{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:28:32Z","timestamp":1790364512918,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"vor","delay-in-days":349,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Innovative Medicines Initiative Joint Undertaking","award":["155005"],"award-info":[{"award-number":["155005"]}]},{"DOI":"10.13039\/501100004963","name":"European Union's Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EFPIA companies'"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["3100A0B-128657"],"award-info":[{"award-number":["3100A0B-128657"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council Advanced Grant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["MR\/J0003042\/1"],"award-info":[{"award-number":["MR\/J0003042\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/J015873\/1"],"award-info":[{"award-number":["BB\/J015873\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society for a Wolfson Research Merit Award","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust for a Senior Investigator Award","doi-asserted-by":"publisher","award":["WT098424AIA"],"award-info":[{"award-number":["WT098424AIA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.molmet.2017.01.009","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T08:30:26Z","timestamp":1485419426000},"page":"340-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-5360","authenticated-orcid":false,"given":"C\u00e9line","family":"Cruciani-Guglielmacci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Denom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-248X","authenticated-orcid":false,"given":"Ne\u00efk\u00e9","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Normandie-Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier P.","family":"Berney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim","family":"Kassis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Rouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dairou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-4776","authenticated-orcid":false,"given":"Robin","family":"Liechti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-947X","authenticated-orcid":false,"given":"Dmitry","family":"Kuznetsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-0265","authenticated-orcid":false,"given":"Leonore","family":"Wigger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Burdet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4660-1963","authenticated-orcid":false,"given":"Anne-Laure","family":"Lef\u00e8vre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Wehrle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Uphues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Rust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ktorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Scharfmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-6841","authenticated-orcid":false,"given":"Ioannis","family":"Xenarios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Le Stunff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Thorens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Magnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ibberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2017.01.009_bib1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2337\/diab.44.8.863","article-title":"Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications","volume":"44","author":"Unger","year":"1995","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.molmet.2017.01.009_bib2","first-page":"698","article-title":"Epidemiology of diabetes","volume":"42","author":"Forouhi","year":"2014","journal-title":"Medicine (Abingdon)"},{"issue":"2","key":"10.1016\/j.molmet.2017.01.009_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20141384","article-title":"Pancreatic beta-cell identity, glucose sensing and the control of insulin secretion","volume":"466","author":"Rutter","year":"2015","journal-title":"The Biochemical Journal"},{"issue":"3","key":"10.1016\/j.molmet.2017.01.009_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbalip.2009.10.006","article-title":"Lipid homeostasis, lipotoxicity and the metabolic syndrome","volume":"1801","author":"Unger","year":"2010","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"10.1016\/j.molmet.2017.01.009_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/endo.143.2.8623","article-title":"Minireview: secondary beta-cell failure in type 2 diabetes\u2013a convergence of glucotoxicity and lipotoxicity","volume":"143","author":"Poitout","year":"2002","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.molmet.2017.01.009_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1517\/14728222.2015.1028359","article-title":"Targeting sphingolipid metabolism in the treatment of obesity\/type 2 diabetes","volume":"19","author":"Bellini","year":"2015","journal-title":"Expert Opinion on Therapeutic Targets"},{"issue":"6","key":"10.1016\/j.molmet.2017.01.009_bib7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.07.029","article-title":"Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure","volume":"150","author":"Talchai","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.molmet.2017.01.009_bib8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1056\/NEJMcibr1214034","article-title":"Beta-cell dedifferentiation and type 2 diabetes","volume":"368","author":"Dor","year":"2013","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"10.1016\/j.molmet.2017.01.009_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.molmet.2017.01.009_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11892-014-0551-8","article-title":"Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits","volume":"14","author":"Marullo","year":"2014","journal-title":"Current Diabetes Reports"},{"issue":"9","key":"10.1016\/j.molmet.2017.01.009_bib11","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.molmet.2014.09.006","article-title":"Defective insulin secretory response to intravenous glucose in C57Bl\/6J compared to C57Bl\/6N mice","volume":"3","author":"Fergusson","year":"2014","journal-title":"Molecular Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2017.01.009_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00125-005-1680-z","article-title":"A genetic and physiological study of impaired glucose homeostasis control in C57BL\/6J