{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:19:10Z","timestamp":1786994350728,"version":"build-2736575974"},"reference-count":76,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM067260"],"award-info":[{"award-number":["R01 GM067260"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM135158"],"award-info":[{"award-number":["R01 GM135158"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.molmed.2024.04.015","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T12:16:17Z","timestamp":1717589777000},"page":"1010-1019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Amyloid and collagen templates in aortic valve calcification"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-5347","authenticated-orcid":false,"given":"Shobini","family":"Jayaraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-3645","authenticated-orcid":false,"given":"Navneet","family":"Narula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-3996","authenticated-orcid":false,"given":"Jagat","family":"Narula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-4824","authenticated-orcid":false,"given":"Olga","family":"Gursky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2024.04.015_bb0005","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41569-023-00845-7","article-title":"Calcific aortic valve disease: mechanisms, prevention and treatment","volume":"20","author":"Moncla","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0010","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.actbio.2022.03.003","article-title":"Nuclear and cellular, micro and nano calcification in Alzheimer\u2019s disease patients and correlation to phosphorylated Tau","volume":"143","author":"Tsolaki","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/342984","article-title":"Morphological and chemical study of pathological deposits in human aortic and mitral valve stenosis: a biomineralogical contribution","volume":"2015","author":"Cottignoli","year":"2015","journal-title":"Pathol. Res. Int."},{"key":"10.1016\/j.molmed.2024.04.015_bb0020","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.119.043391","article-title":"Global, regional, and national burden of calcific aortic valve and degenerative mitral valve diseases, 1990\u20132017","volume":"141","author":"Yadgir","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2024.04.015_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.783543","article-title":"Uncoupling the vicious cycle of mechanical stress and inflammation in calcific aortic valve disease","volume":"9","author":"Dayawansa","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.molmed.2024.04.015_bb0030","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41569-022-00818-2","article-title":"The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis","volume":"20","author":"Sud","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0035","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/jcp.33.3.262","article-title":"Microscopic amyloid deposits in the heart valves: a common local complication of chronic damage and scarring","volume":"33","author":"Goffin","year":"1980","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0040","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.carpath.2009.04.005","article-title":"High prevalence of amyloid in 150 surgically removed heart valves \u2013 a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions","volume":"19","author":"Kristen","year":"2010","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0045","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1365-2559.2012.04265.x","article-title":"Amyloid substance within stenotic aortic valves promotes mineralization","volume":"61","author":"Audet","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.molmed.2024.04.015_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/jcm13010221","article-title":"Cardiac amyloidosis and valvular heart disease","volume":"13","author":"Duca","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.molmed.2024.04.015_bb0055","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015700","article-title":"ApoC-III is a novel inducer of calcification in human aortic valves","volume":"296","author":"Schlotter","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2024.04.015_bb0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10741-023-10350-1","article-title":"Valvular heart disease in patients with cardiac amyloidosis","volume":"29","author":"Aimo","year":"2024","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.molmed.2024.04.015_bb0065","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.0910136107","article-title":"Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I","volume":"107","author":"Wong","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2024.04.015_bb0070","doi-asserted-by":"crossref","first-page":"10958","DOI":"10.1074\/jbc.M114.630442","article-title":"Myeloperoxidase-mediated methionine oxidation promotes an amyloidogenic outcome for apolipoprotein A-I","volume":"290","author":"Chan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2024.04.015_bb0075","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0968-0004(91)90098-G","article-title":"Acidic macromolecules of mineralized tissues: the controllers of crystal formation","volume":"16","author":"Weiner","year":"1991","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0080","doi-asserted-by":"crossref","first-page":"19201","DOI":"10.1073\/pnas.2007838117","article-title":"Protein nanoribbons template enamel mineralization","volume":"117","author":"Bai","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2024.04.015_bb0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2106965119","article-title":"Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites","volume":"119","author":"Akkineni","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2024.04.015_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1063970","article-title":"Calcium interactions in amelogenin-derived peptide assembly","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201704476","article-title":"Phase-transited lysozyme as a universal route to bioactive hydroxyapatite crystalline film","volume":"28","author":"Ha","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0100","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.cell.2021.08.013","article-title":"The expanding amyloid family: structure, stability, function, and pathogenesis","volume":"184","author":"Sawaya","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2024.04.015_bb0105","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tibs.2021.05.003","article-title":"Protein amyloid cofactors: charged side-chain arrays meet their match?","volume":"46","author":"Lewkowicz","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.abm7285","article-title":"Cryo-EM structures of amyloid-\u03b2 42 filaments from human brains","volume":"375","author":"Yang","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.molmed.2024.04.015_bb0115","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","article-title":"Bone formation and inflammation in cardiac valves","volume":"103","author":"Mohler","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2024.04.015_bb0120","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1093\/cvr\/cvab038","article-title":"From