{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:40:39Z","timestamp":1649176839770},"reference-count":7,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.molmed.2018.10.002","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T22:33:25Z","timestamp":1540420405000},"page":"978-981","source":"Crossref","is-referenced-by-count":0,"title":["Novel Approach to Tracking Mutant Huntingtin in Biosamples"],"prefix":"10.1016","volume":"24","author":[{"given":"Katarina","family":"Trajkovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Krainc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2018.10.002_bib0005","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.molmed.2018.10.002_bib0010","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1091\/mbc.12.5.1393","article-title":"Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation","volume":"12","author":"Waelter","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.molmed.2018.10.002_bib0015","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"Ross","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.molmed.2018.10.002_bib0020","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.molcel.2018.07.032","article-title":"mHTT Seeding activity: a marker of disease progression and neurotoxicity in models of Huntington's disease","volume":"71","author":"Ast","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molmed.2018.10.002_bib0025","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nn.3761","article-title":"Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons","volume":"17","author":"Pecho-Vrieseling","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molmed.2018.10.002_bib0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00401-016-1582-9","article-title":"Human-to-mouse prion-like propagation of mutant huntingtin protein","volume":"132","author":"Jeon","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.molmed.2018.10.002_bib0035","doi-asserted-by":"crossref","first-page":"9000","DOI":"10.1523\/JNEUROSCI.0118-17.2017","article-title":"Mutant huntingtin is secreted via a late endosomal\/lysosomal unconventional secretory pathway","volume":"37","author":"Trajkovic","year":"2017","journal-title":"J. Neurosci."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491418301886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491418301886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:03:15Z","timestamp":1543363395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491418301886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S1471491418301886"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2018.10.002","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}