{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:48:17Z","timestamp":1792133297656,"version":"4.4.0"},"reference-count":137,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.molmed.2024.03.006","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T17:45:10Z","timestamp":1712339110000},"page":"484-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Molecular mechanisms in the pathogenesis of dengue infections"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-0449","authenticated-orcid":false,"given":"Gathsaurie Neelika","family":"Malavige","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham S.","family":"Ogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2024.03.006_bb0005","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2024.03.006_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijid.2023.08.026","article-title":"Bangladesh's 2023 Dengue outbreak \u2013 age\/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens","volume":"136","author":"Haider","year":"2023","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/d41586-023-03407-6","article-title":"Dengue is spreading in Europe: how worried should we be?","author":"Naddaf","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2024.03.006_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0002598","article-title":"Facing the escalating burden of dengue: challenges and perspectives","volume":"3","author":"Malavige","year":"2023","journal-title":"PLoS Glob. Public Health"},{"key":"10.1016\/j.molmed.2024.03.006_bb0025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/14760584.2017.1276831","article-title":"Consider stopping dengvaxia administration without immunological screening","volume":"16","author":"Aguiar","year":"2017","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.molmed.2024.03.006_bb0030","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1016\/S2214-109X(23)00522-3","article-title":"Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4.5-year results from a phase 3, randomised, double-blind, placebo-controlled trial","volume":"12","author":"Tricou","year":"2024","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.molmed.2024.03.006_bb0035","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12929-022-00833-y","article-title":"Dengue and COVID-19: two sides of the same coin","volume":"29","author":"Malavige","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.molmed.2024.03.006_bb0040","series-title":"Comprehensive Guidelines for Prevention and Control of Dengue Fever and Dengue Haemorrhagic Fever (SEARO Technical Publication Series Vol. 60)","author":"World Health Organization","year":"2011"},{"key":"10.1016\/j.molmed.2024.03.006_bb0045","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1186\/s12879-021-06793-2","article-title":"Plasma leakage in dengue: a systematic review of prospective observational studies","volume":"21","author":"Rodrigo","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0050","doi-asserted-by":"crossref","first-page":"17485","DOI":"10.1038\/s41598-023-44559-9","article-title":"Early biomarkers for prediction of severe manifestations of dengue fever: a systematic review and a meta-analysis","volume":"13","author":"Moallemi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/cei\/uxac018","article-title":"Clinical significance of differential serum-signatures for early prediction of severe dengue among Eastern Indian patients","volume":"208","author":"Mukherjee","year":"2022","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0060","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S1473-3099(20)30601-0","article-title":"Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis","volume":"21","author":"Sangkaew","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273071","article-title":"A double whammy: the association between comorbidities and severe dengue among adult patients \u2013 a matched case\u2013control study","volume":"17","author":"Ng","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081060","article-title":"Risk factors for fatality among confirmed adult dengue inpatients in Singapore: a matched case\u2013control study","volume":"8","author":"Thein","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0075","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.celrep.2018.10.006","article-title":"Genetic variation between Dengue virus type 4 strains impacts human antibody binding and neutralization","volume":"25","author":"Gallichotte","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0080","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.meegid.2009.02.003","article-title":"Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease","volume":"9","author":"Weaver","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0085","doi-asserted-by":"crossref","first-page":"e1074","DOI":"10.1093\/cid\/ciaa1840","article-title":"Higher plasma viremia in the febrile phase is associated with adverse dengue outcomes irrespective of infecting serotype or host immune status: an analysis of 5642 Vietnamese cases","volume":"72","author":"Vuong","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0090","article-title":"Are viral loads in the febrile phase a predictive factor of dengue disease severity?","author":"Dayarathna","year":"2023","journal-title":"MedRxiv"},{"key":"10.1016\/j.molmed.2024.03.006_bb0095","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3201\/eid2604.190435","article-title":"Severe dengue epidemic, Sri Lanka, 2017","volume":"26","author":"Tissera","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0100","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.3201\/eid2808.220550","article-title":"Emergence of dengue virus serotype 2 cosmopolitan genotype, Brazil","volume":"28","author":"Giovanetti","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0105","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1038\/s41598-021-92783-y","article-title":"Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2","volume":"11","author":"Yenamandra","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0110","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.chom.2010.10.007","article-title":"Mouse STAT2 restricts early dengue virus replication","volume":"8","author":"Ashour","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.molmed.2024.03.006_bb0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/CVI.00500-13","article-title":"Dengue virus subverts the interferon induction pathway via NS2B\/3 protease-IkappaB kinase epsilon interaction","volume":"21","author":"Anglero-Rodriguez","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0120","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00553-15","article-title":"Dengue virus NS proteins inhibit RIG-I\/MAVS signaling by blocking TBK1\/IRF3 phosphorylation: dengue virus serotype 1 NS4A is a unique interferon-regulating virulence determinant","volume":"6","author":"Dalrymple","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.molmed.2024.03.006_bb0125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/v9030042","article-title":"Non-canonical roles of dengue virus non-structural