{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:49:05Z","timestamp":1793692145041,"version":"4.5.1"},"reference-count":90,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.molmed.2007.09.001","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T12:12:14Z","timestamp":1195042334000},"page":"449-459","source":"Crossref","is-referenced-by-count":60,"title":["Matrix metalloproteinase dysregulation in HIV infection: implications for therapeutic strategies"],"prefix":"10.1016","volume":"13","author":[{"given":"Claudio M.","family":"Mastroianni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia M.","family":"Liuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2007.09.001_bib1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.molmed.2007.09.001_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1042\/bj3090299","article-title":"Binding of gelatinases A and B to type-I collagen and other matrix components","volume":"309","author":"Allan","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.molmed.2007.09.001_bib3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/10409230290771546","article-title":"Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)","volume":"37","author":"Van den Steen","year":"2002","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib4","first-page":"151","article-title":"Activation mechanisms of matrix metalloproteinases","volume":"378","author":"Nagase","year":"1997","journal-title":"Biol. Chem."},{"key":"10.1016\/j.molmed.2007.09.001_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5728(98)00241-0","article-title":"Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system","volume":"94","author":"Cuzner","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib6","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.1016\/S0021-9258(17)37115-6","article-title":"Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues","volume":"269","author":"Leco","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2007.09.001_bib7","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI1584","article-title":"Divergent effects of tissue inhibitors of matrix metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invation, proliferation, and cell death in vitro. TIMP-3 promotes apoptosis","volume":"101","author":"Baker","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2007.09.001_bib8","first-page":"111","article-title":"Tissue inhibitors of metalloproteinases: structure, regulation and biological functions","volume":"74","author":"Gomez","year":"1997","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10409230701340019","article-title":"The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases","volume":"42","author":"Cauwe","year":"2007","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.5483\/BMBRep.2003.36.1.128","article-title":"Roles of matrix metalloproteinases in tumor metastasis and angiogenesis","volume":"36","author":"Yoon","year":"2003","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2249.2005.02840.x","article-title":"The paradox of matrix metalloproteinases in infectious disease","volume":"142","author":"Elkington","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.coi.2005.06.001","article-title":"Viral and host factors in the pathogenesis of HIV infection","volume":"17","author":"Derdeyn","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib13","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.2174\/092986706778742891","article-title":"The pathology induced by highly active antiretroviral therapy against human immunodeficiency virus: an update","volume":"13","author":"Hofman","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.molmed.2007.09.001_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11904-007-0007-8","article-title":"Role of immune activation in HIV pathogenesis","volume":"4","author":"Hunt","year":"2007","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"10.1016\/j.molmed.2007.09.001_bib15","first-page":"361","article-title":"The role of HIV-1 activated leukocyte adhesion mechanisms and matrix metalloproteinases secretion in AIDS pathogenesis","volume":"1","author":"Weeks","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.molmed.2007.09.001_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306152","article-title":"Matrix metalloproteinases, their production by monocytes and macrophages, and their potential role in HIV-related diseases","volume":"80","author":"Webster","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib17","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nrd2308","article-title":"Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases","volume":"6","author":"Hu","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molmed.2007.09.001_bib18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4049\/jimmunol.154.1.422","article-title":"HIV-1 infection alters monocyte interactions with human microvascular endothelial cells","volume":"154","author":"Dhawan","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib19","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.4049\/jimmunol.159.8.4077","article-title":"Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression","volume":"159","author":"Lafrenie","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib20","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/jlb.52.2.244","article-title":"Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices","volume":"52","author":"Dhawan","year":"1992","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1089\/aid.1993.9.513","article-title":"HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase","volume":"9","author":"Weeks","year":"1993","journal-title":"AIDS Res. Hum. Retroviruses."