{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:26:18Z","timestamp":1793125578606,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Molecular Medicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.molmed.2026.03.007","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:14:01Z","timestamp":1775189641000},"page":"1033-1046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Could venom-derived therapeutics resolve treatment resistance in refractory EAC?"],"prefix":"10.1016","volume":"32","author":[{"given":"Lou","family":"Freuville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Matthys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Gilliaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"D\u2019Hondt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-590X","authenticated-orcid":false,"given":"Jean-Pierre","family":"Gillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmed.2026.03.007_bb0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.molmed.2026.03.007_bb0010","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1007\/s12328-020-01237-x","article-title":"Epidemiology of esophageal cancer: update in global trends, etiology and risk factors","volume":"13","author":"Uhlenhopp","year":"2020","journal-title":"Clin. J. Gastroenterol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1465459","article-title":"Venom-derived peptides for breaking through the glass ceiling of drug development","volume":"12","author":"Freuville","year":"2024","journal-title":"Front. Chem."},{"key":"10.1016\/j.molmed.2026.03.007_bb0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00204-022-03420-0","article-title":"A current perspective on snake venom composition and constituent protein families","volume":"97","author":"Tasoulis","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106978","article-title":"Scorpion venom peptides: molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers","volume":"197","author":"Xia","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.molmed.2026.03.007_bb0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3390\/toxins11100611","article-title":"Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses","volume":"11","author":"Langenegger","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.molmed.2026.03.007_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114096","article-title":"Animal toxins\u2014nature\u2019s evolutionary-refined toolkit for basic research and drug discovery","volume":"181","author":"Herzig","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122352","article-title":"Advances in venomics: modern separation techniques and mass spectrometry","volume":"1160","author":"Abd El-Aziz","year":"2020","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.molmed.2026.03.007_bb0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ueg2.12759","article-title":"Surveillance of Barrett\u2019s esophagus patients in an expert center is associated with low disease-specific mortality","volume":"13","author":"Honing","year":"2025","journal-title":"United Eur. Gastroenterol. J."},{"key":"10.1016\/j.molmed.2026.03.007_bb0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s13402-019-00488-2","article-title":"Esophageal carcinoma: towards targeted therapies","volume":"43","author":"Fatehi Hassanabad","year":"2020","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1200\/JCO.2024.42.3_suppl.250","article-title":"First-line pembrolizumab (pembro) plus chemotherapy (chemo) for advanced esophageal cancer: 5-year outcomes from the phase 3 KEYNOTE-590 study","volume":"42","author":"Shah","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0060","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1021\/acs.jmedchem.5b01409","article-title":"Analysis of past and present synthetic methodologies on medicinal chemistry: where have all the new reactions gone? Miniperspective","volume":"59","author":"Brown","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.molmed.2026.03.007_bb0065","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3389\/fphar.2020.01132","article-title":"From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery","volume":"11","author":"Bordon","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0070","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10637-017-0438-z","article-title":"First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors","volume":"35","author":"Fu","year":"2017","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.molmed.2026.03.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146192","article-title":"Calcium selective channel TRPV6: structure, function, and implications in health and disease","volume":"817","author":"Khattar","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.molmed.2026.03.007_bb0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40643-024-00805-0","article-title":"Harnessing the potency of scorpion venom-derived proteins: applications in cancer therapy","volume":"11","author":"El-Qassas","year":"2024","journal-title":"Bioresour. Bioprocess."},{"key":"10.1016\/j.molmed.2026.03.007_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108542","article-title":"Scorpion venoms from the Buthidae family: a dual study of proteomic composition and anticancer potentials","volume":"266","author":"Mabunda","year":"2025","journal-title":"Toxicon"},{"key":"10.1016\/j.molmed.2026.03.007_bb0090","article-title":"Snake venom-derived peptides as anticancer candidates: pioneering next-generation therapies","volume":"1880","author":"Almeida","year":"2025","journal-title":"Biochim. Biophys. Acta BBA Rev. Cancer"},{"key":"10.1016\/j.molmed.2026.03.007_bb0095","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/aps.2012.156","article-title":"Growth inhibitory effects and molecular mechanisms of crotoxin treatment in esophageal Eca-109 cells and transplanted tumors in nude mice","volume":"34","author":"He","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.molmed.2026.03.007_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxicon.2018.10.306","article-title":"Crotoxin from Crotalus durissus terrificus venom: in vitro cytotoxic activity of a heterodimeric phospholipase A2 on human cancer-derived cell lines","volume":"156","author":"Muller","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.molmed.2026.03.007_bb0105","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2147\/OTT.S104767","article-title":"Arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo","volume":"10","author":"Lv","year":"2017","journal-title":"Oncol. Targets Ther."