proteins","volume":"9","author":"Zeidler","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.molmed.2024.03.006_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000926","article-title":"RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection","volume":"5","author":"Nasirudeen","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0135","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1038\/s41467-020-16849-7","article-title":"TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis","volume":"11","author":"Aguilar-Briseno","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2024.03.006_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1004608","article-title":"Innate and adaptive immune evasion by dengue virus","volume":"12","author":"Lee","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010499","article-title":"TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious immature dengue virus particles","volume":"18","author":"Aguilar Briseno","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098785","article-title":"Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN","volume":"9","author":"Richter","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.574067","article-title":"Dengue virus non-structural protein 5 as a versatile, multi-functional effector in host\u2013pathogen interactions","volume":"11","author":"Bhatnagar","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0160","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1128\/JVI.00221-16","article-title":"Dengue virus subverts host innate immunity by targeting adaptor protein MAVS","volume":"90","author":"He","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0165","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/jir.2014.0129","article-title":"Dengue virus control of type I IFN responses: a history of manipulation and control","volume":"35","author":"Castillo Ramirez","year":"2015","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.molmed.2024.03.006_bb0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.aab3369","article-title":"Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness","volume":"350","author":"Manokaran","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.molmed.2024.03.006_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.605087","article-title":"Decreased type I interferon production by plasmacytoid dendritic cells contributes to severe dengue","volume":"11","author":"Upasani","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011613","article-title":"Adipokine levels and their association with clinical disease severity in patients with dengue","volume":"17","author":"Kuruppu","year":"2023","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001309","article-title":"Kinetics of viremia and NS1 antigenemia are shaped by immune status and virus serotype in adults with dengue","volume":"5","author":"Tricou","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0190","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00705-013-1645-3","article-title":"Secondary infection as a risk factor for dengue hemorrhagic fever\/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection","volume":"158","author":"Guzman","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41591-024-02798-x","article-title":"Severe disease during both primary and secondary dengue virus infections in pediatric populations","volume":"30","author":"Aggarwal","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0200","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fimmu.2014.00280","article-title":"Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections","volume":"5","author":"Grange","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0205","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147066","article-title":"Dengue vaccine breakthrough infections reveal properties of neutralizing antibodies linked to protection","volume":"131","author":"Henein","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2024.03.006_bb0210","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05291","article-title":"Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcgamma receptors","volume":"4","author":"Syenina","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.molmed.2024.03.006_bb0215","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1099\/vir.0.82537-0","article-title":"Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells","volume":"88","author":"Chareonsirisuthigul","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0220","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.molmed.2024.03.006_bb0225","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/infdis\/jiw099","article-title":"Homotypic dengue virus reinfections in Nicaraguan children","volume":"214","author":"Waggoner","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0230","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jaci.2016.06.058","article-title":"Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice","volume":"139","author":"Gillis","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0235","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.molmed.2016.09.002","article-title":"Modulating antibody functionality in infectious disease and vaccination","volume":"22","author":"Gunn","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0240","article-title":"Understanding antibody-dependent enhancement in dengue: are afucosylated IgG1s a concern?","volume":"19","author":"Teo","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000718","article-title":"Immature dengue virus: a veiled pathogen?","volume":"6","author":"Rodenhuis-Zybert","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0250","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri3916","article-title":"New insights into the immunopathology and control of dengue virus infection","volume":"15","author":"Screaton","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0255","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.aai8128","article-title":"IgG antibodies to dengue enhanced for FcgammaRIIIA binding determine disease severity","volume":"355","author":"Wang","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.molmed.2024.03.006_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003320","article-title":"Antibody-dependent enhancement infection facilitates dengue virus-regulated signaling of IL-10 production in monocytes","volume":"8","author":"Tsai","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0265","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1038\/s41467-018-07667-z","article-title":"Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection","volume":"9","author":"Jayathilaka","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2024.03.006_bb0270","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molimm.2009.08.033","article-title":"Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation","volume":"47","author":"Cheng","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0275","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.4049\/jimmunol.1500057","article-title":"Dengue virus nonstructural protein 1-induced antibodies cross-react with human plasminogen and enhance its