{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:34:54Z","timestamp":1790836494349,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106262\/Z\/14\/Z"],"award-info":[{"award-number":["106262\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106263\/Z\/14\/Z"],"award-info":[{"award-number":["106263\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["MRC_MC_UU_12012\/3"],"award-info":[{"award-number":["MRC_MC_UU_12012\/3"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015223","name":"Danish Diabetes Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","award":["NNF10CC1016515"],"award-info":[{"award-number":["NNF10CC1016515"]}],"id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.molmet.2018.10.012","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T12:06:56Z","timestamp":1541419616000},"page":"49-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones"],"prefix":"10.1016","volume":"19","author":[{"given":"Olga","family":"Rudenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4307-6668","authenticated-orcid":false,"given":"Alexander","family":"Munk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-1891","authenticated-orcid":false,"given":"Jeppe P.","family":"Ekberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9344-6041","authenticated-orcid":false,"given":"Natalia","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja S.","family":"Engelstoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer L.","family":"Egerod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siv A.","family":"Hjorth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-0872","authenticated-orcid":false,"given":"Yue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-0457","authenticated-orcid":false,"given":"Jacek","family":"Mokrosinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Thams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Reimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4232-2898","authenticated-orcid":false,"given":"Fiona","family":"Gribble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens F.","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-7012","authenticated-orcid":false,"given":"Jonas T.","family":"Treebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thue W.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.neuropharm.2005.11.003","article-title":"Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development","volume":"50","author":"Susens","year":"2006","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.012_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2008.08.040","article-title":"Anatomical profiling of G protein-coupled receptor expression","volume":"135","author":"Regard","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2018.10.012_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1743-7075-5-23","article-title":"A\u00a0high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development","volume":"5","author":"Jones","year":"2008","journal-title":"Nutrition and Metabolism"},{"issue":"18","key":"10.1016\/j.molmet.2018.10.012_bib4","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1016\/j.bmcl.2012.07.063","article-title":"Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus","volume":"22","author":"Lizarzaburu","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"9","key":"10.1016\/j.molmet.2018.10.012_bib5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/ml4000854","article-title":"Aminopyrazole-phenylalanine based GPR142 agonists: discovery of tool compound and in\u00a0vivo efficacy studies","volume":"4","author":"Yu","year":"2013","journal-title":"ACS Medicinal Chemistry Letters"},{"issue":"19","key":"10.1016\/j.molmet.2018.10.012_bib6","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1016\/j.bmcl.2012.08.015","article-title":"Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes","volume":"22","author":"Du","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"8","key":"10.1016\/j.molmet.2018.10.012_bib7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1021\/ml400186z","article-title":"Potent and orally bioavailable GPR142 agonists as novel insulin secretagogues for the treatment of type 2 diabetes","volume":"4","author":"Toda","year":"2013","journal-title":"ACS Medicinal Chemistry Letters"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.012_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157298","article-title":"GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism","volume":"11","author":"Lin","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.molmet.2018.10.012_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molmet.2018.02.008","article-title":"GPR142 prompts glucagon-like Peptide-1 release from islets to improve beta cell function","volume":"11","author":"Lin","year":"2018","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.molmet.2018.10.012_bib10","series-title":"Keystone symposia, Diabetes: new insights into molecular mechanisms and therapeutic strategies (T2)","article-title":"Agonist for the aromatic amino acid receptor GPR142 provides a broad, balanced stimulation of pancreatic and gut hormones strongly stimulating glucose disposal","author":"Rudenko","year":"2015"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.012_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00125-008-1202-x","article-title":"Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells","volume":"52","author":"Parker","year":"2009","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.012_bib12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cmet.2008.11.002","article-title":"Glucose sensing in L cells: a primary cell study","volume":"8","author":"Reimann","year":"2008","journal-title":"Cell Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2018.10.012_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molmet.2014.10.002","article-title":"GPR40 (FFAR1) - combined Gs and Gq signaling in\u00a0vitro is associated with robust incretin secretagogue action ex\u00a0vivo and in\u00a0vivo","volume":"4","author":"Hauge","year":"2015","journal-title":"Molecular Metabolism"},{"issue":"10","key":"10.1016\/j.molmet.2018.10.012_bib14","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1007\/s00125-016-4033-1","article-title":"Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets","volume":"59","author":"Adriaenssens","year":"2016","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.molmet.2018.10.012_bib15","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1210\/en.2011-2170","article-title":"Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry","volume":"153","author":"Habib","year":"2012","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.molmet.2013.08.006","article-title":"Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells","volume":"2","author":"Engelstoft","year":"2013","journal-title":"Molecular Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.012_bib17","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1210\/en.2008-1250","article-title":"G\u00a0protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction","volume":"150","author":"Holst","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmet.2018.10.012_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-1-62703-125-7_19","article-title":"Primary mouse small intestinal epithelial cell cultures","volume":"945","author":"Sato","year":"2013","journal-title":"Methods in Molecular Biology"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib19","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1053\/j.gastro.2018.06.039","article-title":"Inhibiting RHOA signaling in mice increases glucose tolerance and numbers of enteroendocrine and other secretory cells in the intestine","volume":"155","author":"Petersen","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.012_bib20","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/clinchem\/44.5.991","article-title":"Accurate measurement of cholecystokinin in plasma","volume":"44","author":"Rehfeld","year":"1998","journal-title":"Clinical