},{"key":"10.1016\/j.molmed.2007.09.001_bib22","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1006\/bbrc.1994.2600","article-title":"Modulations of 92kDa gelatinase B and its inhibitors are associated with HIV-1 infection in human macrophage cultures","volume":"204","author":"Chapel","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molmed.2007.09.001_bib23","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1128\/JVI.79.7.4479-4491.2005","article-title":"Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation","volume":"79","author":"V\u00e1zquez","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2007.09.001_bib24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0014-5793(99)01487-8","article-title":"Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB","volume":"462","author":"Kumar","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molmed.2007.09.001_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1182\/blood.V98.3.541","article-title":"HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway","volume":"98","author":"Misse","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.molmed.2007.09.001_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jneuroim.2004.08.033","article-title":"Diminished matrix metalloproteinase 9 secretion in human immunodeficiency virus-infected mononuclear phagocytes: modulation of innate immunity and implications for neurological disease","volume":"157","author":"Ciborowski","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/QAD.0b013e328018751d","article-title":"Antiretroviral therapy inhibits matrix metalloproteinase-9 from blood mononuclear cells of HIV-infected patients","volume":"21","author":"Latronico","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.molmed.2007.09.001_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/glia.10266","article-title":"Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia","volume":"44","author":"Suryadevara","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.molmed.2007.09.001_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S1074-7613(03)00060-8","article-title":"Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia","volume":"18","author":"Silvestri","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.molmed.2007.09.001_bib30","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1182\/blood-2003-09-3333","article-title":"Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load","volume":"104","author":"Deeks","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.molmed.2007.09.001_bib31","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1097\/00002030-200309050-00006","article-title":"Persistent immune activation in HIV-1 infection is associated with progression to AIDS","volume":"17","author":"Hazenberg","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.molmed.2007.09.001_bib32","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1086\/374786","article-title":"T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus\u2013infected patients with sustained viral suppression during antiretroviral therapy","volume":"187","author":"Hunt","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molmed.2007.09.001_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nm1380","article-title":"Pathogenesis of HIV infection: what the virus spares is as important as what it destroys","volume":"12","author":"Grossman","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2007.09.001_bib34","first-page":"187","article-title":"Cytokines and cytokine therapies in HIV infection","author":"Valdez","year":"1997","journal-title":"AIDS Clin. Rev."},{"key":"10.1016\/j.molmed.2007.09.001_bib35","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection","volume":"12","author":"Brenchley","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2007.09.001_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11904-007-0005-x","article-title":"Current concepts of HIV transmission","volume":"4","author":"Morrow","year":"2007","journal-title":"Curr HIV\/AIDS Rep."},{"key":"10.1016\/j.molmed.2007.09.001_bib37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nri1960","article-title":"Dendritic-cell interactions with HIV: infection and viral dissemination","volume":"6","author":"Wu","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.virusres.2005.04.009","article-title":"Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus","volume":"111","author":"Kramer-Hammerle","year":"2005","journal-title":"Virus Res."},{"key":"10.1016\/j.molmed.2007.09.001_bib39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10571-004-1383-x","article-title":"Mechanisms of the blood-brain barrier disruption in HIV-1 infection","volume":"25","author":"Toborek","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.molmed.2007.09.001_bib40","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4049\/jimmunol.178.1.520","article-title":"Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases","volume":"178","author":"Zozulya","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib41","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2174\/138161206776055877","article-title":"Developments in HIV neuropathogenesis","volume":"12","author":"Rumbaugh","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.molmed.2007.09.001_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/13550280390194109","article-title":"Human immunodeficiency virus-associated dementia: an evolving disease","volume":"9","author":"McArthur","year":"2003","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.molmed.2007.09.001_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00001756-199412300-00040","article-title":"Myelin degrading activity in the CSF of HIV-1-infected patients with neurological diseases","volume":"6","author":"Liuzzi","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.molmed.2007.09.001_bib44","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nn1127","article-title":"HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration","volume":"6","author":"Zhang","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molmed.2007.09.001_bib45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1468-1331.1994.tb00051.x","article-title":"Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases","volume":"1","author":"Paemen","year":"1994","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.molmed.2007.09.001_bib46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0165-5728(99)00170-8","article-title":"Human immunodeficiency virus type-1 Nef protein induces blood\u2013brain barrier disruption in the rat: role of matrix metalloproteinase-9","volume":"102","author":"Sporer","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib47","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1006\/nbdi.1999.0261","article-title":"Microglial activation and neurological symptoms in the SIV model of NeuroAIDS: association of MHC-II and MMP-9 expression with behavioral deficits and evoked potential changes","volume":"6","author":"Berman","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.molmed.2007.09.001_bib48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/1531-8249(199909)46:3<391::AID-ANA15>3.0.CO;2-0","article-title":"Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia","volume":"46","author":"Conant","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.molmed.2007.09.001_bib49","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1086\/515342","article-title":"Presence