{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:15:29Z","timestamp":1791908129827,"version":"4.3.4"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation (several grants)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012654","name":"Olga Mayenfisch Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012654","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008494","name":"Vontobel Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"University of Zurich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.molmet.2017.11.009","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T20:46:25Z","timestamp":1511469985000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["Amylin \u2013 Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity"],"prefix":"10.1016","volume":"8","author":[{"given":"Christina Neuner","family":"Boyle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Alexander","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Le Foll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2017.11.009_bib1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2337\/diab.39.6.752","article-title":"Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans","volume":"39","author":"Butler","year":"1990","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2017.11.009_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1210\/edrv-15-2-163","article-title":"Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease","volume":"15","author":"Cooper","year":"1994","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.molmet.2017.11.009_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF00404025","article-title":"Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans","volume":"34","author":"Hartter","year":"1991","journal-title":"Diabetologia"},{"key":"10.1016\/j.molmet.2017.11.009_bib4","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cmet.2015.10.012","article-title":"Hypothalamic amylin acts in concert with leptin to regulate food intake","volume":"22","author":"Li","year":"2015","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2012.03.019","article-title":"Brainstem sensing of meal-related signals in energy homeostasis","author":"Young","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib6","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00018-011-0905-1","article-title":"Control of energy homeostasis by amylin","volume":"69","author":"Lutz","year":"2012","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.molmet.2017.11.009_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-015-0693-3","article-title":"GLP-1 and amylin in the treatment of obesity","volume":"16","author":"Jorsal","year":"2016","journal-title":"Current Diabetes Reports"},{"key":"10.1016\/j.molmet.2017.11.009_bib8","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1124\/pr.115.010629","article-title":"Amylin: pharmacology, physiology, and clinical potential","volume":"67","author":"Hay","year":"2015","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.molmet.2017.11.009_bib9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.physbeh.2010.03.001","article-title":"Brainstem mechanisms of amylin-induced anorexia","volume":"100","author":"Potes","year":"2010","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib10","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/db14-0645","article-title":"Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling","volume":"64","author":"Le Foll","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2017.11.009_bib11","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00326.2016","article-title":"Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat","author":"Johnson","year":"2016","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib12","first-page":"E1116","article-title":"Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake","volume":"308","author":"Mietlicki-Baase","year":"2015","journal-title":"American Journal of Physiology: Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib13","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/npp.2013.66","article-title":"Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake","volume":"38","author":"Mietlicki-Baase","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2016.12.028","article-title":"Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through gamma-aminobutyric acid signaling","author":"Reiner","year":"2017","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.molmet.2017.11.009_bib15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/npp.2014.180","article-title":"Amylin modulates the mesolimbic dopamine\u00a0system to control energy balance","volume":"40","author":"Mietlicki-Baase","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.physbeh.2017.03.023","article-title":"The area postrema (AP) and the parabrachial nucleus (PBN) are important sites for salmon calcitonin (sCT) to decrease evoked phasic dopamine release in the nucleus accumbens (NAc)","volume":"176","author":"Whiting","year":"2017","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib17","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/bph.13496","article-title":"Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development","volume":"173","author":"Bower","year":"2016","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1124\/mol.56.1.235","article-title":"Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product","volume":"56","author":"Christopoulos","year":"1999","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2017.11.009_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.13163","article-title":"Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons","author":"Liberini","year":"2016","journal-title":"The European Journal of Neuroscience"},{"key":"10.1016\/j.molmet.2017.11.009_bib21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0306-4522(94)90388-3","article-title":"In\u00a0vitro autoradiographic localization of amylin binding sites in rat brain","volume":"62","author":"Sexton","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2017.11.009_bib22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1124\/mol.104.008615","article-title":"Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes","volume":"67","author":"Hay","year":"2005","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0169-328X(01)00179-6","article-title":"Expression