{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:51:04Z","timestamp":1793199064825,"version":"4.5.0"},"reference-count":213,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.molmed.2022.11.001","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T16:13:30Z","timestamp":1670516010000},"page":"152-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["ABC transporters: human disease and pharmacotherapeutic potential"],"prefix":"10.1016","volume":"29","author":[{"given":"Jonathan M.","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-6140","authenticated-orcid":false,"given":"Alastair S.","family":"Garfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2022.11.001_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2017.02.020","article-title":"Targeted pharmacotherapies for defective ABC transporters","volume":"136","author":"Vauthier","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0010","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/humu.24418","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"43","author":"Dean","year":"2022","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.molmed.2022.11.001_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-981-13-7647-4_2","article-title":"ABC Family Transporters","volume":"1141","author":"Liu","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101036","article-title":"Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration","volume":"89","author":"Molday","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0025","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1021\/acs.chemrev.0c00659","article-title":"Structure and Function of Hepatobiliary ATP Binding Cassette Transporters","volume":"121","author":"Kroll","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.molmed.2022.11.001_bb0030","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00424-006-0142-x","article-title":"The peroxisomal ABC transporter family","volume":"453","author":"Wanders","year":"2007","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2022.11.001_bb0035","doi-asserted-by":"crossref","first-page":"19810","DOI":"10.1038\/s41598-021-99184-1","article-title":"Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment","volume":"11","author":"Shaughnessy","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0040","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1002\/1873-3468.13967","article-title":"An inventory of lysosomal ABC transporters","volume":"594","author":"Szakacs","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molmed.2022.11.001_bb0045","doi-asserted-by":"crossref","DOI":"10.4155\/fdd-2020-0025","article-title":"Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development","volume":"2","author":"Stefan","year":"2020","journal-title":"Future Drug Discov."},{"key":"10.1016\/j.molmed.2022.11.001_bb0050","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev-biochem-011520-105201","article-title":"Structural and Mechanistic Principles of ABC Transporters","volume":"89","author":"Thomas","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0055","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1002\/1873-3468.13935","article-title":"Structural and functional diversity calls for a new classification of ABC transporters","volume":"594","author":"Thomas","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molmed.2022.11.001_bb0060","article-title":"Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters","volume":"2","author":"Pahnke","year":"2021","journal-title":"Free Neuropathol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0065","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1042\/EBC20210012","article-title":"ATP-binding cassette transporters and neurodegenerative diseases","volume":"65","author":"Katzeff","year":"2021","journal-title":"Essays Biochem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100743","article-title":"Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance","volume":"54","author":"Wang","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.molmed.2022.11.001_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107554","article-title":"Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders","volume":"213","author":"Gil-Martins","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.molmed.2022.11.001_bb0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.semcancer.2019.10.004","article-title":"The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer","volume":"60","author":"Pasello","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0085","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbagen.2018.09.019","article-title":"ABC transporters as cancer drivers: Potential functions in cancer development","volume":"1863","author":"Domenichini","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.molmed.2022.11.001_bb0090","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.3748\/wjg.v24.i29.3222","article-title":"ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?","volume":"24","author":"Adamska","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0095","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/hep.22683","article-title":"Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing","volume":"49","author":"Byrne","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0100","first-page":"95","article-title":"Progressive familial intrahepatic cholestasis: diagnosis, management, and treatment","volume":"10","author":"Gunaydin","year":"2018","journal-title":"Hepat. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010273","article-title":"Gene Therapy for Progressive Familial Intrahepatic Cholestasis: Current Progress and Future Prospects","volume":"22","author":"Bosma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0110","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0115","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1074\/jbc.273.16.10046","article-title":"The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver","volume":"273","author":"Gerloff","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0120","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3748\/wjg.v23.i5.763","article-title":"Current and future therapies for inherited cholestatic liver diseases","volume":"23","author":"van der Woerd","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0125","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41422-020-0302-0","article-title":"Cryo-EM structure of human bile salts exporter ABCB11","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jhep.2021.02.011","article-title":"Bile formation and secretion: An update","volume":"75","author":"Boyer","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3389\/fphar.2018.00931","article-title":"Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH","volume":"9","author":"Al-Dury","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0140","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jhep.2020.02.007","article-title":"Genotype correlates with the natural history of severe bile salt export pump deficiency","volume":"73","author":"van Wessel","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jhep.2020.04.036","article-title":"Variants in ABCB4 (MDR3) across the spectrum of cholestatic liver diseases in adults","volume":"73","author":"Stattermayer","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/hep4.2051","article-title":"Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1","author":"Nayagam","year":"2022","journal-title":"Hepatol Commun."