{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:15:15Z","timestamp":1784783715053,"version":"3.55.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.molmed.2019.03.001","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T10:33:51Z","timestamp":1556188431000},"page":"571-584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Hard-To-Close Window of T-Type Calcium Channels"],"prefix":"10.1016","volume":"25","author":[{"given":"Anna","family":"Visa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soni","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00eda","family":"Alza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Herreros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Cant\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2019.03.001_bib0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","article-title":"Nomenclature of voltage-gated calcium channels","volume":"25","author":"Ertel","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.molmed.2019.03.001_bib0010","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00424-018-2163-7","article-title":"Calcium channel gating","volume":"470","author":"Hering","year":"2018","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2019.03.001_bib0015","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1111\/j.1460-9568.2006.04761.x","article-title":"T-Type Cav3.3 calcium channels produce spontaneous low-threshold action potentials and intracellular calcium oscillations","volume":"23","author":"Chevalier","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.molmed.2019.03.001_bib0020","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.biochi.2011.07.015","article-title":"Cell proliferation, calcium influx and calcium channels","volume":"93","author":"Capiod","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.molmed.2019.03.001_bib0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1574892811308010004","article-title":"The need for calcium channels in cell proliferation","volume":"8","author":"Capiod","year":"2013","journal-title":"Recent Pat. Anticancer. Drug Discov."},{"key":"10.1016\/j.molmed.2019.03.001_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.1984.sp015154","article-title":"Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro","volume":"349","author":"Jahnsen","year":"1984","journal-title":"J. Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0035","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0006-3495(84)84037-0","article-title":"A low voltage-activated calcium conductance in embryonic chick sensory neurons","volume":"46","author":"Carbone","year":"1984","journal-title":"Biophys. J."},{"key":"10.1016\/j.molmed.2019.03.001_bib0040","first-page":"K37","article-title":"Possible functional significance of a novel type of cardiac Ca channel","volume":"45","author":"Nilius","year":"1986","journal-title":"Biomed. Biochim. Acta"},{"key":"10.1016\/j.molmed.2019.03.001_bib0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s12311-011-0277-y","article-title":"T-Type calcium channel as a new therapeutic target for tremor","volume":"10","author":"Miwa","year":"2011","journal-title":"Cerebellum"},{"key":"10.1016\/j.molmed.2019.03.001_bib0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fneur.2014.00045","article-title":"The role of T-type calcium channel genes in absence seizures","volume":"5","author":"Chen","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0055","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ajhg.2015.09.007","article-title":"A recurrent mutation in CACNA1G alters Cav3.1 T-type calcium-channel conduction and causes autosomal-dominant cerebellar ataxia","volume":"97","author":"Coutelier","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molmed.2019.03.001_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13041-015-0180-4","article-title":"A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia","volume":"8","author":"Morino","year":"2015","journal-title":"Mol. Brain"},{"key":"10.1016\/j.molmed.2019.03.001_bib0065","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/jhg.2017.51","article-title":"SCA42 mutation analysis in a case series of Japanese patients with spinocerebellar ataxia","volume":"62","author":"Kimura","year":"2017","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.molmed.2019.03.001_bib0070","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/bcp.12205","article-title":"Low threshold T-type calcium channels as targets for novel epilepsy treatments","volume":"77","author":"Powell","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0075","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1073\/pnas.1100869108","article-title":"T-Type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome","volume":"108","author":"Marger","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2019.03.001_bib0080","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/nmo.12860","article-title":"Colonic overexpression of the T-type calcium channel Cav3. 2 in a mouse model of visceral hypersensitivity and in irritable bowel syndrome patients","volume":"28","author":"Scanzi","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.molmed.2019.03.001_bib0085","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1097\/WNR.0000000000000676","article-title":"Expression patterns of T-type Cav3.2 channel and insulin-like growth factor-1 receptor in dorsal root ganglion neurons of mice after sciatic nerve axotomy","volume":"27","author":"Lin","year":"2016","journal-title":"Neuroreport"},{"key":"10.1016\/j.molmed.2019.03.001_bib0090","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/j.pain.0000000000000565","article-title":"Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain","volume":"157","author":"Sekiguchi","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.molmed.2019.03.001_bib0095","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/j.pain.0000000000000774","article-title":"Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy","volume":"158","author":"Li","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.molmed.2019.03.001_bib0100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biocel.2019.01.008","article-title":"T-type