{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:32:01Z","timestamp":1790775121938,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.molmet.2022.101611","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T02:13:40Z","timestamp":1665195220000},"page":"101611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice"],"prefix":"10.1016","volume":"66","author":[{"given":"Eliza","family":"Bollinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Peloquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Libera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanthia","family":"Pashos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Shipstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hadjipanayis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Clasquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Stansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Parker","family":"Siddall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Greizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Geoly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily C.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Steppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Filipski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei B.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2754-828X","authenticated-orcid":false,"given":"Rachel J.","family":"Roth Flach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.molmet.2022.101611_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A\u00a0branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2022.101611_bib2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"Wang","year":"2011","journal-title":"Nature Medicine"},{"issue":"11","key":"10.1016\/j.molmet.2022.101611_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002179","article-title":"Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis","volume":"13","author":"Lotta","year":"2016","journal-title":"PLoS Medicine"},{"issue":"12","key":"10.1016\/j.molmet.2022.101611_bib4","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.2337\/db13-0570","article-title":"Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach","volume":"62","author":"Menni","year":"2013","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.molmet.2022.101611_bib5","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.2337\/db18-0927","article-title":"Targeting BCAA catabolism to treat obesity-associated insulin resistance","volume":"68","author":"Zhou","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2022.101611_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ebiom.2017.12.008","article-title":"Elevated plasma levels of 3-hydroxyisobutyric acid are associated with incident type 2 diabetes","volume":"27","author":"Mardinoglu","year":"2018","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.molmet.2022.101611_bib7","first-page":"1022","article-title":"Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach","volume":"7","author":"Lai","year":"2014","journal-title":"Circulation: Heart Failure"},{"issue":"21","key":"10.1016\/j.molmet.2022.101611_bib8","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/CIRCULATIONAHA.115.020226","article-title":"Catabolic defect of branched-chain amino acids promotes heart failure","volume":"133","author":"Sun","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.molmet.2022.101611_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12933-019-0892-3","article-title":"Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure","volume":"18","author":"Uddin","year":"2019","journal-title":"Cardiovascular Diabetology"},{"issue":"5","key":"10.1016\/j.molmet.2022.101611_bib10","doi-asserted-by":"crossref","first-page":"H1160","DOI":"10.1152\/ajpheart.00114.2016","article-title":"Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction","volume":"311","author":"Wang","year":"2016","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"issue":"2","key":"10.1016\/j.molmet.2022.101611_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cmet.2016.11.005","article-title":"Defective branched-chain amino acid catabolism disrupts glucose metabolism and sensitizes the heart to ischemia-reperfusion injury","volume":"25","author":"Li","year":"2017","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2022.101611_bib12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00726-014-1894-9","article-title":"Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease","volume":"47","author":"Lake","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.molmet.2022.101611_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3389\/fendo.2020.00534","article-title":"Adverse outcomes in obese cardiac surgery patients correlates with altered branched-chain amino acid catabolism in adipose tissue and heart","volume":"11","author":"Biswas","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"key":"10.1016\/j.molmet.2022.101611_bib14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-physiol-020518-114455","article-title":"Branched chain amino acids","volume":"81","author":"Neinast","year":"2019","journal-title":"Annual Review of Physiology"},{"issue":"12","key":"10.1016\/j.molmet.2022.101611_bib15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nature Reviews Endocrinology"},{"issue":"8","key":"10.1016\/j.molmet.2022.101611_bib16","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1096\/fj.201802842RR","article-title":"Role of branched-chain amino acid-catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis","volume":"33","author":"Biswas","year":"2019","journal-title":"The FASEB Journal"},{"issue":"6","key":"10.1016\/j.molmet.2022.101611_bib17","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1172\/JCI38151","article-title":"Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells","volume":"119","author":"Lu","year":"2009","journal-title":"Journal of Clinical Investigation"},{"issue":"7","key":"10.1016\/j.molmet.2022.101611_bib18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/d41573-021-00107-6","article-title":"BCKDK: an emerging kinase target for metabolic diseases and cancer","volume":"20","author":"East","year":"2021","journal-title":"Nature Reviews Drug Discovery"},{"issue":"2","key":"10.1016\/j.molmet.2022.101611_bib19","doi-asserted-by":"crossref","first-page":"E216","DOI":"10.1152\/ajpendo.00334.2019","article-title":"Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats","volume":"318","author":"McGarrah","year":"2020","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.molmet.2022.101611_bib20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.celrep.2016.05.092","article-title":"Decreased consumption of branched-chain amino acids improves metabolic health","volume":"16","author":"Fontana","year":"2016","journal-title":"Cell Reports"},{"issue":"6","key":"10.1016\/j.molmet.2022.101611_bib21","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cmet.2018.04.015","article-title":"The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase","volume":"27","author":"White","year":"2018","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/j.molmet.2022.101611_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2007.08.003","article-title":"Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle","volume":"6","author":"She","year":"2007","journal-title":"Cell Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2022.101611_bib23","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/ajcn\/nqz191","article-title":"Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial","volume":"110","author":"Karusheva","year":"2019","journal-title":"American Journal of Clinical