{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:25:19Z","timestamp":1792045519378,"version":"4.4.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"am","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK095072"],"award-info":[{"award-number":["R01-DK095072"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R35-HL139424"],"award-info":[{"award-number":["R35-HL139424"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG027002"],"award-info":[{"award-number":["R01-AG027002"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.molmed.2024.12.004","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:47:47Z","timestamp":1736038067000},"page":"669-681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["NAD+ metabolism in acute kidney injury and chronic kidney disease transition"],"prefix":"10.1016","volume":"31","author":[{"given":"Rahil","family":"Alhumaidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christelle","family":"Saade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1038-981X","authenticated-orcid":false,"given":"Samir M.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2024.12.004_bb0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41556-019-0287-4","article-title":"NAD+ metabolism governs the proinflammatory senescence-associated secretome","volume":"21","author":"Nacarelli","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00583517","article-title":"Contribution of long chain fatty acids to the energy supply of the rat kidney cortex","volume":"356","author":"Bertermann","year":"1975","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.molmed.2024.12.004_bb0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.molcel.2020.12.012","article-title":"Increased demand for NAD+ relative to ATP drives aerobic glycolysis","volume":"81","author":"Luengo","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molmed.2024.12.004_bb0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells plays a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0025","article-title":"Changes in metabolic profiles during acute kidney injury and recovery following ischemia\/reperfusion","volume":"9","author":"Wei","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molmed.2024.12.004_bb0030","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","article-title":"PGC1\u03b1 drives NAD biosynthesis linking oxidative metabolism to renal protection","volume":"531","author":"Tran","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2024.12.004_bb0035","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1681\/ASN.2015010107","article-title":"Urine metabolite profiles predictive of human kidney allograft status","volume":"27","author":"Suhre","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0040","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41591-018-0138-z","article-title":"De novo NAD+ biosynthetic impairment in acute kidney injury in humans","volume":"24","author":"Poyan Mehr","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0045","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.kint.2023.09.013","article-title":"Hepatocyte nuclear factor 4\u03b1 mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury","volume":"104","author":"Clark","year":"2023","journal-title":"Kidney Int."},{"key":"10.1016\/j.molmed.2024.12.004_bb0050","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41586-018-0645-6","article-title":"De novo NAD+ synthesis enhances mitochondrial function and improves health","volume":"563","author":"Katsyuba","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2024.12.004_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0210-x","article-title":"Kynurenine 3-monooxygenase is a critical regulator of renal ischemia\u2013reperfusion injury","volume":"51","author":"Zheng","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1070435","article-title":"States of quinolinic acid excess in urine: a systematic review of human studies","volume":"9","author":"Saade","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.molmed.2024.12.004_bb0065","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3390\/antiox12040821","article-title":"NAD+ Biosynthesis impairment and acute kidney injury after major vascular surgery","volume":"12","author":"Mede","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.molmed.2024.12.004_bb0070","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.153019","article-title":"Cell stress response impairs de novo NAD+ biosynthesis in the kidney","volume":"7","author":"Bignon","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.molmed.2024.12.004_bb0075","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1002\/hep.31907","article-title":"Admission urinary and serum metabolites predict renal outcomes in hospitalized patients with cirrhosis","volume":"74","author":"Bajaj","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.molmed.2024.12.004_bb0080","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.ekir.2021.03.036","article-title":"POS-030 urine quinolinate to tryptophan ratio at discharge and renal recovery at 4 months after community acquired AKI: a prospective cohort study","volume":"6","author":"Jose","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.molmed.2024.12.004_bb0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/metabo11080533","article-title":"Kidney allograft function is a confounder of urine metabolite profiles in kidney allograft recipients","volume":"11","author":"Suhre","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.molmed.2024.12.004_bb0090","first-page":"R1834","article-title":"Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats","volume":"279","author":"Martin","year":"2000","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.molmed.2024.12.004_bb0095","doi-asserted-by":"crossref","first-page":"F387","DOI":"10.1152\/ajprenal.00436.2003","article-title":"Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury","volume":"288","author":"Zheng","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0100","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ki.2012.64","article-title":"Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity","volume":"82","author":"Kim","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.molmed.2024.12.004_bb0105","first-page":"R843","article-title":"Cisplatin