of receptor-activity modifying protein (RAMP) mRNAs in the mouse brain","volume":"93","author":"Ueda","year":"2001","journal-title":"Brain Research. Molecular Brain Research"},{"key":"10.1016\/j.molmet.2017.11.009_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2004.10.012","article-title":"Immunohistochemical mapping of calcitonin receptors in the adult rat brain","volume":"1030","author":"Becskei","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.molmet.2017.11.009_bib25","article-title":"Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity","author":"Dunn-Meynell","year":"2015","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tem.2016.11.004","article-title":"Amylin and leptin: Co-Regulators of energy homeostasis and neuronal development","volume":"28","author":"Levin","year":"2017","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1476-5381.2011.01717.x","article-title":"Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes","volume":"166","author":"Bailey","year":"2012","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1042\/BST20150237","article-title":"Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins","volume":"44","author":"Hay","year":"2016","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.molmet.2017.11.009_bib29","doi-asserted-by":"crossref","first-page":"R1833","DOI":"10.1152\/ajpregu.2001.281.6.R1833","article-title":"Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP","volume":"281","author":"Riediger","year":"2001","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib30","doi-asserted-by":"crossref","first-page":"R340","DOI":"10.1152\/ajpregu.00380.2011","article-title":"Involvement of the extracellular signal-regulated kinase 1\/2 signaling pathway in amylin's eating inhibitory effect","volume":"302","author":"Potes","year":"2012","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.physbeh.2004.01.006","article-title":"Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats","volume":"81","author":"Mollet","year":"2004","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0196-9781(97)00292-1","article-title":"Lesion of the area postrema\/nucleus of the solitary tract (AP\/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats","volume":"19","author":"Lutz","year":"1998","journal-title":"Peptides"},{"key":"10.1016\/j.molmet.2017.11.009_bib33","doi-asserted-by":"crossref","first-page":"R623","DOI":"10.1152\/ajpregu.00791.2009","article-title":"Noradrenergic neurons of the area postrema mediate amylin's hypophagic action","volume":"299","author":"Potes","year":"2010","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib34","article-title":"Control of energy homeostasis by amylin","author":"Lutz","year":"2011","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.molmet.2017.11.009_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2007.06.016","article-title":"Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK","volume":"1162","author":"Becskei","year":"2007","journal-title":"Brain Research"},{"key":"10.1016\/j.molmet.2017.11.009_bib36","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1152\/ajpregu.00333.2003","article-title":"The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis","volume":"286","author":"Riediger","year":"2004","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2010.03.114","article-title":"Identification of central projections from amylin-activated neurons to the lateral hypothalamus","volume":"1334","author":"Potes","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.molmet.2017.11.009_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2012.11.051","article-title":"Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices","volume":"1494","author":"Fukuda","year":"2013","journal-title":"Brain Research"},{"key":"10.1016\/j.molmet.2017.11.009_bib39","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1111\/ejn.12672","article-title":"The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping","volume":"40","author":"Braegger","year":"2014","journal-title":"The European Journal of Neuroscience"},{"key":"10.1016\/j.molmet.2017.11.009_bib40","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0031-9384(95)02067-5","article-title":"Amylin decreases meal size in rats","volume":"58","author":"Lutz","year":"1995","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib41","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0196-9781(98)00018-7","article-title":"Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin","volume":"19","author":"Banks","year":"1998","journal-title":"Peptides"},{"key":"10.1016\/j.molmet.2017.11.009_bib42","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/0024-3205(95)02197-Q","article-title":"Permeability of the blood-brain barrier to amylin","volume":"57","author":"Banks","year":"1995","journal-title":"Life Sciences"},{"key":"10.1016\/j.molmet.2017.11.009_bib43","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2174\/1871527315666160920124928","article-title":"Involvement of the blood-brain barrier in metabolic regulation","volume":"15","author":"Kastin","year":"2016","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.molmet.2017.11.009_bib44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cmet.2013.12.015","article-title":"Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain","volume":"19","author":"Balland","year":"2014","journal-title":"Cell Metabolism"},{"issue":"Suppl 5","key":"10.1016\/j.molmet.2017.11.009_bib45","doi-asserted-by":"crossref","first-page":"197s","DOI":"10.1038\/oby.2006.308","article-title":"Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance","volume":"14","author":"Berthoud","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.molmet.2017.11.009_bib46","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuron.2015.02.018","article-title":"Pleasure systems in the brain","volume":"86","author":"Berridge","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2017.11.009_bib47","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.neubiorev.2007.03.004","article-title":"Liking vs. wanting food: importance for human appetite control and weight