{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:05Z","timestamp":1792798805017,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,11]],"date-time":"2027-02-11T00:00:00Z","timestamp":1802304000000},"content-version":"am","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE027679"],"award-info":[{"award-number":["DE027679"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.molmed.2025.06.002","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T17:06:39Z","timestamp":1751648799000},"page":"133-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Burden of hereditary enamel disorders"],"prefix":"10.1016","volume":"32","author":[{"given":"Guilherme H.S.","family":"Bomfim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Mighell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo S.","family":"Lacruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2025.06.002_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12398","article-title":"Oral health's inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions","volume":"87","author":"Kapila","year":"2021","journal-title":"Periodontology"},{"key":"10.1016\/j.molmed.2025.06.002_bb0010","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CMR.13.4.547","article-title":"Systemic diseases caused by oral infection","volume":"13","author":"Li","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.molmed.2025.06.002_bb0015","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1152\/physrev.00030.2016","article-title":"Dental enamel formation and implications for oral health and disease","volume":"97","author":"Lacruz","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.molmed.2025.06.002_bb0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/10454411980090020101","article-title":"Cellular and chemical events during enamel maturation","volume":"9","author":"Smith","year":"1998","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.molmed.2025.06.002_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceca.2017.03.006","article-title":"Enamel: molecular identity of its transepithelial ion transport system","volume":"65","author":"Lacruz","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.molmed.2025.06.002_bb0030","first-page":"863","article-title":"Dental enamel: genes define biomechanics","volume":"37","author":"Rauth","year":"2009","journal-title":"J. Calif. Dent. Assoc."},{"key":"10.1016\/j.molmed.2025.06.002_bb0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/biomedicines10010186","article-title":"Oral microbiome, oral health and systemic health: a multidirectional link","volume":"10","author":"Varoni","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.molmed.2025.06.002_bb0040","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fphys.2017.00435","article-title":"Amelogenesis imperfecta; genes, proteins, and pathways","volume":"8","author":"Smith","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0045","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1002\/ajmg.a.31358","article-title":"The molecular etiologies and associated phenotypes of amelogenesis imperfecta","volume":"140","author":"Wright","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.molmed.2025.06.002_bb0050","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1113\/JP272775","article-title":"Ca(2+) transport and signalling in enamel cells","volume":"595","author":"Nurbaeva","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0055","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejmg.2008.02.009","article-title":"The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders","volume":"51","author":"Bailleul-Forestier","year":"2008","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0060","first-page":"236","article-title":"Hereditary defects in enamel and dentin","volume":"7","author":"Witkop","year":"1957","journal-title":"Acta Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0065","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1600-0714.1988.tb01332.x","article-title":"Amelogenesis imperfecta, dentinogenesis imperfecta and dentin dysplasia revisited: problems in classification","volume":"17","author":"Witkop","year":"1988","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.molmed.2025.06.002_bb0070","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0888-7543(91)90187-J","article-title":"A deletion in the amelogenin gene (AMG) causes X-linked amelogenesis imperfecta (AIH1)","volume":"10","author":"Lagerstrom","year":"1991","journal-title":"Genomics"},{"key":"10.1016\/j.molmed.2025.06.002_bb0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/genes14030545","article-title":"Enamel phenotypes: genetic and environmental determinants","volume":"14","author":"Wright","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.molmed.2025.06.002_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03008209509013730","article-title":"The mineral and protein content of enamel in amelogenesis imperfecta","volume":"31","author":"Wright","year":"1995","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.molmed.2025.06.002_bb0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0030-4220(93)90204-H","article-title":"Enamel ultrastructure and protein content in X-linked amelogenesis imperfecta","volume":"76","author":"Wright","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0090","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ajhg.2012.07.020","article-title":"Mutations in C4orf26, encoding a peptide with in vitro hydroxyapatite crystal nucleation and growth activity, cause amelogenesis imperfecta","volume":"91","author":"Parry","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0095","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2174\/0113894501257011231030161427","article-title":"Crucial role of microRNAs as new targets for amelogenesis disorders