{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:08:56Z","timestamp":1791587336330,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009881","name":"Juvenile Diabetes Research Foundation Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018259","name":"Salk Institute for Biological Studies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-03952"],"award-info":[{"award-number":["RGPIN-2016-03952"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM099608"],"award-info":[{"award-number":["T32GM099608"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","award":["2-SRA-2019-700-S-B"],"award-info":[{"award-number":["2-SRA-2019-700-S-B"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["NID DK-110276"],"award-info":[{"award-number":["NID DK-110276"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.molmet.2021.101166","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T02:20:12Z","timestamp":1611109212000},"page":"101166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice"],"prefix":"10.1016","volume":"45","author":[{"given":"Marine L.","family":"Croze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus F.","family":"Flisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Guillaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn M.","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Granziera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Vivot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent C.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-3002","authenticated-orcid":false,"given":"Scott A.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Ghislain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark O.","family":"Huising","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-5053","authenticated-orcid":false,"given":"Vincent","family":"Poitout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.molmet.2021.101166_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrd2782","article-title":"Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes","volume":"8","author":"Ahren","year":"2009","journal-title":"Nature Reviews Drug Discovery"},{"issue":"Pt B","key":"10.1016\/j.molmet.2021.101166_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2015.06.028","article-title":"FFA4 receptor (GPR120): a hot target for the development of anti-diabetic therapies","volume":"763","author":"Liu","year":"2015","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"10.1016\/j.molmet.2021.101166_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.molmet.2021.101166_bib4","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nm.3614","article-title":"A\u00a0Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice","volume":"20","author":"Oh da","year":"2014","journal-title":"Nature Medicine"},{"issue":"2","key":"10.1016\/j.molmet.2021.101166_bib5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbrc.2007.01.028","article-title":"The regulation of adipogenesis through GPR120","volume":"354","author":"Gotoh","year":"2007","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.molmet.2021.101166_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2016.06.009","article-title":"GPR120 promotes adipogenesis through intracellular calcium and extracellular signal-regulated kinase 1\/2 signal pathway","volume":"434","author":"Song","year":"2016","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"6","key":"10.1016\/j.molmet.2021.101166_bib7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.cell.2019.11.005","article-title":"Omega-3 fatty acids activate ciliary FFAR4 to control adipogenesis","volume":"179","author":"Hilgendorf","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2021.101166_bib8","doi-asserted-by":"crossref","first-page":"13479","DOI":"10.1038\/ncomms13479","article-title":"The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes","volume":"7","author":"Quesada-Lopez","year":"2016","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/j.molmet.2021.101166_bib9","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708047","article-title":"The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat","volume":"10","author":"Schilperoort","year":"2018","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.molmet.2021.101166_bib10","doi-asserted-by":"crossref","first-page":"101103","DOI":"10.1016\/j.molmet.2020.101103","article-title":"Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4\/GPR120 in WAT","author":"Husted","year":"2020","journal-title":"Molecular Metabolism"},{"issue":"7","key":"10.1016\/j.molmet.2021.101166_bib11","doi-asserted-by":"crossref","first-page":"pyw014","DOI":"10.1093\/ijnp\/pyw014","article-title":"Central agonism of GPR120 acutely inhibits food intake and food reward and chronically suppresses anxiety-like behavior in mice","volume":"19","author":"Auguste","year":"2016","journal-title":"International Journal of Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.molmet.2021.101166_bib12","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00541.2011","article-title":"Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice","volume":"303","author":"Lu","year":"2012","journal-title":"American Journal of Physiology - Gastrointestinal and Liver Physiology"},{"issue":"4","key":"10.1016\/j.molmet.2021.101166_bib13","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.molmet.2013.08.006","article-title":"Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells","volume":"2","author":"Engelstoft","year":"2013","journal-title":"Mol Metab"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib14","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1152\/ajpendo.00306.2013","article-title":"G\u00a0protein-coupled receptor 120 signaling regulates ghrelin secretion in\u00a0vivo and in\u00a0vitro","volume":"306","author":"Gong","year":"2014","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm1168","article-title":"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120","volume":"11","author":"Hirasawa","year":"2005","journal-title":"Nature Medicine"},{"issue":"3","key":"10.1016\/j.molmet.2021.101166_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1210\/en.2014-1653","article-title":"Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion","volume":"156","author":"Iwasaki","year":"2015","journal-title":"Endocrinology"},{"issue":"4\u20136","key":"10.1016\/j.molmet.2021.101166_bib17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00210-007-0200-8","article-title":"Free fatty acids induce cholecystokinin secretion through