{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T09:09:41Z","timestamp":1793524181850,"version":"4.5.0"},"reference-count":160,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.molimm.2025.06.008","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T17:53:43Z","timestamp":1750787623000},"page":"112-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Cellular interactions in maintaining an inflammatory microenvironment in rheumatoid arthritis"],"prefix":"10.1016","volume":"184","author":[{"given":"Subothini","family":"Ganeshalingam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Ciciriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Antonipillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-2338","authenticated-orcid":false,"given":"Adrian A.","family":"Achuthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib1","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1172\/JCI87828","article-title":"Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation","volume":"126","author":"Achuthan","year":"2016","journal-title":"J. Clin. Invest"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-018-0332-4","article-title":"Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity","volume":"9","author":"Achuthan","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molimm.2025.06.008_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101523","article-title":"Targeting GM-CSF in inflammatory and autoimmune disorders","volume":"54","author":"Achuthan","year":"2021","journal-title":"Semin Immunol."},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib4","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1002\/art.20499","article-title":"CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid","volume":"50","author":"van Amelsfort","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1559-0275-11-1","article-title":"Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients","volume":"11","author":"Balakrishnan","year":"2014","journal-title":"Clin. Proteom."},{"key":"10.1016\/j.molimm.2025.06.008_bib6","doi-asserted-by":"crossref","first-page":"1196931","DOI":"10.3389\/fimmu.2023.1196931","article-title":"Targeting transcription factors for therapeutic benefit in rheumatoid arthritis","volume":"14","author":"Balendran","year":"2023","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"issue":"12","key":"10.1016\/j.molimm.2025.06.008_bib8","doi-asserted-by":"crossref","first-page":"8268","DOI":"10.4049\/jimmunol.0900007","article-title":"A dual action of rheumatoid arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4+CD25+ regulatory T cells and CD4+CD25- responder T cells","volume":"183","author":"Benito-Miguel","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jaut.2012.05.021","article-title":"Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction","volume":"39","author":"Boissier","year":"2012","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jbspin.2019.11.009","article-title":"Origins of rheumatoid arthritis","volume":"87","author":"Boissier","year":"2020","journal-title":"Jt. Bone Spine"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","article-title":"Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors","volume":"9","author":"Bottini","year":"2013","journal-title":"Nat. Rev. Rheuma"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102758","article-title":"Novel insights into macrophage diversity in rheumatoid arthritis synovium","volume":"20","author":"Boutet","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib13","article-title":"Location, location, location: how the tissue microenvironment affects inflammation in RA (Feb, 10.1038\/s41584-020-00570-2, 2021)","volume":"17","author":"Buckley","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.autrev.2007.02.008","article-title":"B cells in rheumatoid arthritis","volume":"6","author":"Bugatti","year":"2007","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13075-017-1303-3","article-title":"Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis","volume":"19","author":"Bustamante","year":"2017","journal-title":"Arthritis Res Ther."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cbf.3370","article-title":"Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) based on microarray profiles of human joint fibroblast-like synoviocytes","volume":"37","author":"Cai","year":"2019","journal-title":"Cell Biochem Funct."},{"issue":"5","key":"10.1016\/j.molimm.2025.06.008_bib17","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/rheumatology\/keaa625","article-title":"Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis","volume":"60","author":"Chen","year":"2021","journal-title":"Rheumatol. (Oxf. )"},{"key":"10.1016\/j.molimm.2025.06.008_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.709178","article-title":"New insights from single-cell sequencing data: synovial fibroblasts and synovial macrophages in rheumatoid arthritis","volume":"12","author":"Cheng","year":"2021","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12982","article-title":"The roles of small-molecule inflammatory mediators in rheumatoid arthritis","volume":"93","author":"Cheng","year":"2021","journal-title":"Scand. J. Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2025.06.008_bib20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1900\/RDS.2006.3.72","article-title":"Th17 cells in inflammatory conditions","volume":"3","author":"Cooke","year":"2006","journal-title":"Rev. Diabet. Stud."},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11926-013-0352-0","article-title":"Treg cells in rheumatoid arthritis: an update","volume":"15","author":"Cooles","year":"2013","journal-title":"Curr. Rheuma Rep."},{"issue":"2","key":"10.1016\/j.molimm.2025.06.008_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cei\/uxae072","article-title":"Circulating neutrophil extracellular trap-forming neutrophils in rheumatoid arthritis exacerbation are majority dual endothelin-1\/signal peptide receptor+ subtype","volume":"218","author":"Cross","year":"2024","journal-title":"Clin. Exp. Immunol."