{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:15:21Z","timestamp":1772892921418,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515030030"],"award-info":[{"award-number":["2023A1515030030"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","award":["2023A04J2187"],"award-info":[{"award-number":["2023A04J2187"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.molimm.2025.08.021","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T17:30:59Z","timestamp":1756747859000},"page":"11-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["SMAD7-mediated ferroptosis in macrophages drives osteoporosis progression: A multi-omics study"],"prefix":"10.1016","volume":"187","author":[{"given":"Qianning","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucheng","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengyi","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-842X","authenticated-orcid":false,"given":"Weishen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1475-2867-12-19","article-title":"Extracellular cyclophilin-A stimulates ERK1\/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B","volume":"12","author":"Bahmed","year":"2012","journal-title":"Cancer Cell Int"},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/labinvest.2016.116","article-title":"CD68\/macrosialin: not just a histochemical marker","volume":"97","author":"Chistiakov","year":"2017","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib4","first-page":"105","article-title":"The epidemiology of osteoporosis","volume":"133","author":"Clynes","year":"2020","journal-title":"Br. Med. Bull."},{"issue":"16","key":"10.1016\/j.molimm.2025.08.021_bib5","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med"},{"issue":"9","key":"10.1016\/j.molimm.2025.08.021_bib6","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.celrep.2016.02.021","article-title":"Yap1 regulates multiple steps of chondrocyte differentiation during skeletal development and bone repair","volume":"14","author":"Deng","year":"2016","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.molimm.2025.08.021_bib7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.molimm.2025.08.021_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166698","article-title":"Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis","volume":"1869","author":"Duan","year":"2023","journal-title":"Biochim. et Biophys. Acta (BBA) Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s11658-021-00281-w","article-title":"Apoptosis-promoting properties of miR-3074-5p in MC3T3-E1 cells under iron overload conditions","volume":"26","author":"Feng","year":"2021","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.molimm.2025.08.021_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcdb.2021.05.014","article-title":"Interaction between bone and immune cells: implications for postmenopausal osteoporosis","volume":"123","author":"Fischer","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1-2","key":"10.1016\/j.molimm.2025.08.021_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2005.09.008","article-title":"Current insights into the role of transforming growth factor-\u03b2 in bone resorption","volume":"243","author":"Fox","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.molimm.2025.08.021_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111836","article-title":"Ferroptosis - a new target of osteoporosis","volume":"165","author":"Gao","year":"2022","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.molimm.2025.08.021_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-\u03baB p65 and strategies for therapeutic manipulation","author":"Giridharan","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.molimm.2025.08.021_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.642030","article-title":"MiR-21-3p promotes hepatocellular carcinoma progression via SMAD7\/YAP1 regulation","volume":"11","author":"Hong","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12016-015-8519-2","article-title":"Macrophage polarization and bone formation: a review","volume":"51","author":"Horwood","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib16","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2025.08.021_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116732","article-title":"Targeting SAT1 prevents osteoporosis through promoting osteoclast apoptosis","volume":"175","author":"Jin","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.molimm.2025.08.021_bib18","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"7492","key":"10.1016\/j.molimm.2025.08.021_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.molimm.2025.08.021_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/1759720X16670154","article-title":"Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis","volume":"8","author":"Langdahl","year":"2016","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"issue":"9","key":"10.1016\/j.molimm.2025.08.021_bib21","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/bph.15024","article-title":"Overview of treatment approaches to osteoporosis","volume":"178","author":"Langdahl","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molimm.2025.08.021_bib22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bone.2014.06.033","article-title":"Partial loss of Smad7 function impairs bone remodeling, osteogenesis and enhances osteoclastogenesis in mice","volume":"67","author":"Li","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib23","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181290","article-title":"TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt\/beta-catenin signaling","volume":"39","author":"Liang","year":"2019","journal-title":"Biosci. Rep."