activation","volume":"196","author":"Chuang","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0280","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1111\/j.1538-7836.2007.02754.x","article-title":"Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice","volume":"5","author":"Sun","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.molmed.2024.03.006_bb0285","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1160\/TH14-07-0637","article-title":"Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcgammaRIII","volume":"113","author":"Lien","year":"2015","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.molmed.2024.03.006_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abm3151","article-title":"Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection","volume":"14","author":"Dias","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0295","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/bies.201400182","article-title":"Structure-guided insights on the role of NS1 in flavivirus infection","volume":"37","author":"Akey","year":"2015","journal-title":"Bioessays"},{"key":"10.1016\/j.molmed.2024.03.006_bb0300","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1247749","article-title":"Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system","volume":"343","author":"Akey","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.molmed.2024.03.006_bb0305","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1038\/s41467-022-34415-1","article-title":"CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever","volume":"13","author":"Shu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2024.03.006_bb0310","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3863","article-title":"Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity","volume":"7","author":"Modhiran","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0315","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3787","article-title":"Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination","volume":"7","author":"Beatty","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005738","article-title":"Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability","volume":"12","author":"Puerta-Guardo","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006673","article-title":"Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components","volume":"13","author":"Glasner","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105312","article-title":"Dengue NS1 induces phospholipase A2 enzyme activity, prostaglandins, and inflammatory cytokines in monocytes","volume":"202","author":"Silva","year":"2022","journal-title":"Antivir. Res."},{"key":"10.1016\/j.molmed.2024.03.006_bb0335","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3390\/biom10101457","article-title":"Updating phospholipase A2 biology","volume":"10","author":"Murakami","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.molmed.2024.03.006_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003459","article-title":"Platelet activating factor contributes to vascular leak in acute dengue infection","volume":"9","author":"Jeewandara","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0345","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00481","article-title":"Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage","volume":"2","author":"St John","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.molmed.2024.03.006_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008603","article-title":"DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction","volume":"17","author":"Pan","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0355","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-981-10-8727-1_7","article-title":"Plugging the leak in dengue shock","volume":"1062","author":"Watterson","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0360","article-title":"Secreted dengue virus NS1 is predominantly dimeric and in complex with high-density lipoprotein","author":"Chew","year":"2022","journal-title":"BioRxiv"},{"key":"10.1016\/j.molmed.2024.03.006_bb0365","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153600","article-title":"Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins","volume":"23","author":"Benfrid","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0370","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01664-21","article-title":"Dengue virus NS1 uses scavenger receptor B1 as a Cell receptor in cultured cells","volume":"96","author":"Alcala","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0375","article-title":"Human apolipoprotein A-I is associated with dengue virus and enhances virus infection through SR-BI","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0380","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01974-20","article-title":"ApoA1 neutralizes proinflammatory effects of dengue virus NS1 protein and modulates viral immune evasion","volume":"95","author":"Coelho","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0385","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.20092545","article-title":"Antagonism of the complement component C4 by flavivirus nonstructural protein NS1","volume":"207","author":"Avirutnan","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0390","doi-asserted-by":"crossref","first-page":"9570","DOI":"10.1128\/JVI.00912-16","article-title":"Inhibition of the membrane attack complex by dengue virus NS1 through interaction with vitronectin and terminal complement proteins","volume":"90","author":"Conde","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0395","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4049\/jimmunol.1100750","article-title":"Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation","volume":"187","author":"Avirutnan","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0400","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002412","article-title":"Factors associated with dengue shock syndrome: a systematic review and meta-analysis","volume":"7","author":"Huy","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0405","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1128\/JVI.07081-11","article-title":"The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model","volume":"86","author":"Watanabe","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0410","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/imm.12748","article-title":"Pathogenesis of vascular leak in dengue virus infection","volume":"151","author":"Malavige","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.molmed.2024.03.006_bb0415","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/infdis\/jix447","article-title":"Chymase level is a predictive biomarker of dengue hemorrhagic fever in pediatric and adult patients","volume":"216","author":"Tissera","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0420","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67460","article-title":"Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes","volume":"10","author":"Vuong","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.molmed.2024.03.006_bb0425","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/iid3.135","article-title":"Secretory phospholipase A2 in the pathogenesis of