},{"key":"10.1016\/j.molmed.2022.11.001_bb0155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jhep.2009.11.012","article-title":"Liver disease associated with canalicular transport defects: current and future therapies","volume":"52","author":"Stapelbroek","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0160","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S2468-1253(22)00093-0","article-title":"Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial","volume":"7","author":"Thompson","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0165","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3892\/mmr.2014.2645","article-title":"Variations of ABCB4 and ABCB11 genes are associated with primary intrahepatic stones","volume":"11","author":"Pan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0170","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/S2210-7401(12)70019-0","article-title":"Low phospholipid-associated cholestasis and cholelithiasis","volume":"36","author":"Erlinger","year":"2012","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.fpc.0000230418.28091.76","article-title":"Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury","volume":"17","author":"Lang","year":"2007","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.molmed.2022.11.001_bb0180","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/apt.16118","article-title":"Review article: liver disease in adults with variants in the cholestasis-related genes ABCB11, ABCB4 and ATP8B1","volume":"52","author":"Nayagam","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.molmed.2022.11.001_bb0185","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000028011","article-title":"The role of p.Val444Ala variant in the ABCB11 gene and susceptibility to biliary atresia in Vietnamese patients","volume":"100","author":"Van Tung","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.molmed.2022.11.001_bb0190","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/gut.2008.159541","article-title":"Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy","volume":"58","author":"Dixon","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.molmed.2022.11.001_bb0195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00008571-200402000-00003","article-title":"Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy","volume":"14","author":"Pauli-Magnus","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.molmed.2022.11.001_bb0200","series-title":"The role of photoreceptor ABC transporter ABCA4 in retinal and lipid transport and Stargardt macular degeneration","author":"Quazi","year":"2013"},{"key":"10.1016\/j.molmed.2022.11.001_bb0205","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/liv.14518","article-title":"Functional rescue of an ABCB11 mutant by ivacaftor: A new targeted pharmacotherapy approach in bile salt export pump deficiency","volume":"40","author":"Mareux","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.molmed.2022.11.001_bb0210","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1111\/jcmm.14397","article-title":"Potentiation of ABCA3 lipid transport function by ivacaftor and genistein","volume":"23","author":"Kinting","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810758","article-title":"In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators","volume":"23","author":"Mareux","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150098","article-title":"Functional Rescue of Trafficking-Impaired ABCB4 Mutants by Chemical Chaperones","volume":"11","author":"Gordo-Gilart","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2022.11.001_bb0225","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1002\/hep.21630","article-title":"4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps","volume":"45","author":"Hayashi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0230","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/hep.27767","article-title":"Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4-phenylbutyrate","volume":"62","author":"Gonzales","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0235","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/76102","article-title":"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum","volume":"25","author":"Le Saux","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0240","doi-asserted-by":"crossref","DOI":"10.1111\/1346-8138.16379","article-title":"Author reply to comment on \"Clinical practice guidelines for pseudoxanthoma elasticum (2017)\": The importance of mutation analysis","volume":"49","author":"Iwanaga","year":"2022","journal-title":"J. Dermatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0245","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tibs.2018.10.005","article-title":"PXE, a Mysterious Inborn Error Clarified","volume":"44","author":"Borst","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0250","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.0022-202X.2005.23897.x","article-title":"Tissue-specific expression of the ABCC6 gene","volume":"125","author":"Matsuzaki","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0255","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/labinvest.3780444","article-title":"MRP6 (ABCC6) detection in normal human tissues and tumors","volume":"82","author":"Scheffer","year":"2002","journal-title":"Lab. Investig."