{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:37:14Z","timestamp":1790019434502,"version":"4.0.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.molmet.2020.02.014","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T19:49:10Z","timestamp":1583264950000},"page":"100971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Berardinelli\u2013Seip congenital lipodystrophy 2\/SEIPIN determines brown adipose tissue maintenance and thermogenic programing"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-5180","authenticated-orcid":false,"given":"Hongyi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5181-5080","authenticated-orcid":false,"given":"Hakjoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisang","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-5953","authenticated-orcid":false,"given":"Weiqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molmet.2020.02.014_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiological Reviews"},{"issue":"7","key":"10.1016\/j.molmet.2020.02.014_bib2","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2337\/db09-0530","article-title":"High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity","volume":"58","author":"Saito","year":"2009","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.molmet.2020.02.014_bib3","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/oby.2011.125","article-title":"Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans","volume":"19","author":"Yoneshiro","year":"2011","journal-title":"Obesity"},{"issue":"6","key":"10.1016\/j.molmet.2020.02.014_bib4","first-page":"583","article-title":"Effects of age on diet-induced thermogenesis and brown adipose tissue metabolism in the rat","volume":"7","author":"Rothwell","year":"1983","journal-title":"International Journal of Obesity"},{"issue":"6457","key":"10.1016\/j.molmet.2020.02.014_bib5","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/366740a0","article-title":"Development of obesity in transgenic mice after genetic ablation of brown adipose tissue","volume":"366","author":"Lowell","year":"1993","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.molmet.2020.02.014_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nm.2297","article-title":"Brown adipose tissue activity controls triglyceride clearance","volume":"17","author":"Bartelt","year":"2011","journal-title":"Nature Medicine"},{"issue":"2","key":"10.1016\/j.molmet.2020.02.014_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/MED.0b013e328337a81f","article-title":"Brown fat as a therapy for obesity and diabetes","volume":"17","author":"Cypess","year":"2010","journal-title":"Current Opinion in Endocrinology, Diabetes, and Obesity"},{"issue":"8","key":"10.1016\/j.molmet.2020.02.014_bib8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nm.3891","article-title":"Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus","volume":"21","author":"Hanssen","year":"2015","journal-title":"Nature Medicine"},{"issue":"8","key":"10.1016\/j.molmet.2020.02.014_bib9","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1172\/JCI67803","article-title":"Recruited brown adipose tissue as an antiobesity agent in humans","volume":"123","author":"Yoneshiro","year":"2013","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.molmet.2020.02.014_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fendo.2011.00084","article-title":"Control of brown adipose tissue glucose and lipid metabolism by PPARgamma","volume":"2","author":"Festuccia","year":"2011","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.molmet.2020.02.014_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmet.2017.11.004","article-title":"Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing","volume":"7","author":"Gonzalez-Hurtado","year":"2018","journal-title":"Molecular Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2020.02.014_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cmet.2010.05.012","article-title":"Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis","volume":"12","author":"Ellis","year":"2010","journal-title":"Cell Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2020.02.014_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cmet.2016.12.005","article-title":"Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans","volume":"25","author":"Blondin","year":"2017","journal-title":"Cell Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib14","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1096\/fj.14-266247","article-title":"In\u00a0vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis","volume":"29","author":"Labbe","year":"2015","journal-title":"The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cmet.2017.09.004","article-title":"Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not brown adipose tissue","volume":"26","author":"Schreiber","year":"2017","journal-title":"Cell Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2020.02.014_bib16","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1210\/endo.140.9.6972","article-title":"Beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation","volume":"140","author":"Bronnikov","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmet.2020.02.014_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1152\/ajplegacy.1960.198.3.471","article-title":"Regulation