detection","volume":"24","author":"Masunova","year":"2023","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.molmed.2025.06.002_bb0100","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1186\/1471-2164-15-998","article-title":"Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis","volume":"15","author":"Yin","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molmed.2025.06.002_bb0105","doi-asserted-by":"crossref","first-page":"44118","DOI":"10.1038\/srep44118","article-title":"MiR-153 regulates amelogenesis by targeting endocytotic and endosomal\/lysosomal pathways-novel insight into the origins of enamel pathologies","volume":"7","author":"Yin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2025.06.002_bb0110","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1007\/s00204-024-03853-9","article-title":"MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues","volume":"98","author":"Manoharan","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0115","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fphys.2017.00336","article-title":"Multiple calcium export exchangers and pumps are a prominent feature of enamel organ cells","volume":"8","author":"Robertson","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/10454411000110040401","article-title":"Calcium transport across the dental enamel epithelium","volume":"11","author":"Hubbard","year":"2000","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.molmed.2025.06.002_bb0125","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0135","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1177\/0022034515598144","article-title":"Store-operated Ca2+ entry modulates the expression of enamel genes","volume":"94","author":"Nurbaeva","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molmed.2025.06.002_bb0140","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91166","article-title":"Store-operated Ca(2+) entry controls ameloblast cell function and enamel development","volume":"2","author":"Eckstein","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.molmed.2025.06.002_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2020.00538","article-title":"Mitochondrial function in enamel development","volume":"11","author":"Costiniti","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0150","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201291R","article-title":"PMCA Ca(2+) clearance in dental enamel cells depends on the magnitude of cytosolic Ca(2)","volume":"37","author":"Bomfim","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.molmed.2025.06.002_bb0155","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202313372","article-title":"Na+\/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger","volume":"156","author":"Souza Bomfim","year":"2024","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.coisb.2017.03.002","article-title":"Recent developments in models of calcium signalling","volume":"3","author":"Dupont","year":"2017","journal-title":"Curr. Opin. Syst. Biol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wsbm.1261","article-title":"Modeling the intracellular organization of calcium signaling","volume":"6","author":"Dupont","year":"2014","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.molmed.2025.06.002_bb0170","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41598-023-29876-3","article-title":"Computational investigation of IP(3) diffusion","volume":"13","author":"Ornelas-Guevara","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2025.06.002_bb0175","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/bj3580217","article-title":"Endoplasmic reticulum Ca2+-ATPase pump is up-regulated in calcium-transporting dental enamel cells: a non-housekeeping role for SERCA2b","volume":"358","author":"Franklin","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.molmed.2025.06.002_bb0180","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3389\/fphys.2018.00801","article-title":"Evidence that calcium entry into calcium-transporting dental enamel cells is regulated by cholecystokinin, acetylcholine and ATP","volume":"9","author":"Nurbaeva","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102187","article-title":"TRPM7 activation potentiates SOCE in enamel cells but requires ORAI","volume":"87","author":"Souza Bomfim","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.molmed.2025.06.002_bb0190","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1002\/jcp.22965","article-title":"Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling","volume":"227","author":"Lacruz","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0195","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/S0006-3495(03)74572-X","article-title":"A model of calcium waves in pancreatic and parotid acinar cells","volume":"85","author":"Sneyd","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.molmed.2025.06.002_bb0200","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.bbamcr.2018.04.013","article-title":"Altered Ca(2+) signaling in enamelopathies","volume":"1865","author":"Eckstein","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.molmed.2025.06.002_bb0205","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1073\/pnas.1418852112","article-title":"Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation","volume":"112","author":"Maus","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2025.06.002_bb0210","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s13023-024-03445-x","article-title":"A natural history study of Timothy syndrome","volume":"19","author":"Timothy","year":"2024","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.molmed.2025.06.002_bb0215","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jaci.2015.08.051","article-title":"A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency","volume":"137","author":"Parry","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0220","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ajhg.2013.01.003","article-title":"Identification