{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:32:45Z","timestamp":1790703165482,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["19-05356Y"],"award-info":[{"award-number":["19-05356Y"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.molmet.2021.101324","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T02:25:00Z","timestamp":1629339900000},"page":"101324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["A pyrexic effect of FGF21 independent of energy expenditure and UCP1"],"prefix":"10.1016","volume":"53","author":[{"given":"Petr","family":"Zouhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Janovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Stanic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Bardova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Funda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanka","family":"Haberlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rossmeisl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kopecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nedergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2021.101324_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the Physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annual Review of Physiology"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1172\/JCI67353","article-title":"Interplay between FGF21 and insulin action in the liver regulates metabolism","volume":"124","author":"Emanuelli","year":"2014","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molmet.2012.08.007","article-title":"The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue","volume":"2","author":"Adams","year":"2012","journal-title":"Molecular Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/db08-0392","article-title":"Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.molmet.2021.101324_bib5","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast growth factor 21 corrects obesity in mice","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.molmet.2021.101324_bib6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cmet.2015.04.019","article-title":"Pharmacologic effects of FGF21 are independent of the \"browning\" of white adipose tissue","volume":"21","author":"Veniant","year":"2015","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2021.101324_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes & Development"},{"key":"10.1016\/j.molmet.2021.101324_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-444-63912-7.00001-1","article-title":"The thermoregulation system and how it works","volume":"156","author":"Romanovsky","year":"2018","journal-title":"Handbook of Clinical Neurology"},{"issue":"8","key":"10.1016\/j.molmet.2021.101324_bib9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrendo.2017.48","article-title":"Warming the mouse to model human diseases","volume":"13","author":"Ganeshan","year":"2017","journal-title":"Nature Reviews Endocrinology"},{"key":"10.1016\/j.molmet.2021.101324_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.molmet.2017.10.009","article-title":"Optimal housing temperatures for mice to mimic the thermal environment of humans: an experimental study","volume":"7","author":"Fischer","year":"2018","journal-title":"Mol Metab"},{"issue":"7","key":"10.1016\/j.molmet.2021.101324_bib11","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.celrep.2015.04.046","article-title":"Discrete aspects of FGF21 in\u00a0vivo pharmacology do not require UCP1","volume":"11","author":"Samms","year":"2015","journal-title":"Cell Reports"},{"issue":"6","key":"10.1016\/j.molmet.2021.101324_bib12","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.cmet.2018.04.001","article-title":"The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol","volume":"27","author":"Song","year":"2018","journal-title":"Cell Metabolism"},{"issue":"7","key":"10.1016\/j.molmet.2021.101324_bib13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.celrep.2016.01.041","article-title":"Leptin raises defended body temperature without activating thermogenesis","volume":"14","author":"Fischer","year":"2016","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/j.molmet.2021.101324_bib14","doi-asserted-by":"crossref","first-page":"R1396","DOI":"10.1152\/ajpregu.00021.2009","article-title":"Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice","volume":"299","author":"Meyer","year":"2010","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"issue":"6628","key":"10.1016\/j.molmet.2021.101324_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/387090a0","article-title":"Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese","volume":"387","author":"Enerback","year":"1997","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.molmet.2021.101324_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"109","author":"Weir","year":"1949","journal-title":"Journal of Physiology"},{"issue":"6","key":"10.1016\/j.molmet.2021.101324_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.molmet.2015.03.001","article-title":"Integration of body temperature into the analysis of energy expenditure in the mouse","volume":"4","author":"Abreu-Vieira","year":"2015","journal-title":"Mol Metab"},{"issue":"3","key":"10.1016\/j.molmet.2021.101324_bib18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ijo.2016.228","article-title":"Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype","volume":"41","author":"Flachs","year":"2017","journal-title":"International Journal of Obesity"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib19","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0003-2697(87)90587-2","article-title":"Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa","volume":"166","author":"Schagger","year":"1987","journal-title":"Analytical