{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:55:43Z","timestamp":1790618143405,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20240269"],"award-info":[{"award-number":["Y20240269"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Immunology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.molimm.2026.09.002","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:42:30Z","timestamp":1789760550000},"page":"75-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Immune\u2013vascular\u2013fibrotic remodeling defines a neuroimmune tissue niche in systemic sclerosis skin and converges with human peripheral nerve injury programs"],"prefix":"10.1016","volume":"199","author":[{"given":"Yang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molimm.2026.09.002_bib1","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.molimm.2026.09.002_bib2","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.3899\/jrheum.201299","article-title":"Epidemiology and treatment of peripheral neuropathy in systemic sclerosis","volume":"48","author":"AlMehmadi","year":"2021","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.molimm.2026.09.002_bib3","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/acr.25411","article-title":"Evaluating the associations among dysautonomia, gastrointestinal transit, and clinical phenotype in patients with systemic sclerosis","volume":"76","author":"Alvarez-Hernandez","year":"2024","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.molimm.2026.09.002_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2013.05.002","article-title":"Nervous system involvement in systemic sclerosis","author":"Amaral","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.molimm.2026.09.002_bib5","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/art.39289","article-title":"Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis","volume":"67","author":"Assassi","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.molimm.2026.09.002_bib6","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1136\/annrheumdis-2019-215770","article-title":"Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures","volume":"78","author":"Assassi","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2026.09.002_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng1201-365","article-title":"Minimum information about a microarray experiment (MIAME) toward standards for microarray data","volume":"29","author":"Brazma","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molimm.2026.09.002_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.7326\/M14-0697","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis: the TRIPOD statement","volume":"162","author":"Collins","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.molimm.2026.09.002_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-60553-1","article-title":"Heart rate variability helps classify phenotype in systemic sclerosis","volume":"14","author":"Delliaux","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molimm.2026.09.002_bib10","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.molimm.2026.09.002_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/bja\/aet128","article-title":"Neuroinflammation and the generation of neuropathic pain","author":"Ellis","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.molimm.2026.09.002_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41584-022-00864-7","article-title":"Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis","author":"Fang","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.molimm.2026.09.002_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13075-021-02633-5","article-title":"Multiomic study of skin, peripheral blood, and serum: is serum proteome a reflection of disease process at the end-organ level in systemic sclerosis?","volume":"23","author":"Farutin","year":"2021","journal-title":"Arthritis Res. & Ther."},{"key":"10.1016\/j.molimm.2026.09.002_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.molimm.2026.09.002_bib15","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"New. Engl. J. Med."},{"key":"10.1016\/j.molimm.2026.09.002_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2021-220209","article-title":"Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis","author":"Gaydosik","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.molimm.2026.09.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.03.011","article-title":"LGR5 expressing skin fibroblasts define a major cellular hub perturbed in systemic sclerosis","author":"Gur","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2026.09.002_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.molimm.2026.09.002_bib19","article-title":"Autonomic dysfunction in systemic sclerosis: a scoping review","author":"Hughes","year":"2023","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.molimm.2026.09.002_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26099-w","article-title":"Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis","author":"Kuzumi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2026.09.002_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.molimm.2026.09.002_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.molimm.2026.09.002_bib23","first-page":"18","article-title":"Classification and regression by randomForest","volume":"2","author":"Liaw","year":"2002","journal-title":"R. N."},{"key":"10.1016\/j.molimm.2026.09.002_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12974-022-02462-6","article-title":"An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury","volume":"19","author":"Lutz","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.molimm.2026.09.002_bib25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/glia.22899","article-title":"Neuroinflammation in the peripheral nerve: cause, modulator, or bystander in peripheral neuropathies?","volume":"64","author":"Martini","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.molimm.2026.09.002_bib26","unstructured":"Peripheral nerve lesion dataset GSE250152.(n.d.) Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE250152."},{"key":"10.1016\/j.molimm.2026.09.002_bib27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/1756-185X.14042","article-title":"Large fiber peripheral neuropathy in systemic sclerosis: a prospective study using clinical and electrophysiological definition","volume":"24","author":"Raja","year":"2021","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.molimm.2026.09.002_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.molimm.2026.09.002_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.molimm.2026.09.002_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.molimm.2026.09.002_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/life13010034","article-title":"Sympatho-vagal dysfunction in systemic sclerosis: a follow-up study","volume":"13","author":"Rodrigues","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.molimm.2026.09.002_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.899290","article-title":"The systolic pulmonary arterial pressure liaises impaired cardiac autonomic control to pro-inflammatory status in systemic sclerosis patients","volume":"9","author":"Rodrigues","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.molimm.2026.09.002_bib33","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molimm.2026.09.002_bib34","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.molimm.2026.09.002_bib35","unstructured":"Systemic sclerosis and pulmonary hypertension PBMC dataset GSE33463. (n.d.) Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE33463."},{"key":"10.1016\/j.molimm.2026.09.002_bib36","unstructured":"Systemic sclerosis dataset GSE179153. (n.d.) Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE179153."},{"key":"10.1016\/j.molimm.2026.09.002_bib37","unstructured":"Systemic sclerosis single-cell dataset GSE195452. (n.d.) Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE195452."},{"key":"10.1016\/j.molimm.2026.09.002_bib38","unstructured":"Systemic sclerosis skin dataset GSE58095.(n.d.) Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE58095."},{"key":"10.1016\/j.molimm.2026.09.002_bib39","unstructured":"Systemic sclerosis whole-blood dataset GSE130953. (n.d.) Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE130953."},{"key":"10.1016\/j.molimm.2026.09.002_bib40","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1038\/s41467-021-24607-6","article-title":"Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin","volume":"12","author":"Tabib","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molimm.2026.09.002_bib41","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.molimm.2026.09.002_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040296","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology statement: guidelines for reporting observational studies","volume":"4","author":"von Elm","year":"2007","journal-title":"PLoS. Med."},{"key":"10.1016\/j.molimm.2026.09.002_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102172","article-title":"Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair","volume":"208","author":"Wofford","year":"2022","journal-title":"Progress. Neurobiol."},{"key":"10.1016\/j.molimm.2026.09.002_bib44","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41593-021-01005-1","article-title":"Disentangling glial diversity in peripheral nerves at single-nuclei resolution","volume":"25","author":"Yim","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molimm.2026.09.002_bib45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"}],"container-title":["Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016158902600204X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016158902600204X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:58:59Z","timestamp":1790614739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016158902600204X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":45,"alternative-id":["S016158902600204X"],"URL":"https:\/\/doi.org\/10.1016\/j.molimm.2026.09.002","relation":{},"ISSN":["0161-5890"],"issn-type":[{"value":"0161-5890","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune\u2013vascular\u2013fibrotic remodeling defines a neuroimmune tissue niche in systemic sclerosis skin and converges with human peripheral nerve injury programs","name":"articletitle","label":"Article Title"},{"value":"Molecular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molimm.2026.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}