},{"key":"10.1016\/j.molmed.2022.11.001_bb0260","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/ATVBAHA.114.304017","article-title":"ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report","volume":"34","author":"Jansen","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0265","doi-asserted-by":"crossref","first-page":"20206","DOI":"10.1073\/pnas.1319582110","article-title":"ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release","volume":"110","author":"Jansen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2022.11.001_bb0270","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/1346-8138.16301","article-title":"Clinical practice guidelines for pseudoxanthoma elasticum (2017): Clinical Practice Guidelines for Pseudoxanthoma Elasticum Drafting Committee","volume":"49","author":"Iwanaga","year":"2022","journal-title":"J. Dermatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0275","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fgene.2012.00302","article-title":"Generalized arterial calcification of infancy and pseudoxanthoma elasticum: two sides of the same coin","volume":"3","author":"Nitschke","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0280","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/jbmr.4418","article-title":"Ectopic Calcification and Hypophosphatemic Rickets: Natural History of ENPP1 and ABCC6 Deficiencies","volume":"36","author":"Ferreira","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0285","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.atherosclerosis.2021.03.012","article-title":"Genotype-phenotype correlation in pseudoxanthoma elasticum","volume":"324","author":"Bartstra","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.molmed.2022.11.001_bb0290","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jid.2016.10.035","article-title":"Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6(-\/-) Mice","volume":"137","author":"Pomozi","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024738","article-title":"Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver","volume":"6","author":"Le Saux","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2022.11.001_bb0300","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/jid.2013.482","article-title":"Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; pharmacological correction of the mislocalized proteins","volume":"134","author":"Pomozi","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/genes12081241","article-title":"An Overview of the Genetics of ABCA4 Retinopathies, an Evolving Story","volume":"12","author":"Al-Khuzaei","year":"2021","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.molmed.2022.11.001_bb0310","series-title":"Atlas of Inherited Retinal Diseases","first-page":"140","article-title":"Stargardt disease","author":"Tsang","year":"2018"},{"key":"10.1016\/j.molmed.2022.11.001_bb0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/bjophthalmol-2016-308823","article-title":"Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options","volume":"101","author":"Tanna","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0320","doi-asserted-by":"crossref","first-page":"19743","DOI":"10.1074\/jbc.M115.647685","article-title":"Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease","volume":"290","author":"Sabirzhanova","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0325","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6786245","article-title":"ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease","volume":"2016","author":"Kawaguchi","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.molmed.2022.11.001_bb0330","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jdn.10003","article-title":"X-linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies","volume":"80","author":"Turk","year":"2020","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0335","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/a-0804-2715","article-title":"An Update on Addison's Disease","volume":"127","author":"Barthel","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.molmed.2022.11.001_bb0340","doi-asserted-by":"crossref","first-page":"30183","DOI":"10.1038\/srep30183","article-title":"Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1","volume":"6","author":"Kawaguchi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0345","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/brain\/awy127","article-title":"Impaired plasticity of macrophages in X-linked adrenoleukodystrophy","volume":"141","author":"Weinhofer","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.molmed.2022.11.001_bb0350","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s10545-014-9797-1","article-title":"Hematopoietic cell transplantation does not prevent myelopathy in X-linked adrenoleukodystrophy: a retrospective study","volume":"38","author":"van Geel","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0355","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jsbmb.2009.04.006","article-title":"Induction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics","volume":"116","author":"Genin","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0360","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/3242","article-title":"Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy","volume":"4","author":"Kemp","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0365","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/bbrc.1999.0406","article-title":"Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages","volume":"257","author":"Langmann","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molmed.2022.11.001_bb0370","doi-asserted-by":"crossref","first-page":"25448","DOI":"10.1074\/jbc.M301189200","article-title":"Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells","volume":"278","author":"Hoekstra","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0375","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1172\/JCI32057","article-title":"Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo","volume":"117","author":"Wang","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2022.11.001_bb0380","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0022-2275(20)31566-2","article-title":"ABCA1. The gatekeeper for eliminating excess tissue cholesterol","volume":"42","author":"Oram","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0385","doi-asserted-by":"crossref","first-page":"34508","DOI":"10.1074\/jbc.M006738200","article-title":"ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages","volume":"275","author":"Oram","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0390","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nm1546","article-title":"Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment","volume":"13","author":"Brunham","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0395","doi-asserted-by":"crossref","first-page":"33053","DOI":"10.1074\/jbc.M005438200","article-title":"Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0400","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive Review on Alzheimer's Disease: Causes and Treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.molmed.2022.11.001_bb0405","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.bbamem.2018.03.015","article-title":"Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein","volume":"1860","author":"Bharadwaj","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.molmed.2022.11.001_bb0410","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13024-022-00536-w","article-title":"The role of ATP-binding cassette subfamily A in the etiology of Alzheimer's