{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:03:21Z","timestamp":1777874601585,"version":"3.51.4"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.molimm.2026.03.006","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:11:16Z","timestamp":1775178676000},"page":"103-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The association of systemic immune-inflammation index with Th17\/Treg imbalance, disease severity (PASI), and quality of life (DLQI\/PLSI) in patients with psoriasis vulgaris: A cross-sectional study"],"prefix":"10.1016","volume":"193","author":[{"given":"Ling","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xibao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.molimm.2026.03.006_bib1","article-title":"Pan-immune inflammation value and systemic inflammatory index as a measure of systemic inflammation in patients with psoriasis: A retrospective study","volume":"104","author":"Basar Kilic","year":"2025","journal-title":"Med. (Baltim. )"},{"issue":"3","key":"10.1016\/j.molimm.2026.03.006_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11655-012-1007-0","article-title":"Application of the dermatology life quality index in clinical trials of biologics for psoriasis","volume":"18","author":"Basra","year":"2012","journal-title":"Chin. J. Integr. Med"},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib3","article-title":"Disentangling patient, disease, and treatment effects: proteomic and metabolomic differences in early versus established psoriatic arthritis","volume":"10","author":"Bentvelzen","year":"2026","journal-title":"Rheuma Adv. Pr."},{"issue":"3","key":"10.1016\/j.molimm.2026.03.006_bib4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1651-2227.1988.tb10672.x","article-title":"Injuries at school. Influence of schoolmate interaction","volume":"77","author":"Bremberg","year":"1988","journal-title":"Acta Paediatr. Scand."},{"issue":"11","key":"10.1016\/j.molimm.2026.03.006_bib5","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.52586\/5029","article-title":"The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases","volume":"26","author":"Chen","year":"2021","journal-title":"Front Biosci. (Landmark Ed."},{"key":"10.1016\/j.molimm.2026.03.006_bib6","article-title":"Association of the systemic immune-inflammation index with anemia: a population-based study","volume":"15","author":"Chen","year":"2024","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00403-024-03768-6","article-title":"Are IL-17 inhibitors superior to IL-23 inhibitors in reducing systemic inflammation in moderate-to-severe plaque psoriasis? A retrospective cohort study","volume":"317","author":"Demirel Ogut","year":"2025","journal-title":"Arch. Dermatol. Res"},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib8","article-title":"The utility of systemic-immune inflammation index for predicting the disease activation in patients with psoriasis","volume":"75","author":"Dincer Rota","year":"2021","journal-title":"Int J. Clin. Pr."},{"issue":"5","key":"10.1016\/j.molimm.2026.03.006_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1468-3083.2010.03826.x","article-title":"Infliximab efficacy in nail psoriasis. A retrospective study in 48 patients","volume":"25","author":"Fabroni","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000505536","article-title":"Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis","volume":"237","author":"Fan","year":"2021","journal-title":"Dermatology"},{"key":"10.1016\/j.molimm.2026.03.006_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7360975","article-title":"A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris","volume":"2022","author":"Geng","year":"2022","journal-title":"Comput. Math. Methods Med"},{"issue":"10281","key":"10.1016\/j.molimm.2026.03.006_bib12","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.molimm.2026.03.006_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s40257-017-0274-0","article-title":"Severity of Psoriasis Differs Between Men and Women: A Study of the Clinical Outcome Measure Psoriasis Area and Severity Index (PASI) in 5438 Swedish Register Patients","volume":"18","author":"Hagg","year":"2017","journal-title":"Am. J. Clin. Dermatol."},{"issue":"3","key":"10.1016\/j.molimm.2026.03.006_bib14","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.soard.2020.10.021","article-title":"Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes","volume":"17","author":"Harma","year":"2021","journal-title":"Surg. Obes. Relat. Dis."},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib15","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.1800013","article-title":"Discovery of the IL-23\/IL-17 Signaling Pathway and the Treatment of Psoriasis","volume":"201","author":"Hawkes","year":"2018","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.molimm.2026.03.006_bib16","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1111\/jocd.13425","article-title":"Smad7 in psoriasis vulgaris patients: A clinical and immunohistochemical study","volume":"19","author":"Hemida","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"issue":"2","key":"10.1016\/j.molimm.2026.03.006_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/srt.12626","article-title":"Antimicrobial peptides activity in the skin","volume":"25","author":"Herman","year":"2019","journal-title":"Ski. Res Technol."