},{"issue":"7771","key":"10.1016\/j.molimm.2025.06.008_bib23","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","article-title":"Locally renewing resident synovial macrophages provide a protective barrier for the joint","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2025.06.008_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front Immunol."},{"issue":"11","key":"10.1016\/j.molimm.2025.06.008_bib25","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1136\/ard.2006.067793","article-title":"Cellular targets of interleukin-18 in rheumatoid arthritis","volume":"66","author":"Dai","year":"2007","journal-title":"Ann. Rheum. Dis."},{"issue":"21","key":"10.1016\/j.molimm.2025.06.008_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217916","article-title":"Modeling rheumatoid arthritis in vitro: from experimental feasibility to physiological proximity","volume":"21","author":"Damerau","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.molimm.2025.06.008_bib27","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1517\/14656566.7.18.2559","article-title":"Rituximab: novel B-cell depletion therapy for the treatment of rheumatoid arthritis","volume":"7","author":"Dass","year":"2006","journal-title":"Expert Opin. Pharm."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.1758","article-title":"Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis","volume":"206","author":"De Rycke","year":"2005","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41392-023-01331-9","article-title":"Signaling pathways in rheumatoid arthritis: implications for targeted therapy","volume":"8","author":"Ding","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.molimm.2025.06.008_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s44161-023-00413-9","article-title":"Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis","volume":"3","author":"Doring","year":"2024","journal-title":"Nat. Cardiovasc Res"},{"key":"10.1016\/j.molimm.2025.06.008_bib31","first-page":"3","article-title":"Crossroads of B cell activation in autoimmunity: rationale of targeting B cells","volume":"77","author":"Dorner","year":"2006","journal-title":"J. Rheuma Suppl."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00002281-200305000-00011","article-title":"The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets","volume":"15","author":"Dorner","year":"2003","journal-title":"Curr. Opin. Rheuma"},{"issue":"6","key":"10.1016\/j.molimm.2025.06.008_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/03009742.2012.696135","article-title":"Distribution of regulatory T cells and interaction with dendritic cells in the synovium of rheumatoid arthritis","volume":"41","author":"E","year":"2012","journal-title":"Scand. J. Rheumatol."},{"issue":"25","key":"10.1016\/j.molimm.2025.06.008_bib34","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1056\/NEJMoa032534","article-title":"Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis","volume":"350","author":"Edwards","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.molimm.2025.06.008_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/ITT.S243636","article-title":"Role of chemokines and chemokine receptors in rheumatoid arthritis","volume":"9","author":"Elemam","year":"2020","journal-title":"Immunotargets Ther."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.molimm.2025.06.008_bib37","doi-asserted-by":"crossref","first-page":"3830212","DOI":"10.1155\/2020\/3830212","article-title":"Molecular and cellular pathways contributing to joint damage in rheumatoid arthritis","volume":"2020","author":"Fang","year":"2020","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.molimm.2025.06.008_bib38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1189\/jlb.1108702","article-title":"GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling","volume":"86","author":"Fleetwood","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cyto.2009.10.005","article-title":"Expression of MDC\/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"49","author":"Flytlie","year":"2010","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.molimm.2025.06.008_bib40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.rdc.2010.02.004","article-title":"Cell-cell interactions in rheumatoid arthritis synovium","volume":"36","author":"Fox","year":"2010","journal-title":"Rheum. Dis. Clin. North Am."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1568010054022024","article-title":"Macrophages in inflammation","volume":"4","author":"Fujiwara","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib42","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1067\/mai.2003.59","article-title":"Differential expression of thymus- and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) by human fibroblasts from cornea, skin, and lung","volume":"111","author":"Fukuda","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/2326-6066.CIR-16-0297","article-title":"Myeloid-derived suppressor cells","volume":"5","author":"Gabrilovich","year":"2017","journal-title":"Cancer Immunol. Res"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/08830185.2016.1269175","article-title":"Fibroblast-like synoviocytes-dependent effector molecules as a critical mediator for rheumatoid arthritis: current status and future directions","volume":"36","author":"Ganesan","year":"2017","journal-title":"Int. