{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:01:22Z","timestamp":1770969682048,"version":"3.50.1"},"reference-count":12,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.molmed.2015.11.002","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T19:07:57Z","timestamp":1450206477000},"page":"7-9","source":"Crossref","is-referenced-by-count":16,"title":["Polycystins: Mechanosensors with Diagnostic and Prognostic Potential in Cancer"],"prefix":"10.1016","volume":"22","author":[{"given":"Antonios N.","family":"Gargalionis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostas A.","family":"Papavassiliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthimia K.","family":"Basdra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios G.","family":"Papavassiliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2015.11.002_bib0065","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ki.2015.207","article-title":"A polycystin-centric view of cyst formation and disease: the polycystins revisited","volume":"88","author":"Ong","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.molmed.2015.11.002_bib0070","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/ijc.29140","article-title":"Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer","volume":"136","author":"Gargalionis","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.molmed.2015.11.002_bib0075","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s11033-009-9746-5","article-title":"Down-regulation of Pkd2 by siRNAs suppresses cell\u2013cell adhesion in the mouse melanoma cells","volume":"37","author":"Bian","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.molmed.2015.11.002_bib0080","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrneph.2015.46","article-title":"The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease","volume":"11","author":"Seeger-Nukpezah","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.molmed.2015.11.002_bib0085","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/cbf.1417","article-title":"PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro","volume":"25","author":"Zhang","year":"2007","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.molmed.2015.11.002_bib0090","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cellbi.2007.12.014","article-title":"Polycystin-1 induced apoptosis and cell cycle arrest in G0\/G1 phase in cancer cells","volume":"32","author":"Zheng","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.molmed.2015.11.002_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5582\/bst.8.1","article-title":"Transient receptor potential (TRP) channels, promising potential diagnostic and therapeutic tools for cancer","volume":"8","author":"Chen","year":"2014","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.molmed.2015.11.002_bib0100","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2174\/1568026611313030011","article-title":"Oncogenic and anti-oncogenic effects of transient receptor potential channels","volume":"13","author":"Liberati","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.molmed.2015.11.002_bib0105","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/carcin\/bgq019","article-title":"TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner","volume":"31","author":"Nabissi","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.molmed.2015.11.002_bib0110","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1172\/JCI21753","article-title":"Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus","volume":"114","author":"Chauvet","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2015.11.002_bib0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.devcel.2005.12.005","article-title":"Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease","volume":"10","author":"Low","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molmed.2015.11.002_bib0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.devcel.2011.10.028","article-title":"The \u03b3-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism","volume":"22","author":"Merrick","year":"2012","journal-title":"Dev. Cell"}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491415002105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491415002105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:51:44Z","timestamp":1537145504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491415002105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1471491415002105"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2015.11.002","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}