{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:44:03Z","timestamp":1792799043446,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.molimm.2026.02.007","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:20:37Z","timestamp":1771294837000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["OPTN knockout alleviates OVA-induced airway inflammation in a mouse model of asthma"],"prefix":"10.1016","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9664-7732","authenticated-orcid":false,"given":"Yujing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2026.02.007_bib1","doi-asserted-by":"crossref","unstructured":"Autophagy and cytokines. Cytokine. 2011 Nov 1;56(2):140\u2013144.","DOI":"10.1016\/j.cyto.2011.08.022"},{"issue":"2","key":"10.1016\/j.molimm.2026.02.007_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cea.14575","article-title":"Allergen immunotherapy for the prevention and treatment of asthma","volume":"55","author":"Batard","year":"2024","journal-title":"Clin. Exp. Allergy"},{"issue":"2","key":"10.1016\/j.molimm.2026.02.007_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/15548627.2015.1056967","article-title":"IL13 activates autophagy to regulate secretion in airway epithelial cells","volume":"12","author":"Dickinson","year":"2015","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.molimm.2026.02.007_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.70029","article-title":"Exploring the function of OPTN from multiple dimensions","volume":"42","author":"Guo","year":"2024","journal-title":"Cell Biochem. Funct."},{"issue":"7","key":"10.1016\/j.molimm.2026.02.007_bib5","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221212","article-title":"Type 2 inflammation and biological therapies in asthma: targeted medicine taking flight","volume":"220","author":"Howell","year":"2023","journal-title":"J. Exp. Med."},{"issue":"19","key":"10.1016\/j.molimm.2026.02.007_bib6","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J. [Internet]"},{"key":"10.1016\/j.molimm.2026.02.007_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.12688\/f1000research.11236.2","article-title":"Autophagy and airway fibrosis: Is there a link?","volume":"6","author":"Kota","year":"2018","journal-title":"F1000Research"},{"issue":"3","key":"10.1016\/j.molimm.2026.02.007_bib8","first-page":"20","article-title":"An overview of autophagy: morphology, mechanism, and regulation","author":"Kr","year":"2014","journal-title":"Antioxid. Redox Signal. [Internet]"},{"issue":"1","key":"10.1016\/j.molimm.2026.02.007_bib9","doi-asserted-by":"crossref","DOI":"10.4110\/in.2019.19.e5","article-title":"The role of autophagy in eosinophilic airway inflammation","volume":"19","author":"Lee","year":"2019","journal-title":"Immune Netw."},{"key":"10.1016\/j.molimm.2026.02.007_bib10","first-page":"1860","article-title":"Effects and mechanisms of gefitinib on airway inflammation and remodeling in C57BL\/6 mice with asthma","volume":"104","author":"Liqin","year":"2024","journal-title":"Natl. Med. J. China"},{"issue":"7","key":"10.1016\/j.molimm.2026.02.007_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.38","article-title":"The role of autophagy in allergic inflammation: a new target for severe asthma","volume":"48","author":"Liu","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.molimm.2026.02.007_bib12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/978-981-15-4272-5_41","article-title":"Asthma and autophagy","volume":"1207","author":"Lv","year":"2020","journal-title":"Autophagy Biol. Dis."},{"key":"10.1016\/j.molimm.2026.02.007_bib13","series-title":"Precision Approaches to Heterogeneity in Asthma [Internet]","first-page":"143","article-title":"Heterogeneity of treatment response to asthma","author":"Maeda","year":"2023"},{"issue":"15","key":"10.1016\/j.molimm.2026.02.007_bib14","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1038\/sj.emboj.7601250","article-title":"The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation","volume":"25","author":"Martin","year":"2006","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.molimm.2026.02.007_bib15","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.molimm.2026.02.007_bib16","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1080\/15548627.2023.2234797","article-title":"Tethering ATG16L1 or LC3 induces targeted autophagic degradation of protein aggregates and mitochondria","volume":"19","author":"Mei","year":"2023","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.molimm.2026.02.007_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2026.02.007_bib18","doi-asserted-by":"crossref","unstructured":"Novel asthma treatments: Advancing beyond approved novel step-up therapies for asthma. Annals of Allergy, Asthma & Immunology. 2025 Jan 1;134(1):9\u201318.","DOI":"10.1016\/j.anai.2024.09.016"},{"key":"10.1016\/j.molimm.2026.02.007_bib19","first-page":"10379","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet (London, England) [Internet]"},{"key":"10.1016\/j.molimm.2026.02.007_bib20","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.3389\/fimmu.2019.02787","article-title":"Environmental exposures and asthma development: autophagy, mitophagy, and cellular senescence","volume":"10","author":"Sachdeva","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.007_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cdd.2012.72","article-title":"Ubiquitination and selective autophagy","volume":"20","author":"Shaid","year":"2012","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.molimm.2026.02.007_bib22","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.jaci.2022.07.003","article-title":"TSLP, IL-33, and IL-25: not just for allergy and helminth infection","volume":"150","author":"Stanbery","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"12","key":"10.1016\/j.molimm.2026.02.007_bib23","article-title":"Autophagy: a friend or foe in allergic asthma?","volume":"22","author":"Theofani","year":"2021","journal-title":"Int J. Mol. Sci. [Internet]"},{"key":"10.1016\/j.molimm.2026.02.007_bib24","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3389\/fimmu.2018.01017","article-title":"Dysfunction of optineurin in amyotrophic lateral sclerosis and glaucoma","volume":"9","author":"Toth","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.007_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12951-020-00634-1","article-title":"p62\/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-\u03baB activation","volume":"18","author":"Wu","year":"2020","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.molimm.2026.02.007_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1080\/15548627.2017.1421884","article-title":"IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma","volume":"14","author":"Xia","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.molimm.2026.02.007_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103090","article-title":"IL-4 activates ULK1\/Atg9a\/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress","volume":"71","author":"Xu","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.molimm.2026.02.007_bib28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41398-022-02004-x","article-title":"OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy","volume":"12","author":"Xu","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.molimm.2026.02.007_bib29","article-title":"Emerging views of OPTN (optineurin) function in the autophagic process associated with disease","volume":"18","author":"Qiu","year":"2022","journal-title":"Autophagy [Internet]"},{"key":"10.1016\/j.molimm.2026.02.007_bib30","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1038\/s41467-024-50222-2","article-title":"Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes","volume":"15","author":"Yamada","year":"2024","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.molimm.2026.02.007_bib31","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1038\/emboj.2010.214","article-title":"NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo","volume":"29","author":"Yang","year":"2010","journal-title":"EMBO J."},{"issue":"166","key":"10.1016\/j.molimm.2026.02.007_bib32","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0134-2022","article-title":"Role of autophagy in lung diseases and ageing","volume":"31","author":"Zhang","year":"2022","journal-title":"Eur. Respir. Rev."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:31:23Z","timestamp":1772213483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589026000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":32,"alternative-id":["S0161589026000337"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2026.02.007","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OPTN knockout alleviates OVA-induced airway inflammation in a mouse model of asthma","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2026.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}