{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:47:06Z","timestamp":1793296026589,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.molmed.2010.03.003","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T04:17:44Z","timestamp":1272946664000},"page":"238-246","source":"Crossref","is-referenced-by-count":1266,"title":["Inflammatory networks during cellular senescence: causes and consequences"],"prefix":"10.1016","volume":"16","author":[{"given":"Adam","family":"Freund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo V.","family":"Orjalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Desprez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Campisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2010.03.003_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2005.04.009","article-title":"Molecular mechanisms of aging-associated inflammation","volume":"236","author":"Sarkar","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.molmed.2010.03.003_bib2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2010.03.003_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mad.2006.11.015","article-title":"Inflammatory networks in ageing, age-related diseases and longevity","volume":"128","author":"Vasto","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.molmed.2010.03.003_bib4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF03327390","article-title":"A flame burning within","volume":"16","author":"Ferrucci","year":"2004","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib5","first-page":"285","article-title":"The clinical impact of systemic low-level inflammation in elderly populations. With special reference to cardiovascular disease, dementia and mortality","volume":"53","author":"Bruunsgaard","year":"2006","journal-title":"Dan. Med. Bull."},{"key":"10.1016\/j.molmed.2010.03.003_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/gerona\/61.6.575","article-title":"Interleukin-6 in aging and chronic disease: a magnificent pathway","volume":"61","author":"Maggio","year":"2006","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.molmed.2010.03.003_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.molmed.2010.03.003_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/oxfordjournals.bmb.a072967","article-title":"Cytokine expression in chronic inflammatory disease","volume":"51","author":"Brennan","year":"1995","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.molmed.2010.03.003_bib9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s000110050632","article-title":"Unregulated inflammation shortens human functional longevity","volume":"49","author":"Brod","year":"2000","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1322.001","article-title":"Aging, longevity, inflammation, and cancer","volume":"1028","author":"Caruso","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.molmed.2010.03.003_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrc2560","article-title":"Senescence-messaging secretome: SMS-ing cellular stress","volume":"9","author":"Kuilman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molmed.2010.03.003_bib12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.molmed.2010.03.003_bib13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.coi.2009.05.023","article-title":"Immunosenescence: what does it mean to health outcomes in older adults?","volume":"21","author":"McElhaney","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.molmed.2010.03.003_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1242\/jcs.01635","article-title":"Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation","volume":"118","author":"Parrinello","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.molmed.2010.03.003_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.autrev.2005.09.008","article-title":"Aging of the immune system: a risk factor for autoimmunity?","volume":"5","author":"Prelog","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.molmed.2010.03.003_bib17","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1474-9726.2008.00399.x","article-title":"Stem cell review series: aging of the skeletal muscle stem cell niche","volume":"7","author":"Gopinath","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1474-9726.2007.00286.x","article-title":"Loss of stem cell regenerative capacity within aged niches","volume":"6","author":"Carlson","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.it.2005.08.002","article-title":"IGF-1, inflammation and stem cells: interactions during muscle regeneration","volume":"26","author":"Mourkioti","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molmed.2010.03.003_bib20","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/cdd.2009.74","article-title":"IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling","volume":"16","author":"Huang","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.molmed.2010.03.003_bib21","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1182\/blood-2007-06-093328","article-title":"Interleukin-27 directly induces differentiation in hematopoietic stem cells","volume":"111","author":"Seita","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.molmed.2010.03.003_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2009.10.014","article-title":"An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation","volume":"139","author":"Iliopoulos","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib23","doi-asserted-by":"crossref","unstructured":"Copp\u00e9, J.P. et al. (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, 2853\u20132868","DOI":"10.1371\/journal.pbio.0060301"},{"key":"10.1016\/j.molmed.2010.03.003_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/embor.2009.22","article-title":"SASP reflects senescence","volume":"10","author":"Young","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molmed.2010.03.003_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.molmed.2010.03.003_bib26","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1073\/pnas.89.10.4683","article-title":"Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts","volume":"89","author":"Kumar","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2010.03.003_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0047-6374(96)01814-3","article-title":"Characterization of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblasts","volume":"92","author":"Wang","year":"1996","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.molmed.2010.03.003_bib28","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human nevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2010.03.003_bib29","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature03841","article-title":"Oncogene-induced senescence as an initial barrier in lymphoma development","volume":"436","author":"Braig","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2010.03.003_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc2772","article-title":"Senescence in tumours: evidence from mice and humans","volume":"10","author":"Collado","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molmed.2010.03.003_bib31","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.biocel.2004.10.013","article-title":"The signals and pathways activating cellular senescence","volume":"37","author":"Ben-Porath","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.molmed.2010.03.003_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2005.01.028","article-title":"DNA repair, genome stability, and aging","volume":"120","author":"Lombard","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib33","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1158\/0008-5472.CAN-05-4006","article-title":"Oncogene-induced senescence: putting the brakes on tumor development","volume":"66","author":"Braig","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib34","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrc1884","article-title":"The power and the promise of oncogene-induced senescence markers","volume":"6","author":"Collado","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molmed.2010.03.003_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molmed.2010.03.003_bib36","doi-asserted-by":"crossref","first-page":"29568","DOI":"10.1074\/jbc.M603307200","article-title":"Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence","volume":"281","author":"Copp\u00e9","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2010.03.003_bib37","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1073\/pnas.211053698","article-title":"Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging","volume":"98","author":"Krtolica","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2010.03.003_bib38","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1158\/0008-5472.CAN-06-3452","article-title":"Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion","volume":"67","author":"Liu","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib39","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.yexcr.2006.12.027","article-title":"Glioma-associated