{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:49:29Z","timestamp":1792648169937,"version":"4.5.0"},"reference-count":112,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.molmed.2015.06.003","type":"journal-article","created":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T04:36:40Z","timestamp":1436071000000},"page":"492-503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":222,"title":["Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia"],"prefix":"10.1016","volume":"21","author":[{"given":"Heather A.","family":"McCauley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Guasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2015.06.003_bib0565","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbagen.2014.05.003","article-title":"Mucins: a biologically relevant glycan barrier in mucosal protection","volume":"1850","author":"Corfield","year":"2014","journal-title":"Biochim. Biophys. Acta Gen. Sub."},{"key":"10.1016\/j.molmed.2015.06.003_bib0570","first-page":"2127","article-title":"Development of conjunctival goblet cells and their neuroreceptor subtype expression","volume":"41","author":"Rios","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0575","first-page":"2270","article-title":"Presence of nerves and their receptors in mouse and human conjunctival goblet cells","volume":"42","author":"Diebold","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0580","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2003.10.005","article-title":"Control of mucin production by ocular surface epithelial cells","volume":"78","author":"Dartt","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0585","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1167\/iovs.10-7068","article-title":"Mouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4","volume":"52","author":"Gupta","year":"2011","journal-title":"Invest. Opthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0590","doi-asserted-by":"crossref","first-page":"1131S","DOI":"10.1093\/ajcn\/73.6.1131S","article-title":"Microbial modulation of innate defense: goblet cells and the intestinal mucus layer","volume":"73","author":"Delplancke","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.molmed.2015.06.003_bib0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1357-2725(02)00083-3","article-title":"The airway goblet cell","volume":"35","author":"Rogers","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0600","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","article-title":"NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion","volume":"156","author":"Wlodarska","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib0605","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/rr43","article-title":"Role of epidermal growth factor receptor activation in regulating mucin synthesis","volume":"2","author":"Nadel","year":"2001","journal-title":"Respir. Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0610","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0034-5687(00)00209-7","article-title":"Motor control of airway goblet cells and glands","volume":"125","author":"Rogers","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0615","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1083\/jcb.85.3.626","article-title":"Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine","volume":"85","author":"Specian","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0620","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.1000833","article-title":"Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation","volume":"186","author":"Dartt","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0625","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1167\/iovs.07-0770","article-title":"The ocular surface: the challenge to enable and protect vision","volume":"48","author":"Gipson","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0630","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrgastro.2013.35","article-title":"The gastrointestinal mucus system in health and disease","volume":"10","author":"Johansson","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0635","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.stem.2010.11.016","article-title":"Tissue-resident adult stem cell populations of rapidly self-renewing organs","volume":"7","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib0640","first-page":"236","article-title":"Label-retaining cells are preferentially located in fornical epithelium: Implications on conjunctival epithelial homeostasis","volume":"36","author":"Wei","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0645","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/wdev.58","article-title":"Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease","volume":"2","author":"Wansleeban","year":"2013","journal-title":"WIREs Dev. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0650","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-1119(99)00484-9","article-title":"Cloning and expression of the mouse Pse gene encoding a novel Ets family member","volume":"241","author":"Yamada","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.molmed.2015.06.003_bib0655","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1074\/jbc.275.2.1216","article-title":"PDEF, a novel prostate epithelium-specific Ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression","volume":"275","author":"Oettgen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2015.06.003_bib0660","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1053\/j.gastro.2009.06.044","article-title":"The Ets-domain transcription factor Spdef promotes maturation of goblet and Paneth cells in the intestinal epithelium","volume":"137","author":"Gregorieff","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0665","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.yexcr.2009.09.020","article-title":"SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells","volume":"316","author":"Noah","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0670","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI29176","article-title":"SPDEF regulates goblet cell hyperplasia in the airway epithelium","volume":"117","author":"Park","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2015.06.003_bib0675","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajpath.2013.03.017","article-title":"Spdef null mice lack conjunctival goblet cells and provide a model of dry eye","volume":"183","author":"Marko","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0680","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1242\/dev.117804","article-title":"TGF\u03b2 signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium","volume":"141","author":"McCauley","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0685","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.yexcr.2011.09.006","article-title":"Intestinal development and differentiation","volume":"317","author":"Noah","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0690","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.201010127","article-title":"Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium","volume":"192","author":"Gerbe","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0695","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1101\/gad.1674008","article-title":"The