calcium channels: from molecule to therapeutic opportunities","volume":"108","author":"Weiss","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0167-4838(92)90042-C","article-title":"Differential expression of voltage-gated Ca2+-currents in cultivated aortic myocytes","volume":"1160","author":"Richard","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molmed.2019.03.001_bib0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.RES.79.1.14","article-title":"Cell cycle-dependent expression of L- and T-type Ca2+ currents in rat aortic smooth muscle cells in primary culture","volume":"79","author":"Kuga","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0115","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000163066.07472.ff","article-title":"Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes","volume":"96","author":"Rodman","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0120","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/cvr\/cvs257","article-title":"The Cav3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice","volume":"96","author":"Tzeng","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0125","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1006\/jmcc.1998.0675","article-title":"Cell cycle-related changes in the voltage-gated Ca2+ currents in cultured newborn rat ventricular myocytes","volume":"30","author":"Guo","year":"1998","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1203\/01.PDR.0000155756.89681.3C","article-title":"T-type Ca2+ channels are involved in high glucose-induced rat neonatal cardiomyocyte proliferation","volume":"57","author":"Li","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0135","doi-asserted-by":"crossref","first-page":"C1414","DOI":"10.1152\/ajpcell.00488.2009","article-title":"Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytes","volume":"298","author":"Oguri","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0140","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0094","article-title":"Potassium channels in cell cycle and cell proliferation","volume":"369","author":"Urrego","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.molmed.2019.03.001_bib0145","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1172\/JCI39724","article-title":"\u03b11G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice","volume":"119","author":"Nakayama","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2019.03.001_bib0150","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13041-017-0317-8","article-title":"A T-type channel\u2013calmodulin complex triggers \u03b1CaMKII activation","volume":"10","author":"Asmara","year":"2017","journal-title":"Mol. Brain"},{"key":"10.1016\/j.molmed.2019.03.001_bib0155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ceca.2004.07.002","article-title":"Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells","volume":"37","author":"Panner","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.molmed.2019.03.001_bib0160","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.canlet.2008.03.032","article-title":"Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation","volume":"267","author":"Taylor","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0165","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/07357907.2011.568565","article-title":"Blockade of T-type Ca2+ channels inhibits human ovarian cancer cell proliferation","volume":"29","author":"Li","year":"2011","journal-title":"Cancer Invest."},{"key":"10.1016\/j.molmed.2019.03.001_bib0170","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1755-148X.2012.00978.x","article-title":"Functional expression of voltage-gated calcium channels in human melanoma","volume":"25","author":"Das","year":"2012","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0175","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1111\/j.1582-4934.2012.01584.x","article-title":"Epigallocatechin-3-gallate induces mesothelioma cell death via H2O2-dependent T-type Ca2+ channel opening","volume":"16","author":"Ranzato","year":"2012","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.molmed.2019.03.001_bib0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ceca.2014.09.002","article-title":"Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels","volume":"56","author":"Ranzato","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.molmed.2019.03.001_bib0185","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3390\/nu10121936","article-title":"Molecular targets of epigallocatechin-gallate (EGCG): a special focus on signal transduction and cancer","volume":"10","author":"Negri","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.molmed.2019.03.001_bib0190","doi-asserted-by":"crossref","first-page":"9270","DOI":"10.1073\/pnas.93.17.9270","article-title":"Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels","volume":"93","author":"Ragsdale","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2019.03.001_bib0195","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1124\/mol.106.023473","article-title":"State-dependent verapamil block of the cloned human Cav3.1 T-type Ca2+ channel","volume":"70","author":"Freeze","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0200","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","article-title":"Local anesthetics: hydrophilic and hydrophobic pathways for the drug\u2013receptor