{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:11:44Z","timestamp":1778915504197,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5 F32 DK107050"],"award-info":[{"award-number":["5 F32 DK107050"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013528","name":"Diabetes Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.molmet.2018.10.011","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T12:07:06Z","timestamp":1541419626000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice"],"prefix":"10.1016","volume":"19","author":[{"given":"Brandon L.","family":"Panaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew L.","family":"Coppage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline L.","family":"Beaudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie M.","family":"Varin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack H.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wengen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-7244","authenticated-orcid":false,"given":"William W.","family":"Bachovchin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Drucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molmet.2018.10.011_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI30076","article-title":"The role of gut hormones in glucose homeostasis","volume":"117","author":"Drucker","year":"2007","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.011_bib2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/jc.2015-3449","article-title":"Evolving concepts and translational relevance of enteroendocrine cell biology","volume":"101","author":"Drucker","year":"2016","journal-title":"The Journal of Cinical Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2018.10.011_bib3","first-page":"78223","article-title":"Understanding the physiology of FGF21","author":"Fisher","year":"2016","journal-title":"Annual Review of Physiology"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.011_bib4","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1210\/er.2017-00016","article-title":"Fibroblast growth factor 21-metabolic role in mice and men","volume":"38","author":"Staiger","year":"2017","journal-title":"Endocrine Reviews"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.011_bib5","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1172\/JCI97233","article-title":"Discovery, characterization, and clinical development of the glucagon-like peptides","volume":"127","author":"Drucker","year":"2017","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.011_bib6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S1357-2725(03)00262-0","article-title":"Dipeptidyl peptidase IV activity and\/or structure homologues (DASH) and their substrates in cancer","volume":"36","author":"Busek","year":"2004","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.011_bib7","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1210\/er.2014-1035","article-title":"Pharmacology, physiology and mechanisms of action of dipeptidyl peptidase-4 inhibitors","author":"Mulvihill","year":"2014","journal-title":"Endocrine Reviews"},{"issue":"25","key":"10.1016\/j.molmet.2018.10.011_bib8","doi-asserted-by":"crossref","first-page":"22418","DOI":"10.1074\/jbc.M212355200","article-title":"The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in\u00a0vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)","volume":"278","author":"Zhu","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.011_bib9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00125-016-3899-2","article-title":"Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism","volume":"59","author":"Ahren","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.molmet.2018.10.011_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.peptides.2017.10.011","article-title":"Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes","volume":"100","author":"Deacon","year":"2018","journal-title":"Peptides"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.011_bib11","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1073\/pnas.120069197","article-title":"Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26","volume":"97","author":"Marguet","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"11","key":"10.1016\/j.molmet.2018.10.011_bib12","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1073\/pnas.0631828100","article-title":"Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance","volume":"100","author":"Conarello","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.011_bib13","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1046\/j.1432-1327.1998.2540650.x","article-title":"Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease","volume":"254","author":"Niedermeyer","year":"1998","journal-title":"European Journal of Biochemistry"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.011_bib14","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1073\/pnas.91.12.5657","article-title":"Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers","volume":"91","author":"Scanlan","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"8","key":"10.1016\/j.molmet.2018.10.011_bib15","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1742-4658.2011.08051.x","article-title":"Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha","volume":"278","author":"Keane","year":"2011","journal-title":"FEBS Journal"},{"issue":"20","key":"10.1016\/j.molmet.2018.10.011_bib16","doi-asserted-by":"crossref","first-page":"19441","DOI":"10.1074\/jbc.C500092200","article-title":"Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha","volume":"280","author":"Aertgeerts","year":"2005","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.011_bib17","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.febslet.2006.01.087","article-title":"Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity","volume":"580","author":"Edosada","year":"2006","journal-title":"FEBS Letters"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.011_bib18","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1182\/blood-2005-08-3452","article-title":"Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein","volume":"107","author":"Lee","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.molmet.2018.10.011_bib19","first-page":"443","article-title":"Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs","volume":"443","author":"Keane","year":"2013","journal-title":"FEBS Open Bio"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.011_bib20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.20122344","article-title":"Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia","volume":"210","author":"Roberts","year":"2013","journal-title":"Journal of Experimental Medicine"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.011_bib21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00418-014-1292-0","article-title":"Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets","volume":"143","author":"Busek","year":"2015","journal-title":"Histochemistry and Cell Biology"},{"issue":"10","key":"10.1016\/j.molmet.2018.10.011_bib22","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.molmet.2016.07.003","article-title":"Fibroblast activation protein (FAP) as a novel metabolic