{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:44:31Z","timestamp":1789152271585,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010252","name":"\u015al\u0105ski Uniwersytet Medyczny w Katowicach","doi-asserted-by":"publisher","award":["BNW-2\\u2013014\/N\/4\/K"],"award-info":[{"award-number":["BNW-2\\u2013014\/N\/4\/K"]}],"id":[{"id":"10.13039\/501100010252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.molimm.2026.02.005","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:48:55Z","timestamp":1770875335000},"page":"79-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Association of anti-inflammatory microglia interleukins with clinical and radiological parameters in patients with multiple sclerosis - a single-centre study in a Polish population"],"prefix":"10.1016","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-036X","authenticated-orcid":false,"given":"Hubert","family":"Mado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Stasiniewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Nafalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Stopyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Furgo\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Jezierza\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Kisielewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kubicka-B\u0105czyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Niedziela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Sowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Adamczyk-Sowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2026.02.005_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106808","article-title":"The immunoregulatory and neuroprotective effects of human adipose derived stem cells overexpressing IL-11 and IL-13 in the experimental autoimmune encephalomyelitis mice","volume":"87","author":"Azimzadeh","year":"2020","journal-title":"Int Immunopharmacol."},{"issue":"6","key":"10.1016\/j.molimm.2026.02.005_bib2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00702-004-0225-9","article-title":"Correlations between IL-4, IL-12 levels and CCL2, CCL5 levels in serum and cerebrospinal fluid of multiple sclerosis patients","volume":"112","author":"Bartosik-Psujek","year":"2005","journal-title":"J. Neural Transm."},{"issue":"9","key":"10.1016\/j.molimm.2026.02.005_bib3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s12272-013-0161-z","article-title":"Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases","volume":"36","author":"Bose","year":"2013","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.005_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pharmthera.2006.03.005","article-title":"B cells in the pathophysiology of autoimmune neurological disorders: a credible therapeutic target","volume":"112","author":"Dalakas","year":"2006","journal-title":"Pharm. Ther."},{"issue":"9","key":"10.1016\/j.molimm.2026.02.005_bib5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molimm.2026.02.005_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1430080","article-title":"Interleukin-10 contrasts inflammatory synaptopathy and central neurodegenerative damage in multiple sclerosis","volume":"17","author":"Gilio","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.molimm.2026.02.005_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106032","article-title":"Diagnostic and prognostic value of the RUNXOR\/RUNX1 axis in multiple sclerosis","volume":"178","author":"Haridy","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.molimm.2026.02.005_bib8","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1007\/s12035-016-9846-x","article-title":"Cytokine profile in patients with progressive multiple sclerosis and its association with disease progression and disability","volume":"54","author":"Kallaur","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.molimm.2026.02.005_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2025.106540","article-title":"Decoding disease burden in multiple sclerosis: the role of IL-10 as biomarker of neuroinflammation and neurodegeneration","volume":"100","author":"Khedr","year":"2025","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.005_bib10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1523\/JNEUROSCI.2615-05.2006","article-title":"Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation","volume":"26","author":"Kotter","year":"2006","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.005_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neurol.2015.10.006","article-title":"Epidemiology of multiple sclerosis","volume":"172","author":"Leray","year":"2016","journal-title":"Rev. Neurol."},{"issue":"8","key":"10.1016\/j.molimm.2026.02.005_bib12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41582-019-0184-2","article-title":"The pro-remyelination properties of microglia in the central nervous system","volume":"15","author":"Lloyd","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"9","key":"10.1016\/j.molimm.2026.02.005_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211044378","article-title":"Anti-severe acute respiratory syndrome coronavirus-2 antibody responses following Pfizer-BioNTech vaccination in a patient with multiple sclerosis treated with ocrelizumab: a case report","volume":"49","author":"Mado","year":"2021","journal-title":"J. Int. Med. Res."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.005_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/14728222.2020.1709823","article-title":"'Prototypical' proinflammatory cytokine (IL-1) in multiple sclerosis: role in pathogenesis and therapeutic targeting","volume":"24","author":"Musella","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.molimm.2026.02.005_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: from understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front Neurosci."},{"key":"10.1016\/j.molimm.2026.02.005_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-immunol-032414-112306","article-title":"Inflammasome-independent regulation of IL-1-family cytokines","volume":"33","author":"Netea","year":"2015","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.molimm.2026.02.005_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.105004","article-title":"A comparison of serum inflammatory parameters in progressive forms of multiple sclerosis","volume":"79","author":"Nowak-Kiczmer","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"7","key":"10.1016\/j.molimm.2026.02.005_bib18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3390\/biom10071017","article-title":"The regulatory role of IL-10 in neurodegenerative diseases","volume":"10","author":"Porro","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.molimm.2026.02.005_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40478-014-0098-6","article-title":"Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of multiple sclerosis patients","volume":"2","author":"Prins","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.molimm.2026.02.005_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/nyas.12841","article-title":"Pathological differences between white and grey matter multiple sclerosis lesions","volume":"1351","author":"Prins","year":"2015","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"2","key":"10.1016\/j.molimm.2026.02.005_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.molimm.2026.02.005_bib22","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1177\/1352458511410342","article-title":"Potential role of IL-13 in neuroprotection and cortical excitability regulation in multiple sclerosis","volume":"17","author":"Rossi","year":"2011","journal-title":"Mult. Scler."},{"key":"10.1016\/j.molimm.2026.02.005_bib23","doi-asserted-by":"crossref","first-page":"354","DOI":"10.5114\/ceji.2015.54599","article-title":"Influence of fingolimod on basic lymphocyte subsets frequencies in the peripheral blood of multiple sclerosis patients \u2013 preliminary study","volume":"3","author":"Rudnicka","year":"2015","journal-title":"Cent. Eur. J. Immunol. [Internet]"},{"issue":"8","key":"10.1016\/j.molimm.2026.02.005_bib24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.it.2013.04.006","article-title":"Modeling the heterogeneity of multiple sclerosis in animals","volume":"34","author":"Simmons","year":"2013","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.molimm.2026.02.005_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00401-021-02384-2","article-title":"Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function","volume":"143","author":"Spiteri","year":"2022","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.molimm.2026.02.005_bib26","article-title":"Multiple sclerosis: therapeutic strategies on the horizon","volume":"14","author":"Talanki Manjunatha","year":"2022","journal-title":"Cureus"},{"issue":"8","key":"10.1016\/j.molimm.2026.02.005_bib27","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/stem.3374","article-title":"Multifaceted involvement of microglia in gray matter pathology in multiple sclerosis","volume":"39","author":"Tsouki","year":"2021","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.molimm.2026.02.005_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2018.11.005","article-title":"Microglia in central nervous system inflammation and multiple sclerosis pathology","volume":"25","author":"Voet","year":"2019","journal-title":"Trends Mol. Med."},{"issue":"14","key":"10.1016\/j.molimm.2026.02.005_bib29","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.molimm.2026.02.005_bib30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fneur.2019.00604","article-title":"Low serum Interleukin-10 is an independent predictive factor for the risk of second event in clinically isolated syndromes","volume":"10","author":"Wei","year":"2019","journal-title":"Front. Neurol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:53:22Z","timestamp":1777492402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589026000313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":30,"alternative-id":["S0161589026000313"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2026.02.005","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of anti-inflammatory microglia interleukins with clinical and radiological parameters in patients with multiple sclerosis - a single-centre study in a Polish population","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2026.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}