},{"issue":"23","key":"10.1016\/j.molimm.2026.03.006_bib18","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","article-title":"Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma","volume":"20","author":"Hu","year":"2014","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.molimm.2026.03.006_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.788940","article-title":"The Role of Helper T Cells in Psoriasis","volume":"12","author":"Hu","year":"2021","journal-title":"Front Immunol."},{"issue":"12","key":"10.1016\/j.molimm.2026.03.006_bib20","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.humimm.2010.09.005","article-title":"Increased serum leucine, leucine-37 levels in psoriasis: positive and negative feedback loops of leucine, leucine-37 and pro- or anti-inflammatory cytokines","volume":"71","author":"Kanda","year":"2010","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.molimm.2026.03.006_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1005115","article-title":"The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris","volume":"13","author":"Kim","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41598-025-29802-9","article-title":"Evaluation of netrin 1 as a new biomarker in the differentiation of psoriatic arthritis from psoriasis","volume":"16","author":"Kor","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.molimm.2026.03.006_bib23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/bjd.18245","article-title":"Management of psoriasis as a systemic disease: what is the evidence?","volume":"182","author":"Korman","year":"2020","journal-title":"Br. J. Dermatol."},{"issue":"7162","key":"10.1016\/j.molimm.2026.03.006_bib24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide","volume":"449","author":"Lande","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/eji.201344277","article-title":"Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA","volume":"45","author":"Lande","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.molimm.2026.03.006_bib26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12026-020-09149-1","article-title":"The role of Th17 cells in psoriasis","volume":"68","author":"Li","year":"2020","journal-title":"Immunol. Res"},{"issue":"1-2","key":"10.1016\/j.molimm.2026.03.006_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000452541","article-title":"Imbalance of Th17\/Treg in Different Subtypes of Autoimmune Thyroid Diseases","volume":"40","author":"Li","year":"2016","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.molimm.2026.03.006_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177330","article-title":"Cathelicidin-HG alleviates psoriasis by targeting glycoprotein VI to inhibit platelet-neutrophil complexes formation","volume":"991","author":"Li","year":"2025","journal-title":"Eur. J. Pharm."},{"issue":"4","key":"10.1016\/j.molimm.2026.03.006_bib29","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s40744-022-00455-8","article-title":"Exploring the Association Between History of Psoriasis (PSO) and Disease Activity in Patients with Psoriatic Arthritis (PsA)","volume":"9","author":"Li","year":"2022","journal-title":"Rheuma Ther."},{"key":"10.1016\/j.molimm.2026.03.006_bib30","article-title":"Systemic immune-inflammatory biomarkers (SII, NLR, PLR and LMR) linked to non-alcoholic fatty liver disease risk","volume":"15","author":"Liu","year":"2024","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib31","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00403-024-02994-2","article-title":"Associations of novel complete blood count-derived inflammatory markers with psoriasis: a systematic review and meta-analysis","volume":"316","author":"Liu","year":"2024","journal-title":"Arch. Dermatol. Res"},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10238-024-01294-3","article-title":"The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis","volume":"24","author":"Mangoni","year":"2024","journal-title":"Clin. Exp. Med"},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5114\/pdia.2015.48066","article-title":"The role of antimicrobial peptides in chronic inflammatory skin diseases","volume":"33","author":"Marcinkiewicz","year":"2016","journal-title":"Post. Dermatol. Alergol."