disease","volume":"17","author":"Bossaerts","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.molmed.2022.11.001_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041593","article-title":"The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease","volume":"22","author":"Jacobo-Albavera","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0420","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1074\/jbc.M411420200","article-title":"The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease","volume":"280","author":"Koldamova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0425","doi-asserted-by":"crossref","first-page":"43224","DOI":"10.1074\/jbc.M504513200","article-title":"Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice","volume":"280","author":"Koldamova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0430","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1194\/jlr.M006486","article-title":"Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol","volume":"51","author":"Zhu","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0435","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1194\/jlr.TR120000658","article-title":"Lipid rafts as a therapeutic target","volume":"61","author":"Sviridov","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0440","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1083\/jcb.200207113","article-title":"Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts","volume":"160","author":"Ehehalt","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0445","doi-asserted-by":"crossref","first-page":"E2077","DOI":"10.1073\/pnas.1208635109","article-title":"Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid beta (Abeta) production in the trans-Golgi network","volume":"109","author":"Choy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2022.11.001_bb0450","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1096\/fj.10-168633","article-title":"Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis","volume":"25","author":"Marquer","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.molmed.2022.11.001_bb0455","doi-asserted-by":"crossref","first-page":"43236","DOI":"10.1074\/jbc.M508780200","article-title":"Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease","volume":"280","author":"Wahrle","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0460","doi-asserted-by":"crossref","DOI":"10.1042\/AN20090015","article-title":"Memory deficits in APP23\/Abca1+\/- mice correlate with the level of Abeta oligomers","volume":"1","author":"Lefterov","year":"2009","journal-title":"ASN Neuro"},{"key":"10.1016\/j.molmed.2022.11.001_bb0465","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of Abeta","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.molmed.2022.11.001_bb0470","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0896-6273(03)00787-6","article-title":"Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death","volume":"40","author":"Leissring","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.molmed.2022.11.001_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.630502","article-title":"APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics","volume":"15","author":"Husain","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0480","first-page":"671","article-title":"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease","volume":"118","author":"Wahrle","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2022.11.001_bb0485","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3233\/JAD-160467","article-title":"ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies","volume":"54","author":"Boehm-Cagan","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0490","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13195-022-01028-1","article-title":"Effect of the ABCA1 agonist CS-6253 on amyloid-beta and lipoprotein metabolism in cynomolgus monkeys","volume":"14","author":"Noveir","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.molmed.2022.11.001_bb0495","first-page":"770","article-title":"ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism","volume":"35","author":"Hafiane","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131997","article-title":"Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of prebeta-1 HDL In Vitro","volume":"10","author":"Hafiane","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2022.11.001_bb0505","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1161\/ATVBAHA.120.314156","article-title":"E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice","volume":"41","author":"Xu","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0510","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1161\/ATVBAHA.109.194548","article-title":"Stimulation of cholesterol efflux by LXR agonists in cholesterol-loaded human macrophages is ABCA1-dependent but ABCG1-independent","volume":"29","author":"Larrede","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103287","article-title":"Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development","volume":"66","author":"Lewandowski","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.molmed.2022.11.001_bb0520","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/jama.2013.2973","article-title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans","volume":"309","author":"Reitz","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.molmed.2022.11.001_bb0525","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000079","article-title":"ABCA7 frameshift deletion associated with Alzheimer disease in African Americans","volume":"2","author":"Cukier","year":"2016","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0530","doi-asserted-by":"crossref","first-page":"220 e221","DOI":"10.1016\/j.neurobiolaging.2017.07.001","article-title":"Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls","volume":"59","author":"Bellenguez","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.molmed.2022.11.001_bb0535","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00401-017-1714-x","article-title":"Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease","volume":"134","author":"De Roeck","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0540","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1001\/jamaneurol.2017.4198","article-title":"Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis","volume":"75","author":"Apostolova","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0545","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.dadm.2016.12.003","article-title":"The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism","volume":"5","author":"Stage","year":"2016","journal-title":"Alzheimers Dement. (Amst)"},{"key":"10.1016\/j.molmed.2022.11.001_bb0550","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/alz.12220","article-title":"ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease","volume":"17","author":"Lyssenko","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.molmed.2022.11.001_bb0555","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3233\/JAD-170883","article-title":"ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-beta