{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:19:13Z","timestamp":1786994353857,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1116"],"award-info":[{"award-number":["SFB1116"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2576"],"award-info":[{"award-number":["GRK2576"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1118"],"award-info":[{"award-number":["SFB1118"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1118"],"award-info":[{"award-number":["CRC1118"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009318","name":"Helmholtz Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.molmet.2022.101487","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T21:46:50Z","timestamp":1648849610000},"page":"101487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function"],"prefix":"10.1016","volume":"60","author":[{"given":"Gretchen","family":"Wolff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Mhamane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Troullinaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Maida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis K.","family":"Deligiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Morgenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Wieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathi","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Zeigerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bl\u00fcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Poth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Hackert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Wiedmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Angelis Rigotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rodriguez-Vita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Mukthavaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattraranee","family":"Limphong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Tachikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Karmali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmanabh","family":"Chivukula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilgen","family":"Ekim-\u00dcst\u00fcnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia P.","family":"Martinez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Szendr\u00f6di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nawroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2022.101487_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-020-1116-9","article-title":"Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes","author":"Wagner","year":"2021","journal-title":"Natura Med"},{"issue":"1","key":"10.1016\/j.molmet.2022.101487_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrgastro.2016.147","article-title":"NAFLD and diabetes mellitus","volume":"14","author":"Tilg","year":"2017","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"8","key":"10.1016\/j.molmet.2022.101487_bib3","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.cmet.2021.06.005","article-title":"Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication","volume":"33","author":"Loft","year":"2021","journal-title":"Cell Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2022.101487_bib4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/hep.26698","article-title":"Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice","volume":"59","author":"Yang","year":"2014","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.molmet.2022.101487_bib5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1432-1033.1996.460rr.x","article-title":"Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter","volume":"242","author":"Ohta","year":"1996","journal-title":"European Journal of Biochemistry"},{"issue":"4","key":"10.1016\/j.molmet.2022.101487_bib6","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1567-1364.2008.00367.x","article-title":"A\u00a0TSC22-like motif defines a novel antiapoptotic protein family","volume":"8","author":"Khoury","year":"2008","journal-title":"FEMS Yeast Research"},{"issue":"9","key":"10.1016\/j.molmet.2022.101487_bib7","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Natura Med"},{"issue":"1","key":"10.1016\/j.molmet.2022.101487_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1742-4658.2006.05569.x","article-title":"Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress","volume":"274","author":"Fiol","year":"2007","journal-title":"FEBS Journal"},{"issue":"1","key":"10.1016\/j.molmet.2022.101487_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12311-010-0211-8","article-title":"Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse\u00a0depends on development and differentiation","volume":"11","author":"Canterini","year":"2012","journal-title":"The Cerebellum"},{"issue":"2","key":"10.1016\/j.molmet.2022.101487_bib10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/emmm.201201869","article-title":"TSC22D4 is a molecular output of hepatic wasting metabolism","volume":"5","author":"Jones","year":"2013","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.molmet.2022.101487_bib11","doi-asserted-by":"crossref","first-page":"13267","DOI":"10.1038\/ncomms13267","article-title":"Control of diabetic hyperglycaemia and insulin resistance through TSC22D4","volume":"7","author":"Ekim Ustunel","year":"2016","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/j.molmet.2022.101487_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00795-013-0016-1","article-title":"A\u00a0murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma","volume":"46","author":"Fujii","year":"2013","journal-title":"Medical Molecular Morphology"},{"issue":"10","key":"10.1016\/j.molmet.2022.101487_bib13","doi-asserted-by":"crossref","first-page":"E1941","DOI":"10.1073\/pnas.1619653114","article-title":"Systemic delivery of factor IX messenger RNA for protein replacement therapy","volume":"114","author":"Ramaswamy","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"21","key":"10.1016\/j.molmet.2022.101487_bib14","doi-asserted-by":"crossref","first-page":"12992","DOI":"10.1021\/acs.jmedchem.0c01407","article-title":"Property-driven design and development of lipids for efficient delivery of siRNA","volume":"63","author":"Rajappan","year":"2020","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"10.1016\/j.molmet.2022.101487_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A\u00a0simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.molmet.2022.101487_bib16","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.molmet.2022.101487_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.molmet.2022.101487_bib18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2022.101487_bib19","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2337\/dc17-1318","article-title":"Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis","volume":"41","author":"Apostolopoulou","year":"2018","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.molmet.2022.101487_bib20","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1055\/s-0042-123039","article-title":"Diabetes-associated biobanking: more topical than ever?","volume":"125","author":"Lydia Kynast","year":"2017","journal-title":"Experimental and Clinical Endocrinology & Diabetes"},{"key":"10.1016\/j.molmet.2022.101487_bib21","doi-asserted-by":"crossref","first-page":"101353","DOI":"10.1016\/j.molmet.2021.101353","article-title":"STE20-type kinase TAOK3 regulates hepatic lipid