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.molimm.2025.06.008_bib45","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1016\/S2665-9913(20)30033-3","article-title":"Lessons for rituximab therapy in patients with rheumatoid arthritis","volume":"2","author":"Garcia-Montoya","year":"2020","journal-title":"Lancet Rheuma"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib46","first-page":"335","article-title":"MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis","volume":"22","author":"Giannelli","year":"2004","journal-title":"Clin. Exp. Rheuma"},{"key":"10.1016\/j.molimm.2025.06.008_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/rheumatology\/kex383","article-title":"Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis","volume":"57","author":"Guo","year":"2018","journal-title":"Rheumatol. (Oxf. )"},{"key":"10.1016\/j.molimm.2025.06.008_bib49","doi-asserted-by":"crossref","first-page":"1461756","DOI":"10.3389\/fimmu.2024.1461756","article-title":"Overview of mechanisms and novel therapies on rheumatoid arthritis from a cellular perspective","volume":"15","author":"Han","year":"2024","journal-title":"Front Immunol."},{"issue":"11","key":"10.1016\/j.molimm.2025.06.008_bib50","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.molimm.2025.06.008_bib51","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","article-title":"Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model","volume":"204","author":"Hirota","year":"2007","journal-title":"J. Exp. Med"},{"issue":"12","key":"10.1016\/j.molimm.2025.06.008_bib52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/intimm\/dxac041","article-title":"CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis","volume":"34","author":"Honzawa","year":"2022","journal-title":"Int Immunol."},{"issue":"5609","key":"10.1016\/j.molimm.2025.06.008_bib53","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"issue":"29","key":"10.1016\/j.molimm.2025.06.008_bib54","doi-asserted-by":"crossref","first-page":"11415","DOI":"10.1074\/jbc.RA118.002416","article-title":"Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages","volume":"293","author":"Hsu","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0060001","article-title":"Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium","volume":"6","author":"Humby","year":"2009","journal-title":"PLoS Med"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1679\/aohc.63.17","article-title":"Morphology and functional roles of synoviocytes in the joint","volume":"63","author":"Iwanaga","year":"2000","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.molimm.2025.06.008_bib57","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.coi.2015.01.018","article-title":"B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production","volume":"33","author":"Jackson","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/430394","article-title":"The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance","author":"Janikashvili","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.715894","article-title":"Critical role of synovial tissue-resident macrophage and fibroblast subsets in the persistence of joint inflammation","volume":"12","author":"Kemble","year":"2021","journal-title":"Front Immunol."},{"issue":"10","key":"10.1016\/j.molimm.2025.06.008_bib60","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrrheum.2009.185","article-title":"Dendritic cells as targets for therapy in rheumatoid arthritis","volume":"5","author":"Khan","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.molimm.2025.06.008_bib61","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4110\/in.2012.12.5.217","article-title":"Rheumatoid fibroblast-like synoviocytes downregulate foxp3 expression by regulatory T cells via GITRL\/GITR interaction","volume":"12","author":"Kim","year":"2012","journal-title":"Immune Netw."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib62","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/ar86","article-title":"Macrophages in rheumatoid arthritis","volume":"2","author":"Kinne","year":"2000","journal-title":"Arthritis Res"},{"issue":"6","key":"10.1016\/j.molimm.2025.06.008_bib63","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar2333","article-title":"Cells of the synovium in rheumatoid arthritis. macrophages","volume":"9","author":"Kinne","year":"2007","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2025.06.008_bib64","article-title":"Synovial macrophage and fibroblast heterogeneity in joint homeostasis and inflammation","volume":"9","author":"Knab","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib65","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1172\/JCI117414","article-title":"Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis","volume":"94","author":"Koch","year":"1994","journal-title":"J. Clin. Invest"},{"issue":"20","key":"10.1016\/j.molimm.2025.06.008_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222010922","article-title":"Cytokine networks in the pathogenesis of rheumatoid arthritis","volume":"22","author":"Kondo","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib67","doi-asserted-by":"crossref","first-page":"22168","DOI":"10.1038\/s41598-021-01692-7","article-title":"Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis","volume":"11","author":"Koster","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.molimm.2025.06.008_bib68","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000527","article-title":"Synovial tissue macrophages: friend or foe?","volume":"3","author":"Kurowska-Stolarska","year":"2017","journal-title":"RMD Open"},{"issue":"11","key":"10.1016\/j.molimm.2025.06.008_bib69","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.4049\/jimmunol.1103426","article-title":"Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models","volume":"188","author":"Lacey","year":"2012","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib70","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2165\/00044011-200929030-00005","article-title":"Modulation of T-cell co-stimulation in rheumatoid arthritis: clinical experience with abatacept","volume":"29","author":"Lagana","year":"2009","journal-title":"Clin. Drug Invest."