{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:01Z","timestamp":1791846361418,"version":"4.3.4"},"reference-count":95,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD115116"],"award-info":[{"award-number":["R21HD115116"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD101512"],"award-info":[{"award-number":["R01HD101512"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.molmed.2026.02.009","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:34:37Z","timestamp":1773840877000},"page":"937-953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient-specific trophoblast stem cells for placental medicine"],"prefix":"10.1016","volume":"32","author":[{"given":"Sung Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Genceroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-9843","authenticated-orcid":false,"given":"Jonghwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2026.02.009_bb0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.thromres.2004.06.038","article-title":"Growth and function of the normal human placenta","volume":"114","author":"Gude","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.molmed.2026.02.009_bb0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u2018Great obstetrical syndromes\u2019 are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0015","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/humupd\/dmaf007","article-title":"Ethical considerations for advancing research using organoid models derived from the placenta","volume":"31","author":"Sch\u00e4ffers","year":"2025","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.molmed.2026.02.009_bb0020","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Kn\u00f6fler","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.molmed.2026.02.009_bb0025","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014a review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.molmed.2026.02.009_bb0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.placenta.2012.01.020","article-title":"Human placentation from nidation to 5 weeks of gestation. Part I: what do we know about formative placental development following implantation?","volume":"33","author":"James","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.molmed.2026.02.009_bb0035","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1038\/s41598-017-06364-z","article-title":"A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines","volume":"7","author":"Rothbauer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0040","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.placenta.2010.08.011","article-title":"Trophoblast invasion: assessment of cellular models using gene expression signatures","volume":"31","author":"Bilban","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.molmed.2026.02.009_bb0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mce.2003.03.001","article-title":"Endocrine cell lines from the placenta","volume":"228","author":"Sullivan","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0050","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.placenta.2020.10.011","article-title":"Cytogenomics of six human trophoblastic cell lines","volume":"103","author":"Weber","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.molmed.2026.02.009_bb0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/gyno.1999.5599","article-title":"Differential gene expression pattern between normal human trophoblast and choriocarcinoma cell lines: downregulation of heat shock protein-27 in choriocarcinoma in vitro and in vivo","volume":"75","author":"Vegh","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0060","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nbt761","article-title":"BMP4 initiates human embryonic stem cell differentiation to trophoblast","volume":"20","author":"Xu","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0065","doi-asserted-by":"crossref","first-page":"E1212","DOI":"10.1073\/pnas.1303094110","article-title":"Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4","volume":"110","author":"Amita","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2026.02.009_bb0070","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1242\/dev.092155","article-title":"BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a \u0394Np63+ cytotrophoblast stem cell state","volume":"140","author":"Li","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.molmed.2026.02.009_bb0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1604747113","article-title":"Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease","volume":"113","author":"Horii","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2026.02.009_bb0080","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115709119","article-title":"Induction of human trophoblast stem-like cells from primed pluripotent stem cells","volume":"119","author":"Jang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2026.02.009_bb0085","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.stem.2021.03.013","article-title":"Capturing human trophoblast development with naive pluripotent stem cells in vitro","volume":"28","author":"Io","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0090","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.stem.2021.02.025","article-title":"Human naive epiblast cells possess unrestricted lineage potential","volume":"28","author":"Guo","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0095","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.stem.2011.06.015","article-title":"BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages","volume":"9","author":"Bernardo","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0105","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13287-019-1339-1","article-title":"Establishment of human trophoblast stem cells from human induced pluripotent stem cell-derived cystic cells under micromesh culture","volume":"10","author":"Li","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.molmed.2026.02.009_bb0110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52504","article-title":"Derivation of trophoblast stem cells from na\u00efve human pluripotent stem cells","volume":"9","author":"Dong","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.molmed.2026.02.009_bb0115","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.stemcr.2020.06.003","article-title":"Naive human embryonic stem cells can give rise to cells with a trophoblast-like transcriptome and methylome","volume":"15","author":"Cinkornpumin","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41586-020-2734-6","article-title":"Reprogramming roadmap reveals route to human induced trophoblast