acute dengue infection","volume":"5","author":"Jeewandara","year":"2017","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0430","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1172\/JCI128426","article-title":"Dengue virus-elicited tryptase induces endothelial permeability and shock","volume":"130","author":"Rathore","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2024.03.006_bb0435","doi-asserted-by":"crossref","first-page":"19839","DOI":"10.1038\/s41598-020-76836-2","article-title":"Similarities and differences between the 'cytokine storms' in acute dengue and COVID-19","volume":"10","author":"Dayarathna","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0440","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12967-017-1226-4","article-title":"Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease","volume":"15","author":"Yong","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007033","article-title":"Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability","volume":"14","author":"Chen","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0450","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.3389\/fmicb.2019.02637","article-title":"Dengue virus infection activates interleukin-1beta to induce tissue injury and vascular leakage","volume":"10","author":"Pan","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0455","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/1471-2334-13-341","article-title":"Serum IL-10 as a marker of severe dengue infection","volume":"13","author":"Malavige","year":"2013","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0460","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-014-0080-6","article-title":"Immunosuppressive\/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction \u2013 a novel mechanism for maintaining vascular function","volume":"7","author":"Shao","year":"2014","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0465","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s42003-022-03682-5","article-title":"Dengue virus co-opts innate type 2 pathways to escape early control of viral replication","volume":"5","author":"Fonseka","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0470","article-title":"Urinary leukotrienes and histamine in patients with varying severity of acute dengue","volume":"16","author":"Silva","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0475","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/tropicalmed5040170","article-title":"Risk factors for elevated serum lipopolysaccharide in acute dengue and association with clinical disease severity","volume":"5","author":"Shyamali","year":"2020","journal-title":"Trop. Med. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113394","article-title":"Sphingosine 1-phosphate in acute dengue infection","volume":"9","author":"Gomes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0485","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/s41598-018-22285-x","article-title":"A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection","volume":"8","author":"Malavige","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0490","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149236","article-title":"Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality","volume":"131","author":"Snider","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2024.03.006_bb0495","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1194\/jlr.R058123","article-title":"A new era of secreted phospholipase A2","volume":"56","author":"Murakami","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.molmed.2024.03.006_bb0500","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1074\/jbc.M808958200","article-title":"Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability","volume":"284","author":"Knezevic","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2024.03.006_bb0505","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1084\/jem.20190111","article-title":"Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR","volume":"216","author":"Deng","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.molmed.2024.03.006_bb0510","doi-asserted-by":"crossref","first-page":"H1494","DOI":"10.1152\/ajpheart.00462.2010","article-title":"Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. American journal of physiology","volume":"299","author":"Zhang","year":"2010","journal-title":"Heart Circ. Physiol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0515","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-081519-083952","article-title":"Finding a way out: S1P signaling and immune cell migration","volume":"38","author":"Baeyens","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0520","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2015.02.058","article-title":"Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function","volume":"778","author":"Kulinski","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0525","doi-asserted-by":"crossref","first-page":"11856","DOI":"10.1038\/s41598-020-68844-z","article-title":"Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients","volume":"10","author":"Rathore","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0530","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1182\/blood-2018-08-869156","article-title":"Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors","volume":"133","author":"Masri","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.molmed.2024.03.006_bb0535","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jcv.2014.05.001","article-title":"Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection","volume":"60","author":"van de Weg","year":"2014","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003783","article-title":"Influence of mast cells on dengue protective immunity and immune pathology","volume":"9","author":"St John","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0545","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.bjp.0704215","article-title":"VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2","volume":"134","author":"Bernatchez","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0550","doi-asserted-by":"crossref","first-page":"25602","DOI":"10.1074\/jbc.M109.009894","article-title":"The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species","volume":"284","author":"Monaghan-Benson","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2024.03.006_bb0555","article-title":"Mast cell-derived proteases induce endothelial permeability and vascular damage in severe fever with thrombocytopenia syndrome","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.molmed.2024.03.006_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132367","article-title":"Histamine induces vascular hyperpermeability by increasing blood flow and endothelial barrier disruption in vivo","volume":"10","author":"Ashina","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2024.03.006_bb0565","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12879-016-1656-2","article-title":"Patterns and causes of liver involvement in acute dengue infection","volume":"16","author":"Fernando","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009808","article-title":"Predictive