},{"issue":"5814","key":"10.1016\/j.molimm.2025.06.008_bib71","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1137306","article-title":"Cadherin-11 in synovial lining formation and pathology in arthritis","volume":"315","author":"Lee","year":"2007","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41573-020-00092-2","article-title":"B cell depletion therapies in autoimmune disease: advances and mechanistic insights","volume":"20","author":"Lee","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib73","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4049\/jimmunol.2000315","article-title":"CCL17 in inflammation and pain","volume":"205","author":"Lee","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib74","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.3389\/fimmu.2018.02849","article-title":"Roles of myeloid-derived suppressor cell subpopulations in autoimmune arthritis","volume":"9","author":"Li","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib75","doi-asserted-by":"crossref","first-page":"1089621","DOI":"10.3389\/fimmu.2022.1089621","article-title":"Clinical effect and biological mechanism of exercise for rheumatoid arthritis: a mini review","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol."},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib76","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.4049\/jimmunol.180.9.5916","article-title":"Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II","volume":"180","author":"Liang","year":"2008","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.molimm.2025.06.008_bib77","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s10439-024-03523-y","article-title":"Low-intensity pulsed ultrasound: a physical stimulus with immunomodulatory and anti-inflammatory potential","volume":"52","author":"Liang","year":"2024","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040880","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib79","article-title":"Regulatory fibroblast-like synoviocytes cell membrane coated nanoparticles: a novel targeted therapy for rheumatoid arthritis","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib80","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00018-024-05196-1","article-title":"Macrophage re-programming by JAK inhibitors relies on MAFB","volume":"81","author":"Lopez-Navarro","year":"2024","journal-title":"Cell Mol. Life Sci."},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib81","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/imcb.12644","article-title":"CCL17\/TARC in autoimmunity and inflammation-not just a T-cell chemokine","volume":"101","author":"Lupancu","year":"2023","journal-title":"Immunol. Cell Biol."},{"issue":"10","key":"10.1016\/j.molimm.2025.06.008_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108079","article-title":"Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis","volume":"26","author":"Lupancu","year":"2023","journal-title":"iScience"},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19072012","article-title":"Implications of angiogenesis involvement in arthritis","volume":"19","author":"MacDonald","year":"2018","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2025.06.008_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.942417","article-title":"The synovial fluid fibroblast-like synoviocyte: a long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis","volume":"13","author":"Mahmoud","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib85","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nri.2016.124","article-title":"The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting","volume":"17","author":"Malmstrom","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib86","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10753-023-01951-x","article-title":"Neutrophil extracellular traps induce pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes via the NF-kappaB\/Caspase 3\/GSDME pathway","volume":"47","author":"Mao","year":"2024","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib87","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.autrev.2006.02.004","article-title":"Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy","volume":"5","author":"Martinez-Gamboa","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molimm.2025.06.008_bib88","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s41927-018-0016-9","article-title":"Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis","volume":"2","author":"McWilliams","year":"2018","journal-title":"BMC Rheuma"},{"issue":"21","key":"10.1016\/j.molimm.2025.06.008_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10215027","article-title":"Synovial fluid cytokines, chemokines and MMP levels in osteoarthritis patients with knee pain display a profile similar to many rheumatoid arthritis patients","volume":"10","author":"Meehan","year":"2021","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib90","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s40265-020-01309-9","article-title":"Understanding Refractory Rheumatoid Arthritis: Implications for a Therapeutic Approach","volume":"80","author":"Melville","year":"2020","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110719","article-title":"Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization","volume":"39","author":"Ming-Chin Lee","year":"2022","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib92","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/art.1790060406","article-title":"Physical interventions in the management of pain in arthritis: an overview for research and practice","volume":"6","author":"Minor","year":"1993","journal-title":"Arthritis Care Res"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib93","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.molimm.2025.06.008_bib94","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/ijc.23392","article-title":"CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3<SUP>+<\/SUP> regulatory