partitioning","volume":"54","author":"Xia","year":"2021","journal-title":"Molecular Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2022.101487_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nprot.2016.015","article-title":"Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons","volume":"11","author":"Krishnaswami","year":"2016","journal-title":"Nature Protocols"},{"issue":"1","key":"10.1016\/j.molmet.2022.101487_bib23","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41467-021-24543-5","article-title":"Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy","volume":"12","author":"Richter","year":"2021","journal-title":"Nature Communications"},{"issue":"6","key":"10.1016\/j.molmet.2022.101487_bib24","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/cyto.a.22865","article-title":"A\u00a0rapid method to verify single-cell deposition setup for cell sorters","volume":"89","author":"Rodrigues","year":"2016","journal-title":"Cytometry, Part A"},{"issue":"7316","key":"10.1016\/j.molmet.2022.101487_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09414","article-title":"The ploidy conveyor of mature hepatocytes as a source of genetic variation","volume":"467","author":"Duncan","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.molmet.2022.101487_bib26","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/2211068216630741","article-title":"Miniaturization Technologies for efficient single-cell library preparation for next-generation sequencing","volume":"21","author":"Mora-Castilla","year":"2016","journal-title":"Journal of Laboratory Automation"},{"issue":"10","key":"10.1016\/j.molmet.2022.101487_bib27","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s42255-019-0124-x","article-title":"Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity","volume":"1","author":"Seitz","year":"2019","journal-title":"Nat Metab"},{"issue":"8","key":"10.1016\/j.molmet.2022.101487_bib28","first-page":"1315","article-title":"Recent advances in 2D and 3D in\u00a0vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME","volume":"87","author":"Godoy","year":"2013","journal-title":"Archiv f\u00fcr Toxikologie"},{"issue":"1 Suppl","key":"10.1016\/j.molmet.2022.101487_bib29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Labaratory Animals"},{"issue":"5","key":"10.1016\/j.molmet.2022.101487_bib30","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s10620-015-3977-1","article-title":"Animal models of nonalcoholic steatohepatitis: eat, delete, and inflame","volume":"61","author":"Ibrahim","year":"2016","journal-title":"Digestive Diseases and Sciences"},{"issue":"5","key":"10.1016\/j.molmet.2022.101487_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127991","article-title":"Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease","volume":"10","author":"Machado","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.molmet.2022.101487_bib32","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2009.11.030","article-title":"Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model","volume":"52","author":"Rector","year":"2010","journal-title":"Journal of Hepatology"},{"issue":"11","key":"10.1016\/j.molmet.2022.101487_bib33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrgastro.2013.149","article-title":"From NAFLD to NASH to cirrhosis-new insights into disease mechanisms","volume":"10","author":"Wree","year":"2013","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"1","key":"10.1016\/j.molmet.2022.101487_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2022.101487_bib35","doi-asserted-by":"crossref","first-page":"101143","DOI":"10.1016\/j.molmet.2020.101143","article-title":"Metabolic drivers of non-alcoholic fatty liver disease","volume":"50","author":"Bence","year":"2021","journal-title":"Molecular Metabolism"},{"issue":"9","key":"10.1016\/j.molmet.2022.101487_bib36","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.molmet.2022.101487_bib37","doi-asserted-by":"crossref","first-page":"693507","DOI":"10.3389\/fmed.2021.693507","article-title":"NAFLD or MAFLD: which has closer association with all-cause and cause-specific mortality?-results from NHANES III","volume":"8","author":"Huang","year":"2021","journal-title":"Frontiers of Medicine"},{"key":"10.1016\/j.molmet.2022.101487_bib38","doi-asserted-by":"crossref","first-page":"101238","DOI":"10.1016\/j.molmet.2021.101238","article-title":"Metabolic-associated fatty liver disease and lipoprotein metabolism","volume":"50","author":"Heeren","year":"2021","journal-title":"Molecular Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2022.101487_bib39","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s40618-017-0799-3","article-title":"NAFLD\/NASH in patients with type 2 diabetes and related\u00a0treatment options","volume":"41","author":"Radaelli","year":"2018","journal-title":"Journal of Endocrinological Investigation"},{"issue":"5","key":"10.1016\/j.molmet.2022.101487_bib40","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/febs.12123","article-title":"Multiple TSC22D4 iso-\/phospho-glycoforms display idiosyncratic subcellular localizations and interacting protein partners","volume":"280","author":"Canterini","year":"2013","journal-title":"FEBS Journal"},{"issue":"4","key":"10.1016\/j.molmet.2022.101487_bib41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2006.03.032","article-title":"A\u00a0protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration","volume":"125","author":"Lim","year":"2006","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.molmet.2022.101487_bib42","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1152\/physrev.00015.2017","article-title":"Interorgan metabolic crosstalk in human insulin resistance","volume":"98","author":"Gancheva","year":"2018","journal-title":"Physiological Reviews"},{"issue":"2","key":"10.1016\/j.molmet.2022.101487_bib43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/ars.2010.3395","article-title":"Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice","volume":"15","author":"Eccleston","year":"2011","journal-title":"Antioxidants and Redox Signaling"},{"key":"10.1016\/j.molmet.2022.101487_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biocel.2017.12.019","article-title":"Mitochondria in non-alcoholic fatty liver disease","volume":"95","author":"Simoes","year":"2018","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"7","key":"10.1016\/j.molmet.2022.101487_bib45","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/labinvest.2011.55","article-title":"Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice","volume":"91","author":"Aharoni-Simon","year":"2011","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.molmet.2022.101487_bib46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.redox.2017.11.016","article-title":"Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression","volume":"15","author":"Bellanti","year":"2018","journal-title":"Redox Biology"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877822000564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877822000564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:12:15Z","timestamp":1778523135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877822000564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":46,"alternative-id":["S2212877822000564"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2022.101487","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.17.473222","asserted-by":"object"}]},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2022.101487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101487"}}