stem cells","volume":"586","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2026.02.009_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108419","article-title":"Induction of human trophoblast stem cells from somatic cells and pluripotent stem cells","volume":"33","author":"Castel","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0130","doi-asserted-by":"crossref","first-page":"17864","DOI":"10.1073\/pnas.2002449117","article-title":"TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: an implication in early human pregnancy loss","volume":"117","author":"Saha","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2026.02.009_bb0135","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf4416","article-title":"Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells","volume":"7","author":"Wei","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molmed.2026.02.009_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100386","article-title":"Two distinct trophectoderm lineage stem cells from human pluripotent stem cells","volume":"296","author":"Mischler","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2026.02.009_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2021.102507","article-title":"Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts","volume":"56","author":"Bai","year":"2021","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.molmed.2026.02.009_bb0150","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.stemcr.2022.04.013","article-title":"Derivation of functional trophoblast stem cells from primed human pluripotent stem cells","volume":"17","author":"Soncin","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0155","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1016\/j.stemcr.2022.09.008","article-title":"Human primed and na\u00efve PSCs are both able to differentiate into trophoblast stem cells","volume":"17","author":"Viukov","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0160","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/s41467-022-29312-6","article-title":"Functional antagonism between \u0394Np63\u03b1 and GCM1 regulates human trophoblast stemness and differentiation","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0165","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255235","article-title":"Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation","volume":"24","author":"Zorzan","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0170","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1038\/s41467-023-39104-1","article-title":"Pluripotency-independent induction of human trophoblast stem cells from fibroblasts","volume":"14","author":"Naama","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110874","article-title":"Highly efficient generation of self-renewing trophoblast from human pluripotent stem cells","volume":"27","author":"Slamecka","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.molmed.2026.02.009_bb0180","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1038\/s41598-024-53381-w","article-title":"Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5\/7 induction without transitioning through naive state","volume":"14","author":"Tietze","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0185","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202778","article-title":"Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells","volume":"151","author":"Balestrini","year":"2024","journal-title":"Development"},{"key":"10.1016\/j.molmed.2026.02.009_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/ijms26010271","article-title":"Generation of bona fide human induced trophoblast stem cells by direct reprogramming of term umbilical cord cells","volume":"26","author":"Van Voorden","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2026.02.009_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109569","article-title":"iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation","volume":"27","author":"Morey","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.molmed.2026.02.009_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2025.102637","article-title":"Trophoblast stem cell derivation from naive and primed hPSC enables ELF5 functional analysis","volume":"20","author":"Sokka","year":"2025","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-03830-x","article-title":"Stepwise strategy for generating human trophoblast stem-like cells from embryonic stem cells reveals specific role of TFAP2C in acquiring self-renewability","volume":"15","author":"Ohgushi","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0210","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.placenta.2025.07.090","article-title":"Establishment of human trophoblast stem cells from term smooth chorion","volume":"169","author":"Hoshiyama","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.molmed.2026.02.009_bb0215","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ajog.2025.08.030","article-title":"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence","volume":"234","author":"Arthurs","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108505","article-title":"Derivation of human trophoblast stem cells from placentas at birth","volume":"301","author":"Karakis","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.molmed.2026.02.009_bb0225","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/s42003-025-08393-1","article-title":"Leveraging chorionic villus biopsies for the derivation of patient-specific trophoblast stem cells","volume":"8","author":"Varberg","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0230","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1016\/j.ajog.2015.07.046","article-title":"Placental transcriptome in development and pathology: expression, function, and methods of analysis","volume":"213","author":"Cox","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1038358","article-title":"Genetic variation in placental insufficiency: what have we learned over time?","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0240","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41467-022-28365-x","article-title":"Placental genomics mediates genetic associations with complex health traits and disease","volume":"13","author":"Bhattacharya","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0245","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1161\/HYPERTENSIONAHA.119.14509","article-title":"Differential DNA methylation in placenta associated with maternal blood pressure during pregnancy","volume":"75","author":"Workalemahu","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.molmed.2026.02.009_bb0250","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13148-020-00873-x","article-title":"DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases","volume":"12","author":"Tekola-Ayele","year":"2020","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.molmed.2026.02.009_bb0255","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s42003-025-07699-4","article-title":"The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development","volume":"8","author":"Suntharalingham","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0260","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s10020-020-00253-4","article-title":"Genomic imbalances in the placenta are associated with poor fetal growth","volume":"27","author":"Del Gobbo","year":"2021","journal-title":"Mol. Med."