T cells in gastric cancer","volume":"122","author":"Mizukami","year":"2008","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.molimm.2025.06.008_bib95","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/ar2337","article-title":"Cells of the synovium in rheumatoid arthritis. synovial fibroblasts","volume":"9","author":"Muller-Ladner","year":"2007","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2025.06.008_bib96","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.immunol.19.1.423","article-title":"Interleukin-18 regulates both TH1 and TH2 responses","volume":"19","author":"Nakanishi","year":"2001","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.molimm.2025.06.008_bib97","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/annrheumdis-2021-222021","article-title":"Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?","volume":"81","author":"Nemeth","year":"2022","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib98","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12272-024-01504-2","article-title":"Dual roles of myeloid-derived suppressor cells in various diseases: a review","volume":"47","author":"Nepal","year":"2024","journal-title":"Arch. Pharm. Res"},{"issue":"2","key":"10.1016\/j.molimm.2025.06.008_bib99","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/rheumatology\/keab248","article-title":"Long-term persistence of rituximab in patients with rheumatoid arthritis: an evaluation of the UCL cohort from 1998 to 2020","volume":"61","author":"Norris-Grey","year":"2022","journal-title":"Rheumatol. (Oxf. )"},{"key":"10.1016\/j.molimm.2025.06.008_bib100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-065X.2008.00648.x","article-title":"The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis","volume":"223","author":"Noss","year":"2008","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.molimm.2025.06.008_bib101","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s10787-021-00846-3","article-title":"Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target","volume":"29","author":"Nourbakhsh","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.molimm.2025.06.008_bib102","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheuma"},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib103","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/art.11249","article-title":"Activin a induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"48","author":"Ota","year":"2003","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib104","doi-asserted-by":"crossref","first-page":"iv52","DOI":"10.1136\/ard.2005.042424","article-title":"Are fibroblasts involved in joint destruction?","volume":"64","author":"Pap","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib105","article-title":"The role of biologics in rheumatoid arthritis: a narrative review","volume":"15","author":"Patel","year":"2023","journal-title":"Cureus J. Med. Sci."},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/cells13090743","article-title":"Clinical phenotypes, serological biomarkers, and synovial features defining seropositive and seronegative rheumatoid arthritis: a literature review","volume":"13","author":"Perera","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib107","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1038\/s41598-020-60314-w","article-title":"T-cell subset abnormalities predict progression along the inflammatory arthritis disease continuum: implications for management","volume":"10","author":"Ponchel","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib108","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11010-022-04492-3","article-title":"Rheumatoid arthritis: advances in treatment strategies","volume":"478","author":"Prasad","year":"2023","journal-title":"Mol. Cell Biochem"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib109","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1080\/21691401.2019.1687504","article-title":"The role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis; anti- or pro-inflammatory cells?","volume":"47","author":"Rajabinejad","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.molimm.2025.06.008_bib110","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.intimp.2018.10.016","article-title":"Monocytes in rheumatoid arthritis: circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis","volume":"65","author":"Rana","year":"2018","journal-title":"Int Immunopharmacol."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib111","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/07853899109148051","article-title":"Cytokines in rheumatoid arthritis","volume":"23","author":"Ridderstad","year":"1991","journal-title":"Ann. Med"},{"issue":"5","key":"10.1016\/j.molimm.2025.06.008_bib112","first-page":"S40","article-title":"The disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28) in the management of rheumatoid arthritis","volume":"34","author":"van Riel","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"issue":"6","key":"10.1016\/j.molimm.2025.06.008_bib113","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41591-022-01789-0","article-title":"Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial","volume":"28","author":"Rivellese","year":"2022","journal-title":"Nat. Med"},{"key":"10.1016\/j.molimm.2025.06.008_bib114","first-page":"119","article-title":"Tertiary lymphoid organs in rheumatoid arthritis","volume":"426","author":"Rivellese","year":"2020","journal-title":"Curr. Top. Microbiol Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00571","article-title":"The interplay between monocytes\/macrophages and CD4T cell subsets in rheumatoid arthritis","volume":"6","author":"Roberts","year":"2015","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2025.06.008_bib116","doi-asserted-by":"crossref","DOI":"10.1186\/ar2497","article-title":"Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab","volume":"10","author":"Rosengren","year":"2008","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib117","article-title":"NF-\u03baB signaling in rheumatoid arthritis with focus on fibroblast-like synoviocytes","volume":"11","author":"Samimi","year":"2020","journal-title":"Autoimmun. Highlights"},{"key":"10.1016\/j.molimm.2025.06.008_bib118","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2741\/1560","article-title":"Dendritic cells in rheumatoid arthritis","volume":"10","author":"Sarkar","year":"2005","journal-title":"Front Biosci."