{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:09:54Z","timestamp":1778724594922,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073982"],"award-info":[{"award-number":["82073982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20261248"],"award-info":[{"award-number":["20261248"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20251247"],"award-info":[{"award-number":["20251247"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010424"],"award-info":[{"award-number":["2022A1515010424"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011704"],"award-info":[{"award-number":["2024A1515011704"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011060"],"award-info":[{"award-number":["2023A1515011060"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018938","name":"Administration of Traditional Chinese Medicine of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018938","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.molimm.2026.02.012","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:50:54Z","timestamp":1773096654000},"page":"26-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mechanistic study of swertiamarin in treating ulcerative colitis by regulating YAP-mediated Wnt and Notch pathways for intestinal stem cell repair"],"prefix":"10.1016","volume":"193","author":[{"given":"Jiawen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2026.02.012_bib1","first-page":"406","article-title":"Ulcerative colitis: rapid evidence review","volume":"105","author":"Adams","year":"2022","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.molimm.2026.02.012_bib2","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.cgh.2022.06.030","article-title":"Global hospitalization trends for Crohn's disease and ulcerative colitis in the 21st century: a systematic review with temporal analyses","volume":"21","author":"Buie","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.molimm.2026.02.012_bib3","article-title":"Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3\/NF-\u03baB signaling pathway","volume":"31","author":"Chen","year":"2025","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.molimm.2026.02.012_bib4","article-title":"The emerging role of intestinal stem cells in ulcerative colitis","volume":"12","author":"Chen","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.molimm.2026.02.012_bib5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/ecco-jcc\/jjz131","article-title":"Outcomes and strategies to support a treat-to-target approach in inflammatory bowel disease: a systematic review","volume":"14","author":"Colombel","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.molimm.2026.02.012_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41419-017-0244-8","article-title":"YAP triggers the Wnt\/\u03b2-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury","volume":"9","author":"Deng","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molimm.2026.02.012_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.894737","article-title":"The Hippo-YAP\/TAZ signaling pathway in intestinal self-renewal and regeneration after injury","volume":"10","author":"Deng","year":"2022","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.molimm.2026.02.012_bib8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41573-020-0070-z","article-title":"Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine","volume":"19","author":"Dey","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molimm.2026.02.012_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/15548627.2021.1909406","article-title":"How autophagy controls the intestinal epithelial barrier","volume":"18","author":"Foerster","year":"2022","journal-title":"Autophagy"},{"issue":"1389-1401","key":"10.1016\/j.molimm.2026.02.012_bib10","article-title":"LKB1 represses ATOH1 via PDK4 and energy metabolism and regulates intestinal stem cell fate","volume":"158","author":"Gao","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2026.02.012_bib11","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105770","article-title":"Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration","volume":"40","author":"Guillermin","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.molimm.2026.02.012_bib12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1053\/j.gastro.2023.02.030","article-title":"Stiffness restricts the stemness of the intestinal stem cells and skews their differentiation toward goblet cells","volume":"164","author":"He","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2026.02.012_bib13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","article-title":"Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution","volume":"129","author":"Heller","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2026.02.012_bib14","article-title":"Intestinal stem cells and immune cell relationships: potential therapeutic targets for inflammatory bowel diseases","volume":"11","author":"Hou","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2026.02.012_bib15","first-page":"87","article-title":"The application of fangfeng qinjiao decoction in anorectal department","author":"Hu","year":"2007","journal-title":"Sichuan J. Tradit. Chin. Med"},{"key":"10.1016\/j.molimm.2026.02.012_bib16","first-page":"201","article-title":"Clinical study on qingjiaodangshentang decoction combined with smecta enema for treating ulcerative colitis","author":"Huang","year":"2004","journal-title":"Shanxi Med J."},{"key":"10.1016\/j.molimm.2026.02.012_bib17","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1128\/MCB.00311-16","article-title":"Role of Src family kinases in regulation of intestinal epithelial homeostasis","volume":"36","author":"Imada","year":"2016","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.molimm.2026.02.012_bib18","first-page":"424","article-title":"Content determination and HPLC fingerprint analysisof different parts of Gentiana crassicaulis from LijiangYunnan","volume":"34","author":"Ji","year":"2023","journal-title":"Lishizhen Med Mater. Med Res"},{"key":"10.1016\/j.molimm.2026.02.012_bib19","first-page":"4641","article-title":"Chemical constituents of underground part ofGentiana crassicaulis with different processingmethods based on UPLC-LTQ-Orbitrap MS\/MS","volume":"54","author":"Ji","year":"2023","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.molimm.2026.02.012_bib20","article-title":"Overview of three proliferation pathways (Wnt, Notch, and Hippo) in intestine and immune system and their role in inflammatory bowel diseases (IBDs)","volume":"9","author":"Khoramjoo","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.molimm.2026.02.012_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1538\/expanim.48.137","article-title":"Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium","volume":"48","author":"Kitajima","year":"1999","journal-title":"Exp. Anim."