{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:21:09Z","timestamp":1792570869979,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0055001"],"award-info":[{"award-number":["NNF19OC0055001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["34250"],"award-info":[{"award-number":["34250"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["31526"],"award-info":[{"award-number":["31526"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14CC0001"],"award-info":[{"award-number":["NNF14CC0001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.molmet.2020.101080","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T09:57:12Z","timestamp":1599991032000},"page":"101080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"special_numbering":"C","title":["Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis"],"prefix":"10.1016","volume":"42","author":[{"given":"Marie","family":"Winther-S\u00f8rensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine D.","family":"Galsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.J.","family":"Trammell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Sulek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune E.","family":"Kuhre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Hassing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Dall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-7012","authenticated-orcid":false,"given":"Jonas T.","family":"Treebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Gillum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe S.","family":"Torekov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne A.","family":"Windel\u00f8v","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna E.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha A.S.","family":"Kjeldsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara L.","family":"Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine G.","family":"Vasilopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"\u00d8rskov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel P.","family":"Werge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Cathrine","family":"Bisgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Lykke","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Vilstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Lotte","family":"Gluud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai J.","family":"Wewer Albrechtsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2020.101080_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0021-9258(18)85474-6","article-title":"Aqueous extracts of pancreas: III. Some precipitation reactions of insulin","volume":"58","author":"Kimball","year":"1923","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI111272","article-title":"Effects of glucagon on plasma amino acids","volume":"73","author":"Boden","year":"1984","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0261-5614(94)90099-X","article-title":"Regulation of urea synthesis by glucose and glucagon in normal man","volume":"13","author":"Hamberg","year":"1994","journal-title":"Clinical Nutrition"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/diab.26.4.300","article-title":"Glucagon secretion induced by natural and artificial amino acids in the perfused rat pancreas","volume":"26","author":"Assan","year":"1977","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.celrep.2015.06.034","article-title":"Glucagon couples hepatic amino acid catabolism to mTOR-dependent regulation of alpha-cell mass","volume":"12","author":"Solloway","year":"2015","journal-title":"Cell Reports"},{"issue":"6","key":"10.1016\/j.molmet.2020.101080_bib6","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cmet.2017.05.006","article-title":"Amino acid transporter slc38a5 controls glucagon receptor inhibition-induced pancreatic alpha cell hyperplasia in mice","volume":"25","author":"Kim","year":"2017","journal-title":"Cell Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2020.101080_bib7","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.cmet.2017.05.011","article-title":"Interrupted glucagon signaling reveals hepatic alpha cell axis and role for L-glutamine in alpha cell proliferation","volume":"25","author":"Dean","year":"2017","journal-title":"Cell Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2337\/db16-0994","article-title":"Glucagon and amino acids are linked in a mutual feedback cycle: The liver-alpha-cell axis","volume":"66","author":"Holst","year":"2017","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib9","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00125-017-4535-5","article-title":"Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids","volume":"61","author":"Wewer Albrechtsen","year":"2018","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib10","doi-asserted-by":"crossref","first-page":"E93","DOI":"10.1152\/ajpendo.00198.2017","article-title":"Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis","volume":"314","author":"Galsgaard","year":"2018","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib11","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1073\/pnas.0237106100","article-title":"Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice","volume":"100","author":"Gelling","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib12","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2337\/db11-1605","article-title":"Liver-specific disruption of the murine