{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T06:38:15Z","timestamp":1794551895215,"version":"4.9.1"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T00:00:00Z","timestamp":1610236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PI18\/01527"],"award-info":[{"award-number":["PI18\/01527"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.molmet.2021.101165","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T16:14:51Z","timestamp":1610640891000},"page":"101165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation"],"prefix":"10.1016","volume":"45","author":[{"given":"Annalisa","family":"Roberti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn F.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F.","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.molcel.2016.05.029","article-title":"Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes","volume":"62","author":"Etchegaray","year":"2016","journal-title":"Molecular Cell"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1021\/cb500846u","article-title":"Metabolic regulation of histone post-translational modifications","volume":"10","author":"Fan","year":"2015","journal-title":"ACS Chemical Biology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tibs.2017.11.004","article-title":"Spatiotemporal control of acetyl-CoA metabolism in chromatin regulation","volume":"43","author":"Sivanand","year":"2018","journal-title":"Trends in Biochemical Sciences"},{"issue":"5930","key":"10.1016\/j.molmet.2021.101165_bib4","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","article-title":"ATP-citrate lyase links cellular metabolism to histone acetylation","volume":"324","author":"Wellen","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","article-title":"NAD+ homeostasis in health and disease","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nature Metabolism"},{"issue":"361","key":"10.1016\/j.molmet.2021.101165_bib6","doi-asserted-by":"crossref","first-page":"361ra139","DOI":"10.1126\/scitranslmed.aaf5504","article-title":"NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation","volume":"8","author":"Ryu","year":"2016","journal-title":"Science Translational Medicine"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/1479-7364-5-5-485","article-title":"The human sirtuin family: evolutionary divergences and functions","volume":"5","author":"Vassilopoulos","year":"2011","journal-title":"Human Genomics"},{"issue":"2","key":"10.1016\/j.molmet.2021.101165_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.18632\/aging.100272","article-title":"SirT1 brings stemness closer to cancer and aging","volume":"3","author":"Calvanese","year":"2011","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ncb1857","article-title":"STAT3 inhibition of gluconeogenesis is downregulated by SirT1","volume":"11","author":"Nie","year":"2009","journal-title":"Nature Cell Biology"},{"issue":"13","key":"10.1016\/j.molmet.2021.101165_bib10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid\/cholesterol regulator SREBP","volume":"24","author":"Walker","year":"2010","journal-title":"Genes & Development"},{"issue":"7029","key":"10.1016\/j.molmet.2021.101165_bib11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1\u03b1 and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.molmet.2021.101165_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2010.06.009","article-title":"Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis","volume":"12","author":"Kim","year":"2010","journal-title":"Cell Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2021.101165_bib13","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/jcp.24054","article-title":"Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression","volume":"227","author":"Donohoe","year":"2012","journal-title":"Journal of Cellular Physiology"},{"issue":"7","key":"10.1016\/j.molmet.2021.101165_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13148-019-0675-4","article-title":"Epigenetics in cancer therapy and nanomedicine","volume":"11","author":"Roberti","year":"2019","journal-title":"Clinical Epigenetics"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib16","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Experimental & Molecular Medicine"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: a dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2021.101165_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-animal-020518-115206","article-title":"One-carbon metabolism: linking nutritional biochemistry to epigenetic programming of long-term development","volume":"7","author":"Clare","year":"2019","journal-title":"Annual Review of Animal Biosciences"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2015.08.024","article-title":"Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism","volume":"22","author":"Mentch","year":"2015","journal-title":"Cell Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib21","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/s41467-018-04426-y","article-title":"Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width","volume":"9","author":"Dai","year":"2018","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.aninu.2017.08.009","article-title":"Role of methionine on epigenetic modification of DNA methylation and gene expression in animals","volume":"4","author":"Zhang","year":"2018","journal-title":"Animal Nutrition"},{"issue":"12","key":"10.1016\/j.molmet.2021.101165_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19124055","article-title":"Molecular mechanisms underlying the link between diet and DNA methylation","volume":"19","author":"Kadayifci","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S0029665111003302","article-title":"Nutritional influences on epigenetics and age-related disease","volume":"71","author":"Park","year":"2012","journal-title":"Proceedings of the Nutrition Society"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.5","article-title":"TET family dioxygenases and DNA demethylation in stem cells and cancers","volume":"49","author":"An","year":"2017","journal-title":"Experimental & Molecular Medicine"},{"issue":"9","key":"10.1016\/j.molmet.2021.101165_bib26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrg.2017.33","article-title":"TET-mediated active DNA demethylation: