{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:43:23Z","timestamp":1792194203558,"version":"4.4.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.molmed.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T17:15:16Z","timestamp":1477415716000},"page":"997-999","source":"Crossref","is-referenced-by-count":8,"title":["Is it Time to Fold the Cysts Away?"],"prefix":"10.1016","volume":"22","author":[{"given":"Matteus","family":"Krappitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Rachel","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Fedeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2016.10.001_bib0090","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.molmed.2014.01.004","article-title":"Polycystin-1: a master regulator of intersecting cystic pathways","volume":"20","author":"Fedeles","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.molmed.2016.10.001_bib0095","doi-asserted-by":"crossref","first-page":"16981","DOI":"10.1073\/pnas.252484899","article-title":"Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations","volume":"99","author":"Qian","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molmed.2016.10.001_bib0100","doi-asserted-by":"crossref","first-page":"13035","DOI":"10.1021\/bi035074c","article-title":"Transmembrane domain analysis of polycystin-1, the product of the polycystic kidney disease-1 (PKD1) gene: evidence for 11 membrane-spanning domains","volume":"42","author":"Nims","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.molmed.2016.10.001_bib0105","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1172\/JCI67273","article-title":"Altered trafficking and stability of polycystins underlie polycystic kidney disease","volume":"124","author":"Cai","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2016.10.001_bib0110","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","article-title":"The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I","volume":"87","author":"Qian","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2016.10.001_bib0115","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","article-title":"A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1","volume":"13","author":"Piontek","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2016.10.001_bib0120","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1172\/JCI22850","article-title":"Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation","volume":"115","author":"Nishio","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2016.10.001_bib0125","doi-asserted-by":"crossref","DOI":"10.1038\/ng.860","article-title":"A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation","author":"Fedeles","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molmed.2016.10.001_bib0130","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1172\/JCI64313","article-title":"Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity","volume":"122","author":"Hopp","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2016.10.001_bib0135","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/hmg\/ddh336","article-title":"Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease","volume":"13","author":"Lantinga-van","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molmed.2016.10.001_bib0140","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/ki.2008.686","article-title":"Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease","volume":"75","author":"Rossetti","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.molmed.2016.10.001_bib0145","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/emboj.2012.26","article-title":"A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis","volume":"31","author":"Arac","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.molmed.2016.10.001_bib0150","doi-asserted-by":"crossref","first-page":"18688","DOI":"10.1073\/pnas.0708217104","article-title":"Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure","volume":"104","author":"Yu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.molmed.2016.10.001_bib0155","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1172\/JCI78863","article-title":"Sec63 and Xbp1 regulate IRE1alpha activity and polycystic disease severity","volume":"125","author":"Fedeles","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2016.10.001_bib0160","first-page":"3","article-title":"Cystic fibrosis transmembrane regulator correctors and potentiators","author":"Rowe","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.molmed.2016.10.001_bib0165","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ajhg.2016.05.004","article-title":"Mutations in GANAB, Encoding the Glucosidase IIalpha Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease","volume":"98","author":"Porath","year":"2016","journal-title":"Am. J. Hum. Genet."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491416301435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491416301435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T03:55:53Z","timestamp":1536292553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491416301435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1471491416301435"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2016.10.001","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}