glucagon receptor produces alpha-cell hyperplasia: evidence for a circulating alpha-cell growth factor","volume":"62","author":"Longuet","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2020.101080_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1530\/EDM-16-0081","article-title":"Pancreatic \u03b1-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation","volume":"2016","author":"Larger","year":"2016","journal-title":"Endocrinology, Diabetes & Metabolism Case Reports"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7326\/0003-4819-91-2-213","article-title":"Amino acid deficiency and the skin rash associated with glucagonoma","volume":"91","author":"Norton","year":"1979","journal-title":"Annals of Internal Medicine"},{"issue":"8","key":"10.1016\/j.molmet.2020.101080_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/gut.31.8.946","article-title":"Increased amino acid clearance and urea synthesis in a patient with glucagonoma","volume":"31","author":"Almdal","year":"1990","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.molmet.2020.101080_bib16","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1172\/JCI107046","article-title":"Glucagon-stimulating activity of 20 amino acids in dogs","volume":"51","author":"Rocha","year":"1972","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/joim.12462","article-title":"Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia","volume":"279","author":"Junker","year":"2016","journal-title":"Journal of Internal Medicine"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib18","doi-asserted-by":"crossref","first-page":"G91","DOI":"10.1152\/ajpgi.00216.2017","article-title":"Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes","volume":"314","author":"Wewer Albrechtsen","year":"2018","journal-title":"American Journal of Physiology - Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.molmet.2020.101080_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/hep4.1562","article-title":"Nonalcoholic fatty liver disease impairs the liver\u2013alpha cell axis independent of hepatic inflammation and fibrosis","author":"Pedersen","year":"2020","journal-title":"Hepatology Communications"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib20","doi-asserted-by":"crossref","first-page":"E660","DOI":"10.1152\/ajpendo.00410.2018","article-title":"Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling","volume":"316","author":"Galsgaard","year":"2019","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"17","key":"10.1016\/j.molmet.2020.101080_bib21","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1021\/jm7015599","article-title":"Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor","volume":"51","author":"Kodra","year":"2008","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib22","doi-asserted-by":"crossref","first-page":"E60","DOI":"10.1152\/ajpendo.00547.2011","article-title":"Glucose metabolism is altered after loss of L cells and alpha-cells but not influenced by loss of K cells","volume":"304","author":"Pedersen","year":"2013","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2362.1975.tb02280.x","article-title":"The sources of plasma cyclic AMP: studies in the rat using isoprenaline, nicotinic acid and glucagon","volume":"5","author":"Strange","year":"1975","journal-title":"European Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biocel.2006.10.007","article-title":"Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2","volume":"39","author":"Mavri-Damelin","year":"2007","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018222","article-title":"Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience","volume":"6","author":"Bhogal","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2020.101080_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.nutr.22.110801.140547","article-title":"Regulation of enzymes of the urea cycle and arginine metabolism","volume":"22","author":"Morris","year":"2002","journal-title":"Annual Review of Nutrition"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/9658","article-title":"Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter","volume":"22","author":"Camacho","year":"1999","journal-title":"Nature Genetics"},{"key":"10.1016\/j.molmet.2020.101080_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1471-2164-12-281","article-title":"Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes","volume":"12","author":"Yang","year":"2011","journal-title":"BMC Genomics"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.clinre.2019.01.001","article-title":"Non-alcoholic fatty liver disease causes dissociated changes in metabolic liver functions","volume":"43","author":"Eriksen","year":"2019","journal-title":"Clinics and Research in Hepatology and Gastroenterology"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jhep.2018.06.023","article-title":"Urea cycle dysregulation in non-alcoholic fatty liver disease","volume":"69","author":"De Chiara","year":"2018","journal-title":"Journal of Hepatology"},{"issue":"11","key":"10.1016\/j.molmet.2020.101080_bib31","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/liv.14205","article-title":"Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion","volume":"39","author":"Eriksen","year":"2019","journal-title":"Liver International"},{"key":"10.1016\/j.molmet.2020.101080_bib32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jpeds.2016.01.026","article-title":"Amino acid metabolism is altered in adolescents