nephrotoxicity is induced via poly(ADP-ribose) polymerase activation in adult zebrafish and mice","volume":"318","author":"Kim","year":"2020","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.molmed.2024.12.004_bb0110","doi-asserted-by":"crossref","first-page":"F450","DOI":"10.1152\/ajprenal.00059.2011","article-title":"Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction","volume":"301","author":"Kim","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11626-014-9809-3","article-title":"Mechanical stretch induces angiotensinogen expression through PARP1 activation in kidney proximal tubular cells","volume":"51","author":"Lee","year":"2015","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.molmed.2024.12.004_bb0120","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/rheumatology\/kei262","article-title":"Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus","volume":"45","author":"Hur","year":"2006","journal-title":"Rheumatology"},{"key":"10.1016\/j.molmed.2024.12.004_bb0125","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.4049\/jimmunol.0803565","article-title":"Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation","volume":"182","author":"Jog","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2009.10.002","article-title":"Role of the poly(ADP-ribose)polymerase activity in vancomycin-induced renal injury","volume":"192","author":"Dalaklioglu","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.molmed.2024.12.004_bb0135","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/toxres\/tfad091","article-title":"The potential role of upregulated PARP-1\/RIPK1 expressions in amikacin-induced oxidative damage and nephrotoxicity in Wistar rats","volume":"12","author":"El Latif","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.molmed.2024.12.004_bb0140","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41419-018-1012-0","article-title":"Targeting enhancer of zeste homolog 2 protects against acute kidney injury","volume":"9","author":"Zhou","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molmed.2024.12.004_bb0145","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1091\/mbc.E18-10-0650","article-title":"NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival","volume":"30","author":"Murata","year":"2019","journal-title":"MBoC"},{"key":"10.1016\/j.molmed.2024.12.004_bb0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41598-023-50630-2","article-title":"Effects of poly (ADP-ribose) polymerase inhibitor treatment on the repair process of ischemic acute kidney injury","volume":"14","author":"Jeon","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.12.004_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081928","article-title":"PARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade","volume":"8","author":"Kalmar-Nagy","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molmed.2024.12.004_bb0160","first-page":"1304","article-title":"Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.molmed.2024.12.004_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.254","article-title":"Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress","volume":"4","author":"Cheng","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molmed.2024.12.004_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110021","article-title":"Activation of sirtuin1 protects against ischemia\/reperfusion-induced acute kidney injury","volume":"125","author":"Gong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.molmed.2024.12.004_bb0175","doi-asserted-by":"crossref","first-page":"165","DOI":"10.12659\/MSMBR.901909","article-title":"Sirtuin1 (SIRT1) regulates tumor necrosis factor-alpha (TNF-\u03b1-Induced) aquaporin-2 (AQP2) expression in renal medullary collecting duct cells through inhibiting the NF-\u03baB pathway","volume":"22","author":"Lin","year":"2016","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"10.1016\/j.molmed.2024.12.004_bb0180","article-title":"Forskolin modulate silent information regulator 1 (SIRT1) gene expression and halts experimentally-induced acute kidney injury","volume":"9","author":"Sorour","year":"2019","journal-title":"Egypt. J. Basic Clin. Pharmacol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0185","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3389\/fphys.2018.01526","article-title":"SIRT3 protects against acute kidney injury via AMPK\/mTOR-regulated autophagy","volume":"9","author":"Zhao","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0190","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.molmed.2024.12.004_bb0195","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1111\/jcmm.17222","article-title":"NAD + ameliorates endotoxin-induced acute kidney injury in a sirtuin1\u2013dependent manner via GSK-3\u03b2\/Nrf2 signalling pathway","volume":"26","author":"He","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0200","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12967-018-1690-5","article-title":"Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury","volume":"16","author":"Zhang","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0205","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1111\/jcmm.15148","article-title":"Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice","volume":"24","author":"Li","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0210","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI77632","article-title":"Sirtuin 3\u2013dependent mitochondrial dynamic improvements protect against acute kidney injury","volume":"125","author":"Morigi","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.molmed.2024.12.004_bb0215","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2018.03.018","article-title":"Quantitative analysis of NAD synthesis-breakdown