Chemistry"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.012_bib21","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/sj.bjp.0707682","article-title":"The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet","volume":"153","author":"Di Marzo","year":"2008","journal-title":"British Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.012_bib22","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2337\/db11-0100","article-title":"Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice","volume":"61","author":"Attane","year":"2012","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.012_bib23","doi-asserted-by":"crossref","first-page":"C377","DOI":"10.1152\/ajpcell.00297.2009","article-title":"Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle","volume":"298","author":"Treebak","year":"2010","journal-title":"American Journal of Physiology Cell Physiology"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.012_bib24","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.metabol.2016.09.002","article-title":"Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain","volume":"65","author":"Jensen","year":"2016","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2016.08.020","article-title":"Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes","volume":"24","author":"Segerstolpe","year":"2016","journal-title":"Cell Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.012_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-2007-1014752","article-title":"The differential effect of intragastric and intravenous tryptophan on plasma glucose, insulin, glucagon, GLI and GIP in the fasted rat","volume":"16","author":"Tsiolakis","year":"1984","journal-title":"Hormone and Metabolic Research"},{"issue":"1","key":"10.1016\/j.molmet.2018.10.012_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1743-7075-8-45","article-title":"Regulation of blood pressure and glucose metabolism induced by L-tryptophan in stroke-prone spontaneously hypertensive rats","volume":"8","author":"Ardiansyah","year":"2011","journal-title":"Nutrition and Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2018.10.012_bib28","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1210\/jc.2014-1943","article-title":"Effects of intraduodenal infusion of L-tryptophan on ad libitum eating, antropyloroduodenal motility, glycemia, insulinemia, and gut peptide secretion in healthy men","volume":"99","author":"Steinert","year":"2014","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.012_bib29","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1210\/jcem-37-5-826","article-title":"Stimulation of insulin secretion by gastric inhibitory polypeptide in man","volume":"37","author":"Dupre","year":"1973","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.012_bib30","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.2337\/db11-0979","article-title":"Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans","volume":"60","author":"Christensen","year":"2011","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.molmet.2018.10.012_bib31","doi-asserted-by":"crossref","first-page":"E550","DOI":"10.1152\/ajpendo.00326.2004","article-title":"Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP","volume":"290","author":"Theodorakis","year":"2006","journal-title":"American Journal of Physiology Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.012_bib32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00125-017-4450-9","article-title":"Enteroendocrine K and L cells in healthy and type 2 diabetic individuals","volume":"61","author":"Jorsal","year":"2018","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2362.1992.tb01464.x","article-title":"Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man","volume":"22","author":"Eissele","year":"1992","journal-title":"European Journal of Clinical Investigation"},{"issue":"6","key":"10.1016\/j.molmet.2018.10.012_bib34","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1210\/endo-128-6-3175","article-title":"Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides","volume":"128","author":"Brubaker","year":"1991","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.molmet.2018.10.012_bib35","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.2337\/db06-0080","article-title":"Paradoxical stimulation of glucagon secretion by high glucose concentrations","volume":"55","author":"Salehi","year":"2006","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.molmet.2018.10.012_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166758","article-title":"Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: a Randomized, Double-Blind, Parallel-Group Trial","volume":"11","author":"Meyer-Gerspach","year":"2016","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/nu10040463","article-title":"Effects of intragastric administration of tryptophan on the blood glucose response to a nutrient drink and energy intake, in lean and obese men","volume":"10","author":"Ullrich","year":"2018","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.012_bib38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.physbeh.2010.03.019","article-title":"Glucagon regulation of energy metabolism","volume":"100","author":"Heppner","year":"2010","journal-title":"Physiology & Behavior"},{"issue":"2","key":"10.1016\/j.molmet.2018.10.012_bib39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cmet.2017.06.010","article-title":"Insulin regulation of proteostasis and clinical implications","volume":"26","author":"James","year":"2017","journal-title":"Cell Metabolism"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.012_bib40","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1113\/jphysiol.2011.223800","article-title":"The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine","volume":"590","author":"Mace","year":"2012","journal-title":"Journal of Physiology"},{"issue":"11","key":"10.1016\/j.molmet.2018.10.012_bib41","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/ijo.2017.164","article-title":"l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents","volume":"41","author":"Alamshah","year":"2017","journal-title":"International Journal of Obesity (London)"},{"issue":"4","key":"10.1016\/j.molmet.2018.10.012_bib42","doi-asserted-by":"crossref","first-page":"G538","DOI":"10.1152\/ajpgi.00342.2010","article-title":"The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells","volume":"300","author":"Liou","year":"2011","journal-title":"American Journal of Physiology Gastrointestinal and Liver Physiology"},{"issue":"18","key":"10.1016\/j.molmet.2018.10.012_bib43","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1111\/j.1742-4658.2008.06604.x","article-title":"Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells","volume":"275","author":"Hira","year":"2008","journal-title":"FEBS Journal"},{"issue":"5","key":"10.1016\/j.molmet.2018.10.012_bib44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/mnfr.201100666","article-title":"Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells","volume":"56","author":"Nakajima","year":"2012","journal-title":"Molecular Nutrition & Food Research"},{"issue":"12","key":"10.1016\/j.molmet.2018.10.012_bib45","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1007\/s00125-013-3037-3","article-title":"Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor","volume":"56","author":"Diakogiannaki","year":"2013","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.molmet.2018.10.012_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13300-016-0160-4","article-title":"The insulin:glucagon ratio and the choice of glucose-lowering drugs","volume":"7","author":"Kalra","year":"2016","journal-title":"Diabetes Therapy"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287781830930X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287781830930X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:17:16Z","timestamp":1761956236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221287781830930X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":46,"alternative-id":["S221287781830930X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2018.10.012","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2018.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}