Peptide Efflux in an in vitro Model of the Blood-Brain Barrier","volume":"64","author":"Lamartiniere","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0560","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1194\/jlr.M006049","article-title":"Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7","volume":"51","author":"Tanaka","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0565","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","article-title":"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages","volume":"174","author":"Jehle","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0570","doi-asserted-by":"crossref","first-page":"23790","DOI":"10.1073\/pnas.1908529116","article-title":"ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain","volume":"116","author":"Aikawa","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2022.11.001_bb0575","doi-asserted-by":"crossref","first-page":"24152","DOI":"10.1074\/jbc.M115.655076","article-title":"ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing","volume":"290","author":"Satoh","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0580","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1523\/JNEUROSCI.3757-15.2016","article-title":"ABCA7 Deficiency Accelerates Amyloid-beta Generation and Alzheimer's Neuronal Pathology","volume":"36","author":"Sakae","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0585","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1523\/JNEUROSCI.4165-12.2013","article-title":"Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease","volume":"33","author":"Kim","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0590","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1474-4422(18)30232-1","article-title":"The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders","volume":"17","author":"Carmona","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0595","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12061010","article-title":"Role of ABCA1 in Cardiovascular Disease","volume":"12","author":"Wang","year":"2022","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0600","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.atherosclerosis.2009.06.005","article-title":"Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population","volume":"208","author":"Frikke-Schmidt","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.molmed.2022.11.001_bb0605","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1161\/01.ATV.0000014804.35824.DA","article-title":"Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages","volume":"22","author":"Aiello","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0610","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbrc.2010.04.027","article-title":"Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice","volume":"395","author":"Ye","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.molmed.2022.11.001_bb0615","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1038\/s41598-021-82966-y","article-title":"ABCC6 deficiency promotes dyslipidemia and atherosclerosis","volume":"11","author":"Brampton","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0620","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/jmedgenet-2020-107565","article-title":"Clinical and subclinical findings in heterozygous ABCC6 carriers: results from a Belgian cohort and clinical practice guidelines","volume":"59","author":"Nollet","year":"2022","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0625","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2967\/jnumed.119.230276","article-title":"Vascular Calcification: The Evolving Relationship of Vascular Calcification to Major Acute Coronary Events","volume":"60","author":"Strauss","year":"2019","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0630","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/ATVBAHA.111.234872","article-title":"Genetic variation in ABCG1 and risk of myocardial infarction and ischemic heart disease","volume":"32","author":"Schou","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0635","doi-asserted-by":"crossref","DOI":"10.4081\/hi.2012.e12","article-title":"Overexpression of ABCG1 protein attenuates arteriosclerosis and endothelial dysfunction in atherosclerotic rabbits","volume":"7","author":"Munch","year":"2012","journal-title":"Heart Int."},{"key":"10.1016\/j.molmed.2022.11.001_bb0640","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cca.2021.01.019","article-title":"Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs","volume":"516","author":"Zhang","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.molmed.2022.11.001_bb0645","first-page":"3900","article-title":"Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice","volume":"117","author":"Yvan-Charvet","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2022.11.001_bb0650","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/CIRCGEN.119.002871","article-title":"Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease","volume":"13","author":"Nomura","year":"2020","journal-title":"Circ. Genom. Precis. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0655","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1194\/jlr.M600353-JLR200","article-title":"Hepatic ABCG5\/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited","volume":"48","author":"Basso","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0660","doi-asserted-by":"crossref","first-page":"25744","DOI":"10.18632\/aging.104185","article-title":"Alisol B 23-acetate activates ABCG5\/G8 in the jejunum via the LXRalpha\/ACAT2 pathway to relieve atherosclerosis in ovariectomized ApoE(-\/-) mice","volume":"12","author":"Yu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.molmed.2022.11.001_bb0665","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000730","article-title":"Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis","volume":"5","author":"Chasman","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0670","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1016\/j.jmb.2020.07.006","article-title":"Novel Mechanism of Cholesterol Transport by ABCA5 in Macrophages and Its Role in