},{"key":"10.1016\/j.molmed.2026.03.007_bb0110","first-page":"1566","article-title":"Bufadienolides induce p53-mediated apoptosis in esophageal squamous cell carcinoma cells in vitro and in vivo","volume":"15","author":"Lin","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.molmed.2026.03.007_bb0115","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1007\/s13277-014-2146-z","article-title":"Melittin radiosensitizes esophageal squamous cell carcinoma with induction of apoptosis in vitro and in vivo","volume":"35","author":"Zhu","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/ol.2020.12277","article-title":"TERT promoter regulating melittin expression induces apoptosis and G0\/G1 cell cycle arrest in esophageal carcinoma cells","volume":"21","author":"Zhou","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.molmed.2026.03.007_bb0125","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1093\/bbb\/zbab153","article-title":"Melittin suppresses epithelial\u2013mesenchymal transition and metastasis in human gastric cancer AGS cells via regulating Wnt\/BMP associated pathway","volume":"85","author":"Huang","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.molmed.2026.03.007_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1001553","article-title":"Pharmacological effects and mechanisms of bee venom and its main components: recent progress and perspective","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0135","series-title":"Pharmacology of Potassium Channels","first-page":"1","article-title":"Comparison of K+ channel families","volume":"Vol. 267","author":"Taura","year":"2021"},{"key":"10.1016\/j.molmed.2026.03.007_bb0140","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/OTT.S326614","article-title":"Potassium channels as a target for cancer therapy: current perspectives","volume":"15","author":"Z\u00fa\u00f1iga","year":"2022","journal-title":"Oncol. Targets Ther."},{"key":"10.1016\/j.molmed.2026.03.007_bb0145","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/cancers14040856","article-title":"Chloride channels and transporters: roles beyond classical cellular homeostatic pH or ion balance in cancers","volume":"14","author":"Kim","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.molmed.2026.03.007_bb0150","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3389\/fphar.2020.00968","article-title":"Calcium permeable channels in cancer hallmarks","volume":"11","author":"Tajada","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0155","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40364-024-00620-x","article-title":"Voltage-gated sodium channels in cancers","volume":"12","author":"Liu","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.molmed.2026.03.007_bb0160","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00424-023-02902-z","article-title":"Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link?","volume":"476","author":"Gr\u00fcnder","year":"2024","journal-title":"Pfl\u00fcg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0165","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3390\/biom13101557","article-title":"TRP channels in cancer: signaling mechanisms and translational approaches","volume":"13","author":"Marini","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.molmed.2026.03.007_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1258933","article-title":"News and views on ion channels in cancer: is cancer a channelopathy?","volume":"14","author":"Bell","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mehy.2018.06.010","article-title":"Combined targeted ion channel therapy: can it be an alternative choice for esophageal cancer patients?","volume":"117","author":"Zhang","year":"2018","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.molmed.2026.03.007_bb0180","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3390\/ph18101521","article-title":"Targeting ion channels for cancer therapy: from pathophysiological mechanisms to clinical translation","volume":"18","author":"Zhou","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.molmed.2026.03.007_bb0185","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1113\/JP282310","article-title":"The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether-\u00e0-go-go related gene 1 channels","volume":"601","author":"Arcangeli","year":"2023","journal-title":"J. Physiol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0190","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302124","article-title":"KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas","volume":"6","author":"Shorthouse","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.molmed.2026.03.007_bb0195","article-title":"SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinoma","volume":"1870","author":"Foley","year":"2024","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"10.1016\/j.molmed.2026.03.007_bb0200","article-title":"HERG channel and cancer: a mechanistic review of carcinogenic processes and therapeutic potential","volume":"1873","author":"He","year":"2020","journal-title":"Biochim. Biophys. Acta BBA Rev. Cancer"},{"key":"10.1016\/j.molmed.2026.03.007_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810623","article-title":"Prognostic role of hERG1 potassium channels in neuroendocrine tumours of the ileum and