen synthase kinase-3\u03b1\/\u03b2 in macrophage polarization and the regulation of pro-atherogenic pathways in cultured Ldlr-\/- macrophages","volume":"12","author":"Patel","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.04.017_bib56","first-page":"25","article-title":"Mannose ligands for mannose receptor targeting","author":"Paurevi\u0107","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib57","doi-asserted-by":"crossref","first-page":"16540","DOI":"10.1002\/jcp.28324","article-title":"Identification of the molecular subgroups in coronary artery disease by gene expression profiles","volume":"234","author":"Peng","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib58","first-page":"20","article-title":"Molecular docking: shifting paradigms in drug discovery","author":"Pinzi","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib59","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10654-023-01000-9","article-title":"Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study","volume":"38","author":"Qin","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib60","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fonc.2019.00462","article-title":"PP2A: a promising biomarker and therapeutic target in endometrial cancer","volume":"9","author":"Remmerie","year":"2019","journal-title":"Front Oncol."},{"key":"10.1016\/j.molimm.2025.04.017_bib61","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2006-05-024075","article-title":"A transgenic zebrafish model of neutrophilic inflammation","volume":"108","author":"Renshaw","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.molimm.2025.04.017_bib62","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2025.04.017_bib63","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.molimm.2025.04.017_bib64","first-page":"730","article-title":"Acute respiratory distress syndrome: diagnosis and management","volume":"101","author":"Saguil","year":"2020","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.molimm.2025.04.017_bib65","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12859-018-2451-4","article-title":"SVM-RFE: selection and visualization of the most relevant features through non-linear kernels","volume":"19","author":"Sanz","year":"2018","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.molimm.2025.04.017_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105025","article-title":"Neuroprotective and anti-inflammatory phenylethanoidglycosides from the fruits of Forsythia suspensa","volume":"113","author":"Shao","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.molimm.2025.04.017_bib67","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1001\/jama.2020.4783","article-title":"Treatment of 5 critically ill patients with COVID-19 with convalescent plasma","volume":"323","author":"Shen","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.molimm.2025.04.017_bib68","doi-asserted-by":"crossref","first-page":"1039235","DOI":"10.3389\/fphar.2022.1039235","article-title":"Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach","volume":"13","author":"Shen","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.molimm.2025.04.017_bib69","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41392-021-00754-6","article-title":"Mesenchymal stem cell therapy for severe COVID-19","volume":"6","author":"Shi","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.molimm.2025.04.017_bib70","first-page":"32","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","author":"Smith","year":"2003","journal-title":"Int J. Epidemiol."},{"key":"10.1016\/j.molimm.2025.04.017_bib71","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.saa.2011.09.044","article-title":"Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking","volume":"85","author":"Song","year":"2012","journal-title":"Spectrochim Acta A"},{"key":"10.1016\/j.molimm.2025.04.017_bib72","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2025.04.017_bib73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-023-01229-9","article-title":"Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib74","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.molcel.2013.03.022","article-title":"Inhibition of AMPK catabolic action by GSK3","volume":"50","author":"Suzuki","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molimm.2025.04.017_bib75","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1021\/ci034160g","article-title":"Random forest: a classification and regression tool for compound classification and QSAR modeling","volume":"43","author":"Svetnik","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.molimm.2025.04.017_bib76","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2025.04.017_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175022","article-title":"Phillyrin attenuates norepinephrine-induced cardiac hypertrophy and inflammatory response by suppressing p38\/ERK1\/2 MAPK and AKT\/NF-kappaB pathways","volume":"927","author":"Tang","year":"2022","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.molimm.2025.04.017_bib78","article-title":"Single Cell Portal: an interactive home for single-cell genomics data","author":"Tarhan","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.molimm.2025.04.017_bib79","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/acs.jctc.9b00591","article-title":"ff19SB: amino-acid-specific protein backbone parameters trained against quantum mechanics energy surfaces in solution","volume":"16","author":"Tian","year":"2020","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.molimm.2025.04.017_bib80","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3","article-title":"The