Nutrition"},{"issue":"7","key":"10.1016\/j.molmet.2022.101611_bib24","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.molmet.2016.04.006","article-title":"Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export","volume":"5","author":"White","year":"2016","journal-title":"Molecular Metabolism"},{"issue":"4","key":"10.1016\/j.molmet.2022.101611_bib25","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1113\/JP275075","article-title":"Restoration of metabolic health by decreased consumption of branched-chain amino acids","volume":"596","author":"Cummings","year":"2018","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.molmet.2022.101611_bib26","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3389\/fphys.2019.01140","article-title":"BCAA catabolic defect alters glucose metabolism in lean mice","volume":"10","author":"Wang","year":"2019","journal-title":"Frontiers in Physiology"},{"issue":"7","key":"10.1016\/j.molmet.2022.101611_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160447","article-title":"A\u00a0spontaneous missense mutation in branched chain keto acid dehydrogenase kinase in the rat affects both the central and peripheral nervous systems","volume":"11","author":"Zigler","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.molmet.2022.101611_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/BJ20060869","article-title":"Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice","volume":"400","author":"Joshi","year":"2006","journal-title":"Biochemical Journal"},{"issue":"24","key":"10.1016\/j.molmet.2022.101611_bib29","doi-asserted-by":"crossref","first-page":"9728","DOI":"10.1073\/pnas.1303220110","article-title":"Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase","volume":"110","author":"Tso","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"issue":"30","key":"10.1016\/j.molmet.2022.101611_bib30","doi-asserted-by":"crossref","first-page":"20583","DOI":"10.1074\/jbc.M114.569251","article-title":"Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain alpha-ketoacid dehydrogenase kinase","volume":"289","author":"Tso","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.molmet.2022.101611_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2018.10.013","article-title":"Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids","volume":"29","author":"Neinast","year":"2019","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.molmet.2022.101611_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12864-015-2356-9","article-title":"QuickRNASeq lifts large-scale RNA-seq data analyses to the next level of automation and interactive visualization","volume":"17","author":"Zhao","year":"2016","journal-title":"BMC Genomics"},{"issue":"12","key":"10.1016\/j.molmet.2022.101611_bib33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biology"},{"issue":"4","key":"10.1016\/j.molmet.2022.101611_bib34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.molmet.2022.101611_bib35","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.cell.2022.04.002","article-title":"Nutrition, longevity and disease: from molecular mechanisms to interventions","volume":"185","author":"Longo","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2022.101611_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/hep.29465","article-title":"Altered amino acid concentrations in NAFLD: impact of obesity and insulin resistance","volume":"67","author":"Gaggini","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.molmet.2022.101611_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"International Journal of Experimental Pathology"},{"issue":"1","key":"10.1016\/j.molmet.2022.101611_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030668","article-title":"LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease","volume":"7","author":"Bieghs","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.molmet.2022.101611_bib39","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metabolism"},{"issue":"46","key":"10.1016\/j.molmet.2022.101611_bib40","doi-asserted-by":"crossref","first-page":"15597","DOI":"10.1074\/jbc.RA120.013121","article-title":"Branched-chain ketoacid overload inhibits insulin action in the muscle","volume":"295","author":"Biswas","year":"2020","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/j.molmet.2022.101611_bib41","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cmet.2021.03.025","article-title":"The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine","volume":"33","author":"Yu","year":"2021","journal-title":"Cell Metabolism"},{"issue":"10","key":"10.1016\/j.molmet.2022.101611_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101072","article-title":"Animal models of nonalcoholic fatty liver disease-A starter's guide","volume":"9","author":"Van Herck","year":"2017","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.molmet.2022.101611_bib43","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"Journal of Hepatology"},{"issue":"12","key":"10.1016\/j.molmet.2022.101611_bib44","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.7150\/thno.44836","article-title":"Branched chain amino acids exacerbate myocardial ischemia\/reperfusion vulnerability via enhancing GCN2\/ATF6\/PPAR-alpha pathway-dependent fatty acid oxidation","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.molmet.2022.101611_bib45","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41589-018-0132-2","article-title":"Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues","volume":"14","author":"Wallace","year":"2018","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/j.molmet.2022.101611_bib46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2021.04.005","article-title":"Branched chain amino acids selectively promote cardiac growth at the end of the awake period","volume":"157","author":"Latimer","year":"2021","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"1","key":"10.1016\/j.molmet.2022.101611_bib47","doi-asserted-by":"crossref","first-page":"109336","DOI":"10.1016\/j.celrep.2021.109336","article-title":"Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock","volume":"36","author":"Aoyama","year":"2021","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/j.molmet.2022.101611_bib48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF03256872","article-title":"Advances in gene delivery systems","volume":"25","author":"Kamimura","year":"2011","journal-title":"Pharmaceutical Medicine"},{"issue":"7771","key":"10.1016\/j.molmet.2022.101611_bib49","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41586-019-1503-x","article-title":"BCAA catabolism in brown fat controls energy homeostasis through SLC25A44","volume":"572","author":"Yoneshiro","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.molmet.2022.101611_bib50","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s42255-021-00520-6","article-title":"BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16","volume":"4","author":"Ma","year":"2022","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.molmet.2022.101611_bib51","doi-asserted-by":"crossref","first-page":"111813","DOI":"10.1016\/j.ejmech.2019.111813","article-title":"Structural attributes influencing unbound tissue distribution","volume":"185","author":"Orozco","year":"2020","journal-title":"European Journal of Medicinal Chemistry"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877822001806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877822001806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:31:49Z","timestamp":1761957109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877822001806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":51,"alternative-id":["S2212877822001806"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2022.101611","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2022.101611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101611"}}