},{"key":"10.1016\/j.molimm.2026.02.012_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/genes9010020","article-title":"Wnt, RSPO and Hippo signalling in the intestine and intestinal stem cells","volume":"9","author":"Kriz","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.molimm.2026.02.012_bib23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cgh.2019.07.005","article-title":"Ulcerative colitis and Crohn's disease have similar burden and goals for treatment","volume":"18","author":"Le Berre","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.molimm.2026.02.012_bib24","article-title":"\"Remodeling the intestinal immune microenvironment\": immune regulation and tissue regeneration by mesenchymal stem\/stromal cells in the repair microenvironment of inflammatory bowel disease","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2026.02.012_bib25","first-page":"1262","article-title":"Clinical observation on the treatment of ulcerative colitis of large intestine damp - heat type by retention enema with modified Qinjiao Cangzhu decoction","volume":"31","author":"Li","year":"2018","journal-title":"Heilongjiang Med J."},{"key":"10.1016\/j.molimm.2026.02.012_bib26","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"Lindemans","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molimm.2026.02.012_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.trsl.2021.06.001","article-title":"Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier","volume":"236","author":"Liu","year":"2021","journal-title":"Transl. Res"},{"key":"10.1016\/j.molimm.2026.02.012_bib28","series-title":"Chinese pharmacopoeia","author":"National Pharmacopoeia Commission","year":"2025"},{"key":"10.1016\/j.molimm.2026.02.012_bib29","first-page":"597","article-title":"Advance in studies on chemical constituents of Gentianae Macrophyllae Radix and their pharmacological effects","volume":"48","author":"Nie","year":"2017","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.molimm.2026.02.012_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.733992","article-title":"The gut microbiota in inflammatory bowel disease","volume":"12","author":"Qiu","year":"2022","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.molimm.2026.02.012_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147618","article-title":"Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease","volume":"22","author":"Saez","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2026.02.012_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.immuni.2012.05.021","article-title":"Adrenergic nerves govern circadian leukocyte recruitment to tissues","volume":"37","author":"Scheiermann","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.molimm.2026.02.012_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12967-024-05027-8","article-title":"Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer","volume":"22","author":"Schiavoni","year":"2024","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.molimm.2026.02.012_bib34","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2020.01.007","article-title":"AGA technical review on the management of moderate to severe ulcerative colitis","volume":"158","author":"Singh","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2026.02.012_bib35","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1053\/j.gastro.2024.10.001","article-title":"AGA living clinical practice guideline on pharmacological management of moderate-to-severe ulcerative colitis","volume":"167","author":"Singh","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molimm.2026.02.012_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222010912","article-title":"Modeling intestinal stem cell function with organoids","volume":"22","author":"Takahashi","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2026.02.012_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062032","article-title":"Stem cell signaling pathways in the small intestine","volume":"21","author":"Takahashi","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.molimm.2026.02.012_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1132905","article-title":"A multi-mineral intervention to counter pro-inflammatory activity and to improve the barrier in human colon organoids","volume":"11","author":"Varani","year":"2023","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.molimm.2026.02.012_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fimmu.2020.00323","article-title":"The crosstalk between Hippo-YAP pathway and innate immunity","volume":"11","author":"Wang","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.molimm.2026.02.012_bib40","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/labinvest.2008.78","article-title":"Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation","volume":"88","author":"Weber","year":"2008","journal-title":"Lab Invest"},{"key":"10.1016\/j.molimm.2026.02.012_bib41","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molimm.2026.02.012_bib42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/21623945.2021.1906510","article-title":"Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet","volume":"10","author":"Xu","year":"2021","journal-title":"Adipocyte"},{"key":"10.1016\/j.molimm.2026.02.012_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154362","article-title":"Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa","volume":"105","author":"Yan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.molimm.2026.02.012_bib44","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/s41401-024-01250-7","article-title":"Notoginsenoside R1 promotes Lgr5(+) stem cell and epithelium renovation in colitis mice via activating Wnt\/\u03b2-Catenin signaling","volume":"45","author":"Yu","year":"2024","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.molimm.2026.02.012_bib45","article-title":"The Qinjiao chunpi decoction in the treatment of 462 cases of ulcerative colitis","volume":"6","author":"Zhang","year":"1997","journal-title":"Shaanxi J. Tradit. Chin. Med"},{"key":"10.1016\/j.molimm.2026.02.012_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103160","article-title":"Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis","volume":"72","author":"Zhao","year":"2024","journal-title":"Redox Biol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:40:53Z","timestamp":1778722853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589026000441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":46,"alternative-id":["S0161589026000441"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2026.02.012","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic study of swertiamarin in treating ulcerative colitis by regulating YAP-mediated Wnt and Notch pathways for intestinal stem cell repair","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2026.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}