reaction","volume":"69","author":"Hille","year":"1977","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0205","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0304-4157(77)90003-X","article-title":"Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels","volume":"472","author":"Hondeghem","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.molmed.2019.03.001_bib0210","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2017.00286","article-title":"Discovery and development of calcium channel blockers","volume":"8","author":"Godfraind","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0215","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1523\/JNEUROSCI.22-02-00396.2002","article-title":"Differential inhibition of T-type calcium channels by neuroleptics","volume":"22","author":"Santi","year":"2002","journal-title":"J. Neurosci"},{"key":"10.1016\/j.molmed.2019.03.001_bib0220","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/3669","article-title":"Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin","volume":"1","author":"Chuang","year":"1998","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.molmed.2019.03.001_bib0225","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1254\/jphs.09356FP","article-title":"Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2","volume":"112","author":"Ohkubo","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.molmed.2019.03.001_bib0230","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00424-014-1467-5","article-title":"Modulation of T-type calcium channels by bioactive lipids","volume":"466","author":"Chemin","year":"2014","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2019.03.001_bib0235","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12013-009-9057-4","article-title":"Positive allosteric interaction of structurally diverse T-type calcium channel antagonists","volume":"55","author":"Uebele","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.molmed.2019.03.001_bib0240","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1124\/mol.111.073205","article-title":"TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent","volume":"80","author":"Choe","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0245","series-title":"Scaffold Hopping Affords a Highly Selective In Vitro and In Vivo T-Type Calcium Inhibitor Probe Free From IP Issues","author":"Xie","year":"2010"},{"key":"10.1016\/j.molmed.2019.03.001_bib0250","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1158\/0008-5472.CAN-17-3061","article-title":"T-Type Ca 2+ channels: T for targetable","volume":"78","author":"Sall\u00e1n","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0255","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1097\/00004872-199715055-00004","article-title":"Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker","volume":"15","author":"Clozel","year":"1997","journal-title":"J. Hypertens. Suppl."},{"key":"10.1016\/j.molmed.2019.03.001_bib0260","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2165\/00003495-199754050-00010","article-title":"Mibefradil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the management of hypertension and angina pectoris","volume":"54","author":"Brogden","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.molmed.2019.03.001_bib0265","doi-asserted-by":"crossref","first-page":"20C","DOI":"10.1016\/S0002-9149(97)00566-3","article-title":"Antianginal and anti-ischemic effects of mibefradil in the treatment of patients with chronic stable angina pectoris","volume":"80","author":"Alpert","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0270","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000047274","article-title":"Comparative pharmacological properties among calcium channel blockers: T-channel versus L-channel blockade","volume":"89","author":"Noll","year":"1998","journal-title":"Cardiology"},{"key":"10.1016\/j.molmed.2019.03.001_bib0275","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.103.060814","article-title":"NNC 55-0396 (1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels","volume":"309","author":"Huang","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0280","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0026-895X(25)10504-X","article-title":"Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)","volume":"48","author":"Bezprozvanny","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0028-3908(99)00153-7","article-title":"Determinants of voltage-dependent inactivation affect mibefradil block of calcium channels","volume":"39","author":"Jim\u00e9nez","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molmed.2019.03.001_bib0290","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3565(24)38902-5","article-title":"Mibefradil block of cloned T-type calcium channels","volume":"295","author":"Martin","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0295","first-page":"173","article-title":"Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396","volume":"23","author":"Li","year":"2005","journal-title":"Cardiovasc. Rev."},{"key":"10.1016\/j.molmed.2019.03.001_bib0300","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/adt.2013.552","article-title":"Evaluating state dependence and subtype selectivity of calcium channel modulators in automated electrophysiology assays","volume":"12","author":"Kuryshev","year":"2014","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0305","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fphys.2013.00185","article-title":"Membrane potential and cancer progression","volume":"4","author":"Yang","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0310","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000094900","article-title":"Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca2+ channels with distinct inhibitory mechanisms","volume":"78","author":"Lee","year":"2006","journal-title":"Pharmacology"},{"key":"10.1016\/j.molmed.2019.03.001_bib0315","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0022-3565(24)35264-4","article-title":"Effect of mibefradil on voltage-dependent gating and kinetics of T-type Ca2+ channels in