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A."},{"key":"10.1016\/j.molmed.2023.07.010_bb0380","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.nbd.2007.05.003","article-title":"Glycolipid and ganglioside metabolism imbalances in Huntington\u2019s disease","volume":"27","author":"Desplats","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.molmed.2023.07.010_bb0385","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1523\/JNEUROSCI.6348-09.2010","article-title":"Impaired ganglioside metabolism in Huntington\u2019s disease and neuroprotective role of GM1","volume":"30","author":"Maglione","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.molmed.2023.07.010_bb0390","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1471-4159.2010.06964.x","article-title":"Cerebellar lipid differences between R6\/1 transgenic mice and humans with Huntington\u2019s disease","volume":"115","author":"Denny","year":"2010","journal-title":"J. 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Genet."},{"key":"10.1016\/j.molmed.2023.07.010_bb0535","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2015.07.024","article-title":"SomethiNG 2 talk about-transcriptional regulation in embryonic and adult oligodendrocyte precursors","volume":"1638","author":"K\u00fcspert","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.molmed.2023.07.010_bb0540","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tins.2019.01.002","article-title":"Molecular control of oligodendrocyte development","volume":"42","author":"Elbaz","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.molmed.2023.07.010_bb0545","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1242\/dev.128.14.2723","article-title":"Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor","volume":"128","author":"Qi","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.molmed.2023.07.010_bb0550","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/glia.20006","article-title":"Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination","volume":"46","author":"Watanabe","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.molmed.2023.07.010_bb0555","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J. 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