intestinal stem cell","volume":"22","author":"Barker","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.molmed.2015.06.003_bib0700","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1101\/gad.1295405","article-title":"Wnt signaling in the intestinal epithelium: from endoderm to cancer","volume":"19","author":"Gregorieff","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.molmed.2015.06.003_bib0705","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1126\/science.1065718","article-title":"Requirement of Math1 for secretory cell lineage commitment in the mouse intestine","volume":"294","author":"Yang","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.molmed.2015.06.003_bib0710","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.yexcr.2011.07.010","article-title":"Stem cell self-renewal in intestinal crypt","volume":"317","author":"Simons","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0715","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1242\/dev.129.11.2619","article-title":"The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon","volume":"129","author":"Katz","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0720","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1053\/gast.2001.24029","article-title":"Keratinocyte growth factor promotes goblet cell differentiation through regulation of goblet cell silencer inhibitor","volume":"120","author":"Iwakiri","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0725","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1073\/pnas.1120269109","article-title":"Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin","volume":"109","author":"Ambort","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.molmed.2015.06.003_bib0730","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/bj3410461","article-title":"Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from coll-aboration of complex series of positive and negative regulatory elements","volume":"341","author":"Itoh","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.molmed.2015.06.003_bib0735","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/pmj.76.898.473","article-title":"Mucins and inflammatory bowel disease","volume":"76","author":"Shirazi","year":"2000","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.molmed.2015.06.003_bib0740","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1126\/science.1104815","article-title":"Self-renewal and cancer of the gut: two sides of a coin","volume":"307","author":"Radtke","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.molmed.2015.06.003_bib0745","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.devcel.2009.12.010","article-title":"Preparing for the first breath: genetic and cellular mechanisms in lung development","volume":"18","author":"Morrisey","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib0750","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ni.3045","article-title":"Respiratory epithelial cells orchestrate pulmonary innate immunity","volume":"16","author":"Whitsett","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0755","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.molmed.2015.06.003_bib0760","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.stem.2011.04.003","article-title":"Notch-dependent differentiation of adult airway basal stem cells","volume":"8","author":"Rock","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib0765","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/01902148.2013.791733","article-title":"Cellular and molecular mechanisms of goblet cell metaplasia in the respiratory airways","volume":"39","author":"Boucherat","year":"2013","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0770","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1164\/rccm.201103-0495PP","article-title":"Intersections between pulmonary development and disease","volume":"184","author":"Whitsett","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.molmed.2015.06.003_bib0775","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.celrep.2014.12.017","article-title":"Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung","volume":"10","author":"Danahay","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.molmed.2015.06.003_bib0780","doi-asserted-by":"crossref","first-page":"e8248","DOI":"10.1371\/journal.pone.0008248","article-title":"Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated and goblet cells","volume":"4","author":"Tompkins","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molmed.2015.06.003_bib0785","doi-asserted-by":"crossref","first-page":"223302247","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfunction","volume":"363","author":"Fahy","year":"2010","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.molmed.2015.06.003_bib0790","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/103947","article-title":"Ocular surface development and gene expession","volume":"2013","author":"Swamynathan","year":"2013","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0795","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","article-title":"Regulation of mucin and fluid secretion by conjunctival epithelial cells","volume":"21","author":"Dartt","year":"2002","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0800","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1242\/dev.082842","article-title":"Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity","volume":"140","author":"Zhang","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0805","first-page":"753","article-title":"Clonal analysis of the in vivo differentiation potential of keratinocytes","volume":"38","author":"Wei","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0810","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.145.4.769","article-title":"Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface","volume":"145","author":"Pellegrini","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0815","first-page":"1814","article-title":"In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia","volume":"34","author":"Wei","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0820","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ACI.0b013e32830e6b04","article-title":"Functions of ocular surface mucins in health and disease","volume":"8","author":"Mantelli","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0825","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nature03589","article-title":"Notch signals control the fate of immature progenitor cells in the intestine","volume":"435","author":"Fre","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2015.06.003_bib0830","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1242\/dev.029249","article-title":"Notch signaling promotes airway mucous metaplasia and inhibits alveolar development","volume":"136","author":"Guseh","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0835","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1210\/en.2004-0051","article-title":"Minireview: development and differentiation of gut endocrine cells","volume":"145","author":"Schonhoff","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0840","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical Notch signaling pathway: Unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib0845","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.1353905","article-title":"Gfi1 