organic and inorganic phosphates to valvular and vascular calcifications","volume":"117","author":"B\u00e4ck","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.molmed.2024.04.015_bb0125","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nmat3627","article-title":"Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification","volume":"12","author":"Bertazzo","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0130","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1039\/c3ce40803e","article-title":"\u2018Liquid-like\u2019 biomineralization protein assemblies: a key to the regulation of non-classical nucleation","volume":"15","author":"Evans","year":"2013","journal-title":"CrystEngComm"},{"key":"10.1016\/j.molmed.2024.04.015_bb0135","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1039\/C7TB01199G","article-title":"Detection of Posner\u2019s clusters during calcium phosphate nucleation: a molecular dynamics study","volume":"5","author":"Mancardi","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.molmed.2024.04.015_bb0140","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/ncomms2490","article-title":"Ion-association complexes unite classical and non-classical theories for the biomimetic nucleation of calcium phosphate","volume":"4","author":"Habraken","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2024.04.015_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42004-018-0081-4","article-title":"Biomineralization of calcium phosphate revealed by in situ liquid-phase electron microscopy","volume":"1","author":"Wang","year":"2018","journal-title":"Commun. Chem."},{"key":"10.1016\/j.molmed.2024.04.015_bb0150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.actbio.2020.07.038","article-title":"Involvement of prenucleation clusters in calcium phosphate mineralization of collagen","volume":"120","author":"Ma","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0155","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/ijms24032667","article-title":"Ultrastructural and immunohistochemical detection of hydroxyapatite nucleating role by rRNA and nuclear chromatin derivatives in aortic valve calcification: in vitro and in vivo pro-calcific animal models and actual calcific disease in humans","volume":"24","author":"Bonetti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0160","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nmat2875","article-title":"The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors","volume":"9","author":"Nudelman","year":"2010","journal-title":"Nat. Mater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0165","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1021\/acs.nanolett.3c02344","article-title":"Liquid transmission electron microscopy for probing collagen biomineralization","volume":"23","author":"DiCecco","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.molmed.2024.04.015_bb0170","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41467-024-44820-3","article-title":"Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy","volume":"15","author":"Nguyen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2024.04.015_bb0175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/1573403X15666190722154152","article-title":"Transthyretin cardiac amyloidosis and aortic stenosis: connection and therapeutic implications","volume":"16","author":"Penalver","year":"2020","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.molmed.2024.04.015_bb0180","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/ijms25021171","article-title":"Isolated valve amyloid deposition in aortic stenosis: potential clinical and pathophysiological relevance","volume":"25","author":"Conte","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0185","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1161\/CIRCULATIONAHA.122.063402","article-title":"Multiomics of tissue extracellular vesicles identifies unique modulators of atherosclerosis and calcific aortic valve stenosis","volume":"148","author":"Blaser","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2024.04.015_bb0190","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.jacc.2019.01.070","article-title":"Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis","volume":"73","author":"Zheng","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0195","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/MOL.0000000000000823","article-title":"Understanding the ins and outs of lipoprotein (a) metabolism","volume":"33","author":"Boffa","year":"2022","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0200","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1093\/eurheartj\/ehac361","article-title":"Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement","volume":"43","author":"Kronenberg","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.molmed.2024.04.015_bb0205","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/HCO.0000000000000300","article-title":"Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis","volume":"31","author":"Yeang","year":"2016","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/13506129.2022.2147636","article-title":"Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee","volume":"29","author":"Buxbaum","year":"2022","journal-title":"Amyloid"},{"key":"10.1016\/j.molmed.2024.04.015_bb0215","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00018-023-05026-w","article-title":"Molecular modeling of apoE in complexes with Alzheimer\u2019s amyloid-\u03b2 fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids","volume":"80","author":"Lewkowicz","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-3-319-17344-3_8","article-title":"Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights","volume":"855","author":"Das","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0225","first-page":"1186","article-title":"Apolipoprotein A1-derived amyloid in human aortic atherosclerotic plaques","volume":"147","author":"Westermark","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0230","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/01.ATV.0000201930.10103.be","article-title":"Prevalence and pathology of amyloid in atherosclerotic arteries","volume":"26","author":"R\u00f6cken","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0235","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/ijms24010170","article-title":"Lipoprotein(a): cardiovascular disease, aortic stenosis and new therapeutic option","volume":"24","author":"Maloberti","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0240","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.atherosclerosis.2022.04.009","article-title":"Beyond fibrinolysis: the confounding role of Lp(a) in thrombosis","volume":"349","author":"Boffa","year":"2022","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.molmed.2024.04.015_bb0245","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1073\/pnas.1702724114","article-title":"Inducing protein aggregation by extensional flow","volume":"114","author":"Dobson","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2024.04.015_bb0250","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/bs.pmbts.2019.05.008","article-title":"Shear-induced amyloid formation of IDPs in the