cortisol-secreting cells","volume":"292","author":"Gomora","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0320","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/jn.1998.79.1.240","article-title":"Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents","volume":"79","author":"Todorovic","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0325","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s002100000238","article-title":"Pharmacological properties of Cav3.2, a low voltage-activated Ca2+ channel cloned from human heart","volume":"361","author":"Perchenet","year":"2000","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0330","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.bmcl.2004.04.090","article-title":"3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers","volume":"14","author":"Lee","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0335","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1016\/j.bmcl.2006.07.046","article-title":"Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers","volume":"16","author":"Lee","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0340","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1016\/j.bmcl.2008.06.034","article-title":"T-type Ca2+ channel blockers suppress the growth of human cancer cells","volume":"18","author":"Heo","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0345","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bmcl.2011.11.083","article-title":"In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor","volume":"22","author":"Kang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0350","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00424-015-1733-1","article-title":"Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain","volume":"468","author":"M\u2019Dahoma","year":"2016","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2019.03.001_bib0355","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1016\/j.bmcl.2013.10.049","article-title":"In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers","volume":"23","author":"Jang","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0360","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.bmcl.2014.01.071","article-title":"Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist","volume":"24","author":"Choi","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0365","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1016\/j.bmc.2017.07.010","article-title":"Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects","volume":"25","author":"Kim","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.molmed.2019.03.001_bib0370","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.critrevonc.2018.06.004","article-title":"Targeting the cellular schizophrenia. Likely employment of the antipsychotic agent pimozide in treatment of refractory cancers and glioblastoma","volume":"128","author":"Elmaci","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0375","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.bjp.0701140","article-title":"Inhibition by mibefradil, a novel calcium channel antagonist, of Ca2+- and volume-activated Cl\u2212 channels in macrovascular endothelial cells","volume":"121","author":"Nilius","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0380","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/sj.bjp.0703650","article-title":"Effects of mibefradil and nifedipine on arteriolar myogenic responsiveness and intracellular Ca2+","volume":"131","author":"Potocnik","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0385","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00417-004-0886-y","article-title":"Induction of apoptosis by the calcium antagonist mibefradil correlates with depolarization of the membrane potential and decreased integrin expression in human lens epithelial cells","volume":"242","author":"Nebe","year":"2004","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0390","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1158\/0008-5472.CAN-16-2274","article-title":"Membrane-depolarizing channel blockers induce selective glioma cell death by impairing nutrient transport and unfolded protein\/amino acid responses","volume":"77","author":"Niklasson","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0395","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0022-3565(25)24034-4","article-title":"The Ca++-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels","volume":"271","author":"Mehrke","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0400","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-3565(25)10679-4","article-title":"Interaction of Ro 40-5967 and verapamil with the stably expressed alpha 1-subunit of the cardiac L-type calcium channel","volume":"274","author":"Lacinov\u00e1","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0405","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0303-7207(01)00384-7","article-title":"Role of membrane depolarization and T-type Ca2+ channels in angiotensin II and K+ stimulated aldosterone secretion","volume":"175","author":"Lotshaw","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0410","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1254\/jphs.12104FP","article-title":"The T-type Ca2+ channel inhibitor mibefradil inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells","volume":"120","author":"Hong","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.molmed.2019.03.001_bib0415","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00424-007-0438-5","article-title":"Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes","volume":"456","author":"Yoo","year":"2008","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2019.03.001_bib0420","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0022-3565(24)38967-0","article-title":"Characterization of mibefradil block of the human heart delayed rectifier