functions downstream of Math1 to control intestinal secretory cell sybtype allocation and differentiation","volume":"19","author":"Shroyer","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.molmed.2015.06.003_bib0850","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1053\/j.gastro.2007.03.047","article-title":"Intestine-specific ablation of Mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis","volume":"132","author":"Shroyer","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0855","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1101\/gad.341705","article-title":"Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells","volume":"19","author":"Zecchini","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.molmed.2015.06.003_bib0860","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2199-15-3","article-title":"Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine","volume":"15","author":"Aronson","year":"2014","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0865","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2011.01.033","article-title":"GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice","volume":"140","author":"Beuling","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0870","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/jcs.058669","article-title":"Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate","volume":"123","author":"Morimoto","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0875","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/dev.034884","article-title":"Notch signaling controls the balance of ciliated and secretory cell fates in developing airways","volume":"136","author":"Tsao","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0880","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4049\/jimmunol.1003606","article-title":"MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways","volume":"187","author":"Kang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0885","doi-asserted-by":"crossref","first-page":"G490","DOI":"10.1152\/ajpgi.90393.2008","article-title":"KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract","volume":"296","author":"Zheng","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0890","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1158\/1541-7786.MCR-08-0224","article-title":"Notch inhibits expression of the Kruppel-like factor 4 tumor suppressor in the intestinal epithelium","volume":"6","author":"Ghaleb","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib0895","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/bies.20581","article-title":"The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology","volume":"29","author":"McConnell","year":"2007","journal-title":"Bioessays"},{"key":"10.1016\/j.molmed.2015.06.003_bib0900","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/MCB.00846-06","article-title":"Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells","volume":"27","author":"Swamynathan","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0905","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1074\/jbc.271.33.20009","article-title":"Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest","volume":"271","author":"Shields","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2015.06.003_bib0910","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1242\/dev.00477","article-title":"Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier","volume":"130","author":"Jaubert","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0915","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ydbio.2011.05.005","article-title":"Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells","volume":"356","author":"Kenchegowda","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0920","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1074\/jbc.C000870200","article-title":"Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation","volume":"276","author":"Sun","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2015.06.003_bib0925","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2011.01.005","article-title":"Dll1- and Dll4-mediated Notch signaling are required for homeostasis of intestinal stem cells","volume":"140","author":"Pellegrinet","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0930","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2012.12.010","article-title":"Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium","volume":"375","author":"Bell","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0935","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10620-014-3307-z","article-title":"Kruppel-Like factor 5 is required for proper maintenance of adult intestinal crypt cellular proliferation","volume":"60","author":"Bell","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib0940","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bbrc.2008.02.158","article-title":"Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells","volume":"369","author":"Sluis","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molmed.2015.06.003_bib0945","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1053\/j.gastro.2009.08.059","article-title":"Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice","volume":"137","author":"Ye","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2015.06.003_bib0950","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.00966","article-title":"Foxa2 regulates alveolarization and goblet cell hyperplasia","volume":"131","author":"Wan","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0955","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1164\/rccm.201101-0106OC","article-title":"Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation","volume":"184","author":"Maeda","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.molmed.2015.06.003_bib0960","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1152\/ajplung.00172.2005","article-title":"\u03b2-Catenin regulates differentiation of respiratory epithelial cells in vivo","volume":"289","author":"Mucenski","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0965","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1164\/rccm.201306-1181OC","article-title":"Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity","volume":"189","author":"Chen","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.molmed.2015.06.003_bib0970","first-page":"2914","article-title":"SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production","volume":"119","author":"Chen","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2015.06.003_bib0975","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1242\/dev.079699","article-title":"Foxp1\/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2","volume":"139","author":"Li","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.molmed.2015.06.003_bib0980","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1101\/gad.267103","article-title":"Canonical Wnt signals are essential for homeostasis of the intestinal epithelium","volume":"17","author":"Pinto","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.molmed.2015.06.003_bib0985","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1073\/pnas.1309342111","article-title":"Shp2\/MAPK signaling controls goblet\/paneth cell fate decisions in the