GPR120","volume":"377","author":"Tanaka","year":"2008","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"issue":"5","key":"10.1016\/j.molmet.2021.101166_bib18","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1210\/en.2017-00090","article-title":"Long-chain free fatty acid receptor GPR120 mediates oil-induced GIP secretion through CCK in male mice","volume":"158","author":"Sankoda","year":"2017","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.molmet.2021.101166_bib19","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1210\/EN.2015-1388","article-title":"Transcriptional and functional characterization of the G protein-coupled receptor repertoire of gastric somatostatin cells","volume":"156","author":"Egerod","year":"2015","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/CS20180836","article-title":"GPR120 protects lipotoxicity-induced pancreatic \u03b2 cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation","volume":"133","author":"Wang","year":"2019","journal-title":"Clinical Science"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cmet.2012.06.006","article-title":"A\u00a0systems genetics approach identifies genes and pathways for type 2 diabetes in human islets","volume":"16","author":"Taneera","year":"2012","journal-title":"Cell Metabolism"},{"issue":"11","key":"10.1016\/j.molmet.2021.101166_bib22","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/dom.12330","article-title":"Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic beta cells","volume":"16","author":"Moran","year":"2014","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"12","key":"10.1016\/j.molmet.2021.101166_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189060","article-title":"The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1","volume":"12","author":"Sundstrom","year":"2017","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.molmet.2021.101166_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/CS20160545","article-title":"Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states","volume":"131","author":"Zhang","year":"2017","journal-title":"Clinical Science"},{"key":"10.1016\/j.molmet.2021.101166_bib25","doi-asserted-by":"crossref","first-page":"105104","DOI":"10.1016\/j.ejps.2019.105104","article-title":"Pharmacological potential of novel agonists for FFAR4 on islet and enteroendocrine cell function and glucose homeostasis","volume":"142","author":"McCloskey","year":"2020","journal-title":"European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences"},{"key":"10.1016\/j.molmet.2021.101166_bib26","article-title":"Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion","author":"Wu","year":"2020","journal-title":"bioRxiv"},{"issue":"22","key":"10.1016\/j.molmet.2021.101166_bib27","doi-asserted-by":"crossref","first-page":"15751","DOI":"10.1074\/jbc.M114.568683","article-title":"Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion","volume":"289","author":"Suckow","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.molmet.2021.101166_bib28","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1007\/s00125-014-3213-0","article-title":"GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans","volume":"57","author":"Stone","year":"2014","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.molmet.2021.101166_bib29","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa157","article-title":"GPR120 regulates pancreatic polypeptide secretion from male mouse islets via PLC-mediated calcium mobilization","volume":"161","author":"Zhao","year":"2020","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.molmet.2021.101166_bib30","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1007\/s00125-016-4033-1","article-title":"Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets","volume":"59","author":"Adriaenssens","year":"2016","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.molmet.2021.101166_bib31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molmet.2016.04.007","article-title":"Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets","volume":"5","author":"DiGruccio","year":"2016","journal-title":"Mol Metab"},{"issue":"4","key":"10.1016\/j.molmet.2021.101166_bib32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2016.08.020","article-title":"Single cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes","volume":"24","author":"Segerstolpe","year":"2016","journal-title":"Cell Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2021.101166_bib33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2337\/db06-1532","article-title":"GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in\u00a0vivo","volume":"56","author":"Latour","year":"2007","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.molmet.2021.101166_bib34","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuron.2015.02.022","article-title":"Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance","volume":"85","author":"Madisen","year":"2015","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.molmet.2021.101166_bib35","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.celrep.2018.07.031","article-title":"Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits","volume":"24","author":"Muntean","year":"2018","journal-title":"Cell Reports"},{"issue":"3","key":"10.1016\/j.molmet.2021.101166_bib36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.molmet.2017.01.003","article-title":"High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting","volume":"6","author":"Ackermann","year":"2017","journal-title":"Mol Metab"},{"issue":"4","key":"10.1016\/j.molmet.2021.101166_bib37","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cmet.2017.03.017","article-title":"Virgin beta cells persist throughout Life at a neogenic niche within pancreatic islets","volume":"25","author":"van der Meulen","year":"2017","journal-title":"Cell Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2021.101166_bib38","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1124\/mol.113.087783","article-title":"The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4\/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism","volume":"84","author":"Hudson","year":"2013","journal-title":"Molecular Pharmacology"},{"issue":"2","key":"10.1016\/j.molmet.2021.101166_bib39","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2337\/db08-0792","article-title":"Somatostatin secreted by islet delta cells fulfills multiple roles as a paracrine regulator of islet