pancreas","volume":"23","author":"Iorio","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2026.03.007_bb0210","doi-asserted-by":"crossref","first-page":"59535","DOI":"10.18632\/oncotarget.11149","article-title":"hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett\u2019s esophagus and can be exploited for a novel endoscopic surveillance","volume":"7","author":"Lastraioli","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.molmed.2026.03.007_bb0215","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1073\/pnas.1714760115","article-title":"Centipedes subdue giant prey by blocking KCNQ channels","volume":"115","author":"Luo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.molmed.2026.03.007_bb0220","article-title":"Beta-KTx14.3, a scorpion toxin, blocks the human potassium channel KCNQ1","volume":"1871","author":"Titaux-Delgado","year":"2023","journal-title":"Biochim. Biophys. Acta BBA Proteins Proteomics"},{"key":"10.1016\/j.molmed.2026.03.007_bb0225","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ijbiomac.2015.05.027","article-title":"SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity","volume":"79","author":"Chen","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12860-020-00337-3","article-title":"Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization","volume":"22","author":"Matsumura","year":"2021","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0235","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3390\/toxins13060407","article-title":"Colombian scorpion Centruroides margaritatus: purification and characterization of a gamma potassium toxin with full-block activity on the hERG1 channel","volume":"13","author":"Beltr\u00e1n-Vidal","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.molmed.2026.03.007_bb0240","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/md20020147","article-title":"A tale of toxin promiscuity: the versatile pharmacological effects of Hcr 1b-2 sea anemone peptide on voltage-gated ion channels","volume":"20","author":"Pinheiro-Junior","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.molmed.2026.03.007_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411513","article-title":"\u03baO-SrVIA conopeptide, a novel inhibitor peptide for two members of the human EAG potassium channel family","volume":"24","author":"Mart\u00ednez-Hern\u00e1ndez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2026.03.007_bb0250","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3390\/toxins14100709","article-title":"Mechanisms of action of the peptide toxins targeting human and rodent acid-sensing ion channels and relevance to their in vivo analgesic effects","volume":"14","author":"Verkest","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.molmed.2026.03.007_bb0255","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1096\/fj.12-218479","article-title":"A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins","volume":"26","author":"Peigneur","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.molmed.2026.03.007_bb0260","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3390\/cancers12071837","article-title":"Mambalgin-2 induces cell cycle arrest and apoptosis in glioma cells via interaction with ASIC1a","volume":"12","author":"Bychkov","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.molmed.2026.03.007_bb0265","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bcp.2019.03.004","article-title":"The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues","volume":"163","author":"Cristofori-Armstrong","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0270","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1021\/acs.orglett.1c03112","article-title":"Total synthesis of the spider-venom peptide Hi1a","volume":"23","author":"Duggan","year":"2021","journal-title":"Org. Lett."},{"key":"10.1016\/j.molmed.2026.03.007_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108453","article-title":"Mambalgin-1 pain-relieving peptide locks the hinge between \u03b14 and \u03b15 helices to inhibit rat acid-sensing ion channel 1a","volume":"185","author":"Salinas","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molmed.2026.03.007_bb0280","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1161\/CIRCULATIONAHA.121.054360","article-title":"Therapeutic inhibition of acid-sensing ion channel 1a recovers heart function after ischemia\u2013reperfusion injury","volume":"144","author":"Redd","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.molmed.2026.03.007_bb0285","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3390\/biomedicines9101324","article-title":"Mambalgin-2 inhibits growth, migration, and invasion of metastatic melanoma cells by targeting the channels containing an ASIC1a subunit whose up-regulation correlates with poor survival prognosis","volume":"9","author":"Bychkov","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.molmed.2026.03.007_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.904742","article-title":"Mambalgin-2 inhibits lung adenocarcinoma growth and migration by selective interaction with ASIC1\/\u03b1-ENaC\/\u03b3-ENaC heterotrimer","volume":"12","author":"Sudarikova","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0295","doi-asserted-by":"crossref","first-page":"543","DOI":"10.37349\/etat.2021.00063","article-title":"Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma","volume":"2","author":"Cutliffe","year":"2021","journal-title":"Explor. Target. Antitumor Ther."