lasso method for variable selection in the Cox model","volume":"16","author":"Tibshirani","year":"1997","journal-title":"Stat. Med"},{"key":"10.1016\/j.molimm.2025.04.017_bib81","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1021\/acs.jctc.8b01039","article-title":"Assessment of GAFF2 and OPLS-AA general force fields in combination with the water models TIP3P, SPCE, and OPC3 for the solvation free energy of druglike organic molecules","volume":"15","author":"Vassetti","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.molimm.2025.04.017_bib82","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.4049\/jimmunol.181.10.6797","article-title":"IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta","volume":"181","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2025.04.017_bib83","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2025.04.017_bib84","doi-asserted-by":"crossref","first-page":"D400","DOI":"10.1093\/nar\/gkr1132","article-title":"PubChem's BIoassay Database","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molimm.2025.04.017_bib85","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jep.2017.08.040","article-title":"Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: a review","volume":"210","author":"Wang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib86","unstructured":"Westerfield, M., 1995. The zebrafish book: a guide for the laboratory use of zebrafish (Danio rerio)."},{"key":"10.1016\/j.molimm.2025.04.017_bib87","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3389\/fphar.2019.01332","article-title":"Liang-Ge-San, a Classic traditional Chinese medicine formula, attenuates lipopolysaccharide-induced acute lung injury through up-regulating miR-21","volume":"10","author":"Yang","year":"2019","journal-title":"Front Pharm."},{"key":"10.1016\/j.molimm.2025.04.017_bib88","article-title":"Extracellular vesicles derived from M2-like macrophages alleviate acute lung injury in a miR-709-mediated manner","volume":"13","author":"Yang","year":"2024","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.molimm.2025.04.017_bib89","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1159\/000484192","article-title":"Protective effect of phillyrin on lethal LPS-induced neutrophil inflammation in zebrafish","volume":"43","author":"Yang","year":"2017","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.molimm.2025.04.017_bib90","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.3390\/molecules19022390","article-title":"Endotoxin molecule lipopolysaccharide-induced zebrafish inflammation model: a novel screening method for anti-inflammatory drugs","volume":"19","author":"Yang","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.molimm.2025.04.017_bib91","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fcimb.2017.00357","article-title":"GSK-3Beta-dependent activation of GEF-H1\/ROCK signaling promotes LPS-induced lung vascular endothelial barrier dysfunction and acute lung injury","volume":"7","author":"Yi","year":"2017","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.molimm.2025.04.017_bib92","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2147\/JIR.S354619","article-title":"Mendelian randomization study implies causal linkage between telomere length and juvenile idiopathic arthritis in a European population","volume":"15","author":"Zhang","year":"2022","journal-title":"J. Inflamm. Res"},{"key":"10.1016\/j.molimm.2025.04.017_bib93","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/08958378.2022.2134526","article-title":"Heterogeneity of T cells and macrophages in chlorine-induced acute lung injury in mice using single-cell RNA sequencing","volume":"34","author":"Zhao","year":"2022","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.molimm.2025.04.017_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116306","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.molimm.2025.04.017_bib95","article-title":"Analysis and experimental validation of rheumatoid arthritis innate immunity gene CYFIP2 and pan-cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.04.017_bib96","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.fitote.2013.06.003","article-title":"Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-\u03baB activation in acute lung injury mice","volume":"90","author":"Zhong","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.molimm.2025.04.017_bib97","first-page":"27","article-title":"Review on the pharmacological properties of phillyrin","author":"Zhou","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.molimm.2025.04.017_bib98","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1074\/jbc.M110.192377","article-title":"LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA:lysophosphatidylcholine acyltransferase I (LPCAT1)","volume":"286","author":"Zou","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025001142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025001142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:24:08Z","timestamp":1762248248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589025001142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":98,"alternative-id":["S0161589025001142"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2025.04.017","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phillyrin for sepsis-related acute lung injury: A potential strategy suppressing GSK-3\u03b2","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2025.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}