fluxes","volume":"27","author":"Liu","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.molmed.2024.12.004_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2022.10.013","article-title":"The significance of NAD+ biosynthesis alterations in acute kidney injury","volume":"42","author":"Clark","year":"2022","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0225","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1016\/j.ekir.2021.09.001","article-title":"Nicotinamide adenine dinucleotide biosynthetic impairment and urinary metabolomic alterations observed in hospitalized adults with COVID-19-related acute kidney injury","volume":"6","author":"Raines","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.molmed.2024.12.004_bb0230","doi-asserted-by":"crossref","first-page":"F801","DOI":"10.1152\/ajprenal.00044.2007","article-title":"Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells","volume":"293","author":"Mohib","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0235","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-020-2741-7","article-title":"SLC25A51 is a mammalian mitochondrial NAD+ transporter","volume":"588","author":"Luongo","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2024.12.004_bb0240","doi-asserted-by":"crossref","first-page":"21767","DOI":"10.1074\/jbc.M110.213298","article-title":"Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation","volume":"286","author":"Nikiforov","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2024.12.004_bb0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139092","article-title":"DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity","volume":"6","author":"Hama","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.molmed.2024.12.004_bb0250","first-page":"685","article-title":"Platinum-induced kidney damage: unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury. Biochimica et Biophysica Acta (BBA) - Molecular","volume":"1853","author":"Kr\u00fcger","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.molmed.2024.12.004_bb0255","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0165-7992(95)90039-X","article-title":"Preferential binding of cisplatin to mitochondrial DNA of Chinese hamster ovary cells","volume":"346","author":"Olivero","year":"1995","journal-title":"Mutat. Res. Lett."},{"key":"10.1016\/j.molmed.2024.12.004_bb0260","first-page":"831","article-title":"Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia","volume":"140","author":"Schumer","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0265","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1159\/000337358","article-title":"Caspase-3-Independent Internucleosomal DNA fragmentation in ischemic acute kidney injury","volume":"120","author":"Yoshida","year":"2012","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0270","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1568-7864(02)00214-8","article-title":"Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney","volume":"2","author":"Tsuruya","year":"2003","journal-title":"DNA Repair"},{"key":"10.1016\/j.molmed.2024.12.004_bb0275","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00392-6","article-title":"Cumulative DNA damage by repeated low-dose cisplatin injection promotes the transition of acute to chronic kidney injury in mice","volume":"11","author":"Yamashita","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.12.004_bb0280","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2024.12.004_bb0285","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/s41556-023-01280-z","article-title":"NAD+ regulates nucleotide metabolism and genomic DNA replication","volume":"25","author":"Munk","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0290","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41467-018-03234-8","article-title":"NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains","volume":"9","author":"Langelier","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2024.12.004_bb0295","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1021\/jm301431y","article-title":"The 2.5 \u00c5 crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD +) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition","volume":"56","author":"Zhao","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.molmed.2024.12.004_bb0300","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","article-title":"NAD + Replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair","volume":"24","author":"Fang","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.molmed.2024.12.004_bb0305","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0310","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.15252\/embj.201593499","article-title":"SIRT 7 promotes genome integrity and modulates non-homologous end joining DNA repair","volume":"35","author":"Vazquez","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.molmed.2024.12.004_bb0315","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.molcel.2010.07.006","article-title":"SIRT1 regulates UV-induced DNA repair through deacetylating XPA","volume":"39","author":"Fan","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.molmed.2024.12.004_bb0320","first-page":"H962","article-title":"Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice","volume":"310","author":"Pillai","year":"2016","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.molmed.2024.12.004_bb0325","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1021\/acs.biochem.5b00150","article-title":"Kinetic and structural basis for acyl-group selectivity and NAD+ dependence in sirtuin-catalyzed deacylation","volume":"54","author":"Feldman","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.molmed.2024.12.004_bb0330","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrg.2017.80","article-title":"The DNA methyltransferase family: a versatile toolkit for epigenetic regulation","volume":"19","author":"Lyko","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.molmed.2024.12.004_bb0335","first-page":"1199","article-title":"Nicotinamide adenine dinucleotide (NAD) may affect DNA methyltransferase 1 through regulation of BRCA1 in