Dyslipidemia","volume":"432","author":"Ray","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0675","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1161\/ATVBAHA.117.309574","article-title":"ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels","volume":"37","author":"Trigueros-Motos","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0680","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/s41598-021-81573-1","article-title":"Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice","volume":"11","author":"Ibold","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0685","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13148-020-00957-8","article-title":"DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures","volume":"13","author":"Gomez-Alonso","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.molmed.2022.11.001_bb0690","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.gene.2015.05.074","article-title":"Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells","volume":"570","author":"Scherrer","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.molmed.2022.11.001_bb0695","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijbiomac.2020.04.190","article-title":"Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid-lowering mechanism","volume":"157","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0700","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI0216001","article-title":"Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol","volume":"110","author":"Yu","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2022.11.001_bb0705","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cmet.2016.10.001","article-title":"Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion","volume":"24","author":"Jakulj","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.molmed.2022.11.001_bb0710","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.2337\/db11-0081","article-title":"Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules","volume":"60","author":"Kruit","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.molmed.2022.11.001_bb0715","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1194\/jlr.M045294","article-title":"ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity","volume":"55","author":"de Haan","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0720","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948692","article-title":"ABCA12 regulates insulin secretion from beta-cells","volume":"21","author":"Ursino","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0725","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091892","article-title":"Critical Role of the Human ATP-Binding Cassette G1 Transporter in Cardiometabolic Diseases","volume":"18","author":"Hardy","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0730","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1172\/JCI41280","article-title":"An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells","volume":"120","author":"Sturek","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2022.11.001_bb0735","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1161\/CIRCULATIONAHA.107.741314","article-title":"Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus","volume":"117","author":"Mauldin","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2022.11.001_bb0740","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jcjd.2015.04.004","article-title":"ABCG5 and ABCG8 gene polymorphisms in type 2 diabetes mellitus in the Turkish population","volume":"39","author":"Gok","year":"2015","journal-title":"Can. J. Diabetes"},{"key":"10.1016\/j.molmed.2022.11.001_bb0745","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1210\/en.2009-0866","article-title":"Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus","volume":"151","author":"Levy","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0750","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s00125-006-0177-8","article-title":"Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann-Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein","volume":"49","author":"Lally","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.molmed.2022.11.001_bb0755","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3233\/JAD-141320","article-title":"ABCA5 regulates amyloid-beta peptide production and is associated with Alzheimer's disease neuropathology","volume":"43","author":"Fu","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0760","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ijbiomac.2022.07.062","article-title":"Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: Anchor point for innovative Alzheimer's disease therapeutics","volume":"217","author":"Namasivayam","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0765","article-title":"Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro","volume":"10","author":"Jepsen","year":"2021","journal-title":"Biol. Open"},{"key":"10.1016\/j.molmed.2022.11.001_bb0770","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1172\/JCI57867","article-title":"Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice","volume":"121","author":"Krohn","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2022.11.001_bb0775","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10048-007-0087-z","article-title":"Association study of cholesterol-related genes in Alzheimer's disease","volume":"8","author":"Wollmer","year":"2007","journal-title":"Neurogenetics"},{"key":"10.1016\/j.molmed.2022.11.001_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004606","article-title":"Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias","volume":"10","author":"Beecham","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0785","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155400","article-title":"ABCG1 and ABCG4 Suppress gamma-Secretase Activity and Amyloid beta Production","volume":"11","author":"Sano","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2022.11.001_bb0790","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3233\/JAD-2012-112189","article-title":"ABCG2- and ABCG4-mediated efflux of amyloid-beta peptide 1-40 at the mouse blood-brain barrier","volume":"30","author":"Do","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0795","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1194\/jlr.M900250-JLR200","article-title":"Differential expression and function of ABCG1 and ABCG4 during development and aging","volume":"51","author":"Bojanic","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0800","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3233\/JPD-2012-11059","article-title":"Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression","volume":"2","author":"Kim","year":"2012","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0805","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1128\/MCB.25.10.4138-4149.2005","article-title":"ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms","volume":"25","author":"Kubo","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0810","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40035-018-0125-9","article-title":"Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo","volume":"7","author":"Mo","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.molmed.2022.11.001_bb0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135360","article-title":"Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model","volume":"738","author":"Sun","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.molmed.2022.11.001_bb0820","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2019.03.004","article-title":"Activation of the immunoproteasome protects SH-SY5Y cells from the toxicity of rotenone","volume":"73","author":"Sun","year":"2019","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0825","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191660","article-title":"Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain","volume":"217","author":"Bogie","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0830","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1177\/1352458520977045","article-title":"Identification of regulatory T cell molecules associated with severity of multiple sclerosis","volume":"27","author":"Tapia-Maltos","year":"2021","journal-title":"Mult. Scler."