brain","volume":"166","author":"Trumbore","year":"2019","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0255","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1055\/s-2003-44556","article-title":"Shear stress and von Willebrand factor in health and disease","volume":"29","author":"Tsai","year":"2003","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.molmed.2024.04.015_bb0260","doi-asserted-by":"crossref","first-page":"10355","DOI":"10.1021\/acs.jpcb.1c05171","article-title":"Effects of shear rate and protein concentration on amyloidogenesis via interfacial shear","volume":"125","author":"Adam","year":"2021","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.molmed.2024.04.015_bb0265","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbadis.2016.10.010","article-title":"Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: potential implications for treatment of apolipoprotein deposition diseases","volume":"1863","author":"Jayaraman","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.molmed.2024.04.015_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.834503","article-title":"Liquid\u2013liquid phase separation in nucleation process of biomineralization","volume":"10","author":"Qin","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.molmed.2024.04.015_bb0275","article-title":"Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with light chain amyloidosis","author":"Ricagno","year":"2023","journal-title":"Res. Sq."},{"key":"10.1016\/j.molmed.2024.04.015_bb0280","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/13506129.2022.2155133","article-title":"Collagen inhibits phagocytosis of amyloid in vitro and in vivo and may act as a \u2018don\u2019t eat me\u2019 signal","volume":"30","author":"Jackson","year":"2023","journal-title":"Amyloid"},{"key":"10.1016\/j.molmed.2024.04.015_bb0285","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/MCO.0000000000000976","article-title":"Lipoprotein(a) and calcific aortic valve disease: current evidence and future directions","volume":"27","author":"Lan","year":"2024","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.molmed.2024.04.015_bb0290","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCULATIONAHA.115.016757","article-title":"Autotaxin derived from lipoprotein(a) and valve interstitial cells promotes inflammation and mineralization of the aortic valve","volume":"132","author":"Bouchareb","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2024.04.015_bb0295","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jacbts.2020.06.012","article-title":"Interaction of autotaxin with lipoprotein(a) in patients with calcific aortic valve stenosis","volume":"5","author":"Bourgeois","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0300","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1523\/JNEUROSCI.20-11-03937.2000","article-title":"The plasmin system is induced by and degrades amyloid-beta aggregates","volume":"20","author":"Tucker","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0305","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fcvm.2019.00018","article-title":"Autotaxin and lipoprotein metabolism in calcific aortic valve disease","volume":"6","author":"Mathieu","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.molmed.2024.04.015_bb0310","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.3390\/ijms21082946","article-title":"Hydroxyapatite formation coexists with amyloid-like self-assembly of human amelogenin","volume":"21","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtla.2023.101926","article-title":"Proteomics of serum proteins adsorbed onto hydroxyapatite single-crystal particles with an anisotropic structure","volume":"32","author":"Onuma","year":"2023","journal-title":"Materialia"},{"key":"10.1016\/j.molmed.2024.04.015_bb0320","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1177\/0022034513504929","article-title":"Mineral association changes the secondary structure and dynamics of murine amelogenin","volume":"92","author":"Lu","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molmed.2024.04.015_bb0325","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/ijms22020944","article-title":"Biomineralization of collagen-based materials for hard tissue repair","volume":"22","author":"Yu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2024.04.015_bb0330","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MOL.0000000000000856","article-title":"Recent lipoprotein(a) trials","volume":"33","author":"Wei","year":"2022","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200872","article-title":"Amyloid-mediated remineralization in pit and fissure for caries preventive therapy","volume":"11","author":"Yang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0340","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1002\/adma.201306198","article-title":"Amyloid\u2013hydroxyapatite bone biomimetic composites","volume":"26","author":"Li","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.molmed.2024.04.015_bb0345","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s42003-023-04567-x","article-title":"Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration","volume":"6","author":"Yu","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0350","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/heartjnl-2014-307020","article-title":"The modern epidemiology of heart valve disease","volume":"102","author":"Coffey","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.molmed.2024.04.015_bb0355","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jacc.2021.11.060","article-title":"Trends in utilization of aortic valve replacement for severe aortic stenosis","volume":"79","author":"Li","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0360","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","article-title":"The evolving epidemiology of valvular aortic stenosis: the Troms\u00f8 Study","volume":"99","author":"Eveborn","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.molmed.2024.04.015_bb0365","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/CIR.0000000000000029","article-title":"AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Nishimura","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2024.04.015_bb0370","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease","volume":"77","author":"Otto","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0375","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.molmed.2024.04.015_bb0380","first-page":"185","article-title":"Pathogenesis of aortic stenosis: not just a matter of wear and tear","volume":"1","author":"Sverdlov","year":"2011","journal-title":"Am. J. Cardiovasc. Dis."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491424001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491424001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T13:16:59Z","timestamp":1731503819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491424001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":76,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1471491424001151"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2024.04.015","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid and collagen templates in aortic valve calcification","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2024.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}