mechanism, function and beyond","volume":"18","author":"Wu","year":"2017","journal-title":"Nature Reviews Genetics"},{"issue":"20","key":"10.1016\/j.molmet.2021.101165_bib27","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1016\/S0021-9258(17)36700-5","article-title":"Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization","volume":"269","author":"Aksoy","year":"1994","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/BST20180420","article-title":"The chemistry of the vitamin B3 metabolome","volume":"47","author":"Makarov","year":"2019","journal-title":"Biochemical Society Transactions"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib29","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tem.2017.02.004","article-title":"Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme","volume":"28","author":"Pissios","year":"2017","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"6220","key":"10.1016\/j.molmet.2021.101165_bib30","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.molmet.2021.101165_bib31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2337\/db18-0780","article-title":"Genetic nicotinamide N-methyltransferase (Nnmt) deficiency in male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance","volume":"68","author":"Brachs","year":"2019","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.molmet.2021.101165_bib32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cmet.2015.07.017","article-title":"NNMT: a bad actor in fat makes good in liver","volume":"22","author":"Trammell","year":"2015","journal-title":"Cell Metabolism"},{"issue":"8","key":"10.1016\/j.molmet.2021.101165_bib33","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.3882","article-title":"Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization","volume":"21","author":"Hong","year":"2015","journal-title":"Nature Medicine"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib34","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.18632\/oncotarget.12157","article-title":"Sirtuins in glucose and lipid metabolism","volume":"8","author":"Ye","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/ajcn\/85.1.19","article-title":"Methyl balance and transmethylation fluxes in humans","volume":"85","author":"Mudd","year":"2007","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.molmet.2021.101165_bib36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.nutr.28.061807.155438","article-title":"Methionine metabolism and liver disease","volume":"28","author":"Mato","year":"2008","journal-title":"Annual Review of Nutrition"},{"issue":"3","key":"10.1016\/j.molmet.2021.101165_bib37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11248-006-0008-1","article-title":"A\u00a0glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme","volume":"15","author":"Luka","year":"2006","journal-title":"Transgenic Research"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib38","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/hep.22159","article-title":"Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice","volume":"47","author":"Martinez-Chantar","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2021.101165_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700933","article-title":"An epigenetic signature in adipose tissue is linked to nicotinamide N-methyltransferase gene expression","author":"Crujeiras","year":"2018","journal-title":"Molecular Nutrition & Food Research"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib40","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00125-014-3490-7","article-title":"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance","volume":"58","author":"Kannt","year":"2015","journal-title":"Diabetologia"},{"issue":"7495","key":"10.1016\/j.molmet.2021.101165_bib41","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature13198","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib42","doi-asserted-by":"crossref","first-page":"E1132","DOI":"10.1152\/ajpendo.90552.2008","article-title":"Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver","volume":"295","author":"Visinoni","year":"2008","journal-title":"American Journal of Physiology - Endocrinology And Metabolism"},{"key":"10.1016\/j.molmet.2021.101165_bib43","doi-asserted-by":"crossref","first-page":"117474","DOI":"10.1016\/j.lfs.2020.117474","article-title":"Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes","volume":"248","author":"Ehebauer","year":"2020","journal-title":"Life Sciences"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib44","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1038\/s41598-018-21099-1","article-title":"N(1)-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism","volume":"8","author":"Strom","year":"2018","journal-title":"Scientific Reports"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib45","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","journal-title":"Journal of Hepatology"},{"issue":"4","key":"10.1016\/j.molmet.2021.101165_bib46","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1572-0241.2001.03698.x","article-title":"The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production","volume":"96","author":"Pumpo","year":"2001","journal-title":"American Journal of Gastroenterology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib47","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1038\/s41598-018-26882-8","article-title":"NNMT activation can contribute to the development of fatty liver disease by modulating the NAD (+) metabolism","volume":"8","author":"Komatsu","year":"2018","journal-title":"Scientific Reports"},{"issue":"1\u20132","key":"10.1016\/j.molmet.2021.101165_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(03)00218-0","article-title":"High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease","volume":"342","author":"Parsons","year":"2003","journal-title":"Neuroscience Letters"},{"issue":"8","key":"10.1016\/j.molmet.2021.101165_bib49","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1164\/rccm.200906-0936OC","article-title":"Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease","volume":"181","author":"Kim","year":"2010","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"10","key":"10.1016\/j.molmet.2021.101165_bib50","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.1002\/jcp.26636","article-title":"N1-methylnicotinamide (MNAM) as a guardian of cardiovascular system","volume":"233","author":"Nejabati","year":"2018","journal-title":"Journal of Cellular Physiology"},{"issue":"D1","key":"10.1016\/j.molmet.2021.101165_bib51","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.molmet.2021.101165_bib52","doi-asserted-by":"crossref","DOI":"10.1177\/1178646920919770","article-title":"Nicotinamide N-methyltransferase: genomic connection to disease","volume":"13","author":"Ramsden","year":"2020","journal-title":"International Journal of Tryptophan Research"},{"issue":"7479","key":"10.1016\/j.molmet.2021.101165_bib53","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature12745","article-title":"Derivation of novel human ground state naive pluripotent stem cells","volume":"504","author":"Gafni","year":"2013","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.molmet.2021.101165_bib54","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/ncb3264","article-title":"The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition","volume":"17","author":"Sperber","year":"2015","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.molmet.2021.101165_bib55","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3389\/fgene.2018.00427","article-title":"Metabolism and epigenetic interplay in cancer: regulation and putative therapeutic targets","volume":"9","author":"Miranda-Goncalves","year":"2018","journal-title":"Frontiers in Genetics"},{"issue":"9","key":"10.1016\/j.molmet.2021.101165_bib56","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.molmed.2010.07.002","article-title":"IDH mutations in glioma and acute myeloid leukemia","volume":"16","author":"Dang","year":"2010","journal-title":"Trends in Molecular Medicine"},{"issue":"7","key":"10.1016\/j.molmet.2021.101165_bib57","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4161\/cbt.11.7.14948","article-title":"Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies","volume":"11","author":"Bertino","year":"2011","journal-title":"Cancer Biology & Therapy"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib58","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nchembio.1234","article-title":"Metabolism: cancer mistunes methylation","volume":"9","author":"Shlomi","year":"2013","journal-title":"Nature Chemical Biology"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib59","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4149\/neo_2018_171024N680","article-title":"Nicotinamide N-methyltransferase as a potential marker for cancer","volume":"65","author":"Lu","year":"2018","journal-title":"Neoplasma"},{"issue":"2","key":"10.1016\/j.molmet.2021.101165_bib60","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/carcin\/bgq225","article-title":"Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells","volume":"32","author":"Tang","year":"2011","journal-title":"Carcinogenesis"},{"issue":"7758","key":"10.1016\/j.molmet.2021.101165_bib61","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41586-019-1173-8","article-title":"Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts","volume":"569","author":"Eckert","year":"2019","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/j.molmet.2021.101165_bib62","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"10.1016\/j.molmet.2021.101165_bib63","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1158\/1078-0432.CCR-16-1323","article-title":"NNMT silencing activates tumor suppressor PP2A, inactivates oncogenic STKs, and inhibits tumor forming ability","volume":"23","author":"Palanichamy","year":"2017","journal-title":"Clinical Cancer Research"},{"issue":"10","key":"10.1016\/j.molmet.2021.101165_bib64","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90019","article-title":"Nicotinamide metabolism regulates glioblastoma stem cell maintenance","volume":"2","author":"Jung","year":"2017","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib65","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00432-007-0318-6","article-title":"Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells","volume":"134","author":"Tomida","year":"2008","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"issue":"2","key":"10.1016\/j.molmet.2021.101165_bib66","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1210\/me.2004-0215","article-title":"Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells","volume":"19","author":"Xu","year":"2005","journal-title":"Molecular Endocrinology"},{"issue":"10","key":"10.1016\/j.molmet.2021.101165_bib67","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/gut.2007.148189","article-title":"Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer","volume":"57","author":"Feldmann","year":"2008","journal-title":"Gut"},{"issue":"23","key":"10.1016\/j.molmet.2021.101165_bib68","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1158\/0008-5472.CAN-19-1405","article-title":"BRCA1 deficiency upregulates NNMT, which reprograms metabolism and sensitizes ovarian cancer cells to mitochondrial metabolic targeting agents","volume":"79","author":"Kanakkanthara","year":"2019","journal-title":"Cancer Research"},{"issue":"5","key":"10.1016\/j.molmet.2021.101165_bib69","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nchembio.1204","article-title":"NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink","volume":"9","author":"Ulanovskaya","year":"2013","journal-title":"Nature Chemical Biology"},{"issue":"8","key":"10.1016\/j.molmet.2021.101165_bib70","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41389-018-0064-4","article-title":"NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation","volume":"7","author":"Shin","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.molmet.2021.101165_bib71","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3389\/fphys.2018.01407","article-title":"Prognostic value of nicotinamide N-methyltransferase expression in patients with solid tumors: a systematic review and meta-analysis","volume":"9","author":"Li","year":"2018","journal-title":"Frontiers in Physiology"},{"issue":"15","key":"10.1016\/j.molmet.2021.101165_bib72","doi-asserted-by":"crossref","first-page":"19975","DOI":"10.18632\/oncotarget.7891","article-title":"Expression profile and prognostic value of NNMT in patients with pancreatic