with nonalcoholic fatty liver disease-an untargeted, high resolution metabolomics study","volume":"172","author":"Jin","year":"2016","journal-title":"The Journal of Pediatrics"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib33","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ijo.2014.177","article-title":"Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss","volume":"39","author":"Iepsen","year":"2015","journal-title":"International Journal of Obesity"},{"issue":"10","key":"10.1016\/j.molmet.2020.101080_bib34","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s00125-017-4340-1","article-title":"Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study","volume":"60","author":"Isokuortti","year":"2017","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib35","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/er.2018-00251","article-title":"The liver-alpha cell axis and type 2 diabetes","volume":"40","author":"Wewer Albrechtsen","year":"2019","journal-title":"Endocrine Reviews"},{"issue":"7","key":"10.1016\/j.molmet.2020.101080_bib36","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2337\/dc15-1643","article-title":"Evaluation of efficacy and safety of the glucagon receptor antagonist LY2409021 in patients with type 2 diabetes: 12- and 24-week phase 2 studies","volume":"39","author":"Kazda","year":"2016","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib37","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.celrep.2018.10.018","article-title":"Insulin Secretion Depends on Intra-islet Glucagon Signaling","volume":"25","author":"Svendsen","year":"2018","journal-title":"Cell Reports"},{"issue":"48","key":"10.1016\/j.molmet.2020.101080_bib38","doi-asserted-by":"crossref","first-page":"30121","DOI":"10.1016\/S0021-9258(18)43785-4","article-title":"Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes","volume":"269","author":"Hjorth","year":"1994","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib39","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0950-351X(05)80242-3","article-title":"Insulin action on protein metabolism","volume":"7","author":"Biolo","year":"1993","journal-title":"Bailli\u00e8re's Clinical Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib40","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbrc.2008.08.151","article-title":"A novel high-affinity peptide antagonist to the insulin receptor","volume":"376","author":"Schaffer","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1432-1033.1980.tb04640.x","article-title":"The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon","volume":"107","author":"Hensgens","year":"1980","journal-title":"European Journal of Biochemistry"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.201202056","article-title":"Mechanistic insights into the regulation of metabolic enzymes by acetylation","volume":"198","author":"Xiong","year":"2012","journal-title":"The Journal of cell biology"},{"issue":"3","key":"10.1016\/j.molmet.2020.101080_bib43","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","article-title":"Sirtuin 1 and sirtuin 3: physiological modulators of metabolism","volume":"92","author":"Nogueiras","year":"2012","journal-title":"Physiol Rev"},{"issue":"13","key":"10.1016\/j.molmet.2020.101080_bib44","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1016\/S0021-9258(17)30454-4","article-title":"Effects of glucagon and insulin on cytoplasmic protein phosphorylation in hepatocytes","volume":"253","author":"Avruch","year":"1978","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1432-1033.1987.tb13520.x","article-title":"Hormonal regulation of amino acid transport system N in primary cultures of rat hepatocytes","volume":"166","author":"Gebhardt","year":"1987","journal-title":"European Journal of Biochemistry"},{"issue":"6","key":"10.1016\/j.molmet.2020.101080_bib46","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2337\/db19-0715","article-title":"Glucagon resistance at the level of amino acid turnover in obese subjects with hepatic steatosis","volume":"69","author":"Suppli","year":"2020","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.molmet.2020.101080_bib47","doi-asserted-by":"crossref","first-page":"E1092","DOI":"10.1152\/ajpendo.00459.2010","article-title":"Promoter characterization and role of CRE in the basal transcription of the rat SNAT2 gene","volume":"300","author":"Ortiz","year":"2011","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib48","doi-asserted-by":"crossref","first-page":"8713","DOI":"10.3390\/ijms15058713","article-title":"Role of mitochondria in nonalcoholic fatty liver disease","volume":"15","author":"Nassir","year":"2014","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib49","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1152\/ajpendo.00570.2004","article-title":"Alterations in hepatic glucagon receptor density and in Gs\u03b1 and Gi\u03b12 protein content with diet-induced hepatic steatosis: effects of acute exercise","volume":"289","author":"Charbonneau","year":"2005","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"Pt 1","key":"10.1016\/j.molmet.2020.101080_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1113\/jphysiol.2006.121954","article-title":"High-fat diet-induced hepatic steatosis reduces glucagon receptor content in rat hepatocytes: potential interaction with acute exercise","volume":"579","author":"Charbonneau","year":"2007","journal-title":"The Journal of