},{"key":"10.1016\/j.molmed.2026.03.007_bb0300","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/19336950.2018.1499368","article-title":"Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia","volume":"12","author":"Zhang","year":"2018","journal-title":"Channels"},{"key":"10.1016\/j.molmed.2026.03.007_bb0305","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1093\/carcin\/bgt286","article-title":"Genome-wide methylation analysis shows similar patterns in Barrett\u2019s esophagus and esophageal adenocarcinoma","volume":"34","author":"Xu","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.molmed.2026.03.007_bb0310","doi-asserted-by":"crossref","first-page":"92","DOI":"10.21037\/atm-21-7032","article-title":"Analysis of cancer-promoting genes related to chemotherapy resistance in esophageal squamous cell carcinoma","volume":"10","author":"Xie","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.molmed.2026.03.007_bb0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/toxins18010025","article-title":"Scorpion venom neurotoxins: molecular diversity, mechanisms, and drug scaffolds","volume":"18","author":"Huang","year":"2026","journal-title":"Toxins"},{"key":"10.1016\/j.molmed.2026.03.007_bb0320","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1042\/BCJ20200206","article-title":"Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes","volume":"477","author":"de Waard","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.molmed.2026.03.007_bb0325","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf4936","article-title":"Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation","volume":"9","author":"Haji-Ghassemi","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.molmed.2026.03.007_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33133-3","article-title":"CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells","volume":"8","author":"Oliveira-Mendes","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molmed.2026.03.007_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.149490","article-title":"Molecular diversity of peptides from Pandercetes sp. spider venom and antagonistic activity on voltage-gated calcium channels of the \u03ba-LhTx-1 toxin","volume":"337","author":"Tang","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0340","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.3390\/cells10112844","article-title":"CFTR protein: not just a chloride channel?","volume":"10","author":"Hanssens","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.molmed.2026.03.007_bb0345","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3390\/jpm12060868","article-title":"CFTR and gastrointestinal cancers: an update","volume":"12","author":"Bhattacharya","year":"2022","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.molmed.2026.03.007_bb0350","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.3390\/cancers15174244","article-title":"Cystic fibrosis and cancer: unraveling the complex role of CFTR gene in cancer susceptibility","volume":"15","author":"Parisi","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.molmed.2026.03.007_bb0355","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S1470-2045(16)30240-6","article-title":"Genome-wide association studies in oesophageal adenocarcinoma and Barrett\u2019s oesophagus: a large-scale meta-analysis","volume":"17","author":"Gharahkhani","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0360","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.3390\/cancers15133388","article-title":"Diagnostic and therapeutic approaches for glioblastoma and neuroblastoma cancers using chlorotoxin nanoparticles","volume":"15","author":"Boltman","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.molmed.2026.03.007_bb0365","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/cancers15010046","article-title":"Voltage-gated sodium channel NaV1.5 controls NHE-1-dependent invasive properties in colon cancer cells","volume":"15","author":"Lopez-Charcas","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.molmed.2026.03.007_bb0370","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2020.12.017","article-title":"Voltage-gated sodium channel Nav1.5 promotes tumor progression and enhances chemosensitivity to 5-fluorouracil in colorectal cancer","volume":"500","author":"Sui","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.molmed.2026.03.007_bb0375","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.drudis.2021.01.026","article-title":"Sodium ion channels as potential therapeutic targets for cancer metastasis","volume":"26","author":"Horne","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.molmed.2026.03.007_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114107","article-title":"Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases","volume":"181","author":"Cardoso","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0385","article-title":"Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities","volume":"25","author":"Wu","year":"2019","journal-title":"J. Venom. Anim. Toxins Trop. Dis."},{"key":"10.1016\/j.molmed.2026.03.007_bb0390","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1245\/s10434-023-14247-z","article-title":"Cancer stem cells of esophageal adenocarcinoma are suppressed by inhibitors of TRPV2 and SLC12A2","volume":"30","author":"Shiozaki","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0395","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3389\/fphys.2020.00855","article-title":"Oesophageal ion transport mechanisms and significance under pathological conditions","volume":"11","author":"Becskeh\u00e1zi","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0400","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1158\/1078-0432.CCR-07-1054","article-title":"Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma","volume":"14","author":"Boult","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.molmed.2026.03.007_bb0405","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1007\/s13577-023-00890-x","article-title":"Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin","volume":"36","author":"Lee","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.molmed.2026.03.007_bb0410","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s00210-023-02736-7","article-title":"Heteronemin promotes iron-dependent cell death in pancreatic cancer","volume":"397","author":"Kaftan","year":"2024","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0415","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3349\/ymj.2021.62.9.843","article-title":"Temozolomide