cancer","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.molmet.2021.101165_bib73","first-page":"649","article-title":"Nicotinamide N-methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma","volume":"6","author":"Chen","year":"2016","journal-title":"American Journal of Cancer Research"},{"key":"10.1016\/j.molmet.2021.101165_bib74","first-page":"1","article-title":"Nicotinamide N-methyltransferase overexpression may be associated with poor prognosis in ovarian cancer","author":"Harmankaya","year":"2020","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"6","key":"10.1016\/j.molmet.2021.101165_bib75","first-page":"9195","article-title":"Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1","volume":"15","author":"You","year":"2018","journal-title":"Oncology Letters"},{"issue":"3","key":"10.1016\/j.molmet.2021.101165_bib76","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12013-012-9451-1","article-title":"Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test","volume":"65","author":"Sartini","year":"2013","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"6","key":"10.1016\/j.molmet.2021.101165_bib77","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1515\/hsz-2012-0112","article-title":"Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease","volume":"393","author":"Sartini","year":"2012","journal-title":"Biological Chemistry"},{"issue":"Suppl","key":"10.1016\/j.molmet.2021.101165_bib78","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.semcancer.2015.03.001","article-title":"Broad targeting of resistance to apoptosis in cancer","volume":"35","author":"Mohammad","year":"2015","journal-title":"Seminars in Cancer Biology"},{"key":"10.1016\/j.molmet.2021.101165_bib79","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1741-7015-11-106","article-title":"Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity","volume":"11","author":"Hsu","year":"2013","journal-title":"BMC Medicine"},{"issue":"2","key":"10.1016\/j.molmet.2021.101165_bib80","article-title":"Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway","volume":"9","author":"Zhang","year":"2014","journal-title":"PloS One"},{"issue":"29","key":"10.1016\/j.molmet.2021.101165_bib81","doi-asserted-by":"crossref","first-page":"45837","DOI":"10.18632\/oncotarget.9962","article-title":"Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib82","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13058-019-1150-z","article-title":"Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization","volume":"21","author":"Wang","year":"2019","journal-title":"Breast Cancer Research: BCR"},{"key":"10.1016\/j.molmet.2021.101165_bib83","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1756-9966-28-20","article-title":"Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis","volume":"28","author":"Kim","year":"2009","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"issue":"9","key":"10.1016\/j.molmet.2021.101165_bib84","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1002\/1878-0261.12544","article-title":"Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform","volume":"13","author":"Li","year":"2019","journal-title":"Molecular Oncology"},{"issue":"7","key":"10.1016\/j.molmet.2021.101165_bib85","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"International Journal of Biological Sciences"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib86","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-978","article-title":"Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"14","author":"Hao","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.molmet.2021.101165_bib87","doi-asserted-by":"crossref","first-page":"113833","DOI":"10.1016\/j.ab.2020.113833","article-title":"Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase","volume":"604","author":"Iyamu","year":"2020","journal-title":"Analytical Biochemistry"},{"issue":"21","key":"10.1016\/j.molmet.2021.101165_bib88","doi-asserted-by":"crossref","first-page":"9837","DOI":"10.1021\/acs.jmedchem.9b01238","article-title":"High-affinity alkynyl bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT)","volume":"62","author":"Policarpo","year":"2019","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"10.1016\/j.molmet.2021.101165_bib89","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/s41598-018-22081-7","article-title":"A\u00a0small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders","volume":"8","author":"Kannt","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/j.molmet.2021.101165_bib90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bcp.2017.11.007","article-title":"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice","volume":"147","author":"Neelakantan","year":"2018","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.molmet.2021.101165_bib91","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bcp.2019.02.008","article-title":"Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle","volume":"163","author":"Neelakantan","year":"2019","journal-title":"Biochemical Pharmacology"},{"issue":"6292","key":"10.1016\/j.molmet.2021.101165_bib92","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.molmet.2021.101165_bib93","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1086\/430409","article-title":"A\u00a0genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project","volume":"76","author":"Souto","year":"2005","journal-title":"The American Journal of Human Genetics"},{"issue":"2","key":"10.1016\/j.molmet.2021.101165_bib94","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.atherosclerosis.2008.09.015","article-title":"Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine","volume":"204","author":"Riederer","year":"2009","journal-title":"Atherosclerosis"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877821000053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877821000053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:23:40Z","timestamp":1761956620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877821000053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":94,"alternative-id":["S2212877821000053"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2021.101165","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2021.101165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101165"}}