},{"key":"10.1016\/j.molmed.2022.11.001_bb0835","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.bbadis.2019.02.015","article-title":"Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability","volume":"1865","author":"Fu","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.molmed.2022.11.001_bb0840","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gene.2013.07.073","article-title":"Dementia from the ABCD1 mutation c.1415-1416delAG in a female carrier","volume":"530","author":"Finsterer","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.molmed.2022.11.001_bb0845","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s00415-003-0172-7","article-title":"Adult-onset dementia with prominent frontal lobe dysfunction in X-linked adrenoleukodystrophy with R152C mutation in ABCD1 gene","volume":"250","author":"Larner","year":"2003","journal-title":"J. Neurol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0850","doi-asserted-by":"crossref","first-page":"21348","DOI":"10.1038\/s41598-021-00870-x","article-title":"Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia","volume":"11","author":"He","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0855","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009106","article-title":"A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease","volume":"16","author":"Mederer","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0860","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092251","article-title":"Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice","volume":"20","author":"Luu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0865","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211006603","article-title":"SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury","volume":"17","author":"Tsymbalyuk","year":"2021","journal-title":"Mol. Pain"},{"key":"10.1016\/j.molmed.2022.11.001_bb0870","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1016\/j.pain.2011.08.003","article-title":"Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord","volume":"152","author":"Wu","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.molmed.2022.11.001_bb0875","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202059","article-title":"Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain","volume":"218","author":"Navia-Pelaez","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0880","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ajhg.2009.11.003","article-title":"A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression","volume":"85","author":"Knight","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molmed.2022.11.001_bb0885","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015997","article-title":"ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking","volume":"296","author":"Nakato","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0890","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1665-2681(19)31170-6","article-title":"The nuclear receptor FXR, but not LXR, up-regulates bile acid transporter expression in non-alcoholic fatty liver disease","volume":"14","author":"Aguilar-Olivos","year":"2015","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0895","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00535-015-1148-y","article-title":"The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease","volume":"51","author":"Okushin","year":"2016","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0900","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/liv.14423","article-title":"Absence of Bsep\/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice","volume":"40","author":"Fuchs","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.molmed.2022.11.001_bb0905","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1074\/jbc.M307363200","article-title":"Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis","volume":"279","author":"Figge","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2022.11.001_bb0910","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s11605-011-1473-2","article-title":"Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis","volume":"15","author":"Chai","year":"2011","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.molmed.2022.11.001_bb0915","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/hep.21158","article-title":"Mrp4-\/- mice have an impaired cytoprotective response in obstructive cholestasis","volume":"43","author":"Mennone","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0920","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3349\/ymj.2019.60.11.1045","article-title":"TNFalpha Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis","volume":"60","author":"Lian","year":"2019","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.molmed.2022.11.001_bb0925","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/j.gastro.2021.03.026","article-title":"Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model Organisms","volume":"161","author":"Pham","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmed.2022.11.001_bb0930","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1194\/jlr.M500511-JLR200","article-title":"The mechanism of ABCG5\/ABCG8 in biliary cholesterol secretion in mice","volume":"47","author":"Kosters","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb0935","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.14309\/ajg.0000000000000328","article-title":"Intrahepatic Cholestasis Owing to a Novel Heterozygous ABCG8 Mutation and SLC4A2 Polymorphism With Favorable Outcome Under Ursodeoxycholic Acid","volume":"114","author":"Ciocan","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0940","doi-asserted-by":"crossref","first-page":"775","DOI":"10.17235\/reed.2019.6168\/2019","article-title":"Clinical characteristics and genetic profiles of young and adult patients with cholestatic liver