of matrix metalloproteinase-9 activity in the cerebrospinal fluid of human immunodeficiency virus-infected patients","volume":"178","author":"Sporer","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molmed.2007.09.001_bib50","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/13550280009013159","article-title":"Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases","volume":"6","author":"Liuzzi","year":"2000","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.molmed.2007.09.001_bib51","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1128\/JVI.74.16.7211-7220.2000","article-title":"Lentivirus infection in the brain induces matrix metalloproteinase expression: role of envelope diversity","volume":"74","author":"Johnston","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2007.09.001_bib52","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1600-0560.2006.00567.x","article-title":"Matrix metalloproteinases in the progression and regression of Kaposi's sarcoma","volume":"33","author":"Pantanowitz","year":"2006","journal-title":"J. Cutan. Pathol."},{"key":"10.1016\/j.molmed.2007.09.001_bib53","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1091\/mbc.12.10.2934","article-title":"Activation of matrix-metalloproteinase-2 and membrane-type-1-matrix-metalloproteinase in endothelial cells and induction of vascular permeability in vivo by human immunodeficiency virus-1 Tat protein and basic fibroblast growth factor","volume":"12","author":"Toschi","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molmed.2007.09.001_bib54","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1600-0765.2006.00887.x","article-title":"The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients","volume":"41","author":"Alpagot","year":"2006","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.molmed.2007.09.001_bib55","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1600-0714.2006.00449.x","article-title":"Matrix metalloproteinase-7, -8, -9, -25, and -26 and CD43, -45, and -68 cell-markers in HIV-infected patients\u2019 saliva and gingival tissue","volume":"35","author":"Mellanen","year":"2006","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.molmed.2007.09.001_bib56","doi-asserted-by":"crossref","first-page":"c100","DOI":"10.1159\/000074323","article-title":"Matrix metalloproteinase-9 expression in renal biopsies of patients with HIV-associated nephropathy","volume":"95","author":"Ahuja","year":"2003","journal-title":"Nephron Clin. Pract."},{"key":"10.1016\/j.molmed.2007.09.001_bib57","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1310\/U9LJ-MFF9-ARE1-257H","article-title":"Matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 in plasma of patients co-infected with HCV and HIV","volume":"3","author":"Mastroianni","year":"2002","journal-title":"HIV Clin. Trials"},{"key":"10.1016\/j.molmed.2007.09.001_bib58","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1530-0277.1999.tb04202.x","article-title":"Cytokine regulation of hepatic stellate cells in liver fibrosis","volume":"23","author":"Tsukamoto","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.molmed.2007.09.001_bib59","doi-asserted-by":"crossref","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","article-title":"Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis","volume":"279","author":"Arthur","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.molmed.2007.09.001_bib60","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa062744","article-title":"Class of antiretroviral drugs and the risk of myocardial infarction","volume":"356","author":"Friis-Moller","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molmed.2007.09.001_bib61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1468-1293.2007.00436.x","article-title":"Interruption of combination antiretroviral therapy and risk of clinical disease progression to AIDS or death","volume":"8","author":"Holkmann Olsen","year":"2007","journal-title":"HIV Med."},{"key":"10.1016\/j.molmed.2007.09.001_bib62","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nri1882","article-title":"The immune response in atherosclerosis: a double-edged sword","volume":"6","author":"Hansson","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molmed.2007.09.001_bib63","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.mol.0000245262.48258.b4","article-title":"Do metalloproteinases destabilize vulnerable atherosclerotic plaques?","volume":"17","author":"Newby","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.molmed.2007.09.001_bib64","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1586\/14779072.5.2.265","article-title":"Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability","volume":"5","author":"Johnson","year":"2007","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.molmed.2007.09.001_bib65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2174\/138161207779313551","article-title":"Matrix metalloproteinases as valid clinical targets","volume":"13","author":"Fingleton","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.molmed.2007.09.001_bib66","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1086\/509627","article-title":"Immune-based therapy for HIV infection: are acute and chronic HIV infection different diseases?","volume":"194","author":"Hunt","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molmed.2007.09.001_bib67","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00002030-200102160-00004","article-title":"Placebo-controlled trial of prednisone in advanced HIV-1 infection","volume":"15","author":"McComsey","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.molmed.2007.09.001_bib68","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1097\/00002030-200107270-00007","article-title":"Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression","volume":"15","author":"Havlir","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.molmed.2007.09.001_bib69","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00126334-200204010-00005","article-title":"Placebo-controlled trial of cyclosporine-A in HIV-1 disease: implications for solid organ transplantation","volume":"29","author":"Lederman","year":"2002","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.molmed.2007.09.001_bib70","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/00002030-200409240-00008","article-title":"Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patients","volume":"18","author":"Sankatsing","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.molmed.2007.09.001_bib71","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1021\/cr9804543","article-title":"Design and therapeutic application of matrix metalloproteinase inhibitors","volume":"99","author":"Whittaker","year":"1999","journal-title":"Chem. Rev."