},{"issue":"9","key":"10.1016\/j.molimm.2025.08.021_bib24","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1242\/bio.20122204","article-title":"SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages","volume":"1","author":"Lim","year":"2012","journal-title":"Biol. Open"},{"issue":"4","key":"10.1016\/j.molimm.2025.08.021_bib25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bone.2007.06.017","article-title":"PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats","volume":"41","author":"Lin","year":"2007","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib26","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12672-025-02269-w","article-title":"Single-cell profiling uncovers the intricate pathological niche diversity in brain, lymph node, bone, and adrenal metastases of lung cancer","volume":"16","author":"Liu","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.molimm.2025.08.021_bib27","article-title":"Ferroptosis: a new regulatory mechanism in osteoporosis","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.molimm.2025.08.021_bib28","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa1407250","article-title":"Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn\u2019s disease","volume":"372","author":"Monteleone","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib29","article-title":"Atorvastatin inhibits ferroptosis of H9C2 cells by regulatingSMAD7\/hepcidin expression to improve ischemia-reperfusion injury","volume":"2022","author":"Peng","year":"2022","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.molimm.2025.08.021_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2015.05.025","article-title":"Bone morphogenetic protein signaling in bone homeostasis","volume":"80","author":"S\u00e1nchez-Duffhues","year":"2015","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.molimm.2025.08.021_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/08820139.2013.822766","article-title":"The role of cytokines in inflammatory bone loss","volume":"42","author":"Souza","year":"2013","journal-title":"Immunol. Invest"},{"key":"10.1016\/j.molimm.2025.08.021_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10266-013-0140-3","article-title":"TGF-\u03b2 in dentin matrix extract induces osteoclastogenesis in vitro","volume":"103","author":"Sriarj","year":"2015","journal-title":"Odontology"},{"issue":"2","key":"10.1016\/j.molimm.2025.08.021_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2025.08.021_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.06.019","article-title":"Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2\/ARE signaling","volume":"309","author":"Tian","year":"2019","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.molimm.2025.08.021_bib35","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1111\/cas.14496","article-title":"Ferroptosis at the crossroads of infection, aging and cancer","volume":"111","author":"Toyokuni","year":"2020","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.molimm.2025.08.021_bib36","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41576-023-00580-2","article-title":"Methods and applications for single-cell and spatial multi-omics","volume":"24","author":"Vandereyken","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.molimm.2025.08.021_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clinthera.2005.01.005","article-title":"Capecitabine: a review","volume":"27","author":"Walko","year":"2005","journal-title":"Clin. Ther."},{"issue":"12","key":"10.1016\/j.molimm.2025.08.021_bib38","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tem.2010.08.006","article-title":"PPAR\u03b3 in bone homeostasis","volume":"21","author":"Wan","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.molimm.2025.08.021_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20043129","article-title":"Hypoxia pathway in osteoporosis: laboratory data for clinical prospects","volume":"20","author":"Wang","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.molimm.2025.08.021_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1234563","article-title":"Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-kappaB signaling","volume":"14","author":"Xue","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"9","key":"10.1016\/j.molimm.2025.08.021_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092093","article-title":"The role of macrophage in the pathogenesis of osteoporosis","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.molimm.2025.08.021_bib42","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1128\/MCB.02415-06","article-title":"Heme induces ubiquitination and degradation of the transcription factor Bach1","volume":"27","author":"Zenke-Kawasaki","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molimm.2025.08.021_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.593310","article-title":"The smad dependent TGF-\u03b2 and BMP signaling pathway in bone remodeling and therapies","volume":"8","author":"Zou","year":"2021","journal-title":"Front. Mol. Biosci."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025002159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589025002159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:34:21Z","timestamp":1772818461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589025002159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":43,"alternative-id":["S0161589025002159"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2025.08.021","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SMAD7-mediated ferroptosis in macrophages drives osteoporosis progression: A multi-omics study","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2025.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}