physiology"},{"issue":"11","key":"10.1016\/j.molmet.2020.101080_bib51","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/dom.12958","article-title":"Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes","volume":"19","author":"Guzman","year":"2017","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/hep.29465","article-title":"Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance","volume":"67","author":"Gaggini","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3945\/an.116.013730","article-title":"Nutritional approaches to achieve weight loss in nonalcoholic fatty liver disease","volume":"8","author":"Hsu","year":"2017","journal-title":"Advances in Nutrition"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib54","doi-asserted-by":"crossref","first-page":"F2","DOI":"10.1152\/ajprenal.00614.2014","article-title":"Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea","volume":"309","author":"Bankir","year":"2015","journal-title":"American Journal of Physiology-Renal Physiology"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/00365518509161013","article-title":"A method for determination of the capacity of urea synthesis in the rat","volume":"45","author":"Hansen","year":"1985","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib56","doi-asserted-by":"crossref","first-page":"E302","DOI":"10.1152\/ajpendo.00119.2016","article-title":"Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes","volume":"311","author":"Wewer Albrechtsen","year":"2016","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib57","doi-asserted-by":"crossref","first-page":"E834","DOI":"10.1152\/ajpendo.00332.2001","article-title":"Heterogeneous metabolic adaptation of C57BL\/6J mice to high-fat diet","volume":"282","author":"Burcelin","year":"2002","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib58","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/pr400051s","article-title":"Early metabolic adaptation in C57BL\/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways","volume":"12","author":"Boulange","year":"2013","journal-title":"Journal of Proteome Research"},{"issue":"36","key":"10.1016\/j.molmet.2020.101080_bib59","doi-asserted-by":"crossref","first-page":"13304","DOI":"10.1074\/jbc.RA118.006756","article-title":"Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity","volume":"294","author":"Dall","year":"2019","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.molmet.2020.101080_bib60","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1530\/EJE-15-1116","article-title":"Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3\u201336","volume":"174","author":"Iepsen","year":"2016","journal-title":"European Journal of Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2020.101080_bib61","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13104-016-1872-2","article-title":"The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs","volume":"9","author":"Wewer Albrechtsen","year":"2016","journal-title":"BMC Research Notes"},{"issue":"2","key":"10.1016\/j.molmet.2020.101080_bib62","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/bj1870337","article-title":"Evidence that glicentin contains the entire sequence of glucagon","volume":"187","author":"Holst","year":"1980","journal-title":"Biochemical Journal"},{"issue":"4","key":"10.1016\/j.molmet.2020.101080_bib63","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2337\/diab.43.4.535","article-title":"Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans","volume":"43","author":"\u00d8rskov","year":"1994","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.molmet.2020.101080_bib64","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/BF00274797","article-title":"Pancreatic and intestinal processing of proglucagon in man","volume":"30","author":"\u00d8rskov","year":"1987","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.molmet.2020.101080_bib65","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biology"},{"issue":"5","key":"10.1016\/j.molmet.2020.101080_bib66","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"issue":"W1","key":"10.1016\/j.molmet.2020.101080_bib67","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Research"},{"issue":"6","key":"10.1016\/j.molmet.2020.101080_bib68","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.ftd.0000179845.53213.39","article-title":"METLIN: a metabolite mass spectral database","volume":"27","author":"Smith","year":"2005","journal-title":"Therapeutic Drug Monitoring"},{"issue":"Database issue","key":"10.1016\/j.molmet.2020.101080_bib69","first-page":"D801","article-title":"HMDB 3.0--The Human Metabolome Database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"10.1016\/j.molmet.2020.101080_bib70","first-page":"D440","article-title":"MetaboLights: a resource evolving in response to the needs of its scientific community","volume":"48","author":"Haug","year":"2019","journal-title":"Nucleic Acids Research"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287782030154X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287782030154X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:19:36Z","timestamp":1778851176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221287782030154X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":70,"alternative-id":["S221287782030154X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2020.101080","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2020.101080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101080"}}