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jdermsci.2017.03.014","article-title":"Serum peptides as putative modulators of inflammation in psoriasis","volume":"87","author":"Matsuura","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.molimm.2026.03.006_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2025-100253","article-title":"Application of machine learning in the discovery of antimicrobial peptides: exploring their potential for ulcerative colitis therapy","volume":"3","author":"Miao","year":"2025","journal-title":"eGastroenterology"},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-010-1080-1","article-title":"Definition of treatment goals for moderate to severe psoriasis: a European consensus","volume":"303","author":"Mrowietz","year":"2011","journal-title":"Arch. Dermatol. Res"},{"issue":"2","key":"10.1016\/j.molimm.2026.03.006_bib37","article-title":"Association Between Systemic Inflammation, Metabolic Syndrome and Quality of Life in Psoriasis Patients","volume":"15","author":"Mustata","year":"2025","journal-title":"Life (Basel)"},{"issue":"20","key":"10.1016\/j.molimm.2026.03.006_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207607","article-title":"Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis","volume":"21","author":"Nguyen","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.molimm.2026.03.006_bib39","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/1346-8138.17723","article-title":"The required absolute PASI score to achieve DLQI remission","volume":"52","author":"Nishida","year":"2025","journal-title":"J. Dermatol."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/bjd.19380","article-title":"Role of regulatory T cells in psoriasis pathogenesis and treatment","volume":"184","author":"Nussbaum","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.molimm.2026.03.006_bib41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Identification, Management of P, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J. Invest Dermatol."},{"issue":"45","key":"10.1016\/j.molimm.2026.03.006_bib42","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1556\/650.2016.30589","article-title":"Psoriasis and oxidative stress","volume":"157","author":"Peter","year":"2016","journal-title":"Orv. Hetil."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s13555-014-0043-4","article-title":"Health-related quality of life worsens disproportionately to objective signs of psoriasis after withdrawal of adalimumab therapy","volume":"4","author":"Poulin","year":"2014","journal-title":"Dermatol. Ther. (Heide )"},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib44","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s10753-023-01883-6","article-title":"Low-dose Interleukin-2 For Psoriasis Therapy Based on the Regulation of Th17\/Treg Cell Balance in Peripheral Blood","volume":"46","author":"Qiao","year":"2023","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.molimm.2026.03.006_bib45","first-page":"700","article-title":"Correlation analysis of Treg\/Th17 cells and related cytokines in patients with psoriasis vulgaris","volume":"39","author":"Qu","year":"2019","journal-title":"J. Tradit. Chin. Med"},{"issue":"3","key":"10.1016\/j.molimm.2026.03.006_bib46","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaad.2013.11.013","article-title":"Psoriasis prevalence among adults in the United States","volume":"70","author":"Rachakonda","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.molimm.2026.03.006_bib47","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s43441-019-00065-7","article-title":"Defining Efficacy Estimands in Clinical Trials: Examples Illustrating ICH E9(R1) Guidelines","volume":"54","author":"Ratitch","year":"2020","journal-title":"Ther. Innov. Regul. Sci."},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib48","first-page":"651","article-title":"Exploring the Association between Blood Indices and Skin and Joint Activity of Psoriatic Arthritis","volume":"23","author":"Rostamian","year":"2024","journal-title":"Iran. J. Allergy Asthma Immunol."},{"issue":"8","key":"10.1016\/j.molimm.2026.03.006_bib49","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/art.34477","article-title":"Brief report: inhibition of interleukin-6 function corrects Th17\/Treg cell imbalance in patients with rheumatoid arthritis","volume":"64","author":"Samson","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"18","key":"10.1016\/j.molimm.2026.03.006_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186604","article-title":"Role of Innate Immune Cells in Psoriasis","volume":"21","author":"Sato","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.molimm.2026.03.006_bib51","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","article-title":"Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition","volume":"15","author":"Scher","year":"2019","journal-title":"Nat. Rev. Rheuma"},{"issue":"2","key":"10.1016\/j.molimm.2026.03.006_bib52","first-page":"100","article-title":"CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials","volume":"1","author":"Schulz","year":"2010","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.molimm.2026.03.006_bib53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.5604\/17322693.1111127","article-title":"Peripheral blood Th17\/Treg imbalance in patients with low-active systemic lupus erythematosus","volume":"68","author":"Szmyrka-Kaczmarek","year":"2014","journal-title":"Post. Hig. Med Dosw (Online)"},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib54","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1007\/s10067-025-07400-4","article-title":"Hyperuricemia in psoriatic arthritis: clinical correlations and implications","volume":"44","author":"Tabra","year":"2025","journal-title":"Clin. Rheuma"},{"issue":"2","key":"10.1016\/j.molimm.2026.03.006_bib55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jdermsci.2014.10.003","article-title":"Important