hKv1.5","volume":"295","author":"Perchenet","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0425","first-page":"195","article-title":"Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs","volume":"55","author":"Chouabe","year":"2000","journal-title":"Therapie"},{"key":"10.1016\/j.molmed.2019.03.001_bib0430","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/sj.bjp.0702321","article-title":"Mibefradil (Ro 40-5967) inhibits several Ca2+ and K+ currents in human fusion-competent myoblasts","volume":"126","author":"Liu","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0435","first-page":"1192","article-title":"Mibefradil potently blocks ATP-activated K+ channels in adrenal cells","volume":"56","author":"Gomora","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0440","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/jcp.25448","article-title":"Gating modulation of the tumor-related Kv10.1 channel by mibefradil","volume":"232","author":"G\u00f3mez-Lagunas","year":"2017","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0445","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00424-015-1772-7","article-title":"Mibefradil represents a new class of benzimidazole TRPM7 channel agonists","volume":"468","author":"Sch\u00e4fer","year":"2016","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2019.03.001_bib0450","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3892\/etm.2017.4071","article-title":"Impact of gabapentin on neuronal high voltage-activated Ca2+ channel properties of injured-side axotomized and adjacent uninjured dorsal root ganglions in a rat model of spinal nerve ligation","volume":"13","author":"Zhu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.molmed.2019.03.001_bib0455","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.3892\/ol.2017.6457","article-title":"Voltage-gated calcium channels: novel targets for cancer therapy","volume":"14","author":"Phan","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0460","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/BF00168921","article-title":"Effects of mibefradil on intracellular Ca2+ release in cultured rat cardiac fibroblasts and human platelets","volume":"353","author":"Eberhard","year":"1995","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0465","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13046-015-0171-4","article-title":"T-Type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines","volume":"34","author":"Huang","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0470","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2016.01.012","article-title":"PI3K\/Akt\/mTOR and Ras\/Raf\/MEK\/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives","volume":"109","author":"Asati","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.molmed.2019.03.001_bib0475","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2015.03.005","article-title":"Nuclear factor of activated T cells in cancer development and treatment","volume":"361","author":"Shou","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0480","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.18632\/oncotarget.6783","article-title":"Triptolide induces protective autophagy through activation of the CaMKK\u03b2\u2013AMPK signaling pathway in prostate cancer cells","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.molmed.2019.03.001_bib0485","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1016\/j.bmcl.2007.08.070","article-title":"Discovery of potent T-type calcium channel blocker","volume":"17","author":"Seo","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0490","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1016\/j.bmcl.2012.09.076","article-title":"T-Type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells","volume":"22","author":"Rim","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0495","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.3390\/molecules19079864","article-title":"T-Type Ca2+ channel blocker, KYS05090 induces autophagy and apoptosis in A549 cells through inhibiting glucose uptake","volume":"19","author":"Rim","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.molmed.2019.03.001_bib0500","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.110.171058","article-title":"In vitro characterization of T-TYPE CALCIUM CHANNEL ANTAGONIST TTA-A2 and in vivo effects on arousal in mice","volume":"335","author":"Kraus","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0505","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuropharm.2015.09.032","article-title":"Blockade of T-type calcium channels prevents tonic\u2013clonic seizures in a maximal electroshock seizure model","volume":"101","author":"Sakkaki","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molmed.2019.03.001_bib0510","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pain.2012.10.023","article-title":"State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects","volume":"154","author":"Francois","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.molmed.2019.03.001_bib0515","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/pcmr.12155","article-title":"T-Type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells","volume":"26","author":"Das","year":"2013","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0520","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1158\/1541-7786.MCR-13-0485","article-title":"T-Type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38\u2013MAPK in colon cancer cells","volume":"12","author":"Dziegielewska","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0525","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bcp.2012.12.017","article-title":"Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells","volume":"85","author":"Valerie","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0530","first-page":"267","article-title":"T-Type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells","volume":"41","author":"Ohkubo","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0535","doi-asserted-by":"crossref","first-page":"352794","DOI":"10.1155\/2015\/352794","article-title":"Calcium