{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:28:42Z","timestamp":1789867722291,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"vor","delay-in-days":653,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK094004"],"award-info":[{"award-number":["R01DK094004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA196986"],"award-info":[{"award-number":["R01CA196986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["1F30AA024385-01"],"award-info":[{"award-number":["1F30AA024385-01"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.molmet.2016.04.001","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T21:00:59Z","timestamp":1460408459000},"page":"422-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["Raptor\/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease"],"prefix":"10.1016","volume":"5","author":[{"given":"Peter L.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Guertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2016.04.001_bib1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2014.732","article-title":"Prevalence of childhood and adult obesity in the United States, 2011\u20132012","volume":"311","author":"Ogden","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.molmet.2016.04.001_bib2","unstructured":"NIDDK, http:\/\/www.niddk.nih.gov\/health-information\/health-statistics\/Pages\/overweight-obesity-statistics.aspx."},{"key":"10.1016\/j.molmet.2016.04.001_bib3","unstructured":"Eurostat, http:\/\/ec.europa.eu\/eurostat\/en\/web\/products-press-releases\/-\/3-24112011-BP."},{"key":"10.1016\/j.molmet.2016.04.001_bib4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2016.04.001_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"Wolfson","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molmet.2016.04.001_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.02.035","article-title":"The CASTOR proteins are arginine sensors for the mTORC1 pathway","author":"Chantranupong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2016.04.001_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2011.02.005","article-title":"Transcriptional control of adipose lipid handling by IRF4","volume":"13","author":"Eguchi","year":"2011","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2016.04.001_bib8","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2337\/db12-1089","article-title":"Lessons on conditional gene targeting in mouse adipose tissue","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2016.04.001_bib9","doi-asserted-by":"crossref","first-page":"18656","DOI":"10.1073\/pnas.1314863110","article-title":"Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARgamma","volume":"110","author":"Wang","year":"2013","journal-title":"Proceedings of the National Academy of Sciences U S A"},{"key":"10.1016\/j.molmet.2016.04.001_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1210\/me.2012-1267","article-title":"A\u00a0novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods","volume":"27","author":"Mullican","year":"2013","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/j.molmet.2016.04.001_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4161\/adip.29674","article-title":"Characterization of Cre recombinase models for the study of adipose tissue","volume":"3","author":"Jeffery","year":"2014","journal-title":"Adipocyte"},{"key":"10.1016\/j.molmet.2016.04.001_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2008.09.003","article-title":"Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration","volume":"8","author":"Polak","year":"2008","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2016.04.001_bib13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2011.06.034","article-title":"mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway","volume":"146","author":"Peterson","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2016.04.001_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1194\/jlr.M600287-JLR200","article-title":"Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat","volume":"48","author":"Xue","year":"2007","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.molmet.2016.04.001_bib15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cmet.2012.08.003","article-title":"PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors","volume":"16","author":"Sanchez-Gurmaches","year":"2012","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2016.04.001_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcb.2016.01.004","article-title":"Emerging complexities in adipocyte origins and identity","author":"Sanchez-Gurmaches","year":"2016","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.molmet.2016.04.001_bib17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/db09-1602","article-title":"Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage","volume":"59","author":"Chakrabarti","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2016.04.001_bib18","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s11745-010-3488-y","article-title":"mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes","volume":"45","author":"Soliman","year":"2010","journal-title":"Lipids"},{"key":"10.1016\/j.molmet.2016.04.001_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature10986","article-title":"A\u00a0novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism","volume":"484","author":"Herman","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2016.04.001_bib20","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.4161\/auto.26563","article-title":"Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes","volume":"9","author":"Ro","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.molmet.2016.04.001_bib21","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/ncb3217","article-title":"Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation","volume":"17","author":"Wang","year":"2015","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.molmet.2016.04.001_bib22","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2337\/diabetes.53.11.2757","article-title":"CCAAT\/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue","volume":"53","author":"Park","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2016.04.001_bib23","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.2337\/diabetes.54.6.1744","article-title":"C\/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer","volume":"54","author":"Qiao","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2016.04.001_bib24","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1210\/en.2005-1030","article-title":"Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid","volume":"147","author":"Qiao","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmet.2016.04.001_bib25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrendo.2015.123","article-title":"Congenital generalized lipodystrophies\u2013new insights into metabolic dysfunction","volume":"11","author":"Patni","year":"2015","journal-title":"Nature Reviews Endocrinology"},{"key":"10.1016\/j.molmet.2016.04.001_bib26","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1194\/jlr.M060244","article-title":"Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals","volume":"56","author":"Zhou","year":"2015","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.molmet.2016.04.001_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cmet.2009.01.002","article-title":"Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy","volume":"9","author":"Cortes","year":"2009","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2016.04.001_bib28","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.2337\/db13-0729","article-title":"Adipose-specific knockout of SEIPIN\/BSCL2 results in progressive lipodystrophy","volume":"63","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2016.04.001_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molmet.2014.12.013","article-title":"Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis","volume":"4","author":"Talukder","year":"2015","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.molmet.2016.04.001_bib30","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1073\/pnas.022634399","article-title":"Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin","volume":"99","author":"Huffman","year":"2002","journal-title":"Proceedings of the National Academy of Sciences U S A"},{"key":"10.1016\/j.molmet.2016.04.001_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/83685","article-title":"Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin","volume":"27","author":"Peterfy","year":"2001","journal-title":"Nature Genetics"},{"key":"10.1016\/j.molmet.2016.04.001_bib32","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.1199498","article-title":"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling","volume":"332","author":"Hsu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.molmet.2016.04.001_bib33","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.1199484","article-title":"Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling","volume":"332","author":"Yu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.molmet.2016.04.001_bib34","doi-asserted-by":"crossref","DOI":"10.2337\/db15-0502","article-title":"Rapamycin blocks induction of the thermogenic program in white adipose tissue","author":"Tran","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2016.04.001_bib35","doi-asserted-by":"crossref","DOI":"10.1172\/JCI83532","article-title":"Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning","author":"Liu","year":"2016","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.molmet.2016.04.001_bib36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2337\/db14-0427","article-title":"Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch","volume":"64","author":"Xiang","year":"2015","journal-title":"Diabetes"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877816300059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877816300059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T03:32:38Z","timestamp":1539747158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877816300059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S2212877816300059"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2016.04.001","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Raptor\/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2016.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Published by Elsevier GmbH","name":"copyright","label":"Copyright"}]}}