Biochemistry"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib20","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1152\/ajpendo.00253.2019","article-title":"UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia","volume":"318","author":"Zouhar","year":"2020","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2307\/1538741","article-title":"Heat regulation in some arctic and tropical mammals and birds","volume":"99","author":"Scholander","year":"1950","journal-title":"Biology Bulletin"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib22","doi-asserted-by":"crossref","first-page":"E202","DOI":"10.1152\/ajpendo.00093.2016","article-title":"No insulating effect of obesity","volume":"311","author":"Fischer","year":"2016","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1086\/physzool.53.2.30152577","article-title":"On estimating thermal conductance in endotherms","volume":"53","author":"Mcnab","year":"1980","journal-title":"Physiological Zoology"},{"issue":"12","key":"10.1016\/j.molmet.2021.101324_bib24","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1002\/j.1460-2075.1991.tb04940.x","article-title":"Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes","volume":"10","author":"Nahmias","year":"1991","journal-title":"The EMBO Journal"},{"issue":"7","key":"10.1016\/j.molmet.2021.101324_bib25","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0003-9993(94)90143-0","article-title":"Fever of central origin in traumatic brain injury controlled with propranolol","volume":"75","author":"Meythaler","year":"1994","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"issue":"5","key":"10.1016\/j.molmet.2021.101324_bib26","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.bbalip.2013.01.009","article-title":"UCP1 mRNA does not produce heat","volume":"1831","author":"Nedergaard","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"10.1016\/j.molmet.2021.101324_bib27","doi-asserted-by":"crossref","first-page":"E515","DOI":"10.1152\/ajpendo.00097.2017","article-title":"Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice","volume":"313","author":"von Essen","year":"2017","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2008.12.014","article-title":"UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality","volume":"9","author":"Feldmann","year":"2009","journal-title":"Cell Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00394-015-0834-0","article-title":"Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers","volume":"55","author":"Bargut","year":"2016","journal-title":"European Journal of Nutrition"},{"issue":"11","key":"10.1016\/j.molmet.2021.101324_bib30","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/ijo.2015.112","article-title":"The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue","volume":"39","author":"Garcia-Ruiz","year":"2015","journal-title":"International Journal of Obesity"},{"issue":"3","key":"10.1016\/j.molmet.2021.101324_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1474-9726.2005.00157.x","article-title":"UCP1 deficiency increases susceptibility to diet-induced obesity with age","volume":"4","author":"Kontani","year":"2005","journal-title":"Aging Cell"},{"issue":"7","key":"10.1016\/j.molmet.2021.101324_bib32","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/oby.21542","article-title":"Sarcolipin and uncoupling protein 1 play distinct roles in diet-induced thermogenesis and do not compensate for one another","volume":"24","author":"Rowland","year":"2016","journal-title":"Obesity"},{"issue":"5","key":"10.1016\/j.molmet.2021.101324_bib33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0031-9384(90)90025-Y","article-title":"Thermal biology of the laboratory rat","volume":"47","author":"Gordon","year":"1990","journal-title":"Physiology & Behavior"},{"issue":"40","key":"10.1016\/j.molmet.2021.101324_bib34","doi-asserted-by":"crossref","first-page":"16241","DOI":"10.1073\/pnas.1310300110","article-title":"Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor alpha1","volume":"110","author":"Warner","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"3","key":"10.1016\/j.molmet.2021.101324_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4161\/adip.28815","article-title":"Brown fat and vascular heat dissipation: the new cautionary tail","volume":"3","author":"Warner","year":"2014","journal-title":"Adipocyte"},{"issue":"6","key":"10.1016\/j.molmet.2021.101324_bib36","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1210\/en.2016-1951","article-title":"3-Iodothyronamine induces tail vasodilation through central action in male mice","volume":"158","author":"Gachkar","year":"2017","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1210\/en.2010-1262","article-title":"Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance","volume":"153","author":"Hale","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib38","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41598-018-37198-y","article-title":"Liver derived FGF21 maintains core body temperature during acute cold exposure","volume":"9","author":"Ameka","year":"2019","journal-title":"Scientific Reports"},{"issue":"5315","key":"10.1016\/j.molmet.2021.101324_bib39","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.276.5315.1132","article-title":"On raising energy expenditure in ob\/ob mice","volume":"276","author":"Himms-Hagen","year":"1997","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2337\/db09-1471","article-title":"A\u00a0recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes","volume":"59","author":"Butler","year":"2010","journal-title":"Diabetes"},{"issue":"Pt 2","key":"10.1016\/j.molmet.2021.101324_bib41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1242\/jeb.050989","article-title":"Nonshivering