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib119","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.immuni.2008.01.012","article-title":"Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition","volume":"28","author":"Sarris","year":"2008","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071627","article-title":"Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases","volume":"9","author":"Sehnert","year":"2020","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.molimm.2025.06.008_bib121","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1172\/JCI25265","article-title":"BLyS and april in rheumatoid arthritis","volume":"115","author":"Seyler","year":"2005","journal-title":"J. Clin. Invest"},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib122","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell Physiol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib123","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/14397595.2014.900847","article-title":"TNFalpha, PDGF, and TGFbeta synergistically induce synovial lining hyperplasia via inducible PI3Kdelta","volume":"25","author":"Shibuya","year":"2015","journal-title":"Mod. Rheuma"},{"key":"10.1016\/j.molimm.2025.06.008_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108078","article-title":"Mechanistic insights into the role of B cells in rheumatoid arthritis","volume":"99","author":"Singh","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.molimm.2025.06.008_bib125","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bcp.2019.03.029","article-title":"The many facets of macrophages in rheumatoid arthritis","volume":"165","author":"Siouti","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib126","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/art.23545","article-title":"Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium","volume":"58","author":"Smith","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib127","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/ard.62.4.303","article-title":"Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints","volume":"62","author":"Smith","year":"2003","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.molimm.2025.06.008_bib128","doi-asserted-by":"crossref","DOI":"10.1186\/ar2073","article-title":"Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal\/fibrotic characteristics","volume":"8","author":"Steenvoorden","year":"2006","journal-title":"Arthritis Res. Ther."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib129","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/1529-0131(200004)43:4<775::AID-ANR8>3.0.CO;2-7","article-title":"Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis","volume":"43","author":"Stuhlmuller","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2025.06.008_bib130","doi-asserted-by":"crossref","first-page":"1161148","DOI":"10.3389\/fimmu.2023.1161148","article-title":"The role of dendritic cells and their immunometabolism in rheumatoid arthritis","volume":"14","author":"Suwa","year":"2023","journal-title":"Front Immunol."},{"issue":"11","key":"10.1016\/j.molimm.2025.06.008_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102397","article-title":"Macrophage M1\/M2 polarization and rheumatoid arthritis: a systematic review","volume":"18","author":"Tardito","year":"2019","journal-title":"Autoimmun. Rev."},{"issue":"8","key":"10.1016\/j.molimm.2025.06.008_bib132","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1002\/art.22748","article-title":"Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis","volume":"56","author":"Timmer","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.molimm.2025.06.008_bib133","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fimmu.2019.00475","article-title":"Prostaglanin-E2 potentiates the suppressive functions of human mononuclear myeloid-derived suppressor cells and increases their capacity to expand IL-10-producing regulatory T cell subsets","volume":"10","author":"Tomic","year":"2019","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib134","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.berh.2014.10.024","article-title":"Molecular and cellular heterogeneity in the rheumatoid arthritis synovium: clinical correlates of synovitis","volume":"28","author":"Townsend","year":"2014","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib135","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s41232-021-00157-8","article-title":"Multiomics landscape of synovial fibroblasts in rheumatoid arthritis","volume":"41","author":"Tsuchiya","year":"2021","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.molimm.2025.06.008_bib136","doi-asserted-by":"crossref","first-page":"1583647","DOI":"10.1155\/2020\/1583647","article-title":"Synovial macrophages in rheumatoid arthritis: the past, present, and future","volume":"2020","author":"Tu","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.molimm.2025.06.008_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01467","article-title":"Ontology and function of fibroblast-like and macrophage-like synoviocytes: how do they talk to each other and can they be targeted for rheumatoid arthritis therapy?","volume":"9","author":"Tu","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2025.06.008_bib138","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1172\/JCI115480","article-title":"Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines","volume":"88","author":"Unemori","year":"1991","journal-title":"J. Clin. Invest"},{"issue":"8","key":"10.1016\/j.molimm.2025.06.008_bib139","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib140","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fphar.2020.00515","article-title":"Anti-rheumatic properties of gentiopicroside are associated with suppression of ROS-NF-kappaB-NLRP3 axis in fibroblast-like synoviocytes and NF-kappaB pathway in adjuvant-induced arthritis","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharm."},{"issue":"9","key":"10.1016\/j.molimm.2025.06.008_bib141","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202350823","article-title":"MDSCs are important osteoclast precursors primed by B cells in rheumatoid arthritis","volume":"54","author":"Wang","year":"2024","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.molimm.2025.06.008_bib142","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00296-010-1710-0","article-title":"The Th17\/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis","volume":"32","author":"Wang","year":"2012","journal-title":"Rheuma Int"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib143","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cei.13256","article-title":"Dendritic cells, T cells and their interaction in rheumatoid arthritis","volume":"196","author":"Wehr","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib144","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.2003.tb06042.x","article-title":"Ectopic germinal center formation in rheumatoid synovitis","volume":"987","author":"Weyand","year":"2003","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2025.06.008_bib146","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/ar1737","article-title":"B cells in rheumatoid synovitis","volume":"7","author":"Weyand","year":"2005","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.molimm.2025.06.008_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.584116","article-title":"Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species, and neutrophil extracellular traps","volume":"11","author":"Wright","year":"2021","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.molimm.2025.06.008_bib148","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrrheum.2014.80","article-title":"The multifactorial role of neutrophils in rheumatoid arthritis","volume":"10","author":"Wright","year":"2014","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.molimm.2025.06.008_bib149","article-title":"B cells in rheumatoid arthritis\uff1apathogenic mechanisms and treatment prospects","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2025.06.008_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107392","article-title":"Fibroblast-like synoviocytes in rheumatoid arthritis: surface markers and phenotypes","volume":"93","author":"Wu","year":"2021","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib151","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12026-023-09421-0","article-title":"Diverse functions of myeloid-derived suppressor cells in autoimmune diseases","volume":"72","author":"Xiong","year":"2024","journal-title":"Immunol. Res"},{"issue":"10","key":"10.1016\/j.molimm.2025.06.008_bib152","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00018-022-04563-0","article-title":"Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential","volume":"79","author":"Yan","year":"2022","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib153","doi-asserted-by":"crossref","DOI":"10.3390\/cells11010132","article-title":"Regulation of TNF-induced osteoclast differentiation","volume":"11","author":"Yao","year":"2022","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.molimm.2025.06.008_bib154","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109775","article-title":"Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA)","volume":"9","author":"Yoon","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/intimm\/dxu079","article-title":"CCR4 and its ligands: from bench to bedside","volume":"27","author":"Yoshie","year":"2015","journal-title":"Int Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib156","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/s41598-023-48248-5","article-title":"Exploring the mechanism of celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics","volume":"14","author":"Zeng","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.molimm.2025.06.008_bib157","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41540-024-00337-5","article-title":"Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis","volume":"10","author":"Zerrouk","year":"2024","journal-title":"NPJ Syst. Biol. Appl."},{"issue":"7","key":"10.1016\/j.molimm.2025.06.008_bib158","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat. Immunol."},{"issue":"7987","key":"10.1016\/j.molimm.2025.06.008_bib159","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2025.06.008_bib160","article-title":"Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment","volume":"14","author":"Zhang","year":"2022","journal-title":"Mater. Today Bio"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025001609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025001609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:32:27Z","timestamp":1752579147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589025001609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":160,"alternative-id":["S0161589025001609"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2025.06.008","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular interactions in maintaining an inflammatory microenvironment in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2025.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}