{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:54:40Z","timestamp":1783472080986,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB21036"],"award-info":[{"award-number":["20242BAB21036"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["GZYDRF-202301\\u201303"],"award-info":[{"award-number":["GZYDRF-202301\\u201303"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.molimm.2026.01.002","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:06:36Z","timestamp":1768435596000},"page":"72-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Liposome-mediated simvastatin in vaccine adjuvants: Its application and mechanism"],"prefix":"10.1016","volume":"190","author":[{"given":"Zhijie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7951-9233","authenticated-orcid":false,"given":"Ziyan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2026.01.002_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-024-03151-2","article-title":"Repurposing simvastatin in cancer treatment: an updated review on pharmacological and nanotechnological aspects","author":"Ara","year":"2024","journal-title":"NaunynSchmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.molimm.2026.01.002_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122379","article-title":"A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect","volume":"629","author":"Bj\u00f8rnstad","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.molimm.2026.01.002_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1177\/1060028020962050","article-title":"Heplisav-B: a Hepatitis B vaccine with a novel adjuvant","volume":"55","author":"Champion","year":"2021","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.molimm.2026.01.002_bib4","article-title":"Comparing simvastatin monotherapy V\/S simvastatin-ezetimibe combination therapy for the treatment of hyperlipidemia: a meta-analysis and review","volume":"14","author":"Chauhan","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.molimm.2026.01.002_bib5","article-title":"A synergistic lipid nanoparticle encapsulating mRNA shingles vaccine induces potent immune responses and protects guinea pigs from viral challenges","volume":"36","author":"Cheng","year":"2024","journal-title":"Adv. Mater. (Deerfield Beach Fla)"},{"key":"10.1016\/j.molimm.2026.01.002_bib6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1603800","article-title":"Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older","volume":"375","author":"Cunningham","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2026.01.002_bib7","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1080\/01443615.2022.2033964","article-title":"Simvastatin-loaded liposome nanoparticles treatment for uterine leiomyoma in a patient-derived xenograft mouse model: a pilot study","volume":"42","author":"El Sabeh","year":"2022","journal-title":"J. Obstet. Gynaecol. J. Inst. Obstet. Gynaecol."},{"key":"10.1016\/j.molimm.2026.01.002_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-0716-1892-9_8","article-title":"Developments in vaccine adjuvants","volume":"2412","author":"Firdaus","year":"2022","journal-title":"Methods Mol. Biol. (Clifton NJ)"},{"issue":"11","key":"10.1016\/j.molimm.2026.01.002_bib9","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1002\/eji.200636567","article-title":"Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases","volume":"36","author":"Ghittoni","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.molimm.2026.01.002_bib10","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1056\/NEJMoa2309995","article-title":"Simvastatin in critically Ill patients with covid-19","volume":"389","author":"Hills","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molimm.2026.01.002_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molimm.2026.01.002_bib12","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/cid\/ciab125","article-title":"Recombinant zoster vaccine (Shingrix): real-world effectiveness in the first 2 years post-licensure","volume":"73","author":"Izurieta","year":"2021","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.molimm.2026.01.002_bib13","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1021\/acsbiomaterials.1c00462","article-title":"Simvastatin-incorporated drug delivery systems for bone regeneration","volume":"7","author":"Jin","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.molimm.2026.01.002_bib14","article-title":"Salmonella enteritidis subunit vaccine candidate based on SseB protein co-delivered with simvastatin as adjuvant","volume":"11","author":"Kang","year":"2022","journal-title":"Pathogens (Basel Switz.)"},{"key":"10.1016\/j.molimm.2026.01.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114861","article-title":"D SM. Lipid nanoparticle-mediated drug delivery to the brain","volume":"197","author":"Khare","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.molimm.2026.01.002_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12951-022-01478-7","article-title":"Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects","volume":"20","author":"Kiaie","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.molimm.2026.01.002_bib17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijpharm.2017.10.011","article-title":"Enhanced solubility and bioavailability of simvastatin by mechanochemically obtained complexes","volume":"534","author":"Kong","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.molimm.2026.01.002_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/tgh-22-12","article-title":"Efficacy of a two-dose hepatitis B vaccination with a novel immunostimulatory sequence adjuvant (Heplisav-B) on patients with chronic liver disease: a retrospective study","volume":"8","author":"Kwon","year":"2023","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"10.1016\/j.molimm.2026.01.002_bib19","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.immuni.2024.03.015","article-title":"Vaccine adjuvants: tailoring innate recognition to send the right message","volume":"57","author":"Lavelle","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2026.01.002_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.37201\/req\/122.2022","article-title":"Insights for COVID-19 in 2023","volume":"36","author":"Mart\u00edn S\u00e1nchez","year":"2023","journal-title":"Rev. Esp. De. Quimioter. Publ. Of. De. la Soc. Esp. De. Quimioter."},{"key":"10.1016\/j.molimm.2026.01.002_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/acs.molpharmaceut.3c00733","article-title":"Immuno-enhancing effect of ginsenoside Rh2 liposomes on foot-and-mouth disease vaccine","volume":"21","author":"Miao","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.molimm.2026.01.002_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.870347","article-title":"Active tumor-targeting nano-formulations containing simvastatin and doxorubicin inhibit melanoma growth and angiogenesis","volume":"13","author":"Negrea","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molimm.2026.01.002_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg0564","article-title":"The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity","volume":"383","author":"Sharma","year":"2024","journal-title":"Science (New York NY)"},{"key":"10.1016\/j.molimm.2026.01.002_bib24","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.vaccine.2019.04.055","article-title":"Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity","volume":"37","author":"Shi","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.molimm.2026.01.002_bib25","unstructured":"Talreja O., Kerndt C.C., Cassagnol M.Simvastatin. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. Bookshelf ID: NBK532919."},{"key":"10.1016\/j.molimm.2026.01.002_bib26","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid nanoparticles\u2500from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS nano"},{"key":"10.1016\/j.molimm.2026.01.002_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/22221751.2021.1898291","article-title":"Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic","volume":"10","author":"To","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.molimm.2026.01.002_bib28","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.immuni.2022.10.014","article-title":"Innate immune mechanisms of mRNA vaccines","volume":"55","author":"Verbeke","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2026.01.002_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/07853890.2017.1407035","article-title":"Understanding modern-day vaccines: what you need to know","volume":"50","author":"Vetter","year":"2018","journal-title":"Ann. Med."},{"key":"10.1016\/j.molimm.2026.01.002_bib30","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2147\/IJN.S384675","article-title":"Anti-oxidative, anti-apoptotic, and M2 polarized DSPC liposome nanoparticles for selective treatment of atherosclerosis","volume":"18","author":"Wan","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.molimm.2026.01.002_bib31","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cell.2018.08.070","article-title":"The mevalonate pathway is a druggable target for vaccine adjuvant discovery","volume":"175","author":"Xia","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2026.01.002_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jcmm.16058","article-title":"Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti-inflammation property and AMPK\/MAPK\/NF-kB inhibition","volume":"25","author":"Xu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molimm.2026.01.002_bib33","article-title":"Characterization of T-cell subsets in response to foot-and-mouth disease bivalent inactivated vaccine in Chinese Holstein cows","volume":"11","author":"Zhang","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.molimm.2026.01.002_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:14:09Z","timestamp":1778508849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589026000088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":34,"alternative-id":["S0161589026000088"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2026.01.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liposome-mediated simvastatin in vaccine adjuvants: Its application and mechanism","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2026.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}