target","volume":"5","author":"Sanchez-Garrido","year":"2016","journal-title":"Mol Metab"},{"issue":"10","key":"10.1016\/j.molmet.2018.10.011_bib23","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/jm950732f","article-title":"Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides","volume":"39","author":"Coutts","year":"1996","journal-title":"Journal of Medicinal Chemistry"},{"issue":"19","key":"10.1016\/j.molmet.2018.10.011_bib24","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1021\/jm800390n","article-title":"Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in\u00a0vivo efficacy and safety","volume":"51","author":"Connolly","year":"2008","journal-title":"Journal of Medicinal Chemistry"},{"issue":"7","key":"10.1016\/j.molmet.2018.10.011_bib25","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1021\/jm100972f","article-title":"Pro-soft Val-boroPro: a strategy for enhancing in\u00a0vivo performance of boronic acid inhibitors of serine proteases","volume":"54","author":"Poplawski","year":"2011","journal-title":"Journal of Medicinal Chemistry"},{"issue":"8","key":"10.1016\/j.molmet.2018.10.011_bib26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nchembio.1578","article-title":"A\u00a0high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity","volume":"10","author":"Bachovchin","year":"2014","journal-title":"Nature Chemical Biology"},{"issue":"7","key":"10.1016\/j.molmet.2018.10.011_bib27","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1021\/jm500031w","article-title":"Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP)","volume":"57","author":"Jansen","year":"2014","journal-title":"Journal of Medicinal Chemistry"},{"issue":"26","key":"10.1016\/j.molmet.2018.10.011_bib28","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0904187106","article-title":"FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response","volume":"106","author":"Potthoff","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.011_bib29","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2337\/db09-0955","article-title":"Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice","volume":"59","author":"Sauve","year":"2010","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.molmet.2018.10.011_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cmet.2016.10.007","article-title":"Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis","volume":"25","author":"Mulvihill","year":"2017","journal-title":"Cell Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2018.10.011_bib31","doi-asserted-by":"crossref","first-page":"12524","DOI":"10.1038\/s41598-017-12900-8","article-title":"Selective homogeneous assay for circulating endopeptidase fibroblast activation protein (FAP)","volume":"7","author":"Bainbridge","year":"2017","journal-title":"Scientific Reports"},{"issue":"11","key":"10.1016\/j.molmet.2018.10.011_bib32","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1074\/jbc.M115.710582","article-title":"Fibroblast activation protein cleaves and inactivates fibroblast growth factor 21","volume":"291","author":"Dunshee","year":"2016","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.011_bib33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1042\/BJ20151085","article-title":"Circulating FGF21 proteolytic processing mediated by fibroblast activation protein","volume":"473","author":"Zhen","year":"2016","journal-title":"Biochemical Journal"},{"issue":"9","key":"10.1016\/j.molmet.2018.10.011_bib34","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1517\/13543784.16.9.1459","article-title":"Talabostat","volume":"16","author":"Cunningham","year":"2007","journal-title":"Expert Opinion on Investigational Drugs"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.011_bib35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1021\/ml300410d","article-title":"Selective inhibitors of fibroblast activation protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold","volume":"4","author":"Jansen","year":"2013","journal-title":"ACS Medicinal Chemistry Letters"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.011_bib36","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1463-1326.2011.01550.x","article-title":"The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients","volume":"14","author":"Fadini","year":"2012","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"10","key":"10.1016\/j.molmet.2018.10.011_bib37","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1210\/jc.2017-01257","article-title":"FGF21 is an insulin-dependent postprandial hormone in adult humans","volume":"102","author":"Samms","year":"2017","journal-title":"The Journal of Cinical Endocrinology and Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.011_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/cei.12757","article-title":"Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and\/or structure homologue (DASH) proteins","volume":"184","author":"Wagner","year":"2016","journal-title":"Clinical and Experimental Immunology"},{"issue":"9","key":"10.1016\/j.molmet.2018.10.011_bib39","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1158\/0008-5472.CAN-05-1245","article-title":"The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices","volume":"66","author":"Ghersi","year":"2006","journal-title":"Cancer Research"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.011_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ijo.2013.79","article-title":"Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta)","volume":"38","author":"Nygaard","year":"2014","journal-title":"International Journal of Obesity (Lond)"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.011_bib41","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.011_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148252","article-title":"Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas","volume":"11","author":"Singhal","year":"2016","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.011_bib43","first-page":"277","article-title":"Diet polyphenol curcumin stimulates hepatic Fgf21 production and restores its sensitivity in high-fat-diet-fed male mice","volume":"158","author":"Zeng","year":"2017","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.011_bib44","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1128\/MCB.20.3.1089-1094.2000","article-title":"Targeted disruption of mouse fibroblast activation protein","volume":"20","author":"Niedermeyer","year":"2000","journal-title":"Molecular and Cellular Biology"},{"issue":"19","key":"10.1016\/j.molmet.2018.10.011_bib45","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92232","article-title":"Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma","volume":"2","author":"Lo","year":"2017","journal-title":"JCI Insight"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877818309621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877818309621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:17:57Z","timestamp":1761956277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877818309621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":45,"alternative-id":["S2212877818309621"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2018.10.011","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2018.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}