function","volume":"58","author":"Hauge-Evans","year":"2009","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.molmet.2021.101166_bib40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cmet.2010.04.007","article-title":"GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis","volume":"11","author":"De Marinis","year":"2010","journal-title":"Cell Metabolism"},{"issue":"10","key":"10.1016\/j.molmet.2021.101166_bib41","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db17-1215","article-title":"Endogenous fatty acids are essential signaling factors of pancreatic \u03b2 cells and insulin secretion","volume":"67","author":"Hauke","year":"2018","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41467-017-02539-4","article-title":"20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1","volume":"9","author":"Tunaru","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.molmet.2021.101166_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fendo.2017.00131","article-title":"Somatostatin-IRES-cre mice: between knockout and wild-type?","volume":"8","author":"Viollet","year":"2017","journal-title":"Frontiers in Endocrinology"},{"issue":"16","key":"10.1016\/j.molmet.2021.101166_bib44","doi-asserted-by":"crossref","first-page":"8912","DOI":"10.1073\/pnas.2001936117","article-title":"Primary cilia control glucose homeostasis via islet paracrine interactions","volume":"117","author":"Hughes","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"9","key":"10.1016\/j.molmet.2021.101166_bib45","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1073\/pnas.85.9.3066","article-title":"Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin","volume":"85","author":"Fong","year":"1988","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.molmet.2021.101166_bib46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2016.07.020","article-title":"Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta cell function and survival","volume":"436","author":"Khan","year":"2016","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1210\/endo.141.1.7263","article-title":"Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in\u00a0vitro study of pancreatic islets from somatostatin receptor 2 knockout mice","volume":"141","author":"Strowski","year":"2000","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.molmet.2021.101166_bib48","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.2337\/db17-0880","article-title":"Somatostatin is only partly required for the glucagonostatic effect of glucose but is necessary for the glucagonostatic effect of K(ATP) channel blockers","volume":"67","author":"Lai","year":"2018","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.molmet.2021.101166_bib49","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41574-018-0020-6","article-title":"The somatostatin-secreting pancreatic \u03b4 cell in health and disease","volume":"14","author":"Rorsman","year":"2018","journal-title":"Nature Reviews Endocrinology"},{"issue":"3","key":"10.1016\/j.molmet.2021.101166_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13464","article-title":"In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion","volume":"229","author":"Xu","year":"2020","journal-title":"Acta Physiologica"},{"issue":"6","key":"10.1016\/j.molmet.2021.101166_bib51","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF01236274","article-title":"Streptozotocin diabetes: a glucoreceptor dysfunction affecting D cells as well as B and A cells","volume":"17","author":"Hermansen","year":"1979","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.molmet.2021.101166_bib52","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2337\/diab.30.7.590","article-title":"Islet secretion in a new experimental model for non-insulin-dependent diabetes","volume":"30","author":"Weir","year":"1981","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.molmet.2021.101166_bib53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1748-1716.1993.tb09551.x","article-title":"Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats","volume":"148","author":"Abdel-Halim","year":"1993","journal-title":"Acta Physiologica Scandinavica"},{"issue":"14","key":"10.1016\/j.molmet.2021.101166_bib54","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/j.febslet.2005.04.069","article-title":"SSTR5 ablation in islet results in alterations in glucose homeostasis in mice","volume":"579","author":"Wang","year":"2005","journal-title":"FEBS Letters"},{"issue":"11","key":"10.1016\/j.molmet.2021.101166_bib55","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1210\/en.2017-00639","article-title":"Regulation of endogenous (male) rodent GLP-1 secretion and human islet insulin secretion by antagonism of somatostatin receptor 5","volume":"158","author":"Farb","year":"2017","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101166_bib56","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2337\/db11-0690","article-title":"Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats","volume":"61","author":"Yue","year":"2012","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.molmet.2021.101166_bib57","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.2337\/db13-0164","article-title":"Somatostatin receptor type 2 antagonism improves glucagon counterregulation in biobreeding diabetic rats","volume":"62","author":"Karimian","year":"2013","journal-title":"Diabetes"},{"issue":"7389","key":"10.1016\/j.molmet.2021.101166_bib58","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature10798","article-title":"Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human","volume":"483","author":"Ichimura","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2021.101166_bib59","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab002","article-title":"Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice","author":"Croze","year":"2021","journal-title":"Endocrinology"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877821000065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877821000065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:23:20Z","timestamp":1761956600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877821000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":59,"alternative-id":["S2212877821000065"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2021.101166","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.17.208637","asserted-by":"object"}]},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2021.101166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101166"}}