markers for the early prognosis of dengue severity: a systematic review and meta-analysis","volume":"15","author":"Thach","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0575","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001676","article-title":"Clinical relevance and discriminatory value of elevated liver aminotransferase levels for dengue severity","volume":"6","author":"Lee","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0580","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.humpath.2014.01.022","article-title":"Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar","volume":"45","author":"Aye","year":"2014","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0585","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21037\/tgh-20-125","article-title":"Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease","volume":"6","author":"Prasun","year":"2021","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0590","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.actatropica.2008.03.001","article-title":"Oxidative stress induced changes in plasma protein can be a predictor of imminent severe dengue infection","volume":"106","author":"Soundravally","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.molmed.2024.03.006_bb0595","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01551-20","article-title":"Dengue virus targets Nrf2 for NS2B3-mediated degradation leading to enhanced oxidative stress and viral replication","volume":"94","author":"Ferrari","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0600","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.4254\/wjh.v13.i12.1968","article-title":"Dengue hemorrhagic fever and the liver","volume":"13","author":"Leowattana","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0605","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/cid\/ciz499","article-title":"Dengue infection complicated by hemophagocytic lymphohistiocytosis: experiences from 180 patients with severe dengue","volume":"70","author":"Kan","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0610","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/bjh.12293","article-title":"Advances in understanding the pathogenesis of HLH","volume":"161","author":"Usmani","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0615","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010123","article-title":"Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: a randomised, double blind, placebo-controlled trial","volume":"16","author":"Malavige","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0620","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1086\/341410","article-title":"Coagulation abnormalities in dengue hemorrhagic fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome","volume":"35","author":"Wills","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.molmed.2024.03.006_bb0625","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/trstmh\/trx079","article-title":"Prophylactic and therapeutic interventions for bleeding in dengue: a systematic review","volume":"111","author":"Rajapakse","year":"2017","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.molmed.2024.03.006_bb0630","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/qjmed\/hcl039","article-title":"Patterns of disease among adults hospitalized with dengue infections","volume":"99","author":"Malavige","year":"2006","journal-title":"QJM"},{"key":"10.1016\/j.molmed.2024.03.006_bb0635","doi-asserted-by":"crossref","first-page":"41697","DOI":"10.1038\/srep41697","article-title":"Platelet activation determines the severity of thrombocytopenia in dengue infection","volume":"7","author":"Ojha","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.03.006_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006385","article-title":"Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue","volume":"13","author":"Trugilho","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0645","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jinf.2011.11.023","article-title":"Dengue virus nonstructural protein NS1 binds to prothrombin\/thrombin and inhibits prothrombin activation","volume":"64","author":"Lin","year":"2012","journal-title":"J. infect."},{"key":"10.1016\/j.molmed.2024.03.006_bb0650","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007625","article-title":"Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage","volume":"15","author":"Chao","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.molmed.2024.03.006_bb0655","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1182\/blood.V59.3.582.582","article-title":"Effect of platelet-activating factor (PAF) on human platelets","volume":"59","author":"Chesney","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.molmed.2024.03.006_bb0660","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1160\/TH13-02-0149","article-title":"Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities","volume":"110","author":"Chuang","year":"2013","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.molmed.2024.03.006_bb0665","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1258\/ebm.2011.010339","article-title":"Molecular mimicry between virus and host and its implications for dengue disease pathogenesis","volume":"236","author":"Lin","year":"2011","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.molmed.2024.03.006_bb0670","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coviro.2020.07.009","article-title":"Recent advances in antiviral drug development towards dengue virus","volume":"43","author":"Troost","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.molmed.2024.03.006_bb0675","first-page":"1115","article-title":"Montelukast reduces the risk of dengue shock syndrome in dengue patients","volume":"35","author":"Ahmad","year":"2018","journal-title":"Trop. Biomed."},{"key":"10.1016\/j.molmed.2024.03.006_bb0680","doi-asserted-by":"crossref","first-page":"e306","DOI":"10.1016\/S2214-109X(22)00547-2","article-title":"Differentiating dengue from other febrile illnesses: a dilemma faced by clinicians in dengue endemic countries","volume":"11","author":"Malavige","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.molmed.2024.03.006_bb0685","doi-asserted-by":"crossref","first-page":"e361","DOI":"10.1016\/S2214-109X(22)00514-9","article-title":"Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study","volume":"11","author":"Rosenberger","year":"2023","journal-title":"Lancet Glob. Health"}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491424000613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491424000613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T16:14:03Z","timestamp":1715184843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491424000613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":137,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1471491424000613"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2024.03.006","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanisms in the pathogenesis of dengue infections","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2024.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}