of shivering and non-shivering heat production during acclimation of rats","volume":"198","author":"Davis","year":"1960","journal-title":"The American Journal of Physiology"},{"issue":"9","key":"10.1016\/j.molmet.2020.02.014_bib18","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molmed.2004.07.009","article-title":"Seipin: a mysterious protein","volume":"10","author":"Agarwal","year":"2004","journal-title":"Trends in Molecular Medicine"},{"issue":"10","key":"10.1016\/j.molmet.2020.02.014_bib19","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/en.2009-0236","article-title":"The human lipodystrophy gene product BSCL2\/seipin plays a key role in adipocyte differentiation","volume":"150","author":"Chen","year":"2009","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.molmet.2020.02.014_bib20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magre","year":"2001","journal-title":"Nature Genetics"},{"issue":"8","key":"10.1016\/j.molmet.2020.02.014_bib21","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.2337\/db08-0184","article-title":"The human lipodystrophy gene BSCL2\/seipin may be essential for normal adipocyte differentiation","volume":"57","author":"Payne","year":"2008","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng1313","article-title":"Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome","volume":"36","author":"Windpassinger","year":"2004","journal-title":"Nature Genetics"},{"issue":"6","key":"10.1016\/j.molmet.2020.02.014_bib23","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1128\/MCB.06465-11","article-title":"Berardinelli-Seip congenital lipodystrophy 2\/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation","volume":"32","author":"Chen","year":"2012","journal-title":"Molecular and Cellular Biology"},{"issue":"15","key":"10.1016\/j.molmet.2020.02.014_bib24","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/hmg\/ddr205","article-title":"Seipin ablation in mice results in severe generalized lipodystrophy","volume":"20","author":"Cui","year":"2011","journal-title":"Human Molecular Genetics"},{"issue":"8","key":"10.1016\/j.molmet.2020.02.014_bib25","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00125-013-2926-9","article-title":"Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2\/seipin-deficient mice","volume":"56","author":"Prieur","year":"2013","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200711136","article-title":"Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast","volume":"180","author":"Fei","year":"2008","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib27","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.cell.2018.05.047","article-title":"The inner nuclear membrane is a metabolically active territory that generates nuclear lipid droplets","volume":"174","author":"Romanauska","year":"2018","journal-title":"Cell"},{"issue":"52","key":"10.1016\/j.molmet.2020.02.014_bib28","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.molmet.2020.02.014_bib29","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1038\/s41467-018-05278-2","article-title":"Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum","volume":"9","author":"Wang","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.molmet.2020.02.014_bib30","doi-asserted-by":"crossref","first-page":"e16582","DOI":"10.7554\/eLife.16582","article-title":"Seipin is required for converting nascent to mature lipid droplets","volume":"5","author":"Wang","year":"2016","journal-title":"Elife"},{"issue":"6","key":"10.1016\/j.molmet.2020.02.014_bib31","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.celrep.2016.10.037","article-title":"SEIPIN regulates lipid droplet expansion and adipocyte development by modulating the activity of glycerol-3-phosphate acyltransferase","volume":"17","author":"Pagac","year":"2016","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib32","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2014.03.028","article-title":"Seipin promotes adipose tissue fat storage through the ER Ca(2)(+)-ATPase SERCA","volume":"19","author":"Bi","year":"2014","journal-title":"Cell Metabolism"},{"issue":"17","key":"10.1016\/j.molmet.2020.02.014_bib33","doi-asserted-by":"crossref","first-page":"e97572","DOI":"10.15252\/embj.201797572","article-title":"Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism","volume":"37","author":"Ding","year":"2018","journal-title":"The EMBO Journal"},{"issue":"2","key":"10.1016\/j.molmet.2020.02.014_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.devcel.2018.09.010","article-title":"Human SEIPIN binds anionic phospholipids","volume":"47","author":"Yan","year":"2018","journal-title":"Developmental Cell"},{"issue":"12","key":"10.1016\/j.molmet.2020.02.014_bib35","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1083\/jcb.201809067","article-title":"Cryo-electron microscopy structure of the lipid droplet-formation protein