roles of platelets as immune cells in the skin","volume":"77","author":"Tamagawa-Mineoka","year":"2015","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib56","article-title":"Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression","volume":"14","author":"Tiuca","year":"2024","journal-title":"Life (Basel)"},{"issue":"3-6","key":"10.1016\/j.molimm.2026.03.006_bib57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000287013","article-title":"Psychometric investigation in 48 Dutch patients suffering from psoriasis","volume":"27","author":"van der Schaar","year":"1976","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.molimm.2026.03.006_bib58","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.biopha.2017.06.055","article-title":"MiR-200a expression in CD4+ T cells correlates with the expression of Th17\/Treg cells and relevant cytokines in psoriasis vulgaris: A case control study","volume":"93","author":"Wang","year":"2017","journal-title":"Biomed. Pharm."},{"issue":"9","key":"10.1016\/j.molimm.2026.03.006_bib59","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ni1497","article-title":"Development, cytokine profile and function of human interleukin 17-producing helper T cells","volume":"8","author":"Wilson","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molimm.2026.03.006_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103351","article-title":"AIM2 deficiency in CD4(+) T cells promotes psoriasis-like inflammation by regulating Th17-Treg axis via AIM2-IKZF2 pathway","volume":"150","author":"Xin","year":"2025","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.molimm.2026.03.006_bib61","article-title":"SIRI and SII as potential biomarkers of disease activity and lupus nephritis in systemic lupus erythematosus","volume":"16","author":"Yang","year":"2025","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib62","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12890-023-02583-5","article-title":"Association between systemic immune-inflammation index and chronic obstructive pulmonary disease: a population-based study","volume":"23","author":"Ye","year":"2023","journal-title":"BMC Pulm. Med"},{"issue":"4","key":"10.1016\/j.molimm.2026.03.006_bib63","first-page":"493","article-title":"Efficacy and safety of external application of Chinese herbal medicine for psoriasis vulgaris: a systematic review of randomized controlled trials","volume":"42","author":"Yi","year":"2022","journal-title":"J. Tradit. Chin. Med"},{"issue":"4","key":"10.1016\/j.molimm.2026.03.006_bib64","first-page":"352","article-title":"Systemic Immune-Inflammation Index (SII) Predicts Increased Severity in Psoriasis and Psoriatic Arthritis","volume":"46","author":"Yorulmaz","year":"2020","journal-title":"Curr. Health Sci. J."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-32707-2","article-title":"Peptidomics analysis of serum in patients suffered from generalized anxiety disorder","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.molimm.2026.03.006_bib66","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.clim.2009.11.008","article-title":"Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity","volume":"135","author":"Zhang","year":"2010","journal-title":"Clin. Immunol."},{"issue":"3","key":"10.1016\/j.molimm.2026.03.006_bib67","article-title":"Systemic immune-inflammation index is a promising noninvasive marker to predict survival of lung cancer: A meta-analysis","volume":"98","author":"Zhang","year":"2019","journal-title":"Med. (Baltim. )"},{"issue":"6","key":"10.1016\/j.molimm.2026.03.006_bib68","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00403-024-02972-8","article-title":"Evaluation of the inflammatory parameters as potential biomarkers of systemic inflammation extent and the disease severity in psoriasis patients","volume":"316","author":"Zhang","year":"2024","journal-title":"Arch. Dermatol. Res"},{"issue":"10","key":"10.1016\/j.molimm.2026.03.006_bib69","first-page":"6106","article-title":"Imbalance of peripheral blood Th17\/Treg increases neutrophil-to-lymphocyte ratio in patients with dermatomyositis","volume":"15","author":"Zhang","year":"2023","journal-title":"Am. J. Transl. Res"},{"key":"10.1016\/j.molimm.2026.03.006_bib70","article-title":"Association between systemic immune-inflammation index and psoriasis: a population-based study","volume":"15","author":"Zhao","year":"2024","journal-title":"Front Immunol."}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161589026000593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:04:05Z","timestamp":1777579445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161589026000593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":70,"alternative-id":["S0161589026000593"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2026.03.006","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of systemic immune-inflammation index with Th17\/Treg imbalance, disease severity (PASI), and quality of life (DLQI\/PLSI) in patients with psoriasis vulgaris: A cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2026.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}