of mutations in SLC24A4, encoding a potassium-dependent sodium\/calcium exchanger, as a cause of amelogenesis imperfecta","volume":"92","author":"Parry","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0225","doi-asserted-by":"crossref","first-page":"94S","DOI":"10.1177\/0022034514527971","article-title":"STIM1 and SLC24A4 are critical for enamel maturation","volume":"93","author":"Wang","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molmed.2025.06.002_bb0230","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/hmg\/ddt616","article-title":"A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta","volume":"23","author":"Poulter","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0235","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ajhg.2016.08.020","article-title":"Mutations in the pH-sensing G-protein-coupled receptor GPR68 cause amelogenesis imperfecta","volume":"99","author":"Parry","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0240","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1038\/s41388-019-0682-0","article-title":"Cnnm4 deficiency suppresses Ca(2+) signaling and promotes cell proliferation in the colon epithelia","volume":"38","author":"Yamazaki","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.molmed.2025.06.002_bb0245","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ajhg.2009.01.006","article-title":"Mutations in CNNM4 cause recessive cone-rod dystrophy with amelogenesis imperfecta","volume":"84","author":"Polok","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.molmed.2025.06.002_bb0250","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41559-019-0865-7","article-title":"The evolutionary history of the human face","volume":"3","author":"Lacruz","year":"2019","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.molmed.2025.06.002_bb0255","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.3390\/ijerph18179022","article-title":"Psychological and social effects of oral health and dental aesthetic in adolescence and early adulthood: an observational study","volume":"18","author":"Militi","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.molmed.2025.06.002_bb0260","doi-asserted-by":"crossref","first-page":"620","DOI":"10.14219\/jada.archive.2005.0233","article-title":"The psychosocial impact of developmental dental defects in people with hereditary amelogenesis imperfecta","volume":"136","author":"Coffield","year":"2005","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.molmed.2025.06.002_bb0265","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0022034517750572","article-title":"Global-, regional-, and country-level economic impacts of dental diseases in 2015","volume":"97","author":"Righolt","year":"2018","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molmed.2025.06.002_bb0270","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/00220345211056247","article-title":"Global burden and inequality of dental caries, 1990 to 2019","volume":"101","author":"Wen","year":"2022","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.molmed.2025.06.002_bb0275","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s40368-021-00638-x","article-title":"The burden of dental care in amelogenesis imperfecta paediatric patients in the UK NHS: a retrospective, multi-centred analysis","volume":"22","author":"Lafferty","year":"2021","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"10.1016\/j.molmed.2025.06.002_bb0280","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1186\/s12889-024-20652-0","article-title":"Inequalities in oral health: estimating the longitudinal economic burden of dental caries by deprivation status in six countries","volume":"24","author":"Dunleavy","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.molmed.2025.06.002_bb0285","series-title":"Oral Health in America: Advances and Challenges","author":"National Institure of Dental and Craniofacial Research","year":"2021"},{"key":"10.1016\/j.molmed.2025.06.002_bb0290","doi-asserted-by":"crossref","DOI":"10.5888\/pcd15.170225","article-title":"Hours lost to planned and unplanned dental visits among US adults","volume":"15","author":"Kelekar","year":"2018","journal-title":"Prev. Chronic Dis."},{"key":"10.1016\/j.molmed.2025.06.002_bb0295","first-page":"245","article-title":"Dentition abnormalities in a Timothy syndrome patient with a novel genetic mutation: a case report","volume":"36","author":"Papineau","year":"2014","journal-title":"Pediatr. Dent."},{"key":"10.1016\/j.molmed.2025.06.002_bb0300","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/ejo\/cjad051","article-title":"Costs and duration of orthodontic-surgical treatment with mandibular advancement surgery","volume":"45","author":"Niemi","year":"2023","journal-title":"Eur. J. Orthod."},{"key":"10.1016\/j.molmed.2025.06.002_bb0305","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40246-021-00315-6","article-title":"How to design a national genomic project-a systematic review of active projects","volume":"15","author":"Kovanda","year":"2021","journal-title":"Hum. Genomics"}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142500142X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142500142X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:28:47Z","timestamp":1783027727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149142500142X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S147149142500142X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2025.06.002","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Burden of hereditary enamel disorders","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2025.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}