regulation","volume":"31","author":"Finlayson","year":"2007","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.molmet.2017.11.009_bib48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnut.2016.00006","article-title":"Hedonics act in unison with the homeostatic system to unconsciously control body weight","volume":"3","author":"Munzberg","year":"2016","journal-title":"Frontiers in Nutrition"},{"key":"10.1016\/j.molmet.2017.11.009_bib49","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1523\/JNEUROSCI.6326-11.2012","article-title":"The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors","volume":"32","author":"Dickson","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.molmet.2017.11.009_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fnins.2013.00181","article-title":"The central GLP-1: implications for food and drug reward","volume":"7","author":"Skibicka","year":"2013","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/j.molmet.2017.11.009_bib51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.physbeh.2009.02.044","article-title":"\u2018Liking\u2019 and \u2018wanting\u2019 food rewards: brain substrates and roles in eating disorders","volume":"97","author":"Berridge","year":"2009","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuropharm.2017.05.024","article-title":"Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior","volume":"123","author":"Mietlicki-Baase","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.physbeh.2011.02.015","article-title":"Amylinergic control of food intake in lean and obese rodents","volume":"105","author":"Boyle","year":"2011","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib54","first-page":"636","article-title":"Short-term, but not extended, access to palatable diet diminishes amylin responsiveness in rat","volume":"54","author":"Boyle","year":"2010","journal-title":"Appetite"},{"key":"10.1016\/j.molmet.2017.11.009_bib55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.physbeh.2011.04.044","article-title":"Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin","volume":"104","author":"Boyle","year":"2011","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2014.02.026","article-title":"Dopamine signaling in the amygdala, increased by food ingestion and GLP-1, regulates feeding behavior","author":"Anderberg","year":"2014","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.molmet.2017.11.009_bib57","first-page":"E1367","article-title":"The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA\/kainate receptors","volume":"305","author":"Mietlicki-Baase","year":"2013","journal-title":"American Journal of Physiology: Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib58","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1210\/jc.2006-2003","article-title":"Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study","volume":"92","author":"Aronne","year":"2007","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib59","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/oby.2004.76","article-title":"Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients","volume":"12","author":"Hollander","year":"2004","journal-title":"Obesity Research"},{"key":"10.1016\/j.molmet.2017.11.009_bib60","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2337\/dc08-0029","article-title":"Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity","volume":"31","author":"Smith","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.molmet.2017.11.009_bib61","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2174\/1381612013397357","article-title":"Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control","volume":"7","author":"Weyer","year":"2001","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.molmet.2017.11.009_bib62","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1038\/oby.2009.184","article-title":"Enhanced weight loss with pramlintide\/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy","volume":"17","author":"Ravussin","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.molmet.2017.11.009_bib63","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.0706473105","article-title":"Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies","volume":"105","author":"Roth","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.molmet.2017.11.009_bib64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/oby.2009.187","article-title":"Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats","volume":"18","author":"Trevaskis","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.molmet.2017.11.009_bib65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/en.2009-0546","article-title":"Mechanisms of amylin\/leptin synergy in rodent models","volume":"151","author":"Turek","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmet.2017.11.009_bib66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnbeh.2017.00077","article-title":"Reward network immediate early gene expression in mood disorders","volume":"11","author":"Manning","year":"2017","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"10.1016\/j.molmet.2017.11.009_bib67","doi-asserted-by":"crossref","first-page":"R676","DOI":"10.1152\/ajpregu.00090.2012","article-title":"Amylin blunts hyperphagia and reduces weight and fat gain during recovery in socially stressed rats","volume":"303","author":"Smeltzer","year":"2012","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.molmet.2017.11.009_bib68","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/archneurol.2008.581","article-title":"Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications","volume":"66","author":"Roth","year":"2009","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.molmet.2017.11.009_bib69","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ijo.2009.238","article-title":"Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight","volume":"34","author":"Mack","year":"2010","journal-title":"International Journal of Obesity (London)"},{"key":"10.1016\/j.molmet.2017.11.009_bib70","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1208\/s12249-013-9987-4","article-title":"Preparation and characterization of PEGylated amylin","volume":"14","author":"Guerreiro","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.molmet.2017.11.009_bib71","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1021\/jm401418s","article-title":"Bifunctional