thermogenesis and its adequate measurement in metabolic studies","volume":"214","author":"Cannon","year":"2011","journal-title":"Journal of Experimental Biology"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.1806","article-title":"A\u00a0guide to analysis of mouse energy metabolism","volume":"9","author":"Tschop","year":"2011","journal-title":"Nature Methods"},{"issue":"28","key":"10.1016\/j.molmet.2021.101324_bib43","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1073\/pnas.1006962107","article-title":"Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway","volume":"107","author":"Chau","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"4","key":"10.1016\/j.molmet.2021.101324_bib44","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cmet.2017.03.005","article-title":"FGF21 regulates metabolism through adipose-dependent and -independent mechanisms","volume":"25","author":"BonDurant","year":"2017","journal-title":"Cell Metabolism"},{"issue":"7","key":"10.1016\/j.molmet.2021.101324_bib45","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1210\/en.2014-2001","article-title":"Central fibroblast growth factor 21 Browns white fat via sympathetic action in male mice","volume":"156","author":"Douris","year":"2015","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.molmet.2021.101324_bib46","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cmet.2014.07.012","article-title":"FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss","volume":"20","author":"Owen","year":"2014","journal-title":"Cell Metabolism"},{"issue":"8","key":"10.1016\/j.molmet.2021.101324_bib47","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.celrep.2015.10.021","article-title":"FGF21-Mediated improvements in glucose clearance require uncoupling protein 1","volume":"13","author":"Kwon","year":"2015","journal-title":"Cell Reports"},{"issue":"11","key":"10.1016\/j.molmet.2021.101324_bib48","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.molmet.2017.09.003","article-title":"FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1\/betaKlotho complex in non-adipocytes","volume":"6","author":"Chen","year":"2017","journal-title":"Molecular Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2021.101324_bib49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.molmet.2015.06.008","article-title":"FGF21, energy expenditure and weight loss - how much brown fat do you need?","volume":"4","author":"Straub","year":"2015","journal-title":"Molecular Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2021.101324_bib50","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2015.05.018","article-title":"The sum of all browning in FGF21 therapeutics","volume":"21","author":"Lee","year":"2015","journal-title":"Cell Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2021.101324_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuron.2018.02.022","article-title":"Regulation of body temperature by the nervous system","volume":"98","author":"Tan","year":"2018","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.molmet.2021.101324_bib52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2020.06.008","article-title":"FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake","volume":"32","author":"Jensen-Cody","year":"2020","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2021.101324_bib53","doi-asserted-by":"crossref","first-page":"45819","DOI":"10.1038\/srep45819","article-title":"Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2\/Nesfatin-1 neurons to produce satiety under fed states","volume":"7","author":"Santoso","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.molmet.2021.101324_bib54","article-title":"Thermogenic recruitment of brown and brite\/beige adipose tissues is not obligatorily associated with macrophage accretion or attrition","author":"Boulet","year":"2020","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.molmet.2021.101324_bib55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.biochi.2017.01.007","article-title":"UCP1 in adipose tissues: two steps to full browning","volume":"134","author":"Kalinovich","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.molmet.2021.101324_bib56","doi-asserted-by":"crossref","first-page":"11382","DOI":"10.1038\/srep11382","article-title":"FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance","volume":"5","author":"Bernardo","year":"2015","journal-title":"Scientific Reports"},{"issue":"11","key":"10.1016\/j.molmet.2021.101324_bib57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/BF01114893","article-title":"Responses to cafeteria feeding in mice after the removal of interscapular brown adipose tissue","volume":"2","author":"Connolly","year":"1982","journal-title":"Bioscience Reports"},{"issue":"2 Pt 2","key":"10.1016\/j.molmet.2021.101324_bib58","first-page":"R253","article-title":"Surgical removal of brown fat results in rapid and complete compensation by other depots","volume":"257","author":"Rothwell","year":"1989","journal-title":"American Journal of Physiology"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287782100171X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221287782100171X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:27:59Z","timestamp":1761956879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221287782100171X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":58,"alternative-id":["S221287782100171X"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2021.101324","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pyrexic effect of FGF21 independent of energy expenditure and UCP1","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2021.101324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101324"}}