endothelial cells show evidence of replicative senescence","volume":"313","author":"Charalambous","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib40","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1158\/0008-5472.CAN-08-0400","article-title":"Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner","volume":"68","author":"Studebaker","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature05529","article-title":"Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas","volume":"445","author":"Xue","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2010.03.003_bib42","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2010.03.003_bib43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mad.2006.11.008","article-title":"Accumulation of senescent cells in mitotic tissue of aging primates","volume":"128","author":"Jeyapalan","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.molmed.2010.03.003_bib44","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krizhanovsky","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2010.03.003_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1474-9728.2002.00008.x","article-title":"The role of chondrocyte senescence in osteoarthritis","volume":"1","author":"Price","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib46","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1096\/fj.00-0051com","article-title":"Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF\/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis","volume":"15","author":"Vasile","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.molmed.2010.03.003_bib47","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.exger.2005.04.010","article-title":"Cellular senescence in vivo: its relevance in ageing and cardiovascular disease","volume":"40","author":"Erusalimsky","year":"2005","journal-title":"Exp. Gerontol."},{"issue":"Suppl. 3","key":"10.1016\/j.molmed.2010.03.003_bib48","article-title":"Senescence in human intervertebral discs","volume":"15","author":"Roberts","year":"2006","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.molmed.2010.03.003_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/pros.10204","article-title":"Cellular senescence in the pathogenesis of benign prostatic hyperplasia","volume":"55","author":"Castro","year":"2003","journal-title":"Prostate"},{"key":"10.1016\/j.molmed.2010.03.003_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0090-4295(00)00538-0","article-title":"Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia","volume":"56","author":"Choi","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.molmed.2010.03.003_bib51","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence","volume":"133","author":"Acosta","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2007.12.032","article-title":"Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7","volume":"132","author":"Wajapeyee","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib53","doi-asserted-by":"crossref","first-page":"16472","DOI":"10.1073\/pnas.0605752103","article-title":"The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis","volume":"103","author":"Yang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2010.03.003_bib54","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib56","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molmed.2010.03.003_bib57","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc2440","article-title":"Living on a break: cellular senescence as a DNA-damage response","volume":"8","author":"d\u2019Adda di Fagagna","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.molmed.2010.03.003_bib58","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1186\/gb-2005-6-5-r43","article-title":"Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis","volume":"6","author":"Elkon","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.molmed.2010.03.003_bib59","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.bbamcr.2007.03.010","article-title":"p38 MAP-kinases pathway regulation, function and role in human diseases","volume":"1773","author":"Cuenda","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molmed.2010.03.003_bib60","doi-asserted-by":"crossref","first-page":"11237","DOI":"10.1074\/jbc.M808327200","article-title":"p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms","volume":"284","author":"Kwong","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2010.03.003_bib61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2443.2003.00620.x","article-title":"Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway","volume":"8","author":"Iwasa","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.molmed.2010.03.003_bib62","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1128\/MCB.22.10.3389-3403.2002","article-title":"Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3\/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence","volume":"22","author":"Wang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.molmed.2010.03.003_bib63","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1128\/MCB.13.10.6231","article-title":"Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop","volume":"13","author":"Hiscott","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.molmed.2010.03.003_bib64","doi-asserted-by":"crossref","first-page":"16452","DOI":"10.1074\/jbc.M309789200","article-title":"Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells","volume":"279","author":"Niu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2010.03.003_bib65","doi-asserted-by":"crossref","first-page":"17031","DOI":"10.1073\/pnas.0905299106","article-title":"Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6\/IL-8 cytokine network","volume":"106","author":"Orjalo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2010.03.003_bib66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","article-title":"NF-kappaB and cancer-identifying targets and mechanisms","volume":"18","author":"Naugler","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.molmed.2010.03.003_bib67","doi-asserted-by":"crossref","first-page":"402","DOI":"10.18632\/aging.100042","article-title":"MicroRNAs miR-146a\/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8","volume":"1","author":"Bhaumik","year":"2009","journal-title":"Aging"},{"key":"10.1016\/j.molmed.2010.03.003_bib68","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2010.03.003_bib69","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00412-007-0115-7","article-title":"Cellular senescence and chromatin structure","volume":"116","author":"Funayama","year":"2007","journal-title":"Chromosoma"},{"key":"10.1016\/j.molmed.2010.03.003_bib70","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1196\/annals.1395.027","article-title":"Alterations to nuclear architecture and genome behavior in senescent cells","volume":"1100","author":"Mehta","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.molmed.2010.03.003_bib71","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.gene.2007.04.020","article-title":"Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging","volume":"397","author":"Adams","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.molmed.2010.03.003_bib72","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/sj.bjc.6603636","article-title":"Cellular senescence and chromatin organisation","volume":"96","author":"Narita","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.molmed.2010.03.003_bib73","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molmed.2010.03.003_bib74","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1474-9726.2007.00313.x","article-title":"Remodeling chromatin for senescence","volume":"6","author":"Adams","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.molmed.2010.03.003_bib75","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1158\/0008-5472.CAN-05-1716","article-title":"The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms","volume":"66","author":"Bavik","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2010.03.003_bib76","doi-asserted-by":"crossref","first-page":"e9188","DOI":"10.1371\/journal.pone.0009188","article-title":"A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen","volume":"5","author":"Coppe","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2010.03.003_bib77","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0531-5565(95)02013-6","article-title":"Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence","volume":"31","author":"West","year":"1996","journal-title":"Exp. Gerontol."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491410000468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491410000468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:02:18Z","timestamp":1559070138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491410000468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1471491410000468"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2010.03.003","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}