PEGylated exenatide-amylinomimetic hybrids to treat metabolic disorders: an example of long-acting dual hormonal therapeutics","volume":"56","author":"Sun","year":"2013","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.molmet.2017.11.009_bib72","doi-asserted-by":"crossref","first-page":"8142","DOI":"10.1039\/C4OB01208A","article-title":"Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism","volume":"12","author":"Kowalczyk","year":"2014","journal-title":"Organic & Biomolecular Chemistry"},{"key":"10.1016\/j.molmet.2017.11.009_bib73","first-page":"15084","article-title":"Glycosylation of pramlintide: synthetic glycopeptides that display in\u00a0vitro and in\u00a0vivo activities as amylin receptor agonists","volume":"19","author":"Tomabechi","year":"2013","journal-title":"Chemistry (Weinheim an der Bergstrasse, Germany)"},{"key":"10.1016\/j.molmet.2017.11.009_bib74","first-page":"E24","article-title":"A\u00a0novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats","volume":"307","author":"Andreassen","year":"2014","journal-title":"American Journal of Physiology: Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib75","first-page":"E821","article-title":"KBP-088, a novel DACRA with prolonged receptor activation, is superior to davalintide in terms of efficacy on body weight","volume":"310","author":"Gydesen","year":"2016","journal-title":"American Journal of Physiology: Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib76","article-title":"Optimization of tolerability and efficacy of dual amylin and calcitonin receptor agonist, KBP-089, through dose escalation and combination with a GLP-1 analogue","author":"Gydesen","year":"2017","journal-title":"American Journal of Physiology: Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2017.11.009_bib77","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejphar.2015.05.051","article-title":"KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration","volume":"762","author":"Hjuler","year":"2015","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib78","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.117.241281","article-title":"The dual amylin- and calcitonin-receptor agonist KBP-042 works as adjunct to Metformin on fasting hyperglycemia and HbA1c in a rat model of type 2 diabetes","volume":"362","author":"Hjuler","year":"2017","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.molmet.2017.11.009_bib79","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1002\/oby.21563","article-title":"The dual amylin- and calcitonin-receptor agonist KBP-042 increases insulin sensitivity and induces weight loss in rats with obesity","volume":"24","author":"Hjuler","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.molmet.2017.11.009_bib80","doi-asserted-by":"crossref","DOI":"10.1111\/bph.13723","article-title":"A\u00a0novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference","author":"Gydesen","year":"2017","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib81","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.regpep.2012.08.006","article-title":"[D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK\/6-m db\/db mice","volume":"179","author":"Leinung","year":"2012","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.molmet.2017.11.009_bib82","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/0091270010372625","article-title":"Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials","volume":"51","author":"Karsdal","year":"2011","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib83","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/GME.0b013e31827c58ab","article-title":"Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats","volume":"20","author":"Feigh","year":"2013","journal-title":"Menopause (New York, N.Y.)"},{"key":"10.1016\/j.molmet.2017.11.009_bib84","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2014.05.016","article-title":"Oral salmon calcitonin enhances insulin action and glucose metabolism in diet-induced obese streptozotocin-diabetic rats","volume":"737","author":"Feigh","year":"2014","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.molmet.2017.11.009_bib85","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.copbio.2017.03.011","article-title":"Synthetic RNA-based switches for mammalian gene expression control","volume":"48","author":"Auslander","year":"2017","journal-title":"Current Opinion in Biotechnology"},{"key":"10.1016\/j.molmet.2017.11.009_bib86","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-4939-7223-4_19","article-title":"Design of synthetic promoters for gene circuits in mammalian cells","volume":"1651","author":"Saxena","year":"2017","journal-title":"Methods in Molecular Biology (Clifton, N.J.)"},{"key":"10.1016\/j.molmet.2017.11.009_bib87","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.copbio.2017.06.004","article-title":"Synthetic biology-inspired therapies for metabolic diseases","volume":"47","author":"Teixeira","year":"2017","journal-title":"Current Opinion in Biotechnology"},{"key":"10.1016\/j.molmet.2017.11.009_bib88","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1126\/science.aaf4006","article-title":"beta-cell-mimetic designer cells provide closed-loop glycemic control","volume":"354","author":"Xie","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molmet.2017.11.009_bib89","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1038\/ncomms3825","article-title":"A\u00a0closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice","volume":"4","author":"Rossger","year":"2013","journal-title":"Nature Communications"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877817308700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877817308700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T15:48:15Z","timestamp":1589816895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877817308700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":89,"alternative-id":["S2212877817308700"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2017.11.009","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amylin \u2013 Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2017.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 The Authors. Published by Elsevier GmbH","name":"copyright","label":"Copyright"}]}}