intestine","volume":"111","author":"Heuberger","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molmed.2015.06.003_bib0990","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ncb1240","article-title":"Wnt signalling induces maturation of Paneth cells in intestinal crypts","volume":"7","author":"vanEs","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib0995","first-page":"1","article-title":"Disruption of TGF-\u03b2 signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca","volume":"6","author":"DePaiva","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molmed.2015.06.003_bib1000","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","article-title":"Specificity and versatility in TGF-\u03b2 signaling through smads","volume":"21","author":"Feng","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib1005","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads: Transcriptional activators of TGF-\u03b2 responses","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib1010","first-page":"31","article-title":"Signaling moderation: TGF-\u03b2 in exocrine gland development, maintenance, and regulation","volume":"23","author":"McNairn","year":"2013","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.molmed.2015.06.003_bib1015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ccr.2007.08.020","article-title":"Loss of TGF\u03b2 signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia","volume":"12","author":"Guasch","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.molmed.2015.06.003_bib1020","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1158\/0008-5472.CAN-05-2448","article-title":"Heliobacter infection is required for inflammation and colon cancer in Smad3-deficient mice","volume":"66","author":"Maggio-Price","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib1025","first-page":"6113","article-title":"Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice","volume":"59","author":"Takaku","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib1030","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1016\/j.febslet.2014.02.049","article-title":"Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis","volume":"588","author":"Asselin","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molmed.2015.06.003_bib1035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1126\/science.1237910","article-title":"Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals","volume":"342","author":"Shan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molmed.2015.06.003_bib1040","first-page":"198","article-title":"Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon","volume":"8","author":"Knoop","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2015.06.003_bib1045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature10863","article-title":"Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine","volume":"483","author":"McDole","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2015.06.003_bib1050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.it.2015.01.005","article-title":"Lung ILC2s link innate and adaptive responses in allergic inflammation","volume":"36","author":"Martinez-Gonzalez","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.molmed.2015.06.003_bib1055","doi-asserted-by":"crossref","first-page":"16630","DOI":"10.1073\/pnas.1208092109","article-title":"SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia","volume":"109","author":"Korfhagen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molmed.2015.06.003_bib1060","first-page":"3970408","article-title":"Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13","volume":"4","author":"DePaiva","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.molmed.2015.06.003_bib1065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Zhang","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib1070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0120284","article-title":"Immunomodulatory cross-talk between conjunctival goblet cells and dendritic cells","volume":"10","author":"Contreras-Ruiz","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molmed.2015.06.003_bib1075","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.diff.2008.09.008","article-title":"Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis","volume":"77","author":"Gersemann","year":"2009","journal-title":"Differentiation"},{"key":"10.1016\/j.molmed.2015.06.003_bib1080","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.biochem.75.103004.142532","article-title":"CFTR function and prospects for therapy","volume":"77","author":"Riordan","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molmed.2015.06.003_bib1085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a009589","article-title":"CFTR, mucins, and mucus obstruction in cystic fibrosis","volume":"2","author":"Kreda","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.molmed.2015.06.003_bib1090","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.eye.6702867","article-title":"Impression cytology of the conjunctival epithelial cells in patients with cystic fibrosis","volume":"22","author":"Mrugacz","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.molmed.2015.06.003_bib1095","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1076\/ceyr.24.3.182.8297","article-title":"Presence of CFTR in the conjunctival epithelium","volume":"24","author":"Turner","year":"2002","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.molmed.2015.06.003_bib1100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/MCB.00934-12","article-title":"FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation","volume":"33","author":"Ren","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molmed.2015.06.003_bib1105","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1242\/bio.20121701","article-title":"The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways","volume":"1","author":"Boucherat","year":"2012","journal-title":"Biol. Open"},{"key":"10.1016\/j.molmed.2015.06.003_bib1110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1164\/rccm.200705-795OC","article-title":"Down-regulation of the Notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease","volume":"179","author":"Tilley","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.molmed.2015.06.003_bib1115","first-page":"1004","article-title":"Decreased levels of the goblet cell mucin Muc5AC in tears of patients with Sj\u00f6gren syndrome","volume":"43","author":"Argueso","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.molmed.2015.06.003_bib1120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jaut.2014.02.006","article-title":"Sj\u00f6gren's syndrome: where do we stand, and where shall we go?","volume":"51","author":"Cornec","year":"2014","journal-title":"J. Autoimmun."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491415001203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491415001203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T16:42:53Z","timestamp":1652805773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491415001203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":112,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S1471491415001203"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2015.06.003","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2015.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}