},{"key":"10.1016\/j.molmed.2026.02.009_bb0265","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2008.07.041","article-title":"Disease-specific induced pluripotent stem cells","volume":"134","author":"Park","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0270","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/pr.116.013003","article-title":"Patient and disease\u2013specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics","volume":"72","author":"Paik","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.molmed.2026.02.009_bb0275","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.stem.2016.07.006","article-title":"Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro","volume":"19","author":"Matsa","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0280","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature22403","article-title":"Common genetic variation drives molecular heterogeneity in human iPSCs","volume":"546","author":"Kilpinen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2026.02.009_bb0285","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.042317","article-title":"Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility","volume":"13","author":"Volpato","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.molmed.2026.02.009_bb0290","doi-asserted-by":"crossref","first-page":"326","DOI":"10.5858\/arpa.2012-0090-RA","article-title":"Pathologic examination of fetal and placental tissue obtained by dilation and evacuation","volume":"137","author":"Ernst","year":"2013","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.molmed.2026.02.009_bb0295","article-title":"Optimal aspiration pressure of suction pump for oocyte retrieval in infertile patients undergoing in vitro fertilization","volume":"20","author":"Kim","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.molmed.2026.02.009_bb0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s41232-023-00294-2","article-title":"A disease-specific iPS cell resource for studying rare and intractable diseases","volume":"43","author":"Saito","year":"2023","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.molmed.2026.02.009_bb0305","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neubiorev.2020.12.025","article-title":"Patient-derived iPSC modeling of rare neurodevelopmental disorders: molecular pathophysiology and prospective therapies","volume":"121","author":"Sabitha","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.molmed.2026.02.009_bb0310","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.stemcr.2016.01.006","article-title":"What is trophoblast? A combination of criteria define human first-trimester trophoblast","volume":"6","author":"Lee","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0315","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.stem.2016.06.011","article-title":"Molecular criteria for defining the naive human pluripotent state","volume":"19","author":"Theunissen","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0320","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1038\/s41467-025-59245-9","article-title":"Chromosomal instability in human trophoblast stem cells and placentas","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0325","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13287-015-0112-3","article-title":"Generation of human iPSCs from cells of fibroblastic and epithelial origin by means of the oriP\/EBNA-1 episomal reprogramming system","volume":"6","author":"Drozd","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.molmed.2026.02.009_bb0330","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2010.04.014","article-title":"A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts","volume":"7","author":"Li","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0335","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nbt.1667","article-title":"Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells","volume":"28","author":"Polo","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0340","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1038\/s41467-022-30775-w","article-title":"The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells","volume":"13","author":"Kobayashi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0345","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.cell.2019.01.006","article-title":"Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming","volume":"176","author":"Schiebinger","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0350","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1038\/s41467-022-31131-8","article-title":"Comparative parallel multi-omics analysis during the induction of pluripotent and trophectoderm states","volume":"13","author":"Jaber","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0355","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.stem.2015.08.006","article-title":"Extensive nuclear reprogramming underlies lineage conversion into functional trophoblast stem-like cells","volume":"17","author":"Benchetrit","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0360","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.stem.2015.08.005","article-title":"Direct induction of trophoblast stem cells from murine fibroblasts","volume":"17","author":"Kubaczka","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0365","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature24033","article-title":"Genome editing reveals a role for OCT4 in human embryogenesis","volume":"550","author":"Fogarty","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.molmed.2026.02.009_bb0370","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1210\/me.2008-0371","article-title":"Estrogen receptor \u03b1 (ER\u03b1) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta","volume":"23","author":"Kumar","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0375","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.stem.2023.12.013","article-title":"Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy","volume":"31","author":"Li","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0380","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163428","article-title":"Development of the human placenta","volume":"146","author":"Turco","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.molmed.2026.02.009_bb0385","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/1471-0528.17613","article-title":"The great obstetrical syndromes and the placenta","volume":"130","author":"Hoffman","year":"2023","journal-title":"BJOG"},{"key":"10.1016\/j.molmed.2026.02.009_bb0390","doi-asserted-by":"crossref","first-page":"8342","DOI":"10.1038\/srep08342","article-title":"Extensive load of somatic CNVs in the human placenta","volume":"5","author":"Kasak","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2026.02.009_bb0395","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1038\/s41467-025-63296-3","article-title":"Deep genome sequencing reveals extensive genetic heterogeneity in early human placentas","volume":"16","author":"Miceikaite","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.molmed.2026.02.009_bb0400","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1097\/AOG.0000000000001405","article-title":"Practice bulletin No. 162: prenatal diagnostic testing for genetic disorders","volume":"127","author":"Committee on Genetics, Committee on PractIice Bulletins\u2013Obstetrics, and Society for Maternal\u2013Fetal Medicine","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0405","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/pd.1970110503","article-title":"Randomized clinical trial of transabdominal versus transcervical chorionic villus sampling methods","volume":"11","author":"Brambati","year":"1991","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.molmed.2026.02.009_bb0410","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1056\/NEJM199208273270903","article-title":"A randomized comparison of transcervical and transabdominal chorionic-villus sampling","volume":"327","author":"Jackson","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.molmed.2026.02.009_bb0415","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/14767058.2014.900748","article-title":"More chorionic villi obtained at a single center compared to previously published reports","volume":"28","author":"Vora","year":"2015","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.molmed.2026.02.009_bb0420","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1471-0528.2004.00483.x","article-title":"A randomised controlled trial of biopsy forceps and cannula aspiration for transcervical chorionic villus sampling","volume":"112","author":"von Dadelszen","year":"2005","journal-title":"BJOG"},{"key":"10.1016\/j.molmed.2026.02.009_bb0425","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/uog.15945","article-title":"ISUOG practice guidelines: invasive procedures for prenatal diagnosis: ISUOG guidelines","volume":"48","author":"Ghi","year":"2016","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0430","article-title":"Instruments for chorionic villus sampling for prenatal diagnosis","volume":"2013","author":"Young","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.molmed.2026.02.009_bb0435","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(97)02449-5","article-title":"Randomised study of risk of fetal loss related to early amniocentesis versus chorionic villus sampling","volume":"350","author":"Sundberg","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.molmed.2026.02.009_bb0440","series-title":"Weight Gain During Pregnancy: Reexamining the Guidelines","first-page":"12584","article-title":"Composition and components of gestational weight gain: physiology and metabolism","author":"Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines","year":"2009"},{"key":"10.1016\/j.molmed.2026.02.009_bb0445","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/uog.20353","article-title":"Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis","volume":"54","author":"Salomon","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0450","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/uog.22041","article-title":"New approach for estimating risk of miscarriage after chorionic villus sampling","volume":"56","author":"Gil","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.molmed.2026.02.009_bb0455","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/pd.6357","article-title":"Position statement from the International Society for Prenatal Diagnosis on the use of non-invasive prenatal testing for the detection of fetal chromosomal conditions in singleton pregnancies","volume":"43","author":"Hui","year":"2023","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.molmed.2026.02.009_bb0460","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1089\/bio.2019.0008","article-title":"The utilization of biospecimens: impact of the choice of biobanking model","volume":"17","author":"Grizzle","year":"2019","journal-title":"Biopreserv. Biobank."},{"key":"10.1016\/j.molmed.2026.02.009_bb0465","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.45719","article-title":"Association of preeclampsia and perinatal complications with offspring neurodevelopmental and psychiatric disorders","volume":"5","author":"Kong","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.molmed.2026.02.009_bb0470","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.stem.2022.04.004","article-title":"Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens","volume":"29","author":"Karvas","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmed.2026.02.009_bb0475","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jcyt.2024.11.015","article-title":"Considerations for manufacturing of cell and gene medicines for clinical development","volume":"27","author":"Lowdell","year":"2025","journal-title":"Cytotherapy"}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491426000390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471491426000390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:25:08Z","timestamp":1788985508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471491426000390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":95,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1471491426000390"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2026.02.009","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient-specific trophoblast stem cells for placental medicine","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2026.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}