},{"key":"10.1016\/j.molmed.2007.09.001_bib72","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1200\/JCO.2005.04.2614","article-title":"Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study","volume":"24","author":"Dezube","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.molmed.2007.09.001_bib73","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00005-006-0047-6","article-title":"The effects of the initial treatment phase and of adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in the saliva and peripheral blood of patients with chronic periodontitis","volume":"54","author":"G\u00f3rska","year":"2006","journal-title":"Arch. Immunol. Ther. Exp. (Warsz.)"},{"key":"10.1016\/j.molmed.2007.09.001_bib74","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1128\/IAI.01949-05","article-title":"Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis","volume":"74","author":"Meli","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.molmed.2007.09.001_bib75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0006-2952(96)00168-2","article-title":"The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors","volume":"52","author":"Paemen","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molmed.2007.09.001_bib76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/01.wnf.0000150867.98887.3e","article-title":"The potential of minocycline for neuroprotection in human neurologic disease","volume":"27","author":"Zemke","year":"2004","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.molmed.2007.09.001_bib77","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.293.16.2003","article-title":"Neuroprotective and anti-human immunodeficiency virus activity of minocycline","volume":"293","author":"Zink","year":"2005","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.molmed.2007.09.001_bib78","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.ATV.0000068646.76823.AE","article-title":"Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages","volume":"23","author":"Luan","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2007.09.001_bib79","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.HYP.36.3.325","article-title":"Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells","volume":"36","author":"Ikeda","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.molmed.2007.09.001_bib80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/CS20060110","article-title":"Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction","volume":"112","author":"Yasuda","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.molmed.2007.09.001_bib81","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1051\/rnd:2004034","article-title":"Alteration of polyunsaturated fatty acid status and metabolism in health and disease","volume":"44","author":"Zamaria","year":"2004","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.molmed.2007.09.001_bib82","article-title":"Inhibitory effect of polyunsaturated fatty acids on MMP-9 release from microglial cells \u2013 implications for complementary multiple sclerosis treatment","volume":"11","author":"Liuzzi","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.molmed.2007.09.001_bib83","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/brain\/awh049","article-title":"Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia","volume":"127","author":"Liuzzi","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.molmed.2007.09.001_bib84","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/jac\/dkg086","article-title":"HIV protease inhibitors: antiretroviral agents with anti-inflammatory, anti-angiogenic and anti-tumour activity","volume":"51","author":"Monini","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.molmed.2007.09.001_bib85","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10495-006-5699-5","article-title":"HIV protease inhibitor therapy reverses neutrophil apoptosis in AIDS patients by direct calpain inhibition","volume":"11","author":"Lichtner","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.molmed.2007.09.001_bib86","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1124\/jpet.106.111849","article-title":"Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9","volume":"320","author":"De Barros","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2007.09.001_bib87","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1517\/13543784.9.9.2167","article-title":"Ongoing trials with matrix metalloproteinase inhibitors","volume":"9","author":"Brown","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.molmed.2007.09.001_bib88","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1023047431869","article-title":"Matrix metalloproteinase inhibitors (MMPIs): the beginning of phase I or the termination of phase III clinical trials","volume":"22","author":"Pavlaki","year":"2003","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.molmed.2007.09.001_bib89","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.2174\/0929867043364018","article-title":"The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors","volume":"11","author":"Skiles","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.molmed.2007.09.001_bib90","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1191\/1352458505ms1143oa","article-title":"Lipoic acid in multiple sclerosis: a pilot study","volume":"11","author":"Yadav","year":"2005","journal-title":"Mult. Scler."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491407001815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491407001815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T18:36:14Z","timestamp":1684089374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491407001815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":90,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S1471491407001815"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2007.09.001","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}