mice","volume":"48","author":"Toye","year":"2005","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.molmet.2017.01.009_bib13","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.2337\/db13-1383","article-title":"RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate","volume":"63","author":"Cnop","year":"2014","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.molmet.2017.01.009_bib14","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2337\/diabetes.51.4.977","article-title":"Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function","volume":"51","author":"Busch","year":"2002","journal-title":"Diabetes"},{"issue":"17","key":"10.1016\/j.molmet.2017.01.009_bib15","doi-asserted-by":"crossref","first-page":"11973","DOI":"10.1074\/jbc.M112.422527","article-title":"Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832\/13 beta-cells accompany functional adaptations to lipotoxicity","volume":"288","author":"Malmgren","year":"2013","journal-title":"The Journal of Biological Chemistrty"},{"issue":"11","key":"10.1016\/j.molmet.2017.01.009_bib16","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1210\/endo.142.11.8483","article-title":"The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray","volume":"142","author":"Xiao","year":"2001","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.molmet.2017.01.009_bib17","doi-asserted-by":"crossref","first-page":"e86815","DOI":"10.1371\/journal.pone.0086815","article-title":"Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL\/6J mice","volume":"9","author":"Roat","year":"2014","journal-title":"PLoS One"},{"issue":"Suppl. 3","key":"10.1016\/j.molmet.2017.01.009_bib18","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.2337\/diabetes.53.suppl_3.S215","article-title":"The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes","volume":"53","author":"Winzell","year":"2004","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.molmet.2017.01.009_bib19","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.2337\/db09-1452","article-title":"Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass","volume":"59","author":"Peyot","year":"2010","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.molmet.2017.01.009_bib20","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00125-013-2846-8","article-title":"Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding","volume":"56","author":"Montgomery","year":"2013","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.molmet.2017.01.009_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0026-0495(95)90123-X","article-title":"Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL\/6J and A\/J mice","volume":"44","author":"Surwit","year":"1995","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2017.01.009_bib22","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.2337\/db11-0338","article-title":"Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis","volume":"60","author":"Poussin","year":"2011","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.molmet.2017.01.009_bib23","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1093\/jn\/134.12.3264","article-title":"Metabolic adaptations of three inbred strains of mice (C57BL\/6, DBA\/2, and 129T2) in response to a high-fat diet","volume":"134","author":"Funkat","year":"2004","journal-title":"The Journal of Nutrition"},{"issue":"2","key":"10.1016\/j.molmet.2017.01.009_bib24","doi-asserted-by":"crossref","first-page":"e1668","DOI":"10.1371\/journal.pone.0001668","article-title":"Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice","volume":"3","author":"Fearnside","year":"2008","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.molmet.2017.01.009_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/sj.ijo.0803110","article-title":"Distinct phenotypes of obesity-prone AKR\/J, DBA2J and C57BL\/6J mice compared to control strains","volume":"30","author":"Alexander","year":"2006","journal-title":"International Journal of Obesity (London)"},{"issue":"1","key":"10.1016\/j.molmet.2017.01.009_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1677\/joe.1.06333","article-title":"Differential effect of inbred mouse strain (C57BL\/6, DBA\/2, 129T2) on insulin secretory function in response to a high fat diet","volume":"187","author":"Andrikopoulos","year":"2005","journal-title":"The Journal of Endocrinology"},{"issue":"8","key":"10.1016\/j.molmet.2017.01.009_bib27","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/oby.2007.238","article-title":"C57BL\/6J and A\/J mice fed a high-fat diet delineate components of metabolic syndrome","volume":"15","author":"Gallou-Kabani","year":"2007","journal-title":"Obesity (Silver Spring)"},{"issue":"7","key":"10.1016\/j.molmet.2017.01.009_bib28","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1210\/en.2003-1400","article-title":"Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL\/6, C57BLKS\/6, DBA\/2, and 129X1","volume":"145","author":"Goren","year":"2004","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.molmet.2017.01.009_bib29","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/endo.143.6.8859","article-title":"Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure","volume":"143","author":"Kooptiwut","year":"2002","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.molmet.2017.01.009_bib30","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2337\/db07-1615","article-title":"Glucose metabolism in vivo in four commonly used inbred mouse strains","volume":"57","author":"Berglund","year":"2008","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.molmet.2017.01.009_bib31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cmet.2008.03.014","article-title":"Comparisons of diets used in animal models of high-fat feeding","volume":"7","author":"Warden","year":"2008","journal-title":"Cell Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2017.01.009_bib32","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1172\/JCI58447","article-title":"A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion","volume":"121","author":"Ravassard","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.molmet.2017.01.009_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B"},{"key":"10.1016\/j.molmet.2017.01.009_bib34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"10.1016\/j.molmet.2017.01.009_bib35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nmeth.2810","article-title":"Similarity network fusion for aggregating data types on a genomic scale","volume":"11","author":"Wang","year":"2014","journal-title":"Nature Methods"},{"issue":"43","key":"10.1016\/j.molmet.2017.01.009_bib36","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.molmet.2017.01.009_bib37","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Statistical Applications in Genetics and Molecular