disease","volume":"111","author":"Huynh","year":"2019","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"10.1016\/j.molmed.2022.11.001_bb0945","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1038\/s41598-017-11626-x","article-title":"An expanded role for heterozygous mutations of ABCB4, ABCB11, ATP8B1, ABCC2 and TJP2 in intrahepatic cholestasis of pregnancy","volume":"7","author":"Dixon","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2022.11.001_bb0950","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.859294","article-title":"Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats","volume":"13","author":"Alaei Faradonbeh","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0955","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000464","article-title":"Multiple common and rare variants of ABCG2 cause gout","volume":"3","author":"Higashino","year":"2017","journal-title":"RMD Open"},{"key":"10.1016\/j.molmed.2022.11.001_bb0960","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study","volume":"372","author":"Dehghan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.molmed.2022.11.001_bb0965","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22040589","article-title":"ABC Transport Proteins in Cardiovascular Disease-A Brief Summary","volume":"22","author":"Schumacher","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.molmed.2022.11.001_bb0970","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126193","article-title":"New Therapies to Correct the Cystic Fibrosis Basic Defect","volume":"22","author":"Bergeron","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2022.11.001_bb0975","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/joim.12314","article-title":"Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients","volume":"277","author":"Amaral","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0980","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1002\/ppul.25075","article-title":"Drug development for cystic fibrosis","volume":"56","author":"Sanders","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.molmed.2022.11.001_bb0985","series-title":"Am I Eligible for TRIKAFTA\u00ae?","author":"Vertex","year":"2022"},{"key":"10.1016\/j.molmed.2022.11.001_bb0990","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa1908639","article-title":"Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele","volume":"381","author":"Middleton","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molmed.2022.11.001_bb0995","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fphar.2019.00121","article-title":"Emerging Therapeutic Approaches for Cystic Fibrosis. From Gene Editing to Personalized Medicine","volume":"10","author":"Pranke","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2022.11.001_bb1000","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/hep.28929","article-title":"Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770)","volume":"65","author":"Delaunay","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.molmed.2022.11.001_bb1005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1194\/jlr.M027193","article-title":"Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate","volume":"54","author":"Sorrenson","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2022.11.001_bb1010","doi-asserted-by":"crossref","DOI":"10.1002\/prot.26406","article-title":"Plastic structures for diverse substrates: a revisit of human ABC transporters","author":"Hou","year":"2022","journal-title":"Proteins"},{"key":"10.1016\/j.molmed.2022.11.001_bb1015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127524","article-title":"Cryo-EM as a powerful tool for drug discovery","volume":"30","author":"Van Drie","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.molmed.2022.11.001_bb1020","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.11.014","article-title":"Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator","volume":"167","author":"Zhang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2022.11.001_bb1025","doi-asserted-by":"crossref","first-page":"400","DOI":"10.33594\/000000146","article-title":"The CFTR Corrector, VX-809 (Lumacaftor), Rescues ABCA4 Trafficking Mutants: a Potential Treatment for Stargardt Disease","volume":"53","author":"Liu","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.molmed.2022.11.001_bb1030","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cell.2021.12.009","article-title":"Mechanism of CFTR correction by type I folding correctors","volume":"185","author":"Fiedorczuk","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2022.11.001_bb1035","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1016\/j.csbj.2021.11.035","article-title":"Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics","volume":"19","author":"Namasivayam","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.molmed.2022.11.001_bb1040","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/liv.14839","article-title":"Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants","volume":"41","author":"Ben Saad","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.molmed.2022.11.001_bb1045","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2022.11.001_bb1050","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8295054","article-title":"Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review","volume":"2019","author":"Bauersachs","year":"2019","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.molmed.2022.11.001_bb1055","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/01.CIR.103.9.1198","article-title":"Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease","volume":"103","author":"Clee","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2022.11.001_bb1060","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/nrdp.2015.19","article-title":"Type 2 diabetes mellitus","volume":"1","author":"DeFronzo","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.molmed.2022.11.001_bb1065","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/prot.22250","article-title":"Opening of the ADP-bound active site in the ABC transporter ATPase dimer: evidence for a constant contact, alternating sites model for the catalytic cycle","volume":"75","author":"Jones","year":"2009","journal-title":"Proteins"}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142200291X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142200291X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:26:54Z","timestamp":1761463614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149142200291X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":213,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S147149142200291X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2022.11.001","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ABC transporters: human disease and pharmacotherapeutic potential","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2022.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}