seipin","volume":"217","author":"Sui","year":"2018","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molmet.2014.12.013","article-title":"Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis","volume":"4","author":"Talukder","year":"2015","journal-title":"Molecular Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2020.02.014_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molmet.2012.11.002","article-title":"The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1","volume":"2","author":"Sim","year":"2012","journal-title":"Molecular Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/cells8030268","article-title":"Promethin is a conserved seipin partner protein","volume":"8","author":"Castro","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.devcel.2019.10.006","article-title":"LDAF1 and seipin form a lipid droplet assembly complex","volume":"51","author":"Chung","year":"2019","journal-title":"Developmental Cell"},{"issue":"10","key":"10.1016\/j.molmet.2020.02.014_bib40","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1194\/jlr.M060244","article-title":"Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals","volume":"56","author":"Zhou","year":"2015","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.molmet.2020.02.014_bib41","doi-asserted-by":"crossref","first-page":"35487","DOI":"10.1038\/srep35487","article-title":"Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode","volume":"6","author":"Dollet","year":"2016","journal-title":"Scientific Reports"},{"issue":"15","key":"10.1016\/j.molmet.2020.02.014_bib42","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/MCB.01120-15","article-title":"Berardinelli-Seip congenital lipodystrophy 2\/seipin is not required for brown adipogenesis but regulates Brown adipose tissue development and function","volume":"36","author":"Zhou","year":"2016","journal-title":"Molecular and Cellular Biology"},{"issue":"14","key":"10.1016\/j.molmet.2020.02.014_bib43","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.129781","article-title":"Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy","volume":"4","author":"Zhou","year":"2019","journal-title":"JCI Insight"},{"issue":"Web Server issue","key":"10.1016\/j.molmet.2020.02.014_bib44","doi-asserted-by":"crossref","first-page":"W358","DOI":"10.1093\/nar\/gkn276","article-title":"GOEAST: a web-based software toolkit for gene ontology enrichment analysis","volume":"36","author":"Zheng","year":"2008","journal-title":"Nucleic Acids Research"},{"issue":"11","key":"10.1016\/j.molmet.2020.02.014_bib45","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1210\/en.2014-1292","article-title":"Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2\/Seipin-deficient mice","volume":"155","author":"Chen","year":"2014","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.molmet.2020.02.014_bib46","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1210\/jc.2016-2670","article-title":"Adipocyte browning and higher mitochondrial function in periadrenal but not SC fat in pheochromocytoma","volume":"101","author":"Vergnes","year":"2016","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2020.02.014_bib47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2014.04.049","article-title":"IRF4 is a key thermogenic transcriptional partner of PGC-1alpha","volume":"158","author":"Kong","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.molmet.2020.02.014_bib48","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/21623945.2015.1027848","article-title":"Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12","volume":"4","author":"Martinez-Santibanez","year":"2015","journal-title":"Adipocyte"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib49","first-page":"418","article-title":"Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure","volume":"33","author":"Wikstrom","year":"2014","journal-title":"The EMBO Journal"},{"issue":"6","key":"10.1016\/j.molmet.2020.02.014_bib50","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2020.02.014_bib51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.molmet.2020.02.014_bib52","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.celrep.2018.06.042","article-title":"NAD(+) depletion triggers macrophage necroptosis, a cell death pathway exploited by Mycobacterium tuberculosis","volume":"24","author":"Pajuelo","year":"2018","journal-title":"Cell Reports"},{"issue":"10","key":"10.1016\/j.molmet.2020.02.014_bib53","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nm.3361","article-title":"Brown and beige fat: development, function and therapeutic potential","volume":"19","author":"Harms","year":"2013","journal-title":"Nature Medicine"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib54","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cmet.2012.08.003","article-title":"PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors","volume":"16","author":"Sanchez-Gurmaches","year":"2012","journal-title":"Cell Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2020.02.014_bib55","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2337\/db16-0283","article-title":"Adipocyte-specific deletion of manganese superoxide dismutase protects from diet-induced obesity through increased mitochondrial uncoupling and biogenesis","volume":"65","author":"Han","year":"2016","journal-title":"Diabetes"},{"issue":"3 Pt 1","key":"10.1016\/j.molmet.2020.02.014_bib56","first-page":"E527","article-title":"Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice","volume":"274","author":"Stefl","year":"1998","journal-title":"The American Journal of