homeostasis and ER stress in control of autophagy in cancer cells","volume":"2015","author":"Kania","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.molmed.2019.03.001_bib0540","doi-asserted-by":"crossref","first-page":"121ra19","DOI":"10.1126\/scitranslmed.3003120","article-title":"T-Type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures","volume":"4","author":"Tringham","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molmed.2019.03.001_bib0545","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1124\/mol.60.5.1121","article-title":"Block of cloned human T-type calcium channels by succinimide antiepileptic drugs","volume":"60","author":"Gomora","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0550","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1093\/emboj\/20.24.7033","article-title":"Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide","volume":"20","author":"Chemin","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.molmed.2019.03.001_bib0555","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2001.013269","article-title":"Specific contribution of human T-type calcium channel isotypes (\u03b11G, \u03b11H and \u03b11I) to neuronal excitability","volume":"540","author":"Chemin","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0560","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0006-3495(01)75799-2","article-title":"Evidence for two concentration-dependent processes for \u03b2-subunit effects on \u03b11 B calcium channels","volume":"81","author":"Cant\u00ed","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.molmed.2019.03.001_bib0565","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1085\/jgp.200308967","article-title":"Overexpressed Cav\u03b23 inhibits N-type Cav2.2 calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation","volume":"123","author":"Yasuda","year":"2004","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0570","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.bjp.0704892","article-title":"T-Channel-like pharmacological properties of high voltage-activated, nifedipine-insensitive Ca2+ currents in the rat terminal mesenteric artery","volume":"137","author":"Morita","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0575","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1212\/01.WNL.0000167409.59089.C0","article-title":"CACNA1A mutations causing episodic and progressive ataxia alter channel trafficking and kinetics","volume":"64","author":"Wan","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.molmed.2019.03.001_bib0580","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bmcl.2015.12.010","article-title":"In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells","volume":"26","author":"Byun","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2019.03.001_bib0585","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.1074\/jbc.275.9.6090","article-title":"Molecular and functional properties of the human \u03b11G subunit that forms T-type calcium channels","volume":"275","author":"Monteil","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2019.03.001_bib0590","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/jpet.108.145672","article-title":"Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs","volume":"328","author":"Perez-Reyes","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.molmed.2019.03.001_bib0595","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1124\/mol.54.6.1080","article-title":"Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons","volume":"54","author":"McDonough","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.molmed.2019.03.001_bib0600","doi-asserted-by":"crossref","first-page":"e91467","DOI":"10.1371\/journal.pone.0091467","article-title":"CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy","volume":"9","author":"Obradovic","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2019.03.001_bib0605","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.0000087148.75363.8F","article-title":"Cav3.1 (\u03b11G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation","volume":"93","author":"Wu","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.molmed.2019.03.001_bib0610","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1158\/0008-5472.CAN-16-2347","article-title":"Targetable T-type calcium channels drive glioblastoma","volume":"77","author":"Zhang","year":"2017","journal-title":"Cancer Res."},{"issue":"Suppl. 1","key":"10.1016\/j.molmed.2019.03.001_bib0615","first-page":"S1","article-title":"Measurement of cellular excitability by whole cell patch clamp technique","volume":"59","author":"Karma\u017e\u00ednov\u00e1","year":"2010","journal-title":"Physiol. Res. Acad. Sci. Bohemoslovaca"},{"key":"10.1016\/j.molmed.2019.03.001_bib0620","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tips.2008.10.004","article-title":"Regulation of neuronal T-type calcium channels","volume":"30","author":"Iftinca","year":"2009","journal-title":"Trends Pharmacol. Sci."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491419300516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491419300516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:17:16Z","timestamp":1761463036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491419300516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":124,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1471491419300516"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2019.03.001","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Hard-To-Close Window of T-Type Calcium Channels","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2019.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}