ovarian cancer","volume":"5","author":"Fang","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.molmed.2024.12.004_bb0340","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.3390\/cells10112986","article-title":"NAD modulates DNA methylation and cell differentiation","volume":"10","author":"Ummarino","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.molmed.2024.12.004_bb0345","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1038\/s41598-022-10476-6","article-title":"The significance of NAD+metabolites and nicotinamide N-methyltransferase in chronic kidney disease","volume":"12","author":"Takahashi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2024.12.004_bb0350","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nchembio.1204","article-title":"NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink","volume":"9","author":"Ulanovskaya","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0355","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/jn\/131.11.2811","article-title":"Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice","volume":"131","author":"Caudill","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.molmed.2024.12.004_bb0370","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-022-04713-z","article-title":"Complex roles of nicotinamide N-methyltransferase in cancer progression","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.molmed.2024.12.004_bb0380","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.molmed.2024.12.004_bb0385","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1681\/ASN.2016040385","article-title":"Nicotinamide mononucleotide, an NAD+ precursor, rescues age-associated susceptibility to AKI in a sirtuin 1-dependent manner","volume":"28","author":"Guan","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0390","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/ki.2013.330","article-title":"Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice","volume":"85","author":"Oh","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.molmed.2024.12.004_bb0395","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/ndt\/gfaa124","article-title":"Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease","volume":"36","author":"Faivre","year":"2021","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.molmed.2024.12.004_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.649547","article-title":"Nicotinamide mononucleotide attenuates renal interstitial fibrosis after AKI by suppressing tubular DNA damage and senescence","volume":"12","author":"Jia","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0405","article-title":"Impaired nicotinamide adenine dinucleotide biosynthesis in the kidney of chronic kidney disease","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb2005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/toxins13010050","article-title":"Nicotinamide attenuates the progression of renal failure in a mouse model of adenine-induced chronic kidney disease","volume":"13","author":"Kumakura","year":"2021","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.molmed.2024.12.004_bb0415","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000510943","article-title":"Nicotinamide supplementation attenuates renal interstitial fibrosis via boosting the activity of sirtuins","volume":"7","author":"Zhen","year":"2021","journal-title":"Kidney Dis."},{"key":"10.1016\/j.molmed.2024.12.004_bb0420","doi-asserted-by":"crossref","first-page":"F106","DOI":"10.1152\/ajprenal.00126.2009","article-title":"Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure","volume":"297","author":"Cho","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0410","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1111\/jcmm.14285","article-title":"Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.molmed.2024.12.004_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252554","article-title":"Effect of NAD+ boosting on kidney ischemia-reperfusion injury","volume":"16","author":"Morevati","year":"2021","journal-title":"PLoS ONE"},{"key":"10.1016\/j.molmed.2024.12.004_bb0430","article-title":"Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation","author":"Saleh","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.molmed.2024.12.004_bb0435","doi-asserted-by":"crossref","first-page":"33","DOI":"10.34067\/KID.0006452020","article-title":"Niacinamide may be associated with improved outcomes in COVID-19-related acute kidney injury: an observational study","volume":"2","author":"Raines","year":"2021","journal-title":"Kidney360"},{"key":"10.1016\/j.molmed.2024.12.004_bb0440","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.ekir.2023.02.042","article-title":"WCN23-0889 vitamin B complex in patients with acute kidney injury the VIBAKI Trial","volume":"8","author":"Granado","year":"2023","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.molmed.2024.12.004_bb0445","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1681\/ASN.20233411S160b","article-title":"Niacinamide and renal recovery after AKI: a randomized, controlled trial: SA-OR04","volume":"34","author":"Kohli","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.molmed.2024.12.004_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115492","article-title":"NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1\/p53 pathway","volume":"418","author":"Wu","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142400337X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142400337X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:20:22Z","timestamp":1762546822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149142400337X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":88,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S147149142400337X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2024.12.004","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAD+ metabolism in acute kidney injury and chronic kidney disease transition","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2024.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}