Biology"},{"issue":"11","key":"10.1016\/j.molmet.2017.01.009_bib38","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Research"},{"issue":"5","key":"10.1016\/j.molmet.2017.01.009_bib39","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cmet.2012.10.009","article-title":"Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes","volume":"16","author":"Mahdi","year":"2012","journal-title":"Cell Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2017.01.009_bib40","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1172\/JCI72674","article-title":"Development of a conditionally immortalized human pancreatic beta cell line","volume":"124","author":"Scharfmann","year":"2014","journal-title":"The Journal of Clinical Investigation"},{"issue":"9","key":"10.1016\/j.molmet.2017.01.009_bib41","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1172\/JCI58899","article-title":"Finally! A human pancreatic beta cell line","volume":"121","author":"Weir","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"10.1016\/j.molmet.2017.01.009_bib42","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","article-title":"The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice","volume":"49","author":"Guillou","year":"2010","journal-title":"Progress in Lipid Research"},{"issue":"43","key":"10.1016\/j.molmet.2017.01.009_bib43","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1073\/pnas.1005572107","article-title":"ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis","volume":"107","author":"Ohno","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/j.molmet.2017.01.009_bib44","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1083\/jcb.149.3.707","article-title":"Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids","volume":"149","author":"Tvrdik","year":"2000","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.molmet.2017.01.009_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuint.2015.08.014","article-title":"Essential role of docosahexaenoic acid towards development of a smarter brain","volume":"89","author":"Gharami","year":"2015","journal-title":"Neurochemistry International"},{"issue":"10","key":"10.1016\/j.molmet.2017.01.009_bib46","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2337\/db09-1554","article-title":"Antiobesity effect of eicosapentaenoic acid in high-fat\/high-sucrose diet-induced obesity: importance of hepatic lipogenesis","volume":"59","author":"Sato","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2017.01.009_bib47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1476-511X-12-109","article-title":"Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice","volume":"12","author":"Liu","year":"2013","journal-title":"Lipids in Health and Disease"},{"issue":"6","key":"10.1016\/j.molmet.2017.01.009_bib48","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jnutbio.2015.02.001","article-title":"Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids","volume":"26","author":"Bhaswant","year":"2015","journal-title":"The Journal of Nutritional Biochemistry"},{"issue":"2","key":"10.1016\/j.molmet.2017.01.009_bib49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1194\/jlr.M011346","article-title":"ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice","volume":"52","author":"Zadravec","year":"2011","journal-title":"Journal of Lipid Research"},{"issue":"4","key":"10.1016\/j.molmet.2017.01.009_bib50","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1194\/jlr.M046151","article-title":"Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice","volume":"55","author":"Pauter","year":"2014","journal-title":"Journal of Lipid Research"},{"issue":"Suppl. 1","key":"10.1016\/j.molmet.2017.01.009_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/dom.12728","article-title":"Mass production of functional human pancreatic beta-cells: why and how?","volume":"18","author":"Scharfmann","year":"2016","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2017.01.009_bib52","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.2337\/db15-0039","article-title":"Novel observations from next-generation RNA sequencing of highly purified human adult and fetal islet cell subsets","volume":"64","author":"Blodgett","year":"2015","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.molmet.2017.01.009_bib53","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI66514","article-title":"Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming","volume":"123","author":"Bramswig","year":"2013","journal-title":"The Journal of Clinical Investigation"},{"issue":"11","key":"10.1016\/j.molmet.2017.01.009_bib54","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1096\/fj.14-257667","article-title":"LKB1 and AMPK differentially regulate pancreatic beta-cell identity","volume":"28","author":"Kone","year":"2014","journal-title":"FASEB Journal"},{"issue":"34","key":"10.1016\/j.molmet.2017.01.009_bib55","doi-asserted-by":"crossref","first-page":"20934","DOI":"10.1074\/jbc.M115.639237","article-title":"Loss of liver kinase B1 (LKB1) in beta cells enhances glucose-stimulated insulin secretion despite profound mitochondrial defects","volume":"290","author":"Swisa","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.molmet.2017.01.009_bib56","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbalip.2015.10.003","article-title":"N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells","volume":"1861","author":"Pinel","year":"2016","journal-title":"Biochimica et Biophysica Acta"},{"issue":"12","key":"10.1016\/j.molmet.2017.01.009_bib57","doi-asserted-by":"crossref","first-page":"e114942","DOI":"10.1371\/journal.pone.0114942","article-title":"The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120","volume":"9","author":"Bjursell","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2017.01.009_bib58","doi-asserted-by":"crossref","first-page":"160018","DOI":"10.1038\/sdata.2016.18","article-title":"The FAIR guiding principles for scientific data management and stewardship","volume":"3","author":"Wilkinson","year":"2016","journal-title":"Scientific Data"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287781730008X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287781730008X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T02:29:52Z","timestamp":1719023392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221287781730008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S221287781730008X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2017.01.009","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2017.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 The Authors. Published by Elsevier GmbH","name":"copyright","label":"Copyright"}]}}