Physiology"},{"issue":"2","key":"10.1016\/j.molmet.2020.02.014_bib57","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"issue":"7766","key":"10.1016\/j.molmet.2020.02.014_bib58","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41586-019-1400-3","article-title":"H(+) transport is an integral function of the mitochondrial ADP\/ATP carrier","volume":"571","author":"Bertholet","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.molmet.2020.02.014_bib59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2020.02.014_bib60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra","year":"2016","journal-title":"The Journal of Cell Biology"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib61","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nature Cell Biology"},{"issue":"25","key":"10.1016\/j.molmet.2020.02.014_bib62","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1073\/pnas.1107402108","article-title":"Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation","volume":"108","author":"Rambold","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6054","key":"10.1016\/j.molmet.2020.02.014_bib63","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.molmet.2020.02.014_bib64","doi-asserted-by":"crossref","first-page":"H1425","DOI":"10.1152\/ajpheart.00376.2011","article-title":"Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation","volume":"301","author":"Fitzgibbons","year":"2011","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"issue":"8","key":"10.1016\/j.molmet.2020.02.014_bib65","doi-asserted-by":"crossref","first-page":"E676","DOI":"10.1152\/ajpendo.00028.2015","article-title":"Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice","volume":"310","author":"Sakamoto","year":"2016","journal-title":"American Journal of Physiology Endocrinology and Metabolism"},{"issue":"7375","key":"10.1016\/j.molmet.2020.02.014_bib66","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature10653","article-title":"Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis","volume":"480","author":"Nguyen","year":"2011","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.molmet.2020.02.014_bib67","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ijo.2016.19","article-title":"Galectin-3 inhibition prevents adipose tissue remodelling in obesity","volume":"40","author":"Martinez-Martinez","year":"2016","journal-title":"International Journal of Obesity"},{"issue":"5","key":"10.1016\/j.molmet.2020.02.014_bib68","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1074\/jbc.M109.074252","article-title":"Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis","volume":"285","author":"Alkhouri","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"11","key":"10.1016\/j.molmet.2020.02.014_bib69","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans","volume":"46","author":"Cinti","year":"2005","journal-title":"Journal of Lipid Research"},{"issue":"7","key":"10.1016\/j.molmet.2020.02.014_bib70","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm1262","article-title":"Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy","volume":"11","author":"Pajvani","year":"2005","journal-title":"Nature Medicine"},{"key":"10.1016\/j.molmet.2020.02.014_bib71","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev-biochem-060815-014830","article-title":"Necroptosis and inflammation","volume":"85","author":"Newton","year":"2016","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.molmet.2020.02.014_bib72","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1038\/ncomms11869","article-title":"The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance","volume":"7","author":"Gautheron","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.molmet.2020.02.014_bib73","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.2010.05633.x","article-title":"Bioenergetics and cell death","volume":"1201","author":"Kushnareva","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"3","key":"10.1016\/j.molmet.2020.02.014_bib74","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2013.08.003","article-title":"Identification of an adipogenic niche for adipose tissue remodeling and restoration","volume":"18","author":"Lee","year":"2013","journal-title":"Cell Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2020.02.014_bib75","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ncb2740","article-title":"Bi-directional interconversion of brite and white adipocytes","volume":"15","author":"Rosenwald","year":"2013","journal-title":"Nature Cell Biology"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877820300442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877820300442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:22:56Z","timestamp":1761956576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877820300442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":75,"alternative-id":["S2212877820300442"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2020.02.014","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berardinelli\u2013Seip congenital lipodystrophy 2\/SEIPIN determines brown adipose tissue maintenance and thermogenic programing","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2020.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"100971"}}