{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:53:58Z","timestamp":1765040038395},"reference-count":17,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.molmed.2005.06.003","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T11:25:50Z","timestamp":1118748350000},"page":"307-309","source":"Crossref","is-referenced-by-count":12,"title":["NOD2 mutation and mice: no Crohn's disease but many lessons to learn"],"prefix":"10.1016","volume":"11","author":[{"given":"Jan","family":"Wehkamp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard F.","family":"Stange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2005.06.003_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/jama.1932.02740680019005","article-title":"Regional ileitis. A pathological and clinical entity","volume":"99","author":"Crohn","year":"1932","journal-title":"J. Am. Med. Assoc."},{"issue":"Suppl. 1","key":"10.1016\/j.molmed.2005.06.003_bib2","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/00054725-200402001-00003","article-title":"Genetic origin of IBD","volume":"10","author":"Hugot","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.molmed.2005.06.003_bib3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/gast.2003.50045","article-title":"The genetics of inflammatory bowel disease","volume":"124","author":"Bonen","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2005.06.003_bib4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/00001574-200411000-00012","article-title":"The Paneth cell and the innate immune response","volume":"20","author":"Bevins","year":"2004","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.molmed.2005.06.003_bib5","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/gut.52.11.1591","article-title":"Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis","volume":"52","author":"Ogura","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.molmed.2005.06.003_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0016-5085(03)00661-9","article-title":"Crohn's disease and the NOD2 gene: a role for Paneth cells","volume":"125","author":"Lala","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2005.06.003_bib7","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1136\/gut.2003.032805","article-title":"NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal a-defensin expression","volume":"53","author":"Wehkamp","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.molmed.2005.06.003_bib8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.1104911","article-title":"Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract","volume":"307","author":"Kobayashi","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.molmed.2005.06.003_bib9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1103685","article-title":"Nod2 mutation in Crohn's disease potentiates NF-\u03baB activity and IL-1\u03b2 processing","volume":"307","author":"Maeda","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.molmed.2005.06.003_bib10","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1189\/jlb.0904543","article-title":"Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease","volume":"77","author":"Wehkamp","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molmed.2005.06.003_bib11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/ni1092","article-title":"NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses","volume":"5","author":"Watanabe","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molmed.2005.06.003_bib12","doi-asserted-by":"crossref","unstructured":"Inohara, N. et al. NOD-LRR proteins: role in host\u2013microbial interactions and inflammatory disease. Annu. Rev. Biochem. (in press) DOI: 10.1146\/annurev.biochem.74.082803.133347 (http:\/\/www.annualreviews.org)","DOI":"10.1146\/annurev.biochem.74.082803.133347"},{"key":"10.1016\/j.molmed.2005.06.003_bib13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/gut.44.6.812","article-title":"T cell specificity and cross reactivity towards enterobacteria, Bacteroides, Bifidobacterium, and antigens from resident intestinal flora in humans","volume":"44","author":"Duchmann","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.molmed.2005.06.003_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molmed.2005.06.003_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.53.1.1","article-title":"Dysbiosis in inflammatory bowel disease","volume":"53","author":"Tamboli","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.molmed.2005.06.003_bib16","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1053\/j.gastro.2004.03.024","article-title":"Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics","volume":"126","author":"Sartor","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2005.06.003_bib17","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1128\/IAI.72.10.5750-5758.2004","article-title":"NF-\u03baB and AP-1 mediated induction of human \u03b2 defensin-2 in intestinal epithelial cells by E. coli Nissle 1917: a novel effect of a probiotic bacterium","volume":"72","author":"Wehkamp","year":"2004","journal-title":"Infect. Immun."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491405001218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491405001218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T06:07:00Z","timestamp":1551074820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491405001218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S1471491405001218"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2005.06.003","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}