drives ferroptosis via a DMT1-dependent pathway in glioblastoma cells","volume":"62","author":"Song","year":"2021","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.molmed.2026.03.007_bb0420","doi-asserted-by":"crossref","first-page":"G47","DOI":"10.1152\/ajpgi.1998.275.1.G47","article-title":"Altered sodium-hydrogen exchange activity is a mechanism for acid-induced hyperproliferation in Barrett\u2019s esophagus","volume":"275","author":"Fitzgerald","year":"1998","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0425","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/jcp.24896","article-title":"Intrinsic resistance triggered under acid loading within normal esophageal epithelial cells: NHE1- and ROS-mediated survival","volume":"230","author":"Park","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0430","doi-asserted-by":"crossref","first-page":"C798","DOI":"10.1152\/ajpcell.00295.2021","article-title":"Mouse organoid culture is a suitable model to study esophageal ion transport mechanisms","volume":"321","author":"Kors\u00f3s","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0435","first-page":"659","article-title":"The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer","volume":"39","author":"Wang","year":"2023","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0440","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/acs.jnatprod.1c00963","article-title":"Antitumor effects of scorpion peptide Smp43 through mitochondrial dysfunction and membrane disruption on hepatocellular carcinoma","volume":"84","author":"Chai","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.molmed.2026.03.007_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.788874","article-title":"Scorpion venom antimicrobial peptides induce caspase-1 dependant pyroptotic cell death","volume":"12","author":"Elrayess","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.molmed.2026.03.007_bb0450","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","article-title":"Trends in peptide drug discovery","volume":"20","author":"Muttenthaler","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.molmed.2026.03.007_bb0455","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.3390\/ijms26115131","article-title":"Therapeutic peptides: recent advances in discovery, synthesis, and clinical translation","volume":"26","author":"Zheng","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.molmed.2026.03.007_bb0460","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1016\/j.csbj.2021.08.011","article-title":"A review on machine learning approaches and trends in drug discovery","volume":"19","author":"Carracedo-Reboredo","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.molmed.2026.03.007_bb0465","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae275","article-title":"Peptide-based drug discovery through artificial intelligence: towards an autonomous design of therapeutic peptides","volume":"25","author":"Goles","year":"2024","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.molmed.2026.03.007_bb0470","article-title":"In silico discovery of stapled peptide inhibitor targeting the Nur77-PPAR\u03b3 interaction and its anti-breast-cancer efficacy","volume":"11","author":"Bian","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.molmed.2026.03.007_bb0475","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/toxins17100477","article-title":"Anticancer activity of snake venom against breast cancer: a scoping review","volume":"17","author":"Kim","year":"2025","journal-title":"Toxins"},{"key":"10.1016\/j.molmed.2026.03.007_bb0480","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3390\/molecules29071646","article-title":"3-NAntC: a potent crotoxin B-derived peptide against the triple-negative MDA-MB-231 breast cancer cell line","volume":"29","author":"Bezerra","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.molmed.2026.03.007_bb0485","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/toxins10110483","article-title":"Pharmacokinetics of toxin-derived peptide drugs","volume":"10","author":"Stepensky","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.molmed.2026.03.007_bb0490","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00726-025-03454-5","article-title":"Therapeutic peptides: chemical strategies fortify peptides for enhanced disease treatment efficacy","volume":"57","author":"Li","year":"2025","journal-title":"Amino Acids"},{"key":"10.1016\/j.molmed.2026.03.007_bb0495","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/pharmaceutics16020240","article-title":"Peptide-mediated nanocarriers for targeted drug delivery: developments and strategies","volume":"16","author":"Wang","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.molmed.2026.03.007_bb0500","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.trecan.2017.07.004","article-title":"Venom peptides: improving specificity in cancer therapy","volume":"3","author":"Mahadevappa","year":"2017","journal-title":"Trends Cancer"}],"container-title":["Trends in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142600064X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149142600064X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:11:50Z","timestamp":1791990710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149142600064X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":100,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S147149142600064X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmed.2026.03.007","relation":{},"ISSN":["1471-4914"],"issn-type":[{"value":"1471-4914","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Could venom-derived therapeutics resolve treatment resistance in refractory EAC?","name":"articletitle","label":"Article Title"},{"value":"Trends in Molecular Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmed.2026.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}